Cited by 212Neuroinflammation and Neurodegeneration MechanismsDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia

Fan, Zhen, Aman, Yahyah, Ahmed, Imtiaz, Chetelat, Gaël, Landeau, Brigitte, Ray Chaudhuri, K., Brooks, David J., Edison, Paul·2015·Alzheimer's & Dementia

Abstract

Background: Alzheimer's disease (AD) and Parkinson's disease (PD) are the two common neurodegenerative diseases characterized by progressive neuronal dysfunction in the presence of pathological microglial activation. Methods: 10 AD, 10 mild cognitive impairment (MCI), 11 PD dementia (PDD), and 16 controls underwent magnetic resonance imaging, [11C](R)PK11195 (1‐[2‐chlorophenyl]‐N‐methyl‐N‐[1‐methyl‐propyl]‐3‐isoquinoline carboxamide), [11C]PIB (11C‐Pittsburgh compound B), [18F]FDG‐PET (18F‐2‐fluoro‐2‐deoxyglucose positron emission tomography) scans. Parametric images were interrogated using region of interest (ROI), biological parametric mapping (BPM) and statistical parametric mapping analysis, and neuropsychometric tests. Results: Using BPM analysis, AD, MCI, and PDD subjects demonstrated significant correlation between increased microglial activation and reduced glucose metabolism (rCMRGlc). AD and MCI subjects also showed significant positive correlation between amyloid and microglial activation. Levels of cortical microglial activation were negatively correlated with Mini‐Mental State Examination in both AD and PDD. Conclusion: The significant inverse correlations between cortical levels of microglial activation and rCMRGlc in AD and PDD suggest cortical neuroinflammation may drive neuronal dysfunction in these dementias.

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Crossref · 10.1016/j.jalz.2014.06.016

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Authors
Fan, Z., Aman, Y., Ahmed, I., Chetelat, G., Landeau, B., Ray Chaudhuri, K., Brooks, D. J., & Edison, P.
Affiliations
  • Hammersmith Hospital (GB)
  • Inserm-EPHE-University of Caen/Basse-Normandie Caen France
  • Inserm (FR)
  • Department of Neurology, National Parkinson Foundation Centre of Excellence King's College Hospital, and King's Health Partners London UK
Corresponding author
Edison, Paul
Venue
Alzheimer's & Dementia
Publisher
Wiley
Published
2014-09-17
Volume
11
Issue
6
Pages
608
ISSN
  • 1552-5260 (ISSN-L)
  • 1552-5279
OpenAlex
W2082704663
Cited by
212
References
46
Citations by year
2026: 6 · 2025: 17 · 2024: 20 · 2023: 12 · 2022: 25 · 2021: 18 · 2020: 28 · 2019: 21 · 2018: 20 · 2017: 23 · 2016: 11 · 2015: 11
FWCI
7.81
Type
journal article
Language
en
Open access
closed
Locations
  • Alzheimer s & Dementia (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
  • Medical Research Council
  • Alzheimer's Research Foundation
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
microglial activation, Alzheimer's disease
MeSH terms
Alzheimer Disease, Amyloid, Brain, Brain Mapping, Carbon Radioisotopes, Glucose, Humans, Isoquinolines, Magnetic Resonance Imaging, Neuropsychological Tests, Parkinson Disease, Signal Processing, Computer-Assisted, Microglia, Radiopharmaceuticals, Fluorodeoxyglucose F18, Positron-Emission Tomography, Cognitive Dysfunction

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