The Cardiometabolic Syndrome and Sarcopenic Obesity in Older Persons
Abstract
The aging of the world's population is a major contributor to the growing prevalence of the cardiometabolic syndrome (CMS) because older persons are more affected by the constellation of cardiovascular risk factors that constitute the syndrome. The prevalence of CMS has been related to the increasing prevalence of obesity, which is growing progressively even among older age groups. Indeed, obesity and aging are 2 overlapping mounting public health problems. It is currently accepted that CMS predicts cardiovascular mortality and/or the development of type 2 diabetes mellitus, and this is also true in studies including older persons. CMS is further complicated by modifications in body composition and fat redistribution during aging; older adults are at higher risk for developing central obesity and sarcopenia or sarcopenic obesity, a condition characterized by an important reduction in lean body mass associated with obesity, linked to an increased production of inflammatory adipokines that may alter insulin sensitivity and muscle mass and strength. A better understanding of the pathophysiologic mechanisms of sarcopenic obesity may help to elucidate the complex relationship between CMS and mortality/morbidity in older adults.
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Loss of muscle mass leads to less insulin-responsive target tissue, resulting in a severe condition of insulin resistance.
“On the other hand, the loss of muscle mass leads to less insulin-responsive target tissue, resulting in a severe condition of insulin resistance (12, 13).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [12]
Cites
Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) · JAMA · doi:10.1001/jama.287.3.356 · Cited by 6,698 · see citing works
Eckel, R. H., Alberti, K., Grundy, S. M., & Zimmet, P. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61794-3 · Cited by 6,283 · see citing works
Prevalence and trends in obesity among US adults, 1999–2000
Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190 · see citing works
Eckel, R. H., Grundy, S. M., & Zimmet, P. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66378-7 · Cited by 5,565 · see citing works
Exercise capacity and mortality among men referred for exercise testing
Myers, J., Prakash, M., Froelicher, V., Do, D., Partington, S., & Atwood, J. E. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011858 · Cited by 4,114 · see citing works
Body-Mass Index and Mortality in a Prospective Cohort of U.S. Adults
Calle, E. E., Thun, M. J., Petrelli, J. M., Rodriguez, C., & Heath, C. W. (1999) · New England Journal of Medicine · doi:10.1056/nejm199910073411501 · Cited by 3,643 · see citing works
Adipocytokines: mediators linking adipose tissue, inflammation and immunity
Tilg, H., & Moschen, A. R. (2006) · Nature reviews. Immunology · doi:10.1038/nri1937 · Cited by 3,195 · see citing works
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107 · see citing works
Increasing Prevalence of the Metabolic Syndrome Among U.S. Adults
Ford, E. S., Giles, W. H., & Mokdad, A. H. (2004) · Diabetes Care · doi:10.2337/diacare.27.10.2444 · Cited by 1,488 · see citing works
Visceral fat adipokine secretion is associated with systemic inflammation in obese humans
Fontana, L., Eagon, J. C., Trujillo, M. E., Scherer, P. E., & Klein, S. (2007) · Diabetes · doi:10.2337/db06-1656 · Cited by 1,417 · see citing works
Prentice, A. M., & Jebb, S. A. (2001) · Obesity Reviews · doi:10.1046/j.1467-789x.2001.00031.x · Cited by 1,267 · see citing works
Metabolic Syndrome and Risk of Cardiovascular Disease: A Meta-Analysis
Galassi, A., Reynolds, K., & He, J. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.02.031 · Cited by 1,205 · see citing works
Body Composition in Healthy Aging
BAUMGARTNER, R. N. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06498.x · Cited by 1,078 · see citing works
Body Mass Index, Waist Circumference, and Health Risk
Janssen, I., Katzmarzyk, P. T., & Ross, R. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.18.2074 · Cited by 958 · see citing works
Morley, J. E., Baumgartner, R., Roubenoff, R., Mayer, J., & Nair, K. S. (2001) · Journal of Laboratory and Clinical Medicine · doi:10.1067/mlc.2001.113504 · Cited by 938 · see citing works
Sarcopenic Obesity Predicts Instrumental Activities of Daily Living Disability in the Elderly
Baumgartner, R. N., Wayne, S. J., Waters, D. L., Janssen, I., Gallagher, D., & Morley, J. E. (2004) · Obesity Research · doi:10.1038/oby.2004.250 · Cited by 937 · see citing works
Hughes, V. A., Frontera, W. R., Roubenoff, R., Evans, W. J., & Singh, M. A. F. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.2.473 · Cited by 804 · see citing works
The LIFE Study Investigators* [*See Appendix for List of LIFE Study Investigators] (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.11.1157 · Cited by 661 · see citing works
Health consequences of obesity in the elderly: a review of four unresolved questions
Zamboni, M. M., Mazzali, G., Zoico, E., Harris, T. B., Meigs, J. B., Francesco, V. D., Fantin, F., Bissoli, L., & Bosello, O. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803005 · Cited by 649 · see citing works
Obesity, Regional Body Fat Distribution, and the Metabolic Syndrome in Older Men and Women
Goodpaster, B. H., Krishnaswami, S., Harris, T. B., Katsiaras, A., Kritchevsky, S. B., Simonsick, E. M., Nevitt, M., Holvoet, P., & Newman, A. B. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.7.777 · Cited by 637 · see citing works
Prevalence of metabolic syndrome in an urban population: Tehran Lipid and Glucose Study
Azizi, F., Salehi, P., Etemadi, A., & Zahediasl, S. (2003) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(03)00066-4 · Cited by 526 · see citing works
Impairment of health and quality of life in people with large waist circumference
Lean, M., Han, T. S., & Seidell, J. C. (1998) · The Lancet · doi:10.1016/s0140-6736(97)10004-6 · Cited by 501 · see citing works
Nair (2005) · doi:10.1093/ajcn/81.5.953 · Cited by 469 · see citing works
Physical frailty and body composition in obese elderly men and women
Villareal, D. T., Banks, M., Siener, C., Sinacore, D. R., & Klein, S. (2004) · Obesity Research · doi:10.1038/oby.2004.111 · Cited by 459 · see citing works
Long‐Term Safety and Efficacy of Circumferential Ablation with Pulmonary Vein Isolation
Cheema, A., Dong, J., Dalal, D., Vasamreddy, C. R., Marine, J. E., Henrikson, C. A., SPRAGG, D. D., Cheng, A., Nazarian, S., Sinha, S. K., et al. (2006) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2006.00569.x · Cited by 452 · see citing works
Metabolic syndrome amplifies the age-associated increases in vascular thickness and stiffness
Scuteri, A., Najjar, S. S., Muller, D. C., Andres, R., Hougaku, H., Metter, E. J., & Lakatta, E. G. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.10.061 · Cited by 447 · see citing works
Davison, K. K., Ford, E. S., Cogswell, M. E., & Dietz, W. H. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50508.x · Cited by 435 · see citing works
Cesari, M., Kritchevsky, S. B., Baumgartner, R., Atkinson, H. H., Penninx, B. W. J. H., Lenchik, L., Palla, S. L., Ambrosius, W. T., Tracy, R. P., & Pahor, M. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.82.2.428 · Cited by 422 · see citing works
Public Health and Aging: Trends in Aging—United States and Worldwide
(2003) · JAMA · doi:10.1001/jama.289.11.1371 · Cited by 410 · see citing works
Targeting the Metabolic Syndrome with Exercise: Evidence from the HERITAGE Family Study
Katzmarzyk, P. T., Leon, A. S., Wilmore, J. H., Skinner, J. S., Rao, D. C., Rankinen, T., & Bouchard, C. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000089337.73244.9b · Cited by 396 · see citing works
Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance
Barbagallo, M., & Dominguez, L. J. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.05.007 · Cited by 379 · see citing works
Self-citationMetabolic Syndrome, Obesity, and Mortality
Katzmarzyk, P. T., Church, T. S., Janssen, I., Ross, R., & Blair, S. N. (2005) · Diabetes Care · doi:10.2337/diacare.28.2.391 · Cited by 378 · see citing works
Cross-sectional Age Differences in Body Composition in Persons 60 + Years of Age
Baumgartner, R., Stauber, P. M., Mchugh, D., Koehler, K. M., & Garry, P. J. (1995) · The Journals of Gerontology Series A · doi:10.1093/gerona/50a.6.m307 · Cited by 378 · see citing works
Magnesium Intake and Incidence of Metabolic Syndrome Among Young Adults
He, K., Liu, K., Daviglus, M. L., Morris, S. J., Loria, C. M., Horn, L. V., Jacobs, D. R., & Savage, P. J. (2006) · Circulation · doi:10.1161/circulationaha.105.588327 · Cited by 353 · see citing works
Cesari, M., Kritchevsky, S. B., Baumgartner, R., et al. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.2.428 · Cited by 345 · see citing works
Visser, M., Langlois, J. A., Guralnik, J. M., Cauley, J. A., Kronmal, R. A., Robbins, J., Williamson, J. D., & Harris, T. B. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.3.584 · Cited by 328 · see citing works
Angiotensin II-induced NADPH Oxidase Activation Impairs Insulin Signaling in Skeletal Muscle Cells
Wei, Y., Sowers, J. R., Nistala, R., Gong, H., Uptergrove, G. M., Clark, S. E., Morris, E. M., Szary, N. M., Manrique, C. M., & Stump, C. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601320200 · Cited by 297 · see citing works
Exercise and Weight Loss in Obese Older Adults with Knee Osteoarthritis: A Preliminary Study
Messier, S. P., Loeser, R. F., Mitchell, M., Valle, G., Morgan, T., Rejeski, W. J., & Ettinger, W. H. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb04781.x · Cited by 287 · see citing works
Diet-induced Obesity Alters AMP Kinase Activity in Hypothalamus and Skeletal Muscle
Martin, T. L., Alquier, T., Asakura, K., Furukawa, N., Preitner, F., & Kahn, B. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512831200 · Cited by 283 · see citing works
The Metabolic Syndrome in Older Individuals: Prevalence and Prediction of Cardiovascular Events
Scuteri, A., Najjar, S. S., Morrell, C. H., & Lakatta, E. G. (2005) · Diabetes Care · doi:10.2337/diacare.28.4.882 · Cited by 279 · see citing works
A Novel Pathway to the Manifestations of Metabolic Syndrome
Sonnenberg, G. E., Krakower, G. R., & Kissebah, A. H. (2004) · Obesity Research · doi:10.1038/oby.2004.24 · Cited by 257 · see citing works
Villareal, D. T., Miller, B. V., Banks, M., Fontana, L., Sinacore, D. R., & Klein, S. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.6.1317 · Cited by 235 · see citing works
The Physiology of Cellular Liporegulation
Unger, R. H. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142622 · Cited by 202 · see citing works
Metabolic Syndrome and the Risk of Cardiovascular Disease in Older Adults
Butler, J., Rodondi, N., Zhu, Y., Figaro, K., Fazio, S., Vaughan, D. E., Satterfield, S., Newman, A. B., Goodpaster, B. H., Bauer, D. C., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.12.046 · Cited by 191 · see citing works
Longevity, lipotoxicity and leptin: the adipocyte defense against feasting and famine
Unger, R. H. (2005) · Biochimie · doi:10.1016/j.biochi.2004.11.014 · Cited by 184 · see citing works
Magnesium and muscle performance in older persons: the InCHIANTI study
Dominguez, L. J., Barbagallo, M., Lauretani, F., Bandinelli, S., Bós, Â. J. G., Corsi, A. M., Simonsick, E. M., & Ferrucci, L. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.1.419 · Cited by 166 · see citing works
Self-citationHypomagnesemia, oxidative stress, inflammation, and metabolic syndrome
Guerrero‐Romero, F., & Rodríguez‐Morán, M. (2006) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.644 · Cited by 155 · see citing works
Magnesium and muscle performance in older persons: The InCHIANTI study
Dominguez, L. J., Barbagallo, M., Lauretani, F., Bandinelli, S., Bos, A., Corsi, A. M., Simonsick, E. M., & Ferrucci, L. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.2.419 · Cited by 136 · see citing works
Self-citationMazzali, G., Di Francesco, V., Zoico, E., Fantin, F., Zamboni, G., Benati, C., Bambara, V., Negri, M., Bosello, O., & Zamboni, M. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.5.1193 · Cited by 120 · see citing works
Zethelius, B., Lithell, H., Hales, C. N., & Berne, C. (2005) · Diabetologia · doi:10.1007/s00125-005-1711-9 · Cited by 111 · see citing works
Maggi, S., Noale, M., Gallina, P., Bianchi, D., Marzari, C., Limongi, F., Crepaldi, G., & for the ILSA Working Group (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.5.505 · Cited by 99 · see citing works
Obesity in Nursing Homes: An Escalating Problem
Lapane, K. L., & Resnik, L. J. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53420.x · Cited by 89 · see citing works
Cellular Ionic Alterations with Age: Relation to Hypertension and Diabetes
Barbagallo, M., Gupta, R. K., Dominguez, L. J., & Resnick, L. M. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb04788.x · Cited by 79 · see citing works
Self-citationRandomized Controlled Trials Involving Multidisciplinary Interventions in the Community
Pahor, M. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.5.472 · Cited by 73 · see citing works
Relation Between Leptin and the Metabolic Syndrome in Elderly Women
Zamboni, M. M., Zoico, E., Fantin, F., Panourgia, M. P., Francesco, V. D., Tosoni, P., Solerte, B., Vettor, R., & Bosello, O. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.4.m396 · Cited by 66 · see citing works
Metabolic syndrome, abdominal obesity, and cardiovascular risk in elderly women
Cabrera, M. A. S., Gebara, O., Diament, J., Nussbacher, A., Rosano, G. M. C., & Wajngarten, M. (2006) · International Journal of Cardiology · doi:10.1016/j.ijcard.2006.01.019 · Cited by 64 · see citing works
Metabolic Syndrome and the Progression of Carotid Intima-Media Thickness in Elderly Women
Hassinen, M., Komulainen, P., Lakka, T. A., Väisänen, S., Haapala, I., Gylling, H., Alén, M., Schmidt‐Trucksäss, A., Nissinen, A. M., & Rauramaa, R. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.4.444 · Cited by 64 · see citing works
Metabolic Syndrome Predicts Mobility Decline in a Community‐Based Sample of Older Adults
Blazer, D. G., Hybels, C. F., & Fillenbaum, G. G. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.00607.x · Cited by 62 · see citing works
Rathmann, W., Haastert, B., Icks, A., Giani, G., Holle, R., Köenig, W., Löwel, H., & Meisinger, C. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1885 · Cited by 46 · see citing works
Prevalence of metabolic syndrome in an elderly Swedish population
Gause‐Nilsson, I. A. M., Gherman, S., Dey, D. K., Kennerfalk, A., & Steen, B. (2006) · Acta Diabetologica · doi:10.1007/s00592-006-0226-2 · Cited by 32 · see citing works
Rennie, M. J. (2001) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.11.s1.s170 · Cited by 27 · see citing works
Barbagallo, M., & Dominguez, L. J. (2006) · Journal of the CardioMetabolic Syndrome · doi:10.1111/j.1559-4564.2006.06104.x · Cited by 7 · see citing works
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Flagged first, then by citations
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Sarcopenic obesity: definition, cause and consequences
Stenholm, S., Harris, T. B., Rantanen, T., Visser, M., Kritchevsky, S. B., & Ferrucci, L. (2008) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e328312c37d · Cited by 1,070 · see citing works
Kalinkovich, A., & Livshits, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.008 · Cited by 882 · see citing works
Srikanthan, P., & Karlamangla, A. S. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0435 · Cited by 785 · see citing works
Kim, T. N., Yang, S. J., Yoo, H. J., Lim, K. I., Kang, H. J., Song, W., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., et al. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.130 · Cited by 401 · see citing works
Muscle loss and obesity: the health implications of sarcopenia and sarcopenic obesity
Wannamethee, S. G., & Atkins, J. L. (2015) · Proceedings of the Nutrition Society · doi:10.1017/s002966511500169x · Cited by 404 · see citing works
Donini, L. M., Busetto, L., Bauer, J. M., Bischoff, S., Boirie, Y., Cederholm, T., Cruz-Jentoft, A. J., Dicker, D., Frühbeck, G., Giustina, A., et al. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2019.11.024 · Cited by 326 · see citing works
Metabolic Syndrome and Sarcopenia
Nishikawa, H., Asai, A., Fukunishi, S., Nishiguchi, S., & Higuchi, K. (2021) · Nutrients · doi:10.3390/nu13103519 · Cited by 334 · see citing works
Tyrovolas, S., Koyanagi, A., Olaya, B., Ayuso‐Mateos, J. L., Miret, M., Chatterji, S., Tobiasz‐Adamczyk, B., Koskinen, S. V. P., Leonardi, M., & Haro, J. M. (2015) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12076 · Cited by 287 · see citing works
Tian, S., & Xu, Y. (2016) · Geriatrics & Gerontology International · doi:10.1111/ggi.12579 · Cited by 274 · see citing works
Late evening snack: exploiting a period of anabolic opportunity in cirrhosis
Tsien, C. D., McCullough, A. J., & Dasarathy, S. (2012) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06951.x · Cited by 252 · see citing works
Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments
Wang, M., Tan, Y., Shi, Y., Wang, X., Liao, Z., & Wei, P. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00568 · Cited by 231 · see citing works
The implications of sarcopenia and sarcopenic obesity on cardiometabolic disease
Kim, T. N., & Choi, K. M. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25077 · Cited by 225 · see citing works
Anagnostis, P. G., Gkekas, N. K., Achilla, C., Papanastasiou, G., Taouxidou, P., Mitsiou, M., Kenanidis, E. I., Potoupnis, M. E., Tsiridis, E. E., & Goulis, D. G. (2020) · Calcified Tissue International · doi:10.1007/s00223-020-00742-y · Cited by 230 · see citing works
Shih, P., Chan, Y., Liao, J., Wang, M.-F., & Yen, G. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.03.008 · Cited by 220 · see citing works
Sarcopenic obesity is closely associated with metabolic syndrome
Lu, C.-W., Yang, K.-C., Chang, H.-H., Lee, L.-T., Chen, C.-Y., & Huang, K.-C. (2013) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2012.02.003 · Cited by 198 · see citing works
Immunosenescence and Immunogenetics of Human Longevity
Ostan, R., Bucci, L., Capri, M., Salvioli, S., Scurti, M., Pini, E., Monti, D., & Franceschi, C. (2008) · NeuroImmunoModulation · doi:10.1159/000156466 · Cited by 188 · see citing works
Diabetes, Sarcopenia, and Frailty
Morley, J. E. (2008) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2008.03.004 · Cited by 186 · see citing works
Sarcopenia: An Independent Predictor of Mortality in Community-Dwelling Older Korean Men
Kim, J. H., Lim, S. K., Choi, S. H., Kim, K. M., Yoon, J. W., Kim, K. W., Lim, J., Park, K. S., Jang, H. C., & Kritchevsky, S. B. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu050 · Cited by 177 · see citing works
Sarcopenic obesity in aging population: current status and future directions for research
Kohara, K. (2014) · Endocrine · doi:10.1007/s12020-013-9992-0 · Cited by 171 · see citing works
Ju, S.-Y., Lee, J., & Kim, D. (2017) · Medicine · doi:10.1097/md.0000000000008491 · Cited by 172 · see citing works
Sarcopenic obesity: how do we treat it?
Bouchonville, M. F., & Villareal, D. T. (2013) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/01.med.0000433071.11466.7f · Cited by 141 · see citing works
Type 2 diabetes and bone fractures
Moseley, K. F. (2012) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e328350a6e1 · Cited by 138 · see citing works
Shad, B. J., Thompson, J. L., & Breen, L. (2016) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00213.2016 · Cited by 125 · see citing works
Sarcopenic obesity as an independent risk factor of hypertension
Park, S. H., Park, J. H., Song, P. S., Kim, D. K., Kim, K. H., Seol, S. H., Kim, H. K., Jang, H. J., Lee, J. G., Park, H. Y., et al. (2013) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2013.06.002 · Cited by 118 · see citing works
Aggio, D. A., Sartini, C., Papacosta, O., Lennon, L. T., Ash, S., Whincup, P. H., Wannamethee, S. G., & Jefferis, B. J. (2016) · Preventive Medicine · doi:10.1016/j.ypmed.2016.08.040 · Cited by 110 · see citing works
Examination of ‘lipotoxicity’ in skeletal muscle of high‐fat fed and ob / ob mice
Turpin-Nolan, S. M., Ryall, J. G., Southgate, R. J., Darby, I. A., Hevener, A. L., Febbraio, M. A., Kemp, B. E., Lynch, G. S., & Watt, M. J. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.166033 · Cited by 110 · see citing works
Sarcopenic obesity and metabolic syndrome in adult Caucasian subjects
Poggiogalle, E., Lubrano, C., Sergi, G., Coin, A., Gnessi, L., Mariani, S., Lenzi, A., & Donini, L. M. (2016) · The Journal of nutrition, health and aging · doi:10.1007/s12603-015-0638-1 · Cited by 106 · see citing works
Anton, S. D., Karabetian, C., Naugle, K., & Buford, T. W. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.06.007 · Cited by 100 · see citing works
Leptin in Sarcopenic Visceral Obesity: Possible Link between Adipocytes and Myocytes
Kohara, K., Ochi, M., Tabara, Y., Nagai, T., Igase, M., & Miki, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024633 · Cited by 99 · see citing works
Exploring the Impact of Obesity on Skeletal Muscle Function in Older Age
Morgan, P. T., Smeuninx, B., & Breen, L. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.569904 · Cited by 99 · see citing works
Gutierres, J. M., Carvalho, F. B., Schetinger, M. R. C., Agostinho, P. M., Marisco, P. C., Vieira, J. M., da Rosa, M. M., Bohnert, C., Rubin, M. A., Morsch, V. M., et al. (2013) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2013.12.006 · Cited by 97 · see citing works
Yu, S., Guo, X., Yang, H., Zheng, L., & Sun, Y. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-877 · Cited by 93 · see citing works
Coker, R. H., Miller, S., Schutzler, S., Deutz, N., & Wolfe, R. R. (2012) · Nutrition Journal · doi:10.1186/1475-2891-11-105 · Cited by 92 · see citing works
Mok, M. T. C., Allende, R., Leipsic, J. A., Altisent, O. A., Trigo, M. D., Campelo‐Parada, F., DeLarochellière, R., Dumont, É., Doyle, D. J., Côté, M., et al. (2015) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2015.12.015 · Cited by 90 · see citing works
Obesity as a premature aging phenotype — implications for sarcopenic obesity
Nunan, E. L., Wright, C. L., Semola, O. A., Subramanian, M., Balasubramanian, P., Lovern, P. C., Fancher, I. S., & Butcher, J. T. (2022) · GeroScience · doi:10.1007/s11357-022-00567-7 · Cited by 83 · see citing works
Lim, K. I., Yang, S. J., Kim, T. N., Yoo, H. J., Kang, H. J., Song, W., Baik, S. H., Choi, D. S., & Choi, K. M. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03841.x · Cited by 82 · see citing works
Ochi, M., Tabara, Y., Kido, T., Uetani, E., Ochi, N., Igase, M., Miki, T., & Kohara, K. (2010) · Geriatrics & Gerontology International · doi:10.1111/j.1447-0594.2010.00610.x · Cited by 79 · see citing works
Physical performance and disability in schizophrenia
Strassnig, M., Signorile, J. F., Gonzalez, C., & Harvey, P. D. (2014) · Schizophrenia Research Cognition · doi:10.1016/j.scog.2014.06.002 · Cited by 79 · see citing works
The role of muscle mass and body fat on disability among older adults: A cross-national analysis
Tyrovolas, S., Koyanagi, A., Olaya, B., Ayuso‐Mateos, J. L., Miret, M., Chatterji, S., Tobiasz‐Adamczyk, B., Koskinen, S. V. P., Leonardi, M., & Haro, J. M. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.06.002 · Cited by 77 · see citing works
A new approach to defining and diagnosing malnutrition in adult critical illness
Jensen, G. L., & Wheeler, D. (2012) · Current Opinion in Critical Care · doi:10.1097/mcc.0b013e328351683a · Cited by 76 · see citing works
Dynapenic Abdominal Obesity and Metabolic Risk Factors in Adults 50 Years of Age and Older
Sénéchal, M., Dionne, I. J., & Brochu, M. (2012) · Journal of Aging and Health · doi:10.1177/0898264312440324 · Cited by 74 · see citing works
Wittmann, K., Sieber, C. C., von Stengel, S., Kohl, M., Freiberger, E., Jakob, F. J., Lell, M., Engelke, K., & KEMMLER, W. K. (2016) · Clinical Interventions in Aging · doi:10.2147/cia.s116430 · Cited by 73 · see citing works
Liu, Y., Cotillard, A., Vatier, C., Bastard, J.-P., Fellahi, S., Stévant, M., Allatif, O., Langlois, C., Bieuvelet, S., Brochot, A., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0138646 · Cited by 71 · see citing works
Aging, metabolic syndrome and the heart.
Veronica, G., & Esther, R.-R. M. (2012) · Europe PMC (PubMed Central) · Cited by 70 · see citing works
Mostoufi‐Moab, S., Magland, J. F., Isaacoff, E. J., Sun, W., Rajapakse, C. S., Zemel, B. S., Wehrli, F. W., Shekdar, K. V., Baker, J. F., Long, J., et al. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2512 · Cited by 70 · see citing works
Rigo, J. C., Vieira, J. L., Corte, R. R. D., & Reichert, C. L. (2009) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2009000800004 · Cited by 69 · see citing works
Care of elderly patients with diabetes mellitus: A focus on frailty
Chen, L., Chen, Y., Lin, M.-H., Peng, L., & Hwang, S. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.008 · Cited by 67 · see citing works
Low, S. K., Goh, K. S., Ng, T. P., Ang, S. F., Moh, A. M. C., Wang, J., Ang, K., Subramaniam, T., Sum, C. F., & Lim, S. C. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.10.019 · Cited by 65 · see citing works
Additional role of sarcopenia to waist circumference in predicting the odds of metabolic syndrome
Park, S. H., Park, J. H., Park, H. Y., Jang, H. J., Kim, H. K., Park, J., Shin, K. J., Lee, J. G., & Moon, Y. S. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.08.008 · Cited by 61 · see citing works
Comparison of height‐ and weight‐adjusted sarcopenia in a T aiwanese metropolitan older population
Meng, N., Li, C., Liu, C.-S., Lin, C., Wen‐Yuan, L., Chang, C., Li, T., & Lin, C. (2014) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.12227 · Cited by 58 · see citing works
Silveira, É. A., Filho, R. R. D. S., Spexoto, M. C. B., Haghighatdoost, F., Sarrafzadegan, N., & de Oliveira, C. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094339 · Cited by 56 · see citing works
Hwang, J., & Park, S. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20021140 · Cited by 52 · see citing works
Lim, S. K., Kwon, S., Yoon, J. W., Kim, S. Y., Choi, S. H., Park, Y. J., Yoon, H. I., Chang, Y., Lee, J. H., Lee, C., et al. (2010) · Obesity · doi:10.1038/oby.2010.167 · Cited by 52 · see citing works
Choudhary, N. S., Saigal, S., Saraf, N., Mohanka, R., Rastogi, A. N., Goja, S. K., Menon, P. B., Mishra, S. K., Mittal, A., & Soin, A. S. (2014) · Clinical Transplantation · doi:10.1111/ctr.12505 · Cited by 52 · see citing works
Hypothalamic Dysfunction and Multiple Sclerosis: Implications for Fatigue and Weight Dysregulation
Burfeind, K. G., Yadav, V., & Marks, D. L. (2016) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-016-0700-3 · Cited by 51 · see citing works
Park, J. H., Lee, M. Y., Shin, H. R., Yoon, K. J., Lee, J., & Park, J. H. (2023) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3681 · Cited by 51 · see citing works
Atmış, V., Yalçın, A., Sılay, K., kandil, S. U., Bahşi, R., Turgut, T., Sürmeli, D. M., Öztorun, H. S., Yaman, S., Coşarderelioğlu, Ç., et al. (2019) · Aging Clinical and Experimental Research · doi:10.1007/s40520-019-01277-5 · Cited by 48 · see citing works
Metabolic risk factors in U.S. youth with low relative muscle mass
Kim, S. K., & Valdez, R. A. (2014) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2014.05.002 · Cited by 45 · see citing works
The Association Between Muscle Weakness and Incident Diabetes in Older Mexican Americans
McGrath, R., Vincent, B. M., Snih, S. A., Markides, K. S., & Peterson, M. D. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.01.017 · Cited by 44 · see citing works
Mogi, M., Kohara, K., Nakaoka, H., Kan‐no, H., Tsukuda, K., Wang, X., Chisaka, T., Bai, H., Shan, B., Kukida, M., et al. (2015) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12044 · Cited by 44 · see citing works
Jeng, C., Zhao, L., Wu, K., Zhou, Y., Chen, T., & Deng, H. (2018) · JCSM Clinical Reports · doi:10.17987/jcsm-cr.v3i2.27 · Cited by 43 · see citing works
Guinan, E. M., Connolly, E. M., Healy, L., Carroll, P. A., Kennedy, M. J., & Hussey, J. M. (2013) · Cancer Nursing · doi:10.1097/ncc.0b013e3182a40e6d · Cited by 43 · see citing works
Factors Associated With the Development of Sarcopenia in Kidney Transplant Recipients
Yanishi, M., Kimura, Y., Tsukaguchi, H., Koito, Y., Taniguchi, H., Mishima, T., Fukushima, Y., Sugi, M., Kinoshita, H., & Matsuda, T. (2017) · Transplantation Proceedings · doi:10.1016/j.transproceed.2016.12.015 · Cited by 41 · see citing works
The Association between Nonalcoholic Fatty Liver Disease and CT-Measured Skeletal Muscle Mass
Choe, E. K., Kang, H. Y., Park, B., Yang, J. I., & Kim, J. S. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7100310 · Cited by 40 · see citing works
ORWOLL, E. S., Peters, K. E., Hellerstein, M. K., Cummings, S. R., Evans, W. J., & Cawthon, P. M. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa064 · Cited by 40 · see citing works
Obesity in the Context of Aging: Quality of Life Considerations
Corica, F., Bianchi, G. P., Corsonello, A., Mazzella, N., Lattanzio, F., & Marchesini, G. (2014) · PharmacoEconomics · doi:10.1007/s40273-014-0237-8 · Cited by 39 · see citing works
Kim, B. C., Kim, M. K., Han, K., Lee, S.-Y., Lee, S., Ko, S., Kwon, H., Merchant, A. T., Yim, H. W., Lee, W., et al. (2015) · Nutrition Research · doi:10.1016/j.nutres.2015.09.020 · Cited by 38 · see citing works
Zhang, Y., Mei, S., Yang, R., Chen, L., Gao, H., & Li, L. (2016) · BMC Cardiovascular Disorders · doi:10.1186/s12872-016-0398-9 · Cited by 36 · see citing works
Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study
Aubertin‐Leheudre, M., Anton, S. D., Beavers, D. P., Manini, T. M., Fielding, R. A., Newman, A. B., Church, T., Kritchevsky, S. B., Conroy, D. E., McDermott, M. M., et al. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.10.001 · Cited by 36 · see citing works
Barzilay, J. I., Gao, P., Rydén, L., Schumacher, H., Probstfield, J. L., Commerford, P., Dans, A., Ferreira, R., Keltai, M., Paolasso, E., et al. (2011) · Diabetes Care · doi:10.2337/dc11-0545 · Cited by 35 · see citing works
Relative fat-free mass deficiency and left ventricular adaptation to obesity: The Strong Heart Study
SIMONE, G. D., Pasanisi, F., Ferrara, A. L., Roman, M. J., Lee, E. T., Contaldo, F., Howard, B. V., & Devereux, R. B. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.09.055 · Cited by 32 · see citing works
The mechanistic and ergogenic effects of phosphatidic acid in skeletal muscle.
Shad, B. J., Smeuninx, B., Atherton, P., & Breen, L. (2015) · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · doi:10.1139/apnm-2015-0350 · Cited by 23 · see citing works
Mitochondrial Dysfunction and Sarcopenic Obesity: The Role of Exercise
Hadjispyrou, S., Giannopoulos, A., Philippou, Α., & Theos, A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12175628 · Cited by 30 · see citing works
Barbat-Artigas, S., Carvalho, L. P., Rolland, Y., Vellas, B., & Aubertin-Leheudre, M. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.06.026 · Cited by 27 · see citing works
Kim, S., Choi, Y. J., Huh, B. W., Kim, C. S., Park, S. W., Lee, E. J., Cho, Y.-W., & Huh, K. B. (2011) · Diabetes Care · doi:10.2337/dc11-0743 · Cited by 28 · see citing works
Lim, J., Kim, S., Ke, S., & Cho, B. (2011) · Korean Journal of Family Medicine · doi:10.4082/kjfm.2011.32.2.128 · Cited by 28 · see citing works
Pugh, J. K., Faulkner, S. H., Turner, M. C., & Nimmo, M. A. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3721-y · Cited by 27 · see citing works
Variation in Serum Creatinine Level Is Correlated to Risk of Type 2 Diabetes
Moon, J. S., Lee, J. E., & Yoon, J. S. (2013) · Endocrinology and Metabolism · doi:10.3803/enm.2013.28.3.207 · Cited by 26 · see citing works
Screening for muscle loss in patients established on peritoneal dialysis using bioimpedance
Greenhall, G. H. B., & Davenport, A. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2016.202 · Cited by 27 · see citing works
Association between changes in body composition and risk of developing Type 2 diabetes in Koreans
Kim, C., Kim, H. ‐., Kim, E. H., Bae, S. ‐., & Park, J.-Y. (2014) · Diabetic Medicine · doi:10.1111/dme.12527 · Cited by 26 · see citing works
Barbat‐Artigas, S., Garnier, S., Joffroy, S., Riesco, É., Sanguignol, F., Vellas, B. J., Rolland, Y., Andrieu, S., Aubertin‐Leheudre, M., & Mauriège, P. (2015) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12075 · Cited by 26 · see citing works
Mankowski, R. T., Anton, S. D., & Aubertin‐Leheudre, M. (2015) · Current Geriatrics Reports · doi:10.1007/s13670-015-0132-y · Cited by 27 · see citing works
Mitochondrial transplantation as a possible therapeutic option for sarcopenia
Türkel, İ., Özerkliğ, B., Yılmaz, M., Ülger, Ö., Kubat, G. B., & Tuncer, M. (2023) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02326-3 · Cited by 24 · see citing works
Yoo, S., Kim, D., & Lim, H. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02179-3 · Cited by 24 · see citing works
Lee, K. (2016) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2016.07.009 · Cited by 22 · see citing works
Sääksjärvi, K., Härkänen, T., Stenholm, S., Schaap, L. S., Lundqvist, A., Koskinen, S. V. P., Borodulin, K., & Visser, M. (2023) · Gerontology · doi:10.1159/000527804 · Cited by 22 · see citing works
Association between CT-Measured Abdominal Skeletal Muscle Mass and Pulmonary Function
Choe, E. K., Lee, Y., Kang, H. Y., Choi, S. H., & Kim, J. S. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050667 · Cited by 19 · see citing works
Memelink, R. G., Hummel, M., Hijlkema, A., Streppel, M. T., Bautmans, I., Weijs, P. J. M., Berk, K. A., & Tieland, M. (2023) · Diabetic Medicine · doi:10.1111/dme.15096 · Cited by 18 · see citing works
The effect of sarcopenic obesity on cardiovascular disease and all-cause mortality in older people
Atkins, J. L., & Wannamethee, S. G. (2015) · Reviews in Clinical Gerontology · doi:10.1017/s0959259815000076 · Cited by 18 · see citing works
A Simple Ultrasound Correlate of Visceral Fat
Oh, J., Kim, S., Shin, D.-K., Park, K., Park, S. W., & Cho, Y. (2011) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2011.05.844 · Cited by 17 · see citing works
Altered body composition profiles in young adults with childhood-onset inflammatory bowel disease
Sigurdsson, G. V., Schmidt, S., Mellström, D., Ohlsson, C., Karlsson, M. K., Lorentzon, M., & Saalman, R. (2020) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2020.1716061 · Cited by 17 · see citing works
Retinol binding protein 4 and insulin resistance in apparently healthy elderly subjects
Lee, J., Im, J., Park, K. D., Lee, H.-R., Shim, J., & Lee, D. (2008) · Clinica Chimica Acta · doi:10.1016/j.cca.2008.10.004 · Cited by 17 · see citing works
Prevalence and correlates of metabolic syndrome and its components in elderly Korean adults
Kim, S. H., & So, W.-Y. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.09.012 · Cited by 16 · see citing works
Association between sarcopenia and hearing thresholds in postmenopausal women
Kang, S. H., Jung, D. J., Cho, K. H., Park, J. W., Lee, K.-Y., & Do, J. Y. (2017) · International Journal of Medical Sciences · doi:10.7150/ijms.18048 · Cited by 15 · see citing works
Comparisons of different indices of low muscle mass in relationship with cardiometabolic disorder
Kim, J. Y., Oh, S., Park, H. Y., Jun, J. H., & Kim, H. J. (2019) · Scientific Reports · doi:10.1038/s41598-018-37347-3 · Cited by 15 · see citing works
Hamarsland, H., Johansen, M. K., Seeberg, F., Brochmann, M., Garthe, I., Benestad, H. B., & Raastad, T. (2019) · Nutrients · doi:10.3390/nu11092094 · Cited by 14 · see citing works
Heo, S.-J., Park, S.-K., & Jee, Y. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19031845 · Cited by 14 · see citing works
Lim, H., Son, K., & Lim, H. (2023) · Nutrients · doi:10.3390/nu15071574 · Cited by 16 · see citing works
Body composition in sarcopenic obesity: systematic review of the literature
Donini, L. M., Poggiogalle, E., Migliaccio, S., Aversa, A., & Pinto, A. (2013) · Mediterranean Journal of Nutrition and Metabolism · doi:10.1007/s12349-013-0135-1 · Cited by 21 · see citing works
Scott, D. S., & Hirani, V. (2015) · European Geriatric Medicine · doi:10.1016/j.eurger.2015.11.009 · Cited by 14 · see citing works
- Authors
- Dominguez, L. J., & Barbagallo, M.
- Affiliations
- University of Palermo (IT)
- Corresponding author
- Dominguez, Ligia J.
- Venue
- Journal of the CardioMetabolic Syndrome
- Publisher
- Wiley
- Published
- 2007-06
- Volume
- 2
- Issue
- 3
- Pages
- 183-189
- ISSN
- 1559-4564 (ISSN-L)
- 1559-4572
- OpenAlex
- W2001276401
- Cited by
- 185
- References
- 61
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 8 · 2023: 16 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 23 · 2015: 23 · 2014: 15 · 2013: 12 · 2012: 10
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the CardioMetabolic Syndrome (publishedVersion)
- PubMed (publishedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Keywords
- cardiometabolic syndrome, sarcopenic obesity, older adults, aging, obesity, sarcopenia, abdominal obesity, body composition, fat redistribution, adipokines, insulin sensitivity, type 2 diabetes, cardiovascular mortality, lean body mass
- MeSH terms
- Adipose Tissue, Aged, Aging, Body Composition, Cardiovascular Diseases, Humans, Insulin Resistance, Muscular Atrophy, Obesity, Inflammation Mediators, Metabolic Syndrome
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