Cited by 195Stress Responses and CortisolAdrenal Hormones and DisordersGenetic Associations and Epidemiology

Heritability of cortisol responses to human corticotropin-releasing hormone, ergometry, and psychological stress in humans.

Kirschbaum, C, Wüst, S, Faig, H G, Hellhammer, D H·1992·The Journal of Clinical Endocrinology & Metabolism

Abstract

The present study investigated cortisol responses to three different stimulation procedures, with a focus on the contribution of genetic factors. Thirteen monozygotic (MZ) twin pairs and 11 dizygotic (DZ) twin pairs performed bicycle ergometry until exhaustion and were exposed to the psychological stress of public speaking and mental arithmetic in front of an audience. Furthermore, 9 MZ pairs and 10 DZ pairs were injected with 100 micrograms synthetic human CRH (hCRH). The adrenocortical response to these challenges was monitored by determination of cortisol in saliva. Significant intraindividual stability of baseline cortisol levels was found in females, but was less in males. Maximum cortisol responses to all three stimulation procedures were significantly intercorrelated in males, but in females only the cortisol responses to hCRH and ergometer exercise showed a significant correlation. While a decided influence of genetic factors was observed for all three baseline cortisol levels as well as for the response to hCRH, heredity appeared to be play a minor role in the adrenocortical response to psychological stress. Cortisol changes after bicycle ergometry revealed no impact of genetic factors on the secretion of cortisol in response to strenuous physical exercise.

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Crossref · 10.1210/jcem.75.6.1464659

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Authors
Kirschbaum, C., Wüst, S., Faig, H. G., & Hellhammer, D. H.
Affiliations
Universität Trier (DE)
Venue
The Journal of Clinical Endocrinology & Metabolism
Published
1992-12
Volume
75
Issue
6
Pages
1526-1530
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
OpenAlex
W1978954988
Cited by
195
References
35
Citations by year
2025: 1 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 8 · 2017: 2 · 2016: 8 · 2015: 6 · 2014: 11 · 2013: 7 · 2012: 6
FWCI
1.76
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
cortisol, heritability, genetic factors, ergometry, psychological stress, public speaking, mental arithmetic, adrenocortical response, monozygotic twins, dizygotic twins, sex differences, intra-individual stability, exercise stress response
MeSH terms
Adolescent, Adult, Corticotropin-Releasing Hormone, Physical Exertion, Female, Humans, Hydrocortisone, Male, Statistics as Topic, Stress, Psychological, Twins, Dizygotic, Twins, Monozygotic, Ergometry

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