Association between blood pressure and serum thyroid-stimulating hormone concentration within the reference range: a population-based study
Abstract
CONTEXT: The association between thyroid function and blood pressure is insufficiently studied. OBJECTIVE: The objective of the investigation was to study the association between TSH within the reference range and blood pressure. DESIGN AND SETTING: This was a cross-sectional, population-based study. SUBJECTS: A total of 30,728 individuals without previously known thyroid disease were studied. MAIN OUTCOME MEASURES: The main outcome measures were mean systolic and diastolic blood pressure and pulse pressure and odds ratio for hypertension (>140/90 mm Hg or current or previous use of antihypertensive medication), according to categories of TSH. RESULTS: Within the reference range of TSH (0.50-3.5 mU/liter), there was a linear increase in blood pressure with increasing TSH. The average increase in systolic blood pressure was 2.0 mm Hg [95% confidence interval (CI) 1.4-2.6 mm Hg] per milliunit per liter increase in TSH among men, and 1.8 mm Hg (95% CI 1.4-2.3 mm Hg) in women. The corresponding increase in diastolic blood pressure was 1.6 mm Hg (95% CI 1.2-2.0 mm Hg) in men and 1.1 mm Hg (95% CI 0.8-1.3 mm Hg) in women. Comparing TSH of 3.0-3.5 mU/liter (upper part of the reference) with TSH of 0.50-0.99 mU/liter (lower part of the reference), the odds ratio for hypertension was 1.98 (95% CI 1.56-2.53) in men and 1.23 (95% CI 1.04-1.46) in women. CONCLUSION: Within the reference range of TSH, we found a linear positive association between TSH and systolic and diastolic blood pressure that may have long-term implications for cardiovascular health.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Within the reference range of 0.50-3.5 mU/L, blood pressure increased linearly with increasing TSH (systolic blood pressure by 2.0 mmHg in men and 1.8 mmHg in women, diastolic blood pressure increased by 1.6 and 1.1 mmHg).
“Within the reference range of 0.50–3.5 mU/L, blood pressure increased linearly with increasing TSH (SBP by 2.0 mmHg in men and 1.8 mmHg in women, DBP increased by 1.6 and 1.1 mmHg) (101).”
From L-T4 therapy in the presence of pharmacological interferents (2020) · cites this paper as [101]
Comparing TSH of 3.0-3.5 mU/L with 0.50-0.99 mU/L, the odds ratio for hypertension was 1.98 in men and 1.23 in women.
“For instance, comparing TSH of 3.0–3.5 mU/L with 0.50–0.99 mU/L, the OR for hypertension was 1.98 in men and 1.23 in women (101).”
From L-T4 therapy in the presence of pharmacological interferents (2020) · cites this paper as [101]
Higher levels of TSH were associated with worsening of both blood pressure and lipid levels, although these effects were modest.
“In particular higher levels of TSH were associated with worsening of both blood pressure [58–60] and lipid levels [61, 62] although these effects were modest.”
From Age-related variation in thyroid function – a narrative review highlighting important implications for research and clinical practice (2023) · cites this paper as [59]
Cites
Thyroid hormone and the cardiovascular system.
Klein, I., & Ojamaa, K. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102153440707 · Cited by 2,300 · see citing works
Hypothyroidism and Atherosclerosis
Cappola, A. R., & Ladenson, P. W. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030398 · Cited by 640 · see citing works
The Nord-Trøndelag Health Study 1995-97 (HUNT 2): Objectives, contents, methods and participation
Holmen, J., Midthjell, K., Krüger, Ø., Langhammer, A., Holmen, T. L., Bratberg, G. H., Vatten, L., & Lund‐Larsen, P. G. (2003) · Cited by 526 · see citing works
Bjøro, T., Holmen, J., Krüger, Ø., Midthjell, K., Hunstad, K., Schreiner, T., Sandnes, L., & Brochmann, H. (2000) · European Journal of Endocrinology · doi:10.1530/eje.0.1430639 · Cited by 463 · see citing works
Taddei, S., Caraccio, N., Virdis, A., Dardano, A., Versari, D., Ghiadoni, L., Salvetti, A., Ferrannini, E., & Monzani, F. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030039 · Cited by 431 · see citing works
Åsvold, B. O., Vatten, L. J., Nilsen, T. I. L., & Bjøro, T. (2007) · European Journal of Endocrinology · doi:10.1530/eje.1.02333 · Cited by 350 · see citing works
Self-citationThe Thyrotropin Reference Range Should Remain Unchanged
Surks, M. I., Goswami, G., & Daniels, G. H. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0170 · Cited by 287 · see citing works
Risk Factors for Cardiovascular Disease in Women with Subclinical Hypothyroidism
Luboshitzky, R., Aviv, A., Herer, P., & Lavie, L. (2002) · Thyroid · doi:10.1089/105072502760043512 · Cited by 238 · see citing works
Lekakis, J. P., Papamichael, C. M., Alevizaki, M. K., Gd, P., MARAFELIA, P., Mantzos, J. D., Stamatelopoulos, S., & Koutras, D. A. (1997) · Thyroid · doi:10.1089/thy.1997.7.411 · Cited by 236 · see citing works
Effects of thyroid function on blood pressure. Recognition of hypothyroid hypertension.
Streeten, D. H., Anderson, G. H., Howland, T., Chiang, R., & Smulyan, H. (1988) · Hypertension · doi:10.1161/01.hyp.11.1.78 · Cited by 172 · see citing works
Hyperthyroidism: A Secondary Cause of Isolated Systolic Hypertension
Prisant, L. M., Gujral, J., & Mulloy, A. L. (2006) · Journal of Clinical Hypertension · doi:10.1111/j.1524-6175.2006.05180.x · Cited by 152 · see citing works
Increased central arterial stiffness in hypothyroidism
Obuobie, K., Smith, J., Evans, L. M., John, R., Davies, J. S., & Lazarus, J. H. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020493 · Cited by 119 · see citing works
Subclinical thyroid dysfunction and blood pressure: a community‐based study
Walsh, J. P., Bremner, A. P., Bulsara, M. K., O’Leary, P., Leedman, P. J., Feddema, P., & Michelangeli, V. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02619.x · Cited by 117 · see citing works
Dernellis, J., & Panaretou, M. (2002) · American Heart Journal · doi:10.1067/mhj.2002.120766 · Cited by 115 · see citing works
Subclinical Hypothyroidism, Arterial Stiffness, and Myocardial Reserve
Owen, P., Rajiv, C., Vinereanu, D., Mathew, T., Fraser, A. G., & Lazarus, J. H. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2108 · Cited by 110 · see citing works
Thyroid Function and Blood Pressure Homeostasis in Euthyroid Subjects
Gumieniak, O., Perlstein, T. S., Hopkins, P. N., Brown, N. J., Murphey, L. J., Jeunemaı̂tre, X., Hollenberg, N. K., & Williams, G. H. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032143 · Cited by 105 · see citing works
Hypertension in Thyroid Disorders
Saito, I., & Samta, T. (1994) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30103-8 · Cited by 93 · see citing works
Arterial stiffness is increased in subjects with hypothyroidism
Dagre, A. G., Lekakis, J. P., Papaioannou, T. G., Papamichael, C. M., Koutras, D. A., Stamatelopoulos, S., & Alevizaki, M. K. (2004) · International Journal of Cardiology · doi:10.1016/j.ijcard.2004.05.068 · Cited by 87 · see citing works
Hemodynamic Changes After Levothyroxine Treatment in Subclinical Hypothyroidism
Faber, J. O., Petersen, L. R., Wiinberg, N., Schifter, S., & Mehlsen, J. (2002) · Thyroid · doi:10.1089/10507250252949450 · Cited by 82 · see citing works
Hypertension and hypothyroidism
Fletcher, A., & Weetman, A. (1998) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1000574 · Cited by 77 · see citing works
Blood pressure in relation to serum thyrotropin: the Tromsø study
Iqbal, A., Figenschau, Y., & Jorde, R. (2006) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002091 · Cited by 72 · see citing works
The association between subclinical hyperthyroidism and blood pressure in a population-based study
Völzke, H., Alte, D., Dörr, M., Wallaschofski, H., John, U., Felix, S. B., & Rettig, R. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000244942.57417.8e · Cited by 54 · see citing works
Pulse Pressure as a Risk Factor
Franklin, S. S. (2004) · Clinical and Experimental Hypertension · doi:10.1081/ceh-200031962 · Cited by 52 · see citing works
REVERSIBLE HYPERTENSION AND HYPOTHYROIDISM
Bing, R. F., BRIGGS, R. S. J., Burden, A. C., RUSSELL, G. I., Swales, J. D., & Thurston, H. (1980) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1980.tb03393.x · Cited by 51 · see citing works
Klein, I. L., & Ojamaa, K. (2001) · Circulation Research · doi:10.1161/01.res.88.3.260 · Cited by 50 · see citing works
Aggregation of High-Normal Thyroid-Stimulating Hormone in Hypertensive Families
Gumieniak, O., Hurwitz, S., Perlstein, T. S., Ngumezi, U. C., Hopkins, P. N., Jeunemaı̂tre, X., & Williams, G. H. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0373 · Cited by 19 · see citing works
[Excretion of iodine in the urine. A study from 6 different Norwegian districts in 1985].
Kapelrud, H., Frey, H. M. M., & Theodorsen, L. (1987) · PubMed · Cited by 18 · see citing works
Flagged first, then by citations
2 of the 29 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The Clinical Significance of Subclinical Thyroid Dysfunction
Biondi, B., & Cooper, D. S. (2008) · Endocrine Reviews · doi:10.1210/er.2006-0043 · Cited by 1,418 · see citing works
State-of-the-science of endocrine disrupting chemicals, 2012
Bergman, Å., Heindel, J., Jobling, S., Kidd, K., & Zoeller, R. T. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.03.020 · Cited by 1,388 · see citing works
Klein, I., & Danzi, S. (2007) · Circulation · doi:10.1161/circulationaha.106.678326 · Cited by 1,324 · see citing works
Effects of Thyroid Dysfunction on Lipid Profile
Rizos, C. V., Elisaf, M., & Liberopoulos, E. N. (2011) · The Open Cardiovascular Medicine Journal · doi:10.2174/1874192401105010076 · Cited by 403 · see citing works
Thyroid-Disrupting Chemicals: Interpreting Upstream Biomarkers of Adverse Outcomes
Miller, M. D., Crofton, K. M., Rice, D. C., & Zoeller, R. T. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0800247 · Cited by 283 · see citing works
A Review of the Clinical Consequences of Variation in Thyroid Function Within the Reference Range
Taylor, P. N., Razvi, S., Pearce, S. H., & Dayan, C. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1315 · Cited by 274 · see citing works
Ballesteros, V., Costa, O., Iñiguez, C., Fletcher, T., Ballester, F., & Lopez-Espinosa, M.-J. (2017) · Environment International · doi:10.1016/j.envint.2016.10.015 · Cited by 242 · see citing works
Männistö, T. I., Vääräsmäki, M., Pouta, A. M., Hartikainen, A., Ruokonen, A., Surcel, H., Bloigu, A. H., Järvelin, M., & Suvanto, E. T. J. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1904 · Cited by 216 · see citing works
A high normal TSH is associated with the metabolic syndrome
Ruhla, S., Weickert, M. O., Arafat, A. M., Osterhoff, M. A., Isken, F., Spranger, J., Schöfl, C., Pfeiffer, A. F. H., & Möhlig, M. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03698.x · Cited by 225 · see citing works
Waring, A. C., Rodondi, N., Harrison, S. L., Kanaya, A. M., Simonsick, E. M., Miljkovic, I., Satterfield, S., Newman, A. B., Bauer, D. C., & for the Health, A. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04328.x · Cited by 181 · see citing works
Moon, S., Kim, M. J., Yu, J. M., Yoo, H. J., & Park, Y. J. (2018) · Thyroid · doi:10.1089/thy.2017.0414 · Cited by 175 · see citing works
Roef, G. L., Rietzschel, E. R., daele, C. M. V., Taes, Y., Buyzere, M. D., Gillebert, T. C., & Kaufman, J. (2013) · Thyroid · doi:10.1089/thy.2013.0314 · Cited by 167 · see citing works
Duntas, L. H., & Wartofsky, L. (2007) · Thyroid · doi:10.1089/thy.2007.0116 · Cited by 157 · see citing works
The relationship between serum thyrotropin and components of metabolic syndrome
Lai, Y., Wang, J., Jiang, F., Wang, B., Chen, Y., Li, M., Liu, H., Li, C., Xue, H., Li, N., et al. (2010) · Endocrine Journal · doi:10.1507/endocrj.k10e-272 · Cited by 157 · see citing works
Chen, A., Kim, S. S., Chung, E., & Dietrich, K. N. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1205239 · Cited by 152 · see citing works
Hypertension in Thyroid Disorders
Berta, E., Lengyel, I. M., Halmi, S., Zrínyi, M., Erdei, A., Harangi, M., Páll, D., Nagy, E. V., & Bodor, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00482 · Cited by 153 · see citing works
Heritability of serum TSH, free T4 and free T3 concentrations: a study of a large UK twin cohort
Panicker, V., Wilson, S. G., Spector, T. D., Brown, S. J., Falchi, M., Richards, J. B., Surdulescu, G. L., Lim, E. M., Fletcher, S. J., & Walsh, J. P. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03079.x · Cited by 128 · see citing works
Thyrotropin Levels and Risk of Fatal Coronary Heart Disease: The HUNT Study
Åsvold, B. O., Bjøro, T., Nilsen, T. I. L., Gunnell, D., & Vatten, L. J. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.8.855 · Cited by 125 · see citing works
Self-citationThyroid stimulating hormone is associated with metabolic syndrome in euthyroid postmenopausal women
Park, H. T., Cho, G. J., Ahn, K. H., Shin, J., Hong, S., Kim, T., Hur, J. Y., Kim, Y. T., Lee, K. W., & Kim, S. H. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.01.007 · Cited by 121 · see citing works
A cross-sectional survey of relationship between serum TSH level and blood pressure
Liu, D., Jiang, F., Shan, Z., Wang, B., Wang, J., Lai, Y., Chen, Y. A., Li, M., Liu, H., Li, C., et al. (2009) · Journal of Human Hypertension · doi:10.1038/jhh.2009.44 · Cited by 113 · see citing works
Åsvold, B. O., Bjøro, T., Platou, C., & Vatten, L. J. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04477.x · Cited by 107 · see citing works
Self-citationIttermann, T., Haring, R., Wallaschofski, H., Baumeister, S. E., Nauck, M. A., Dörr, M., Lerch, M. M., zu Schwabedissen, H. E. M., Rosskopf, D., & Völzke, H. (2012) · Thyroid · doi:10.1089/thy.2011.0279 · Cited by 107 · see citing works
Reference intervals in the diagnosis of thyroid dysfunction: treating patients not numbers
Jonklaas, J., & Razvi, S. (2019) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30371-1 · Cited by 100 · see citing works
Chaker, L., Baumgartner, C., den Elzen, W. P. J., Collet, T.-H., Ikram, M. A., Blum, M. R., Dehghan, A., Drechsler, C., Luben, R. N., Portegies, M. L. P., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2255 · Cited by 92 · see citing works
Ittermann, T., Thamm, M., Wallaschofski, H., Rettig, R., & Völzke, H. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2768 · Cited by 92 · see citing works
Thyroid disruption: mechanism and clinical implications in human health.
Patrick, L. (2009) · PubMed · Cited by 92 · see citing works
Dekkers, O. M., Horváth–Puhó, E., Cannegieter, S. C., Vandenbroucke, J. P., Sørensen, H. T., & Jørgensen, J. O. L. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0576 · Cited by 85 · see citing works
Castiello, F., Olmedo, P., Gil, F., Molina, M., Mundo, A., Romero, R., Peñas-Ruiz, C., Gómez-Vida, J. M., Vela-Soria, F., & Freire, C. (2019) · Environmental Research · doi:10.1016/j.envres.2019.108958 · Cited by 82 · see citing works
Is subclinical hypothyroidism a cardiovascular risk factor in the elderly?
Pasqualetti, G., Tognini, S., Polini, A., Caraccio, N., & Monzani, F. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3818 · Cited by 79 · see citing works
Subclinical thyroid dysfunction and cardiovascular consequences: An alarming wake-up call?
Manolis, A. S., Manolis, T. A., Melita, H., & Manolis, A. S. (2019) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2019.02.011 · Cited by 81 · see citing works
Åsvold, B. O., Bjøro, T., & VATTEN, L. J. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0087 · Cited by 79 · see citing works
Thyroid Function Within the Normal Range and Risk of Coronary Heart Disease
Åsvold, B. O., VATTEN, L. J., Bjøro, T., Bauer, D. C., Bremner, A., Cappola, A. R., Ceresini, G., den Elzen, W. P. J., Ferrucci, L., Franco, O. H., et al. (2015) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.0930 · Cited by 77 · see citing works
Woodruff, T. J., Zeise, L. A., Axelrad, D. A., Guyton, K. Z., Janssen, S. J., Miller, M. D., Miller, G. G., Schwartz, J. M., Alexeeff, G. V., Anderson, H. A., et al. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11516 · Cited by 77 · see citing works
Ambrosi, B., Masserini, B., Iorio, L., Delnevo, A., Malavazos, A. E., Morricone, L. F., Sburlati, L. F., & Orsi, E. (2010) · Journal of Endocrinological Investigation · doi:10.1007/bf03346663 · Cited by 77 · see citing works
Taylor, P. N., Lansdown, A., Witczak, J., Khan, R., Rees, A., Dayan, C. M., & Okosieme, O. (2023) · Thyroid Research · doi:10.1186/s13044-023-00149-5 · Cited by 72 · see citing works
van de Ven, A. C., Muntjewerff, J.-W., Netea-Maier, R. T., de Vegt, F., Ross, H. A., Sweep, F. C. G. J., Kiemeney, L. A. L. M., Vos, P. E., Buitelaar, J. K., Hermus, A. R. M. M., et al. (2012) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2012.01870.x · Cited by 72 · see citing works
Thyroid Hormone and Coronary Artery Disease: From Clinical Correlations to Prognostic Implications
Coceani, M. A., Iervasi, G., Pingitore, A., Carpeggiani, C., & L’Abbate, A. (2009) · Clinical Cardiology · doi:10.1002/clc.20574 · Cited by 72 · see citing works
Levothyroxine for the Treatment of Subclinical Hypothyroidism and Cardiovascular Disease
Sue, L. Y., & Leung, A. M. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.591588 · Cited by 76 · see citing works
Significant association between thyroid hormones and erythrocyte indices in euthyroid subjects
Bremner, A., Feddema, P., Joske, D. J. L., Leedman, P. J., O'Leary, P. C., Olynyk, J. K., & Walsh, J. P. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04228.x · Cited by 70 · see citing works
Chang, Y., Hua, S., Chang, C., Kao, W.-Y., Lee, H.-L., Chuang, L., Huang, Y., & Lai, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8060817 · Cited by 67 · see citing works
Martin, S. S., Daya, N. R., Lutsey, P. L., Matsushita, K., Fretz, A., McEvoy, J. W., Blumenthal, R. S., Coresh, J., Greenland, P., Köttgen, A., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00986 · Cited by 63 · see citing works
Thyroid disease and the metabolic syndrome
Mehran, L., Amouzegar, A., & Azizi, F. (2019) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000500 · Cited by 63 · see citing works
Subclinical Hypothyroidism and Cardiovascular Disease
Suh, S., & Kim, D. K. (2015) · Endocrinology and Metabolism · doi:10.3803/enm.2015.30.3.246 · Cited by 58 · see citing works
Panicker, V., Wilson, S. G., Walsh, J. P., Richards, J. B., Brown, S. J., Beilby, J. P., Bremner, A., Surdulescu, G. L., Qweitin, E., Gillham‐Nasenya, I., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.08.005 · Cited by 55 · see citing works
Thyrotropin Levels Are Associated with Cardiometabolic Risk Factors in Euthyroid Adolescents
Le, T. N., Celi, F. S., & Wickham, E. P. (2016) · Thyroid® · doi:10.1089/thy.2016.0055 · Cited by 53 · see citing works
Kuś, A., Marouli, E., Fabiola Del Greco, M., Chaker, L., Bednarczuk, T., Peeters, R. P., Teumer, A., Medici, M., & Deloukas, P. (2020) · Thyroid · doi:10.1089/thy.2020.0393 · Cited by 52 · see citing works
Thyroid function and the metabolic syndrome in older persons: a population-based study
Heima, N. E., Eekhoff, E. M. W., Oosterwerff, M. M., Lips, P. T. A. M., van Schoor, N. M., & Şimşek, S. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0375 · Cited by 49 · see citing works
Chrysant, S. G. (2020) · International Journal of Clinical Practice · doi:10.1111/ijcp.13499 · Cited by 48 · see citing works
Byrne, S. C., Miller, P. K., Seguinot-Medina, S., Waghiyi, V., Buck, C. L., von Hippel, F. A., & Carpenter, D. O. (2018) · Scientific Reports · doi:10.1038/s41598-018-20443-9 · Cited by 47 · see citing works
Zhang, J., Jiang, R., Li, L., Li, P., Li, X., Wang, Z., Li, L., & Teng, W. (2014) · International Journal of Endocrinology · doi:10.1155/2014/289503 · Cited by 43 · see citing works
Taylor, P. N., Panicker, V., Sayers, A., Shields, B., Iqbal, A., Bremner, A. P., Beilby, J. P., Leedman, P. J., Hattersley, A. T., Vaidya, B., et al. (2011) · European Journal of Endocrinology · doi:10.1530/eje-10-0938 · Cited by 41 · see citing works
Relationship between serum TSH level with obesity and NAFLD in euthyroid subjects
Zhang, J., Sun, H., Chen, L., Zheng, J., Hu, X., Wang, S., & Chen, T. (2012) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-012-0008-8 · Cited by 42 · see citing works
Kongtip, P., Nankongnab, N., Tipayamongkholgul, M., Bunngamchairat, A., Yimsabai, J., Pataitiemthong, A., & Woskie, S. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15112590 · Cited by 42 · see citing works
High Serum Thyrotropin Levels Are Associated with Current But Not with Incident Hypertension
Ittermann, T., Tiller, D., Meisinger, C., Agger, C., Nauck, M. A., Rettig, R., Albert Hofman, D., Jørgensen, T., Linneberg, A. R., Witteman, J. C. M., et al. (2013) · Thyroid · doi:10.1089/thy.2012.0626 · Cited by 41 · see citing works
Are serum thyrotropin levels within the reference range associated with endothelial function?
Völzke, H., Robinson, D. M., Spielhagen, T., Nauck, M. A., Obst, A., Ewert, R., Wolff, B., Wallaschofski, H., Felix, S. B., & Dörr, M. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn508 · Cited by 41 · see citing works
Amouzegar, A., Kazemian, E., Abdi, H., Mansournia, M. A., Bakhtiyari, M., Hosseini, M. S., & Azizi, F. (2018) · Thyroid · doi:10.1089/thy.2017.0454 · Cited by 41 · see citing works
Godoy, G. A. F., Korevaar, T. I. M., Peeters, R. P., Albert Hofman, D., de Rijke, Y. B., Bongers‐Schokking, J. J., Tiemeier, H. W., Jaddoe, V. W. V., & Gaillard, R. (2014) · Clinical Endocrinology · doi:10.1111/cen.12399 · Cited by 41 · see citing works
Barić, A., Brčić, L., Gračan, S., Škrabić, V., Brekalo, M., Šimunac, M., Lovrić, V. T., Anić, I., Barbalić, M., Zemunik, T., et al. (2018) · Immunological Investigations · doi:10.1080/08820139.2018.1529040 · Cited by 39 · see citing works
van de Ven, A. C., Netea-Maier, R. T., de Vegt, F., Ross, H. A., Sweep, F. C. G. J., Kiemeney, L. A. L. M., Hermus, A. R., & den Heijer, M. (2012) · Thyroid · doi:10.1089/thy.2011.0200 · Cited by 37 · see citing works
He, W., Li, S., Zhang, J., Zhang, J., Mu, K., & Li, X. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00454 · Cited by 37 · see citing works
Relationship between thyroid function and elevated blood pressure in euthyroid adults
Gu, Y., Zheng, L., Zhang, Q., Liu, L., Meng, G., Yao, Z., Wu, H., Xia, Y., Bao, X., Shi, H., et al. (2018) · Journal of Clinical Hypertension · doi:10.1111/jch.13369 · Cited by 37 · see citing works
Arterial hypertension and thyroid disorders: What is important to know in clinical practice?
Mazza, A., Beltramello, G., Armigliato, M., Montemurro, D., Zorzan, S., Zuin, M., Rampin, L., Marzola, M. C., Grassetto, G., AL-NAHHAS, A. M., et al. (2011) · Annales d Endocrinologie · doi:10.1016/j.ando.2011.05.004 · Cited by 36 · see citing works
Güzel, S., Seven, A., Güzel, E. Ç., Buyuk, B., Çelebi, A., & Aydemir, B. (2013) · Endocrine Research · doi:10.3109/07435800.2012.760588 · Cited by 35 · see citing works
Kim, H. J., Bae, J. C., Park, H. K., Byun, D. W., Suh, K., Yoo, M. H., Kim, J. H., Min, Y., Kim, S. W., & Chung, J. H. (2016) · Endocrinology and Metabolism · doi:10.3803/enm.2016.31.2.311 · Cited by 35 · see citing works
Giandalia, A., Russo, G. T., Romeo, E. L., Alibrandi, A., Villari, P., Mirto, A., Armentano, G., Benvenga, S., & Cucinotta, D. (2014) · Endocrine · doi:10.1007/s12020-013-0137-2 · Cited by 34 · see citing works
Żeber‐Lubecka, N., & Hennig, E. E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.606620 · Cited by 33 · see citing works
Chen, Y., Zhu, C., Chen, Y., Wang, N., Li, Q., Han, B., Zhao, L., Chen, C., Zhai, H., Zhang, L., et al. (2018) · Mediators of Inflammation · doi:10.1155/2018/1856137 · Cited by 33 · see citing works
Chen, H., Xi, Q., Zhang, H., Song, B., Liu, X., Mao, X., Li, J., Shen, H., Tang, W., Zhang, J., et al. (2011) · Endocrine · doi:10.1007/s12020-011-9517-7 · Cited by 32 · see citing works
Zhan, M., Chen, G., Pan, C., Gu, Z., Zhao, S., Liu, W. Y., Wang, H.-N., Ye, X.-P., Xie, H.-J., Yu, S.-S., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu250 · Cited by 32 · see citing works
Improvements in Insulin Sensitivity Are Blunted by Subclinical Hypothyroidism
Amati, F., Dubé, J. J., Stefanović-Račić, M., Toledo, F. G. S., & Goodpaster, B. H. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318187c010 · Cited by 32 · see citing works
Thyroid-Stimulating Hormone Levels Are Positively Associated with Insulin Resistance
Zhu, P., Liu, X., & Mao, X. (2018) · Medical Science Monitor · doi:10.12659/msm.905774 · Cited by 31 · see citing works
Moon, S., Kong, S. H., Choi, H. S., Hwangbo, Y., Lee, M., Moon, J. H., Jang, H. C., Cho, N. H., & Park, Y. J. (2018) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2018.03.371 · Cited by 31 · see citing works
Saltiki, K., Voidonikola, P. T., Stamatelopoulos, K. S., Mantzou, E., Papamichael, C. M., & Alevizaki, M. K. (2008) · Thyroid Research · doi:10.1186/1756-6614-1-3 · Cited by 31 · see citing works
Hypothyroidism: Cardiovascular Endpoints of Thyroid Hormone Replacement
Stamatouli, A. M., Bedoya, P., & Yavuz, S. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00888 · Cited by 34 · see citing works
Lambrinoudaki, I. V., Armeni, E., Rizos, D., Georgiopoulos, G. A., Kazani, M. V., Alexandrou, A. P., Deligeoroglou, E., Livada, A., Psychas, C., Creatsa, M. G., et al. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e32834f5076 · Cited by 30 · see citing works
Debeij, J., Dekkers, O. M., Åsvold, B. O., Christiansen, S. C., Næss, I. A., Hammerstrøm, J., Rosendaal, F. R., & Cannegieter, S. C. (2012) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2012.04818.x · Cited by 29 · see citing works
Association of Thyroid-stimulating Hormone and Cardiovascular Risk Factors
Sun, X., Sun, Y., Li, W., Chen, C.-Y., Chiu, Y.-H., Chien, H.-Y., & Wang, Y. (2015) · Internal Medicine · doi:10.2169/internalmedicine.54.4514 · Cited by 29 · see citing works
Khan, K. M., Parvez, F., Zoeller, R. T., Hocevar, B. A., Kamendulis, L. M., Rohlman, D. S., Eunus, M., & Graziano, J. H. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.04.426 · Cited by 28 · see citing works
Ittermann, T., Dörr, M., Völzke, H., Tost, F., Lehmphul, I., Köhrle, J., & Jürgens, C. (2014) · Thyroid · doi:10.1089/thy.2014.0190 · Cited by 28 · see citing works
Boggio, A., Muzio, F., Fiscella, M., Sommariva, D., & Branchi, A. (2011) · Internal and Emergency Medicine · doi:10.1007/s11739-011-0743-z · Cited by 28 · see citing works
Should we treat mild subclinical/mild hyperthyroidism? Yes
Wiersinga, W. M. (2011) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2011.03.008 · Cited by 27 · see citing works
Obesity with and without metabolic syndrome: Do vitamin D and thyroid autoimmunity have a role?
Ağbaht, K., Mercan, Y., Kutlu, S., Alpdemir, M. F., & Sezgin, T. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.08.001 · Cited by 28 · see citing works
Zhang, X., Xie, Y., Ding, C., Xiao, J., Tang, Y., Jiang, X., Shan, H., Lin, Y., Zhu, Y., Li, C., et al. (2017) · Clinical Endocrinology · doi:10.1111/cen.13383 · Cited by 27 · see citing works
Langén, V. L., Niiranen, T., Puukka, P. J., Sundvall, J., & Jula, A. M. (2015) · Clinical Endocrinology · doi:10.1111/cen.12876 · Cited by 25 · see citing works
Okopień, B., & Krysiak, R. G. (2012) · Thrombosis and Haemostasis · doi:10.1160/th12-04-0275 · Cited by 25 · see citing works
Neves, J. S., Fontes‐Carvalho, R., Borges‐Canha, M., Leite, A. R., Martins, S., Oliveira, A. B. F. D., Guimarães, J. T., Carvalho, D. M., Leite-Moreira, A. F., & Azevedo, A. (2020) · European Thyroid Journal · doi:10.1159/000508407 · Cited by 26 · see citing works
Determinants of Hypertension amongst Rice Farmers in West Java, Indonesia
Prihartono, N. A., Fitria, L., Ramdhan, D. H., Fitriyani, F., Fauzia, S., & Woskie, S. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19031152 · Cited by 24 · see citing works
Cardiovascular Risk and Quality of Life in Elderly People with Mild Thyroid Hormone Deficiency
Tognini, S., Pasqualetti, G., Calsolaro, V., Polini, A., Caraccio, N., & Monzani, F. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00153 · Cited by 23 · see citing works
Urrunaga‐Pastor, D., Guarnizo-Poma, M., Moncada–Mapelli, E., Aguirre, L. G., Lázaro-Alcántara, H., Paico-Palacios, S., Pantoja-Torres, B., & Benites-Zapata, V. A. (2017) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2017.12.003 · Cited by 23 · see citing works
Mining Chemical Activity Status from High-Throughput Screening Assays
Soufan, O., Ba-Alawi, W., Afeef, M., Essack, M., Rodionov, V. O., Kalnis, P., & Bajić, V. B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144426 · Cited by 22 · see citing works
Associations Between Thyroid and Blood Pressure in Euthyroid Adults: A 9-Year Longitudinal Study
Abdi, H., Gharibzadeh, S., Tasdighi, E., Amouzegar, A., Mehran, L., Tohidi, M., & Azizi, F. (2018) · Hormone and Metabolic Research · doi:10.1055/s-0044-101756 · Cited by 22 · see citing works
van der Deure, W. M., Peeters, R. P., Uitterlinden, A. G., Albert Hofman, D., Breteler, M. M. B., Witteman, J. C. M., & Visser, T. J. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03447.x · Cited by 22 · see citing works
He, W., Li, S., Wang, B., Mu, K., Shao, X., Yao, Q., Li, L., Li, Q., & Zhang, J.-A. (2019) · Journal of Hypertension · doi:10.1097/hjh.0000000000001826 · Cited by 21 · see citing works
Hypothyroidism, atherosclerosis and cardiovascular risk prevention
Duntas, L. H., & Feldt‐Rasmussen, U. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01202-z · Cited by 22 · see citing works
Metabolic Syndrome in Thyroid Disease
Iwen, K. A., Oelkrug, R., Kalscheuer, H., & Brabant, G. E. (2018) · Frontiers of hormone research · doi:10.1159/000485996 · Cited by 21 · see citing works
Turchi, F., Ronconi, V., di Tizio, V., Boscaro, M., & Giacchetti, G. (2011) · American Journal of Hypertension · doi:10.1038/ajh.2011.144 · Cited by 21 · see citing works
Normal thyroid-stimulating hormone levels, autoimmune activation, and coronary heart disease risk
Onat, A., Aydın, M., Can, G., Çelik, E., Altay, S., Karagöz, A., & Ademoğlu, E. (2014) · Endocrine · doi:10.1007/s12020-014-0269-z · Cited by 21 · see citing works
Kim, T. H., Choi, H. S., Bae, J. C., Moon, J. H., Kim, H., Choi, S. H., Lim, S. K., Park, D. J., Park, K. S., Jang, H. C., et al. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0464 · Cited by 21 · see citing works
Iida, M., 山本, 充., Ishiguro, Y., Yamazaki, M., Honjo, H., & Kamiya, K. (2012) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2012.04.002 · Cited by 20 · see citing works
Zhou, Y., Fang, W., Kao, T., Wang, C., Chang, Y., Peng, T., Wu, C., Yang, H., Chan, J. Y., & Chen, W. (2018) · PLoS ONE · doi:10.1371/journal.pone.0199209 · Cited by 20 · see citing works
- Authors
- Åsvold, B. O., Bjøro, T., Nilsen, T. I. L., & Vatten, L. J.
- Affiliations
- Department of Public Health (B.O. Å., T.I.L.N., L.J.V.), Faculty of Medicine, Norwegian University of Science and Technology, N-7489 Trondheim, Norway
- Oslo University Hospital (NO)
- Norwegian University of Science and Technology (NO)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2007-03-01
- Volume
- 92
- Issue
- 3
- Pages
- 841-845
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2079601862
- Cited by
- 215
- References
- 29
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 8 · 2023: 7 · 2022: 13 · 2021: 9 · 2020: 15 · 2019: 15 · 2018: 17 · 2017: 8 · 2016: 13 · 2015: 12 · 2014: 15 · 2013: 11 · 2012: 18
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Norwegian Institute of Public Health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- thyroid-stimulating hormone, blood pressure, hypertension, thyroid function, reference values, systolic blood pressure, diastolic blood pressure, pulse pressure, cardiovascular health
- MeSH terms
- Adult, Aged, Aged, 80 and over, Blood Pressure, Cross-Sectional Studies, Female, Health Surveys, Humans, Hypertension, Male, Middle Aged, Norway, Reference Values, Thyrotropin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
