Cited by 80Stress Responses and CortisolNeurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Review: HPA‐axis activity in alcoholism: examples for a gene–environment interaction

Clarke, Toni‐Kim, Treutlein, Jens, Zimmermann, Ulrich S., Kiefer, Falk, Skowronek, Markus H., Rietschel, Marcella, Mann, Karl, Schumann, Gunter·2008·Addiction Biology

Abstract

Genetic and environmental influences are both known to be causal factors in the development and maintenance of substance abuse disorders. This review aims to focus on the contributions of genetic and environmental research to the understanding of alcoholism and how gene-environment interactions result in a variety of addiction phenotypes. Gene-environment interactions have been reviewed by focusing on one of the most relevant environmental risk factors for alcoholism, stress. This is examined in more detail by reviewing the functioning of the hypothalamic-pituitary-adrenal (HPA) axis and its genetic and molecular components in this disorder. Recent evidence from animal and human studies have shown that the effects of stress on alcohol drinking are mediated by core HPA axis genes and are associated with genetic variations in those genes. The findings of the studies discussed here suggest that the collaborations of neuroscience, psychobiology and molecular genetics provide a promising framework to elucidate the exact mechanisms of gene-environment interactions as seen to convene upon the HPA axis and effect phenotypes of addiction.

Integrity signals

Registry

Crossref · 10.1111/j.1369-1600.2007.00084.x

Cites

112 of 112 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

1 of the 113 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Clarke, T., Treutlein, J., Zimmermann, U. S., Kiefer, F., Skowronek, M. H., Rietschel, M., Mann, K., & Schumann, G.
Affiliations
  • King's College London (GB)
  • Central Institute of Mental Health (DE)
  • University Hospital Carl Gustav Carus (DE)
Venue
Addiction Biology
Publisher
Wiley
Published
2007-10-02
Volume
13
Issue
1
Pages
1-14
ISSN
  • 1355-6215 (ISSN-L)
  • 1369-1600
OpenAlex
W2012656447
Cited by
80
References
113
Citations by year
2025: 2 · 2024: 1 · 2023: 2 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 10 · 2016: 8 · 2015: 3 · 2014: 4 · 2013: 6 · 2012: 8
FWCI
0.38
Type
journal article
Language
en
Open access
closed
Locations
  • Addiction Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
  • National Institute for Health and Care Research
  • European Commission
  • Bundesministerium für Bildung und Forschung
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
alcoholism, gene-environment interaction, hypothalamic-pituitary-adrenal axis, stress, alcohol consumption, genetic variation, substance use disorders, psychobiology, molecular genetics
MeSH terms
Alcoholism, Animals, Arousal, Genetic Markers, Humans, Hypothalamo-Hypophyseal System, Phenotype, Pituitary-Adrenal System, Risk Factors, Stress, Psychological, Genetic Variation, Gene Expression, Polymorphism, Single Nucleotide

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review