High-Frequency Oscillations in the Output Networks of the Hippocampal–Entorhinal Axis of the Freely Behaving Rat
Open accessAbstract
Population bursts of the CA3 network, which occur during eating, drinking, awake immobility, and slow-wave sleep, produce a large field excitatory postsynaptic potential throughout stratum radiatum of the CA1 field (sharp wave). The CA3 burst sets into motion a short-lived, dynamic interaction between CA1 pyramidal cells and interneurons, the product of which is a 200 Hz oscillatory field potential (ripple) and phase-related discharge of the CA1 network. Although many CA1 pyramidal neurons discharge during the time frame (50–100 msec) of each sharp wave, each wave of a ripple (∼5 msec) reflects the synchronization of more discrete subsets of CA1 neurons. When we used multi-site recordings in freely behaving rats, we observed ripples throughout the longitudinal extent (∼4–5 mm) of the dorsal CA1 region that were coherent for multiple cycles of each ripple. High-frequency ripples were also observed throughout the hippocampal–entorhinal output pathway that were concurrent but less coherent on a cycle-by-cycle basis. Single and multiunit neuronal activity was phase-related to local ripples throughout the hippocampal–entorhinal output pathway. Entorhinal ripples occurred 5–30 msec after the CA1 ripples and were related to the occurrence of an entorhinal sharp wave. Thus, during each hippocampal sharp wave, there is a powerful synchronization among the neuronal networks that connect the hippocampus to the neocortex. We suggest that this population interaction (1) biologically constrains theoretical models of hippocampal function and dysfunction and (2) has the capacity to support an “off-line” memory consolidation process.
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SW-Rs occur mainly during SWS but also during nonexploratory wakefulness.
“SW-Rs occur mainly during SWS but also during nonexploratory wakefulness (e.g., drinking, grooming, and quiet wakefulness).”
From About Sleep's Role in Memory (2013) · cites this paper as [196]
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- Authors
- Chrobak, J. J., & Buzsáki, G.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- ORCID
- Chrobak, James J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1996-05-01
- Volume
- 16
- Issue
- 9
- Pages
- 3056-3066
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6579047
- OpenAlex
- W1612572634
- Cited by
- 587
- References
- 5
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 13 · 2023: 32 · 2022: 16 · 2021: 16 · 2020: 27 · 2019: 16 · 2018: 26 · 2017: 20 · 2016: 20 · 2015: 19 · 2014: 24 · 2013: 28 · 2012: 23
- FWCI
- 9.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Alzheimer's Association
- National Institutes of Health (5p41rr009754-09)
- National Institute of Neurological Disorders and Stroke (R01NS034994, NS-34994)
- National Center for Research Resources (1P41RR-09754)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampal ripples, sharp-wave ripples, CA1 pyramidal neurons, neuronal synchronization, field excitatory postsynaptic potentials, freely moving rats
- MeSH terms
- Animals, Efferent Pathways, Electrophysiology, Hippocampus, Nerve Net, Oscillometry, Rats, Sprague-Dawley, Entorhinal Cortex, Rats
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