Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala

Johnson, L.R.; Farb, C.; Morrison, J.H.; McEwen, B.S.; Ledoux, J.E.

doi:10.1016/j.neuroscience.2005.06.050

Cited by 205Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsStress Responses and Cortisol

Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala

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Johnson, L.R., Farb, C., Morrison, J.H., McEwen, B.S., Ledoux, J.E.·2005·Neuroscience

DOI 10.1016/j.neuroscience.2005.06.050

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Abstract

Glucocorticoids, released in high concentrations from the adrenal cortex during stressful experiences, bind to glucocorticoid receptors in nuclear and peri-nuclear sites in neuronal somata. Their classically known mode of action is to induce gene promoter receptors to alter gene transcription. Nuclear glucocorticoid receptors are particularly dense in brain regions crucial for memory, including memory of stressful experiences, such as the hippocampus and amygdala. While it has been proposed that glucocorticoids may also act via membrane bound receptors, the existence of the latter remains controversial. Using electron microscopy, we found glucocorticoid receptors localized to non-genomic sites in rat lateral amygdala, glia processes, presynaptic terminals, neuronal dendrites, and dendritic spines including spine organelles and postsynaptic membrane densities. The lateral nucleus of the amygdala is a region specifically implicated in the formation of memories for stressful experiences. These newly observed glucocorticoid receptor immunoreactive sites were in addition to glucocorticoid receptor immunoreactive signals observed using electron and confocal microscopy in lateral amygdala principal neuron and GABA neuron soma and nuclei, cellular domains traditionally associated with glucocorticoid immunoreactivity. In lateral amygdala, glucocorticoid receptors are thus also localized to non-nuclear-membrane translocation sites, particularly dendritic spines, where they show an affinity for postsynaptic membrane densities, and may have a specialized role in modulating synaptic transmission plasticity related to fear and emotional memory.

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Glucocorticoid receptor immunoreactivity exists in post-synaptic and other non-nuclear regions of neurons in the rodent brain.
“glucocorticoid receptor immunoreactivity in post-synaptic and other non-nuclear regions of neurons in the rodent brain (Liposits and Bohn, 1993,; Johnson et al., 2005)”
From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Johnson et al., 2005

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GLUCOCORTICOID RECEPTORS AND BEHAVIOR
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Untitled work
Lawson (1996) · doi:10.1002/(sici)1096-9861(19960212)365:3
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(1998) · doi:10.1002/(sici)1096-9861(19980808)395:3

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Physiology and neurobiology of stress and adaptation: central role of the brain
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A Comprehensive Overview on Stress Neurobiology: Basic Concepts and Clinical Implications
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Amygdala volume in major depressive disorder: a meta-analysis of magnetic resonance imaging studies
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Estrogen Effects on Cognitive and Synaptic Health Over the Lifecourse
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Steroid hormone receptor expression and function in microglia
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Metaplasticity of amygdalar responses to the stress hormone corticosterone
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Long-term potentiation in the amygdala: A cellular mechanism of fear learning and memory
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Estrogen effects on the brain: Actions beyond the hypothalamus via novel mechanisms.
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Dynamic plasticity: The role of glucocorticoids, brain-derived neurotrophic factor and other trophic factors
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Effect of brain‐derived neurotrophic factor haploinsufficiency on stress‐induced remodeling of hippocampal neurons
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Basolateral amygdala noradrenergic activity mediates corticosterone-induced enhancement of auditory fear conditioning
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Neural Regulation of the Stress Response: The Many Faces of Feedback
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“There is electron microscopy and neurochemical evidence for GR localization to neuronal membranes, in particular postsynaptic membranes, supporting an alternative role for the so-called nuclear receptor (Johnson et al. 2005; Komatsuzaki et al. 2005; Wang and Wang 2009; Prager et al. 2010).”
Brain mechanisms of HPA axis regulation: neurocircuitry and feedback in context Richard Kvetnansky lecture
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Glucocorticoid Effects on Memory Consolidation Depend on Functional Interactions between the Medial Prefrontal Cortex and Basolateral Amygdala
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Interactions between Temperament, Stress, and Immune Function in Cattle
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Novel Aspects of Glucocorticoid Actions
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Are BDNF and glucocorticoid activities calibrated?
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Glucocorticoid signaling and stress-related limbic susceptibility pathway: About receptors, transcription machinery and microRNA
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Corticotropin-Releasing Factor in the Basolateral Amygdala Enhances Memory Consolidation via an Interaction with the -Adrenoceptor-cAMP Pathway: Dependence on Glucocorticoid Receptor Activation
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Stress at the Synapse: Signal Transduction Mechanisms of Adrenal Steroids at Neuronal Membranes
Prager, E. M., & Johnson, L. R. (2009) · Science Signaling · doi:10.1126/scisignal.286re5 · Cited by 112 · see citing works
Memory consolidation during sleep: Interactive effects of sleep stages and HPA regulation: Review
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Glucocorticoids Modulate the mTOR Pathway in the Hippocampus: Differential Effects Depending on Stress History
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Establishing an Agenda for Translational Research on PTSD
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Self-citation
Mifepristone in the central nucleus of the amygdala reduces yohimbine stress-induced reinstatement of ethanol-seeking
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Glucocorticoid receptors and β-adrenoceptors in basolateral amygdala modulate synaptic plasticity in hippocampal dentate gyrus, but not in area CA1
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Authors: Johnson, L. R., Farb, C., Morrison, J. H., McEwen, B. S., & Ledoux, J. E.
Affiliations: New York University (US)
ORCID: Johnson, L.R.
Morrison, J.H.
McEwen, B.S.
Ledoux, J.E.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2005-01
Volume: 136
Issue: 1
Pages: 289-299
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2005.06.050
OpenAlex: W2017103890
Cited by: 205
References: 117
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 5 · 2020: 11 · 2019: 5 · 2018: 8 · 2017: 16 · 2016: 16 · 2015: 12 · 2014: 13 · 2013: 10 · 2012: 17
FWCI: 3.74
Type: journal article
Language: en
Open access: green
figshare.com
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
QUT ePrints (Queensland University of Technology) (submittedVersion)
Figshare (submittedVersion, cc-by)
Faculty of Health; Institute of Health and Biomedical Innovation
Funders: National Institute of Mental Health (MH-58911, P50MH058911)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: glucocorticoid receptor, lateral amygdala, postsynaptic membrane, dendritic spines, non-genomic steroid action, stress memory, fear memory, synaptic plasticity, presynaptic terminals, GABAergic neurons
MeSH terms: Amygdala, Animals, Immunologic Techniques, Male, Microscopy, Electron, Receptors, Glucocorticoid, Synaptic Membranes, Tissue Distribution, Rats, Sprague-Dawley, Rats

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Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala

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