Nongenomic actions of adrenal steroids in the central nervous system
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Mineralocorticoids and glucocorticoids are steroid hormones that are released by the adrenal cortex in response to stress and hydromineral imbalance. Historically, adrenocorticosteroid actions are attributed to effects on gene transcription. More recently, however, it has become clear that genome‐independent pathways represent an important facet of adrenal steroid actions. These hormones exert nongenomic effects throughout the body, although a significant portion of their actions are specific to the central nervous system. These actions are mediated by a variety of signalling pathways, and lead to physiologically meaningful events in vitro and in vivo. We review the nongenomic effects of adrenal steroids in the central nervous system at the levels of behaviour, neural system activity, individual neurone activity and subcellular signalling activity. A clearer understanding of adrenal steroid activity in the central nervous system will lead to a better ability to treat human disease as well as reduce the side‐effects of the steroid treatments already in use.
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Cortisol can modulate the activity of neural structures through genomic and non-genomic bottom-up actions on glucocorticoid and mineralocorticoid receptors.
“cortisol can also modulate the activity of neural structures through genomic and non-genomic bottom-up actions on GR and MR (Evanson et al. 2010).”
From The HPA axis in bipolar disorder: Systematic review and meta-analysis (2016) · cites this paper as Evanson et al. 2010
These molecular abnormalities might be the consequence of chronic exposure to high cortisol levels and can constitute the basis of abnormal neural responses to glucocorticoids in key structures for the pathophysiology of bipolar disorder.
“These abnormalities might be the consequence of chronic exposure to high levels of CORT, and can also constitute the basis of abnormal neural responses to glucocorticoids (Evanson et al. 2010) in key structures for the pathophysiology of BD (Kupferschmidt and Zakzanis ,2011;Maletic and Raison ,2014).”
From The HPA axis in bipolar disorder: Systematic review and meta-analysis (2016) · cites this paper as Evanson et al. 2010
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The molecular physiology of CRH neurons
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Encoding and decoding mechanisms of pulsatile hormone secretion
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- Authors
- Evanson, N. K., Herman, J. P., Sakai, R. R., & Krause, E. G.
- Affiliations
- University of Cincinnati (US)
- Corresponding author
- Evanson, N. K.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2010-07-16
- Volume
- 22
- Issue
- 8
- Pages
- 846-861
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- PMC
- PMC4676409
- OpenAlex
- W1977011758
- Cited by
- 76
- References
- 168
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 5 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 8 · 2013: 6 · 2012: 9
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R00HL096830, K99HL096830, HL096830)
- National Institute of Mental Health (MH 069725, R01MH069725)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-066596, DK048061, DK79710, R01DK048061, F32DK079710, R01DK066596, R29DK048061)
- National Institute of Neurological Disorders and Stroke (NS007453, T32NS007453)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- non-genomic steroid action, adrenal steroids, mineralocorticoids, glucocorticoids, central nervous system, behavior, neuronal activity, stress, hydromineral balance
- MeSH terms
- Adrenal Glands, Animals, Behavior, Central Nervous System, Glucocorticoids, Humans, Hypothalamo-Hypophyseal System, Mineralocorticoids, Pituitary-Adrenal System, Signal Transduction
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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