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Cited by 691Pregnancy and preeclampsia studiesMaternal Mental Health During Pregnancy and PostpartumNeurological Complications and Syndromes

Depression and anxiety in early pregnancy and risk for preeclampsia

Kurki, T·2000·Obstetrics & Gynecology
DOI 10.1016/s0029-7844(99)00602-x
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Abstract

OBJECTIVE: To examine whether depression and anxiety in early pregnancy are associated with preeclampsia in an unselected nulliparous population. METHODS: In this prospective population-based study during pregnancy at outpatient maternity clinics in the Helsinki metropolitan area, depression was assessed by a Finnish modification of the short form of the Beck Depression Inventory and anxiety by one established question. Preeclampsia was defined as elevated blood pressure (BP) (more than 140/100 mmHg) and proteinuria (0.3 g during 24 hours or more). Age, smoking, alcohol consumption, marital status, socioeconomic status, and bacterial vaginosis were analyzed as potentially confounding factors in a multiple logistic regression analysis. RESULTS: Six hundred twenty-three consecutive nulliparous women with singleton pregnancies were studied at ten to 17 (median 12) weeks' gestation and at delivery. Of them, 28 (4.5%) women developed preeclampsia. Depression (mean Beck score 4.5, range 3-17) was observed in 185 (30%), women and anxiety was observed in 99 (16%) in early pregnancy. In multivariate analysis, after adjustment for potentially confounding factors, depression was associated with increased risk (odds ratio [OR] 2.5; 95% confidence interval [CI] 1.1, 5.4) for preeclampsia, as was anxiety (OR 3.2; 95% CI 1.4, 7.4). Either depression or anxiety, or both, were associated with increased risk (OR 3.1; 95% CI 1.4, 6.9) for preeclampsia. Bacterial vaginosis together with depression was associated with increased risk (OR 5.3; 95% CI 1.8, 15.0) for preeclampsia. CONCLUSION: Depression and anxiety in early pregnancy are associated with risk for subsequent preeclampsia, a risk further increased by bacterial vaginosis.

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  • Considerable research with healthy pregnant women points to serious consequences of depression during the perinatal period, including adverse obstetric and neonatal outcomes.

    “considerable research has been conducted with healthy pregnant women, and findings all point to the serious consequences of depression during the perinatal period, including adverse obstetric and neonatal outcomes.14, 15”

    From Prenatal Depression in Women Hospitalized for Obstetric Risk (2008) · cites this paper as [14]

  • Prenatal psychological distress is associated with preeclampsia.

    “Prenatal psychological distress is widely associated with pregnancy complications, including preeclampsia [10], spontaneous abortion [11], preterm delivery [12], lower birth weight [13], and”

    From Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy (2024) · cites this paper as [10]

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Authors
Kurki, T.
Affiliations
Social Insurance Institution (FI)
Corresponding author
Kurki, T
Venue
Obstetrics & Gynecology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2000-04
Volume
95
Issue
4
Pages
487-490
ISSN
0029-7844 (ISSN-L)
DOI
10.1016/s0029-7844(99)00602-x
OpenAlex
W2019143627
Cited by
690
References
32
Citations by year
2026: 6 · 2025: 15 · 2024: 28 · 2023: 32 · 2022: 36 · 2021: 29 · 2020: 32 · 2019: 33 · 2018: 34 · 2017: 29 · 2016: 25 · 2015: 42 · 2014: 46 · 2013: 49 · 2012: 27
FWCI
11.64
Type
journal article
Language
en
Open access
closed
Locations
  • Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
Keywords
preeclampsia, depression, anxiety, early pregnancy, nulliparous women, bacterial vaginosis, risk factors, maternal mental health, proteinuria, blood pressure
MeSH terms
Adolescent, Adult, Anxiety, Depression, Female, Humans, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Pregnancy Trimester, First, Pregnancy Trimester, Second, Prospective Studies, Risk Factors

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