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Cited by 109

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Respiration metabolism of Group B Streptococcus is activated by environmental haem and quinone and contributes to virulence

Yamamoto, Yuji, Poyart, Claire, Trieu‐Cuot, Patrick, Lamberet, Gilles, Gruss, Alexandra, Gaudu, Philippe·2005·Molecular Microbiology
DOI 10.1111/j.1365-2958.2005.04555.x
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Abstract

Summary: Group B Streptococcus (GBS) is a common constituent of the vaginal microflora, but its transmission to newborns can cause life‐threatening sepsis, pneumonia and meningitis. Energy metabolism of this opportunist pathogen has been deduced to be strictly fermentative. We discovered that GBS undergoes respiration metabolism if its environment supplies two essential respiratory components: quinone and haem. Respiration metabolism led to significant changes in growth characteristics, including a doubling of biomass and an altered metabolite profile under the tested conditions. The GBS respiratory chain is inactivated by: (i) withdrawing haem and/or quinone, (ii) treating cultures with a respiration inhibitor or (iii) inactivating the cydA gene product, a subunit of cytochrome bd quinol oxidase, in all cases resulting in exclusively fermentative growth. cydA inactivation reduced GBS growth in human blood and strongly attenuated virulence in a neonatal rat sepsis model, suggesting that the animal host may supply the components that activate GBS respiration. These results suggest a role of respiration metabolism in GBS dissemination. Our findings show that environmental factors can increase the flexibility of GBS metabolism by activating a newly identified respiration chain. The need for two environmental factors may explain why GBS respiration metabolism was not found in previous studies.

Overview

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Registry

Crossref · 10.1111/j.1365-2958.2005.04555.x

Cites

47 of 47 references verified0 citation errors · 0 not checkable

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Citations

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Metadata

Authors
Yamamoto, Y., Poyart, C., Trieu‐Cuot, P., Lamberet, G., Gruss, A., & Gaudu, P.
Venue
Molecular Microbiology
Publisher
Wiley
Published
2005-03-07
Volume
56
Issue
2
Pages
525-534
ISSN
  • 0950-382X
  • 1365-2958
DOI
10.1111/j.1365-2958.2005.04555.x
Cited by
109
References
47
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.