Timing is essential for rapid effects of corticosterone on synaptic potentiation in the mouse hippocampus
Open accessAbstract
Stress facilitates memory formation, but only when the stressor is closely linked to the learning context. These effects are, at least in part, mediated by corticosteroid hormones. Here we demonstrate that corticosterone rapidly facilitates synaptic potentiation in the mouse hippocampal CA1 area when high levels of the hormone and high-frequency stimulation coincide in time, but not when corticosterone is given either before or after repetitive stimulation. This effect could not be blocked by antagonists of the mineralocorticoid receptor and glucocorticoid receptor (spironolactone and RU 38486, respectively). These data provide a biological substrate for the important behavioral observation that stress and corticosteroid hormones can facilitate learning and memory processes.
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Brief application of corticosterone around the time of tetanizing stimulation enhanced LTP in CA1 in vitro via nongenomic activation of mineralocorticoid receptors.
“Joëls et al. have shown that brief application of corticosterone around the time of tetanizing stimulation enhanced LTP in CA1 in vitro via nongenomic activation of mineralocorticoid receptors (Karst et al. [230]; Wiegert et al. [231]).”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Wiegert et al. [231]
No sooner than several minutes after the onset of a stress experience, corticosterone would begin to activate mechanisms involved in hippocampal plasticity, thereby producing an enhancement of LTP (and memory) via nongenomic activation of mineralocorticoid receptors.
“Thus, no sooner than several minutes after the onset of a stress experience, corticosterone would begin to activate mechanisms involved in hippocampal plasticity, thereby producing an enhancement of LTP (and memory) via nongenomic activation of mineralocorticoid receptors (Karst et al. [230]; Wiegert et al. [231]).”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Wiegert et al. [231]
The relatively brief period in which the hippocampus would be activated by stress would be a sufficient time to initiate NMDA, and perhaps non-NMDA, receptor-mediated plasticity.
“The relatively brief period in which the hippocampus would be activated by stress would be a sufficient time to initiate NMDA, and perhaps non-NMDA, receptor-mediated plasticity (Joëls et al. [258]; Krugers et al. [155]; Wiegert et al. [231]; Morsink et al. [232])”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Wiegert et al. [231]
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- Authors
- Wiegert, O., Joëls, M., & Krugers, H.
- Affiliations
- University of Amsterdam (NL)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2006-03
- Volume
- 13
- Issue
- 2
- Pages
- 110-113
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- OpenAlex
- W1991628876
- Cited by
- 162
- References
- 6
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 2 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 7 · 2015: 4 · 2014: 13 · 2013: 12 · 2012: 11
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- corticosterone, synaptic potentiation, hippocampal CA1, timing of hormone administration, stress and memory, memory consolidation, high-frequency stimulation, mineralocorticoid receptor, glucocorticoid receptor, spironolactone, mifepristone
- MeSH terms
- Analysis of Variance, Animals, Corticosterone, Electric Stimulation, Hippocampus, Male, Mice, Inbred C57BL, Synaptic Transmission, Neurons, Stress, Physiological, Time Factors, Long-Term Potentiation, Mice, In Vitro Techniques
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