The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Respiration metabolism of Group B Streptococcus is activated by environmental haem and quinone and contributes to virulence
Abstract
Summary: Group B Streptococcus (GBS) is a common constituent of the vaginal microflora, but its transmission to newborns can cause life‐threatening sepsis, pneumonia and meningitis. Energy metabolism of this opportunist pathogen has been deduced to be strictly fermentative. We discovered that GBS undergoes respiration metabolism if its environment supplies two essential respiratory components: quinone and haem. Respiration metabolism led to significant changes in growth characteristics, including a doubling of biomass and an altered metabolite profile under the tested conditions. The GBS respiratory chain is inactivated by: (i) withdrawing haem and/or quinone, (ii) treating cultures with a respiration inhibitor or (iii) inactivating the cydA gene product, a subunit of cytochrome bd quinol oxidase, in all cases resulting in exclusively fermentative growth. cydA inactivation reduced GBS growth in human blood and strongly attenuated virulence in a neonatal rat sepsis model, suggesting that the animal host may supply the components that activate GBS respiration. These results suggest a role of respiration metabolism in GBS dissemination. Our findings show that environmental factors can increase the flexibility of GBS metabolism by activating a newly identified respiration chain. The need for two environmental factors may explain why GBS respiration metabolism was not found in previous studies.
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“For bacteria that do not synthesize heme, heme acquisition allows them to aerobically respire or activate catalases, which protect against the oxidative burst of host phagocytes (29, 129).”
From Overcoming the Heme Paradox: Heme Toxicity and Tolerance in Bacterial Pathogens (2010) · cites this paper as [129]
In the citing paper
“This is exemplified by the inactivation of the S. agalactiae cytochrome bd quinol oxidase cydA , which prevents acquired heme from activating aerobic respiration reducing bacterial fitness in a murine model (129).”
From Overcoming the Heme Paradox: Heme Toxicity and Tolerance in Bacterial Pathogens (2010) · cites this paper as [129]
Citations
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale
DeRisi, J. L., Iyer, V. R., & Brown, P. O. (1997) · Science · doi:10.1126/science.278.5338.680 · Cited by 4,456
Harrison's Principles of Internal Medicine.
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-9-813_1 · Cited by 1,524
Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae
Tettelin, H., Nelson, K. E., Paulsen, I. T., Eisen, J. A., Read, T. D., Peterson, S., Heidelberg, J., DeBoy, R. T., Haft, D. H., Dodson, R. J., et al. (2001) · Science · doi:10.1126/science.1061217 · Cited by 1,342
Bacterial Iron Sources: From Siderophores to Hemophores
Wandersman, C., & Delepelaire, P. (2004) · Annual Review of Microbiology · doi:10.1146/annurev.micro.58.030603.123811 · Cited by 930
A role for excreted quinones in extracellular electron transfer
Newman, D. K., & Kolter, R. (2000) · Nature · doi:10.1038/35011098 · Cited by 884
Déziel, E., Lépine, F., Milot, S., He, J., Mindrinos, M. N., Tompkins, R. G., & Rahme, L. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307694100 · Cited by 637
Tettelin, H., Masignani, V., Cieslewicz, M. J., Eisen, J. A., Peterson, S., Wessels, M. R., Paulsen, I. T., Nelson, K. E., Margarit, I., Read, T. D., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182380799 · Cited by 500
Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease
Glaser, P., Rusniok, C., Buchrieser, C., Chevalier, F., Frangeul, L., Msadek, T., Zouine, M., Couvé, E., Lalioui, L., Poyart, C., et al. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03126.x · Cited by 476
Self-citationHigh-efficiency gene inactivation and replacement system for gram-positive bacteria
Biswas, I., Gruss, A., Ehrlich, S. D., & Maguin, E. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.11.3628-3635.1993 · Cited by 443
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Stress Physiology of Lactic Acid Bacteria.
Papadimitriou, K., Alegría, Á., Bron, P. A., de Angelis, M., Gobbetti, M., Kleerebezem, M., Lemos, J. A., Linares, D. M., Ross, P., Stanton, C., et al. (2016) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00076-15 · Cited by 914
Overcoming the Heme Paradox: Heme Toxicity and Tolerance in Bacterial Pathogens
Anzaldi, L. L., & Skaar, E. P. (2010) · Infection and Immunity · doi:10.1128/iai.00613-10 · Cited by 295
Aerobic Respiration Metabolism in Lactic Acid Bacteria and Uses in Biotechnology
Pedersen, M. B., Gaudu, P., Lechardeur, D., Petit, M.-A., & Gruss, A. (2012) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-022811-101255 · Cited by 197
Self-citationGlucose triggers ATP secretion from bacteria in a growth-phase-dependent manner
Hironaka, I., Iwase, T., Sugimoto, S., Okuda, K.-I., Tajima, A., Yanaga, K., & Mizunoe, Y. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.03871-12 · Cited by 87
Fernandez, A., Lechardeur, D., Derré-Bobillot, A., Couvé, E., Gaudu, P., & Gruss, A. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000860 · Cited by 65
Self-citationKnippel, R. J., Wexler, A. G., Miller, J. M., Beavers, W. N., Weiss, A., de Crécy-Lagard, V., Edmonds, K. A., Giedroc, D. P., & Skaar, E. P. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.05.015 · Cited by 62
Iron acquisition and regulation systems in Streptococcus species
Ge, R., & Sun, X. (2014) · Metallomics · doi:10.1039/c4mt00011k · Cited by 48
Lechardeur, D., Fernandez, A., Robert, B., Gaudu, P., Trieu-Cuot, P., Lamberet, G., & Gruss, A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.024505 · Cited by 47
Self-citationHeme proteins in lactic acid bacteria
Baureder, M., & Hederstedt, L. (2013) · Advances in Microbial Physiology · doi:10.1016/b978-0-12-410515-7.00001-9 · Cited by 45
HrtBA and menaquinones control haem homeostasis in Lactococcus lactis
Joubert, L., Derré‐Bobillot, A., Gaudu, P., Gruss, A., & Lechardeur, D. (2014) · Molecular Microbiology · doi:10.1111/mmi.12705 · Cited by 32
Self-citation
Metadata
- Authors
- Yamamoto, Y., Poyart, C., Trieu‐Cuot, P., Lamberet, G., Gruss, A., & Gaudu, P.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2005-03-07
- Volume
- 56
- Issue
- 2
- Pages
- 525-534
- ISSN
- 0950-382X
- 1365-2958
- Cited by
- 109
- References
- 47
- Language
- en
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
