Frontal and cingulate gray matter volume reduction in heroin dependence: Optimized voxel‐based morphometry
Open accessAbstract
Aims: Repeated exposure to heroin, a typical opiate, causes neuronal adaptation and may result in anatomical changes in specific brain regions, particularly the frontal and limbic cortices. The volume changes of gray matter (GM) of these brain regions, however, have not been identified in heroin addiction. Methods: Using structural magnetic resonance imaging and an optimized voxel‐based morphometry approach, the GM volume difference between 15 Chinese heroin‐dependent and 15 healthy subjects was tested. Results: Compared to healthy subjects, the heroin‐dependent subjects had reduced GM volume in the right prefrontal cortex, left supplementary motor cortex and bilateral cingulate cortices. Conclusion: Frontal and cingulate atrophy may be involved in the neuropathology of heroin dependence.
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Executive systems of individuals with drug addiction typically have lower cortical volume and gray matter density than controls.
“the executive systems of individuals suffering from reinforcer pathologies such as drug addiction typically have lower cortical volume and gray matter density than do controls [50, 51].”
From The behavioral economics and neuroeconomics of reinforcer pathologies: implications for etiology and treatment of addiction (2011) · cites this paper as [51]
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- Authors
- Liu, H., Hao, Y., Kaneko, Y., Ouyang, X., Zhang, Y., Xu, L., Xue, Z., & Liu, Z.
- Affiliations
- Second Xiangya Hospital of Central South University (CN)
- Yale University (US)
- Kunming Institute of Zoology (CN)
- Corresponding author
- Xue, Zhimin
- Liu, Zhening
- Venue
- Psychiatry and Clinical Neurosciences
- Publisher
- Wiley
- Published
- 2009-07-16
- Volume
- 63
- Issue
- 4
- Pages
- 563-568
- ISSN
- 1323-1316 (ISSN-L)
- 1440-1819
- OpenAlex
- W2030254718
- Cited by
- 97
- References
- 42
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 10 · 2020: 4 · 2019: 7 · 2018: 5 · 2017: 5 · 2016: 10 · 2015: 10 · 2014: 5 · 2013: 11 · 2012: 7
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Psychiatry and Clinical Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (30530250)
- National Key Research and Development Program of China (2006CB500800, 2007CB512308)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Keywords
- heroin addiction, opioid use disorder, gray matter volume reduction, prefrontal cortex, supplementary motor area, cingulate cortex, brain atrophy, neuropathology, voxel-based morphometry
- MeSH terms
- Adolescent, Adult, Atrophy, Brain, Female, Gyrus Cinguli, Heroin Dependence, Humans, Image Interpretation, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Motor Cortex, Prefrontal Cortex
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