Cited by 76Estrogen and related hormone effectsStress Responses and CortisolNeuroscience and Neuropharmacology Research

Nongenomic actions of adrenal steroids in the central nervous system

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Evanson, N. K., Herman, J. P., Sakai, R. R., Krause, E. G.·2010·Journal of Neuroendocrinology

Abstract

Mineralocorticoids and glucocorticoids are steroid hormones that are released by the adrenal cortex in response to stress and hydromineral imbalance. Historically, adrenocorticosteroid actions are attributed to effects on gene transcription. More recently, however, it has become clear that genome‐independent pathways represent an important facet of adrenal steroid actions. These hormones exert nongenomic effects throughout the body, although a significant portion of their actions are specific to the central nervous system. These actions are mediated by a variety of signalling pathways, and lead to physiologically meaningful events in vitro and in vivo. We review the nongenomic effects of adrenal steroids in the central nervous system at the levels of behaviour, neural system activity, individual neurone activity and subcellular signalling activity. A clearer understanding of adrenal steroid activity in the central nervous system will lead to a better ability to treat human disease as well as reduce the side‐effects of the steroid treatments already in use.

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Crossref · 10.1111/j.1365-2826.2010.02000.x

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  • Cortisol can modulate the activity of neural structures through genomic and non-genomic bottom-up actions on glucocorticoid and mineralocorticoid receptors.

    “cortisol can also modulate the activity of neural structures through genomic and non-genomic bottom-up actions on GR and MR (Evanson et al. 2010).”

    From The HPA axis in bipolar disorder: Systematic review and meta-analysis (2016) · cites this paper as Evanson et al. 2010

  • These molecular abnormalities might be the consequence of chronic exposure to high cortisol levels and can constitute the basis of abnormal neural responses to glucocorticoids in key structures for the pathophysiology of bipolar disorder.

    “These abnormalities might be the consequence of chronic exposure to high levels of CORT, and can also constitute the basis of abnormal neural responses to glucocorticoids (Evanson et al. 2010) in key structures for the pathophysiology of BD (Kupferschmidt and Zakzanis ,2011;Maletic and Raison ,2014).”

    From The HPA axis in bipolar disorder: Systematic review and meta-analysis (2016) · cites this paper as Evanson et al. 2010

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Authors
Evanson, N. K., Herman, J. P., Sakai, R. R., & Krause, E. G.
Affiliations
University of Cincinnati (US)
Corresponding author
Evanson, N. K.
Venue
Journal of Neuroendocrinology
Publisher
Wiley
Published
2010-07-16
Volume
22
Issue
8
Pages
846-861
ISSN
  • 0953-8194 (ISSN-L)
  • 1365-2826
OpenAlex
W1977011758
Cited by
76
References
168
Citations by year
2026: 1 · 2025: 6 · 2024: 5 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 8 · 2013: 6 · 2012: 9
FWCI
0.78
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Heart, Lung, and Blood Institute (R00HL096830, K99HL096830, HL096830)
  • National Institute of Mental Health (MH 069725, R01MH069725)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK-066596, DK048061, DK79710, R01DK048061, F32DK079710, R01DK066596, R29DK048061)
  • National Institute of Neurological Disorders and Stroke (NS007453, T32NS007453)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
non-genomic steroid action, adrenal steroids, mineralocorticoids, glucocorticoids, central nervous system, behavior, neuronal activity, stress, hydromineral balance
MeSH terms
Adrenal Glands, Animals, Behavior, Central Nervous System, Glucocorticoids, Humans, Hypothalamo-Hypophyseal System, Mineralocorticoids, Pituitary-Adrenal System, Signal Transduction

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