The DOI matches its Crossref record; 208 of the 208 references it cites were found in a registry or an index.
Review: Systemic inflammation andAlzheimer's disease
Abstract
There is a great deal of evidence suggesting an important role for systemic inflammation in the pathogenesis of A lzheimer's disease. The role of systemic inflammation, and indeed inflammation in general, is still largely considered to be as a contributor to the disease process rather than of aetiological importance although there is emerging evidence to suggest that its role may predate the deposition of amyloid. Therapies aimed at reducing inflammation in individuals with mild cognitive impairment and A lzheimer's disease have been disappointing and have largely focused on the need to ameliorate central inflammation with little attention to the importance of dampening down systemic inflammation. Novel approaches in this area require a greater understanding of the effects of systemic inflammation on the development and progression of A lzheimer's disease and of the communicating pathways between the systemic and central innate immune systems.
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“Although the genetic susceptibility, numerous findings support the involvement in AD pathogenesis of other mechanisms such as inflammation [95], imbalance among production and removal of ROS [96], mitochondrial dysfunction [82], in addition to the β-amyloid cascade [97] and the deficiency of central cholinergic neurotransmitters [98] on which are based most of anti-AD drugs so far approved.”
From Treatment of Alzheimer’s Disease: Beyond Symptomatic Therapies (2023) · cites this paper as [95]
In the citing paper
“Crosstalk between systemic and central innate immune systems by the release of inflammatory mediators is observed in AD (Holmes, 2013).”
From The impact of microglial activation on blood-brain barrier in brain diseases (2014) · cites this paper as Holmes, 2013
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The impact of microglial activation on blood-brain barrier in brain diseases
da Fonseca, A. C. C., Matias, D., Garcia, C., Amaral, R., Geraldo, L. H., Freitas, C., & Lima, F. R. S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00362 · Cited by 572
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“Although the genetic susceptibility, numerous findings support the involvement in AD pathogenesis of other mechanisms such as inflammation [95], imbalance among production and removal of ROS [96], mitochondrial dysfunction [82], in addition to the β-amyloid cascade [97] and the deficiency of central cholinergic neurot…”
BackgroundZhang, B., Chen, T., Cao, M., Yuan, C., Reiter, R. J., Zhao, Z., Zhao, Y., Chen, L., Fan, W., Wang, X., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.900132 · Cited by 80
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“…also suggests the association between systemic inflammation and microglial activation, which can play a detrimental role in the progression of neurodegenerative due to the neurotoxicity mediated by oxidative stress and inflammation, leading to neuronal death (Holmes, 2013; Hoogland et al., 2015).”
BackgroundCerebrospinal Fluid Levels of Interleukin-8 in Delirium, Dementia, and Cognitively Healthy Patients
Sajjad, M. U., Blennow, K., Knapskog, A. B., Idland, A.-V., Chaudhry, F. A., Wyller, T. B., Zetterberg, H., & Watne, L. O. (2020) · Journal of Alzheimer’s Disease · doi:10.3233/jad-190941 · Cited by 34
Zhou, Z., Yang, Y., Wei, Y., & Xie, Y. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04115-x · Cited by 30
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Solleiro-Villavicencio, H., & Rivas-Arancibia, S. (2019) · Neurología (English Edition) · doi:10.1016/j.nrleng.2019.03.003 · Cited by 7
Metadata
- Authors
- Holmes, C.
- Affiliations
- Moorgreen Hospital (GB)
- Corresponding author
- Holmes, C.
- ORCID
- Holmes, C.
- Venue
- Neuropathology and Applied Neurobiology
- Publisher
- Wiley
- Published
- 2013-01-22
- Volume
- 39
- Issue
- 1
- Pages
- 51-68
- ISSN
- 0305-1846 (ISSN-L)
- 1365-2990
- OpenAlex
- W1916976076
- Semantic Scholar
- 22fc4893fe1c0cf60f5834083c9fe4f5159933fd
- Cited by
- 356
- References
- 208
- Citations by year
- 2026: 17 · 2025: 12 · 2024: 29 · 2023: 52 · 2022: 48 · 2021: 33 · 2020: 38 · 2019: 32 · 2018: 23 · 2017: 24 · 2016: 15 · 2015: 16 · 2014: 11 · 2013: 4
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropathology and Applied Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alzheimer Society
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- systemic inflammation, Alzheimer's disease, pathogenesis, amyloid deposition, mild cognitive impairment, anti-inflammatory therapy, innate immune system, neuroinflammation
- MeSH terms
- Alzheimer Disease, Animals, Humans, Inflammation
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