Glucagon-like peptide-1 reduces the pulsatile component of testosterone secretion in healthy males
Open accessAbstract
BACKGROUND: Glucagon-like-peptide-1 (7-36) amide (GLP-1), a potent regulator of glucose homeostasis, has been implicated in the control of hypothalamic-pituitary function. In vivo it is a relevant neuroendocrine modulator of gonadotropin-releasing hormone release, suggesting its possible role as a metabolic signal to the reproductive system. The present study was undertaken to establish its effect on luteinizing hormone (LH) and testosterone secretion in nine healthy male volunteers. MATERIALS AND METHODS: Each subject underwent an oral glucose tolerance test to establish LH, testosterone, and GLP-1 responses to glucose. Euglycaemic clamp experiments (6 h) were performed on two occasions with saline or with a constant infusion of GLP-1 (0.4 pmol kg(-1) min (-1)). Blood samples were drawn at 10-min intervals to measure the pulsatile pattern of LH and testosterone secretion. RESULTS: Ingestion of oral glucose resulted in a reduction in plasma testosterone levels at 30 min compared with baseline (P < 0.004) despite unaltered LH levels (P = 0.5). Constant GLP-1 infusion resulted in no change in LH (P = 0.83), testosterone (P = 0.96), follicle stimulating hormone (FSH) (P = 0.86) and leptin levels (P = 0.3). Pulse analysis revealed no significant difference in the number (P = 0.1) or median absolute amplitude (P = 0.3) of the LH pulses. However, there was a significant decrease in the number (3.0 +/- 0.6 vs. 1.3 +/- 0.4; P < 0.05) and a tendency for increased duration of testosterone pulses (97.4 +/- 16.7 vs. 170 +/- 27.1 min; P = 0.06). CONCLUSION: Oral glucose ingestion and intravenous GLP-1 infusion reduce the pulsatile component of testosterone secretion by a mechanism independent of LH release.
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Some animal studies demonstrated the potential involvement of GLP1 in the direct regulation of the hypothalamus-pituitary system.
“some animal studies demonstrated the potential involvement of GLP1 in the direct regulation of the hypothalamus-pituitary system.”
From Effects of liraglutide on obesity-associated functional hypogonadism in men (2019) · cites this paper as [30]
Intracerebroventricular injection of GLP1 increased the levels of LH in rats.
“Intracerebroventricular injection of GLP1 increased the levels of LH in rats (30).”
From Effects of liraglutide on obesity-associated functional hypogonadism in men (2019) · cites this paper as [30]
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The Relationship of Testosterone, Appetite, Food Intake and Exercise in Male Adolescents
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- Authors
- Jeibmann, A., Zahedi, S., Simoni, M., Nieschlag, E., & Byrne, M. M.
- Affiliations
- University of Münster (DE)
- Corresponding author
- Byrne, M. M.
- Venue
- European Journal of Clinical Investigation
- Publisher
- Wiley
- Published
- 2005-08-26
- Volume
- 35
- Issue
- 9
- Pages
- 565-572
- ISSN
- 0014-2972 (ISSN-L)
- 1365-2362
- OpenAlex
- W2104263970
- Cited by
- 57
- References
- 42
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 4 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- European Journal of Clinical Investigation (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Funders
- Westfälische Wilhelms-Universität Münster
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- glucagon-like peptide-1, testosterone secretion, pulsatile hormone secretion, luteinizing hormone, hypothalamic-pituitary function, glucose ingestion, euglycaemic clamp, follicle-stimulating hormone, leptin, male reproductive endocrinology
- MeSH terms
- Administration, Oral, Adult, Blood Glucose, Glucagon-Like Peptides, Glucagon, Glucose, Glucose Tolerance Test, Humans, Infusions, Intravenous, Insulin, Luteinizing Hormone, Male, Peptide Fragments, Testosterone, Glucose Clamp Technique, Leptin, Glucagon-Like Peptide 1
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