The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
HUMAN DIROFILARIASIS
Abstract
Background. Subcutaneous and pulmonary dirofilariasis in humans appears to be a frequent disease in endemic areas, notably the Mediterranean region. Following increased air travel in recent years, the incidence of human dirofilariasis has increased in tourists as well. Methods. The clinical and parasitologic aspects in a series of six patients with cutaneous and pulmonary dirofilariasis, seen in a German unit for infectious and tropical diseases, are reviewed. Results. Four patients presented with subcutaneous tumors due to infection with Dirofilaria repens, whereas two patients had pulmonary infiltrates due to the canine heartworm, D. immitis. All infections were acquired in the Mediterranean region. Symptoms were only slight and nonspecific. Eosinophilia in the blood was absent in all patients. The serum IgE levels were normal and signs of a specific humoral response to antigens of Dirofilaria spp. were absent, although slightly elevated antibody levels to antigens of Onchocerca volvulus could be demonstrated in all patients. The diagnosis was established in all patients by the surgical removal of adult worms from the lesions. Oral treatment with diethylcarbamazine (DEC) (2 mg per kg t.i.d.) over a period of 4 weeks was added to the surgical treatment in all patients. In one patient this therapy was preceded by oral ivermectine (150 mg per kg). Conclusions. Dirofilariasis has to be considered as a differential diagnosis in patients presenting with subcutaneous or pulmonary tumors after travels to endemic areas within the last few years. Effective therapy is possible by surgical removal of the adult worms and oral ivermectine plus diethylcarbamazine.
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“Ocular and subcutaneous infections are usually caused by D. repens , while D. immitis is involved in pulmonary dirofilariasis in humans [7,9].”
From Description of five dirofilariasis cases in South Hungary and review epidemiology of this disease for the country (2015) · cites this paper as [7]
In the citing paper
“Tourism and migration can also contribute to the increase of incidence of human cases outside the endemic areas [7].”
From Description of five dirofilariasis cases in South Hungary and review epidemiology of this disease for the country (2015) · cites this paper as [7]
Citations
Cites
Human Pulmonary Dirofilariasis in the United States: a Critical Review
Ciferri, F. (1982) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1982.31.302 · Cited by 131
Human Infection with Filariae of Animals in the United States
Beaver, P. C., & Orihel, T. C. (1965) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1965.14.1010 · Cited by 122
Intraocular Filariasis: a Brief Review
Beaver, P. C. (1989) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1989.40.40 · Cited by 68
Serologic diagnosis of zoonotic pulmonary dirofilariasis
Glickman, L. T., Grieve, R. B., & Schantz, P. M. (1986) · The American Journal of Medicine · doi:10.1016/0002-9343(86)90003-3 · Cited by 67
Cuticular Morphology of Five Species of Dirofilaria: A Scanning Electron Microscope Study
Wong, M. M., & Brummer, M. (1978) · Journal of Parasitology · doi:10.2307/3279618 · Cited by 36
Infection of Man by Dirofilaria Repens
Gardiner, C. H., Oberdorfer, C. E., Reyes, J. E., & Pinkus, W. H. (1978) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1978.27.1279 · Cited by 26
Bruijning, C. F. A. (1981) · PubMed · Cited by 18
Autochthone pulmonale Dirofilariose in Europa
Tornieporth, N., Brandis, A., Vogel, B., & Disko, R. (2008) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/s-2008-1060361 · Cited by 13
Dissanaike, A. S. (1971) · PubMed · Cited by 10
Subcutaneous dirofilariasis in man—Not so rare
Carneri, I. D., Sacchi, S., & Pazzaglia, A. (1973) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(73)90026-6 · Cited by 7
Flagged first, then by citations
Research works printed but not linked: 5
- Barriga OO, 1982, CRC Handbook “Series in Zoonoses,” section C: parasitic zoonoses, 93
- Dissanaike AS, 1979, Zoonotic aspects of filarial aspects in man, Bull WHO, 57, 349
- Locatelli A., 1971, Sulle filariasi animali in provincia di Pavia, Parassitologia, 13, 197
- Wockel W, 1993, Autochtone eu‐ropäische Lungen‐Dirofilariose, Pneumologie, 47, 227
- Bardach H, 1981, Subkutane Dirofilaria (Nochtiella) repens ‐Infektion beim Menschen. Erste Fallbeschreibung in Österreich und Übersicht der Literatur, Wien Klin Wochenschr, 93, 123
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Chapter 4 Heartworm Disease in Animals and Humans
McCall, J. W., Genchi, C., Kramer, L. H., Guerrero, J., & Venco, L. (2008) · Advances in Parasitology · doi:10.1016/s0065-308x(08)00204-2 · Cited by 609
What is happening outside North America regarding human dirofilariasis?
Simón, F., López-Belmonte, J., Marcos-Atxutegi, C., Morchón, R., & Martín-Pacho, J. R. (2005) · Veterinary Parasitology · doi:10.1016/j.vetpar.2005.03.033 · Cited by 126
Dirofilarial human cases in the Old World, attributed to Dirofilaria immitis : a critical analysis
Pampiglione, S., Rivasi, F., & Gustinelli, A. (2009) · Histopathology · doi:10.1111/j.1365-2559.2008.03197_a.x · Cited by 96
Czajka, C., Becker, N., Poppert, S., Jöst, H., Schmidt-Chanasit, J., & Krüger, A. (2012) · Parasites & Vectors · doi:10.1186/1756-3305-5-14 · Cited by 51
Dóczi, I., Bereczki, L., Gyetvai, T., Fejes, I., Skribek, Á., Szabó, Á., Berkes, S., Tiszlavicz, L., Bartha, N., Bende, B., et al. (2015) · Wiener klinische Wochenschrift · doi:10.1007/s00508-015-0825-4 · Cited by 38
Metadata
- Authors
- JELINEK, T., SCHULTE‐HILLEN, J., & LOSCHER, T.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- Venue
- International Journal of Dermatology
- Publisher
- Wiley
- Published
- 1996-12
- Volume
- 35
- Issue
- 12
- Pages
- 872-875
- ISSN
- 0011-9059 (ISSN-L)
- 1365-4632
- OpenAlex
- W4242142532
- Cited by
- 63
- References
- 11
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2022: 2 · 2021: 2 · 2020: 1 · 2018: 6 · 2017: 1 · 2016: 1 · 2015: 6 · 2014: 2 · 2013: 5 · 2012: 2
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Health Sciences › Medicine › Infectious Diseases › Dermatological diseases and infestations
- Keywords
- human dirofilariasis, Dirofilaria repens, Dirofilaria immitis, pulmonary dirofilariasis, subcutaneous tumor, eosinophilia, Onchocerca volvulus, differential diagnosis, diethylcarbamazine, ivermectin, travel-associated infection
- MeSH terms
- Adult, Antiparasitic Agents, Dirofilariasis, Female, Humans, Lung Diseases, Parasitic, Male, Middle Aged, Skin Diseases, Parasitic
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