Fast effects of glucocorticoids on memory-related network oscillations in the mouse hippocampus
Open accessAbstract
Transient or lasting increases in glucocorticoids accompany deficits in hippocampus‐dependent memory formation. Recent data indicate that the formation and consolidation of declarative and spatial memory are mechanistically related to different patterns of hippocampal network oscillations. These include gamma oscillations during memory acquisition and the faster ripple oscillations (approximately 200 Hz) during subsequent memory consolidation. We therefore analysed the effects of acutely applied glucocorticoids on network activity in mouse hippocampal slices. Evoked field population spikes and paired‐pulse responses were largely unaltered by corticosterone or cortisol, respectively, despite a slight increase in maximal population spike amplitude by 10 μ m corticosterone. Several characteristics of sharp waves and superimposed ripple oscillations were affected by glucocorticoids, most prominently the frequency of spontaneously occurring sharp waves. At 0.1 μ m, corticosterone increased this frequency, whereas maximal (10 μ m) concentrations led to a reduction. In addition, gamma oscillations became slightly faster and less regular in the presence of high doses of corticosteroids. The present study describes acute effects of glucocorticoids on sharp wave‐ripple complexes and gamma oscillations in mouse hippocampal slices, revealing a potential background for memory deficits in the presence of elevated levels of these hormones.
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Conditions such as globally low levels of acetylcholine and glucocorticoids together with the occurrence of SO, spindles and ripples that hallmark SWS facilitate hippocampal replay, output, and the transmission of reactivated memory information toward neocortical long-term storage sites.
“Indeed, conditions such as the globally low levels of acetylcholine and glucocorticoids together with the occurrence of SO, spindles and ripples that hallmark SWS, facilitate hippocampal replay, output, and the transmission of reactivated memory information toward neocortical long-term storage sites.281,[286][287][288][289]”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [281]
The Results report that high-dose corticosterone reduced sharp-wave frequency in mouse hippocampal slices, and the Discussion links elevated glucocorticoids to impaired memory formation during slow-wave sleep. This supports a role for glucocorticoid levels in memory-related oscillations, but the paper does not establish that the combined conditions of low acetylcholine, slow oscillations, spindles and ripples facilitate replay or transfer of memories to neocortex. Page numbers are unavailable in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measuredIn hippocampal slice preparations, low glucocorticoid concentrations increased rates of SPW-Rs typically accompanying memory replay whereas high glucocorticoid concentration suppressed SPW-Rs.
“In hippocampal slice preparations, low glucocorticoid concentrations increased rates of SPW-Rs typically accompanying memory replay whereas high glucocorticoid concentration suppressed SPW-Rs, 281”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [281]
The Results report that low-dose corticosterone increased sharp-wave occurrence in mouse hippocampal slices, while high-dose corticosterone reduced it. The claim generalizes this pattern to glucocorticoids, but the same Results section says high-dose cortisol had no effect on sharp-wave frequency. The measured change was in the occurrence of sharp waves, not the frequency of oscillations within ripples. (LLM, conf=0.85)
Experimental — accuracy not yet measuredNaturally low glucocorticoid concentrations are important for consolidation during nocturnal sleep.
“underlining the importance of naturally low glucocorticoid concentrations for consolidation during nocturnal sleep.”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [281]
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- Authors
- Weiss, E. K., Krupka, N., Bähner, F., Both, M., & Draguhn, A.
- Affiliations
- Heidelberg University (DE)
- Corresponding author
- Draguhn, A.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2008-03-17
- Volume
- 20
- Issue
- 5
- Pages
- 549-557
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2030965773
- Semantic Scholar
- 4cce4142db9ef2d6fb5bad89eae3f43417e246eb
- Cited by
- 23
- References
- 43
- Citations by year
- 2025: 1 · 2023: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB 636)
- Universität Heidelberg
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- glucocorticoids, corticosterone, cortisol, hippocampus, memory consolidation, gamma oscillations, memory impairment
- MeSH terms
- Action Potentials, Animals, Biological Clocks, Corticosterone, Dose-Response Relationship, Drug, Glucocorticoids, Hippocampus, Male, Memory, Memory Disorders, Mice, Inbred C57BL, Nerve Net, Neuronal Plasticity, Mice
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