The association between the ratio of visceral fat to thigh muscle area and metabolic syndrome: the Korean Sarcopenic Obesity Study (KSOS)
Abstract
Summary: Objective A relationship between visceral fat accumulation and metabolic syndrome (MetS) has been established. However, the effect of a relative increase in visceral fat and a decrease in muscle mass on metabolic disorders has not been investigated. The aim of the present study was to examine the association between the ratio of visceral fat to thigh muscle area (VMR) and MetS in Korean adults. Study subject/measurements A total of 264 age‐and gender‐matched subjects recruited from the Korean Sarcopenic Obesity Study (KSOS), an ongoing prospective observational cohort study, were categorized into four groups based on their body mass index (BMI) and VMR. We measured visceral fat area and thigh muscle area using computed tomography. Results Subjects with MetS showed a significantly higher VMR than those without MetS. In both obese and nonobese groups, the subjects with a higher VMR had a higher prevalence of MetS than those in the lower VMR groups. VMR was significantly related to components of the metabolic syndrome, especially in women, and was positively correlated with a number of MetS components in both men and women. In multiple logistic regression analysis, the odds ratio for MetS was 6·72 (highest vs lowest quartile, 95% confidence interval, 1·60–28·14) after an adjustment of potential confounders, including BMI and waist‐to‐hip ratio. Conclusion VMR is significantly increased in subjects with MetS and independently associated with MetS. These results suggest that the VMR may be a potential indicator for MetS risk in Korean adults.
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Two studies used the fat mass to fat-free mass ratio or the visceral adipose tissue area to thigh muscle area ratio to identify sarcopenic obesity.
“Two studies used the FM to FFM or the visceral adipose tissue area to thigh muscle area ratios to identify cases of sarcopenic obesity [41,70].”
From Critical appraisal of definitions and diagnostic criteria for sarcopenic obesity based on a systematic review (2020) · cites this paper as [70]
Similar results were found in the K-NHANES and sarcopenic obesity cohorts in East Asia, where visceral adipose tissue and thigh muscle ratios from CT scans were used.
“Similar results were found in the K-NHANES and the sarcopenic obesity cohorts in East Asia, where visceral adipose tissue and thigh muscle ratios from CT scans were used [63,70].”
From Critical appraisal of definitions and diagnostic criteria for sarcopenic obesity based on a systematic review (2020) · cites this paper as [70]
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- Authors
- Lim, K. I., Yang, S. J., Kim, T. N., Yoo, H. J., Kang, H. J., Song, W., Baik, S. H., Choi, D. S., & Choi, K. M.
- Affiliations
- Korea University (KR)
- Seoul National University (KR)
- Corresponding author
- Choi, D. S.
- Choi, K. M.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2010-07-02
- Volume
- 73
- Issue
- 5
- Pages
- 588-594
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W1782400544
- Cited by
- 82
- References
- 26
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 8 · 2020: 7 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 8 · 2012: 11
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Korea Science and Engineering Foundation
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Keywords
- visceral fat, thigh muscle area, metabolic syndrome, sarcopenic obesity, visceral fat accumulation, muscle mass, obesity, sex differences, Korean adults
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Obesity, Prospective Studies, Cohort Studies, Body Mass Index, Muscle, Skeletal, Metabolic Syndrome, Asian People, Intra-Abdominal Fat, Sarcopenia, Republic of Korea
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