White matter microstructure in opiate addiction
Abstract
Heroin addiction has been associated with impaired neuronal connectivity and cognitive deficits. One mechanism that potentially explains these findings is alterations in white matter connectivity secondary to chronic opiate use. However, few studies have quantitavely examined white matter deficits in opiate addiction (OA). Here, we investigated white matter microstructure in OA using diffusion tensor imaging (DTI). We performed voxel‐wise analysis of fractional anisotropy (FA) in 24 participants with OA and 29 healthy controls. The OA group showed reduced FA in multiple pathways including the corpus callosum, thalamic radiation and inferior longitudinal fasciculus. This FA reduction was mainly the result of increased radial diffusivity (λ⊥), indicative of myelin pathology. Longer duration of OA was also associated with axonal diffusivity (λ 1), most robustly in superior longitudinal fasciculi and right frontal white matter suggesting axonal injury in long‐term users. Together, the findings indicate that chronic OA use has widespread and diverse effects on neuronal connectivity and function.
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Opiate-abusing people consistently show lower FA and lower AD than non-using controls.
“Relative to non-using controls, opiate-abusing individuals consistently exhibit both lower FA (Bora et al., 2012; Fu et al., 2008; Li et al., 2013; Qiu et al., 2013; Wang et al., 2011) and lower AD (Bora et al., 2012; Qiu et al., 2013).”
From Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research (2019) · cites this paper as Bora et al., 2012
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- Authors
- Bora, E., Yücel, M., Fornito, A., Pantelis, C., Harrison, B. J., Cocchi, L., Pell, G., & Lubman, D. I.
- Affiliations
- The University of Melbourne (AU)
- Austin Hospital (AU)
- Eastern Health (AU)
- Corresponding author
- Bora, Emre
- ORCID
- Venue
- Addiction Biology
- Publisher
- Wiley
- Published
- 2010-11-11
- Volume
- 17
- Issue
- 1
- Pages
- 141-148
- ISSN
- 1355-6215 (ISSN-L)
- 1369-1600
- OpenAlex
- W2154991670
- Cited by
- 130
- References
- 37
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 3 · 2022: 11 · 2021: 9 · 2020: 6 · 2019: 13 · 2018: 10 · 2017: 6 · 2016: 16 · 2015: 11 · 2014: 8 · 2013: 12 · 2012: 6
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Addiction Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Health and Medical Research Council
- National Medical Research Council
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- opioid use disorder, heroin addiction, white matter microstructure, fractional anisotropy, radial diffusivity, myelin pathology, axonal injury, corpus callosum, thalamic radiation, inferior longitudinal fasciculus, superior longitudinal fasciculus, frontal white matter, chronic opioid use, neuronal connectivity
- MeSH terms
- Adult, Brain Mapping, Corpus Callosum, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Opioid-Related Disorders, Nerve Fibers, Myelinated, Anisotropy, Diffusion Tensor Imaging
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