Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia
Abstract
Background: Alzheimer's disease (AD) and Parkinson's disease (PD) are the two common neurodegenerative diseases characterized by progressive neuronal dysfunction in the presence of pathological microglial activation. Methods: 10 AD, 10 mild cognitive impairment (MCI), 11 PD dementia (PDD), and 16 controls underwent magnetic resonance imaging, [11C](R)PK11195 (1‐[2‐chlorophenyl]‐N‐methyl‐N‐[1‐methyl‐propyl]‐3‐isoquinoline carboxamide), [11C]PIB (11C‐Pittsburgh compound B), [18F]FDG‐PET (18F‐2‐fluoro‐2‐deoxyglucose positron emission tomography) scans. Parametric images were interrogated using region of interest (ROI), biological parametric mapping (BPM) and statistical parametric mapping analysis, and neuropsychometric tests. Results: Using BPM analysis, AD, MCI, and PDD subjects demonstrated significant correlation between increased microglial activation and reduced glucose metabolism (rCMRGlc). AD and MCI subjects also showed significant positive correlation between amyloid and microglial activation. Levels of cortical microglial activation were negatively correlated with Mini‐Mental State Examination in both AD and PDD. Conclusion: The significant inverse correlations between cortical levels of microglial activation and rCMRGlc in AD and PDD suggest cortical neuroinflammation may drive neuronal dysfunction in these dementias.
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Microglial activation is detected by PET in patients with mild cognitive impairment (MCI).
“Microglial activation has also been detected by PET in patients with mild cognitive impairment (MCI).”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [138]
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Self-citation
- Authors
- Fan, Z., Aman, Y., Ahmed, I., Chetelat, G., Landeau, B., Ray Chaudhuri, K., Brooks, D. J., & Edison, P.
- Affiliations
- Hammersmith Hospital (GB)
- Inserm-EPHE-University of Caen/Basse-Normandie Caen France
- Inserm (FR)
- Department of Neurology, National Parkinson Foundation Centre of Excellence King's College Hospital, and King's Health Partners London UK
- Corresponding author
- Edison, Paul
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2014-09-17
- Volume
- 11
- Issue
- 6
- Pages
- 608
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W2082704663
- Cited by
- 212
- References
- 46
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 20 · 2023: 12 · 2022: 25 · 2021: 18 · 2020: 28 · 2019: 21 · 2018: 20 · 2017: 23 · 2016: 11 · 2015: 11
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Medical Research Council
- Alzheimer's Research Foundation
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- microglial activation, Alzheimer's disease
- MeSH terms
- Alzheimer Disease, Amyloid, Brain, Brain Mapping, Carbon Radioisotopes, Glucose, Humans, Isoquinolines, Magnetic Resonance Imaging, Neuropsychological Tests, Parkinson Disease, Signal Processing, Computer-Assisted, Microglia, Radiopharmaceuticals, Fluorodeoxyglucose F18, Positron-Emission Tomography, Cognitive Dysfunction
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