The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
A review of applications of tea tree oil in dermatology
Abstract
Tea tree oil (TTO) is an essential oil, steam‐distilled from the Australian native plant, Melaleuca alternifolia. It has a minimum content of terpinen‐4‐ol and a maximum content of 1, 8‐cineole. Terpinen‐4‐ol is a major TTO component which exhibits strong antimicrobial and anti‐inflammatory properties. Tea tree oil exerts antioxidant activity and has been reported to have broad‐spectrum antimicrobial activity against bacterial, viral, fungal, and protozoal infections affecting skin and mucosa. Several studies have suggested the uses of TTO for the treatment of acne vulgaris, seborrheic dermatitis, and chronic gingivitis. It also accelerates the wound healing process and exhibits anti‐skin cancer activity. This review opens up new horizons for dermatologists in the use of this herbal agent.
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“Alternative therapies have been reported as well, such as tea tree oil [40,41].”
From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [40]
In the citing paper
“According to the Oxford evidence hierarchy, this would fall under the category of Level IV evidence. Additionally, the paper could benefit from a more critical analysis of the potential risks and side effects associated with the use of tea tree oil in dermatology.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [14]
Citations
Cites
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · Italian Journal of Public Health · doi:10.2427/5768 · Cited by 3,374
Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties
Carson, C. F., Hammer, K. A., & Riley, T. V. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.1.50-62.2006 · Cited by 1,429
A review of the toxicity of Melaleuca alternifolia (tea tree) oil
Hammer, K. A., Carson, C. F., Riley, T. V., et al. (2005) · Food and Chemical Toxicology · doi:10.1016/j.fct.2005.09.001 · Cited by 313
A comparative study of tea‐tree oil versus benzoylperoxide in the treatment of acne
Bassett, I. B., Barnetson, R. S. C., & Pannowitz, D. L. (1990) · Medical Journal of Australia · doi:10.5694/j.1326-5377.1990.tb126150.x · Cited by 286
Teissèdre, P., & Waterhouse, A. L. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf990921x · Cited by 249
Schnitzler, P., Schön, K., & Reichling, J. (2001) · PubMed · Cited by 233
Herbal medicines for treatment of bacterial infections: a review of controlled clinical trials
Martin, K. W. (2003) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg087 · Cited by 226
Hammer, K., Carson, C., & Riley, T. (1998) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/42.5.591 · Cited by 223
Mondello, F., Bernardis, F. D., Girolamo, A., et al. (2006) · BMC Infectious Diseases · doi:10.1186/1471-2334-6-158 · Cited by 222
In vitro and in vivo killing of ocular Demodex by tea tree oil
Gao, Y.-Y. (2005) · British Journal of Ophthalmology · doi:10.1136/bjo.2005.072363 · Cited by 212
Kim, H., Chen, F., Wu, C., Wang, X., Chung, H. Y., & Jin, Z. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf035377d · Cited by 206
Clinical Treatment of Ocular Demodecosis by Lid Scrub With Tea Tree Oil
Gao, Y., Pascuale, M. A. D., Elizondo, A., et al. (2007) · Cornea · doi:10.1097/01.ico.0000244870.62384.79 · Cited by 203
Tea tree oil reduces histamine-induced skin inflammation
Koh, K. J., Pearce, A. L., Marshman, G., Finlay-Jones, J. J., & Hart, P. H. (2002) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2002.05034.x · Cited by 185
Adverse and beneficial effects of plant extracts on skin and skin disorders.
Mantle, D., Gok, M. A., & Lennard, T. W. J. (2001) · PubMed · Cited by 180
Acaricidal Activity of Melaleuca alternifolia (Tea Tree) Oil
Walton, S. F., McKinnon, M., Pizzutto, S. J., Dougall, A. M., Williams, E., & Currie, B. J. (2004) · Archives of Dermatology · doi:10.1001/archderm.140.5.563 · Cited by 178
Jooya, A., Siadat, A., Iraji, F., & Enshaieh, S. (2007) · Indian Journal of Dermatology, Venereology and Leprology · doi:10.4103/0378-6323.30646 · Cited by 165
Studies in vitro on the relative efficacy of current acaricides for Sarcoptes scabiei var. hominis
Walton, S. F., Myerscough, M. R., & Currie, B. J. (2000) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(00)90454-1 · Cited by 162
Cooling the burn wound: evaluation of different modalites
Jandera, V., Hudson, D. A., Wet, P. M. D., et al. (2000) · Burns · doi:10.1016/s0305-4179(99)00133-3 · Cited by 157
Mikus, J., Harkenthal, M., Steverding, D., et al. (2000) · Planta Medica · doi:10.1055/s-2000-8548 · Cited by 154
Treatment of dandruff with 5% tea tree oil shampoo
Satchell, A. C., Saurajen, A., Bell, C., & Barnetson, R. S. (2002) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2002.122734 · Cited by 152
Inhibition of acetylcholinesterase by Tea Tree oil
Mills, C., Cleary, B., Walsh, J. J., & Gilmer, J. F. (2004) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357022773 · Cited by 151
Buck, D. S., Nidorf, D. M., & Addino, J. G. (1998) · Complementary Therapies in Medicine · doi:10.1016/s0965-2299(98)80022-8 · Cited by 138
Natural variation in the essential oil content of Melaleuca alternifolia Cheel (Myrtaceae)
Homer, L. E., Leach, D. N., Lea, D., et al. (2000) · Biochemical Systematics and Ecology · doi:10.1016/s0305-1978(99)00071-x · Cited by 138
Melaleuca alternifolia (tea tree) oil gel (6%) for the treatment of recurrent herpes labialis
Carson, C. F. (2001) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/48.3.450 · Cited by 127
The effects of a tea tree oil-containing gel on plaque and chronic gingivitis.
Soukoulis, S., & Hirsch, R. S. (2004) · Australian dental journal · doi:10.1111/j.1834-7819.2004.tb00054.x · Cited by 120
Role of Antifungal Agents in the Treatment of Seborrheic Dermatitis
Gupta, A. K., Nicol, K., & Batra, R. (2004) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200405060-00006 · Cited by 109
Loughlin, R. G., Gilmore, B., McCarron, P. A., & Tunney, M. M. (2008) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2008.02334.x · Cited by 108
Papadopoulos, C. J., Carson, C. F., Chang, B. J., & Riley, T. V. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.02334-07 · Cited by 106
Syed, T. A., Qureshi, Z. A., Ali, S. M., Ahmad, S., & Ahmad, S. (1999) · Tropical Medicine & International Health · doi:10.1046/j.1365-3156.1999.00396.x · Cited by 105
Satchell, A. C., Saurajen, A., Bell, C., & Barnetson, R. S. (2002) · Australasian Journal of Dermatology · doi:10.1046/j.1440-0960.2002.00590.x · Cited by 81
Tea tree oil reduces histamine-induced oedema in murine ears
Brand, C., Townley, S. L., Finlay‐Jones, J. J., & Hart, P. H. (2002) · Inflammation Research · doi:10.1007/pl00000305 · Cited by 77
The influence of essential oils on the process of wound healing: a review of the current evidence
Woollard, A., Tatham, K. C., & Barker, S. (2007) · Journal of Wound Care · doi:10.12968/jowc.2007.16.6.27064 · Cited by 71
Henley, D. V., & Korach, K. S. (2010) · HORMONES · doi:10.14310/horm.2002.1270 · Cited by 63
Barker, S. C., & Altman, P. M. (2010) · BMC Dermatology · doi:10.1186/1471-5945-10-6 · Cited by 63
Regulation of Wheal and Flare by Tea Tree Oil: Complementary Human and Rodent Studies
Khalil, Z. G., Pearce, A., Satkunanathan, N., Storer, E., Finlay‐Jones, J. J., & Hart, P. H. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.23407.x · Cited by 61
Tea Tree Oil: Cutaneous Effects of the Extracted Oil of Melaleuca alternifolia
Crawford, G. H., Sciacca, J. R., & James, W. D. (2004) · Dermatitis · doi:10.2310/6620.2004.04003 · Cited by 59
Interaction of Tea Tree Oil with Model and Cellular Membranes
Giordani, C., Molinari, A., Toccacieli, L., et al. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm060228i · Cited by 46
Lavender, tea tree and lemon oils as antimicrobials in washing liquids and soft body balms
Kunicka‐Styczyńska, A., Sikora, M., & Kalemba, D. (2010) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2010.00582.x · Cited by 46
Greay, S. J., Ireland, D. J., Kissick, H. T., et al. (2010) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-010-1267-3 · Cited by 45
Tea Tree Oil Might Combat Melanoma
Bozzuto, G., Colone, M., Toccacieli, L., et al. (2010) · Planta Medica · doi:10.1055/s-0030-1250055 · Cited by 39
van de Sande, W. W. J., Fahal, A. H., Riley, T. V., Verbrugh, H. A., & van Belkum, A. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl526 · Cited by 33
Essential Oils for Management of Symptoms in Critically Ill Patients
Halm, M. A. (2008) · American Journal of Critical Care · doi:10.4037/ajcc2008.17.2.160 · Cited by 28
[Effect of mouthwashing with tea tree oil on plaque and inflammation].
Saxer, U. P., Stäuble, A., Szabó, S., et al. (2003) · PubMed · Cited by 26
Millar, B. C., & Moore, J. E. (2008) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2008.05.003 · Cited by 25
Tea Tree Oil as a Novel Antipsoriasis Weapon
Pazyar, N., & Yaghoobi, R. (2012) · Skin Pharmacology and Physiology · doi:10.1159/000337936 · Cited by 23
Self-citationThompson, G., Blackwood, B., McMullan, R., et al. (2008) · BMC Infectious Diseases · doi:10.1186/1471-2334-8-161 · Cited by 21
Medicated shampoos for the treatment of seborrheic dermatitis.
Waldroup, W., & Scheinfeld, N. S. (2008) · PubMed · Cited by 15
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Essential oils used in aromatherapy: A systemic review
Ali, B., Al‐Wabel, N. A., Shams, S., Ahamad, A., Khan, S. A., & Anwar, F. (2015) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/j.apjtb.2015.05.007 · Cited by 1,184
“Cold, fever, flu and chickenpox have called for its use [71,72].”
BackgroundBeneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases
Forni, C., Facchiano, F., Bartoli, M., Pieretti, S., Facchiano, A., D’Arcangelo, D., Norelli, S., Valle, G., Nisini, R., Beninati, S., et al. (2019) · BioMed Research International · doi:10.1155/2019/8748253 · Cited by 546
“The essential oil from Melaleuca alternifolia also shows antioxidant activities potentially useful in dermatitis and skin cancers [160].”
BackgroundPlant-Derived Antioxidants: Significance in Skin Health and the Ageing Process
Michalak, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020585 · Cited by 460
Seborrheic Dermatitis and Dandruff: A Comprehensive Review
(2015) · Journal of Clinical and Investigative Dermatology · doi:10.13188/2373-1044.1000019 · Cited by 398
“Alternative therapies have been reported as well, such as tea tree oil [40,41].”
Skin Wound Healing and Phytomedicine: A Review
Pazyar, N., Yaghoobi, R., Rafiee, E., Mehrabian, A., & Feily, A. (2014) · Skin Pharmacology and Physiology · doi:10.1159/000357477 · Cited by 278
Self-citation
Metadata
- Authors
- Pazyar, N., Yaghoobi, R., Bagherani, N., & Kazerouni, A.
- Affiliations
- Ahvaz Jundishapur University of Medical Sciences (IR)
- Corresponding author
- Pazyar, Nader
- Venue
- International Journal of Dermatology
- Publisher
- Wiley
- Published
- 2012-09-24
- Volume
- 52
- Issue
- 7
- Pages
- 784-790
- ISSN
- 0011-9059 (ISSN-L)
- 1365-4632
- OpenAlex
- W2016711385
- Semantic Scholar
- 8af9fc3638195427a56def3e97838ca793b73aea
- Cited by
- 252
- References
- 46
- Citations by year
- 2026: 14 · 2025: 23 · 2024: 23 · 2023: 32 · 2022: 37 · 2021: 31 · 2020: 23 · 2019: 15 · 2018: 9 · 2017: 14 · 2016: 8 · 2015: 12 · 2014: 7 · 2013: 4
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- tea tree oil, Melaleuca alternifolia, terpinen-4-ol, 1,8-cineole, antimicrobial activity, anti-inflammatory activity, antioxidant activity, acne, seborrheic dermatitis, chronic gingivitis, wound healing, anticancer activity, herbal medicine, skin infections
- MeSH terms
- Anti-Infective Agents, Local, Humans, Skin Diseases, Tea Tree Oil
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