Cited by 178Opioid Use Disorder TreatmentSubstance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on Behavior

Prefrontal and temporal gray matter density decreases in opiate dependence

Lyoo, In Kyoon, Pollack, Mark H., Silveri, Marisa M., Ahn, Kyung Heup, Diaz, Claudia I., Hwang, Jaeuk, Kim, Seog Ju, Yurgelun-Todd, Deborah A. +2 more·2006·Psychopharmacology

Abstract

Rationale There have been only a few structural brain-imaging studies, with varied findings, of opiate-dependent subjects. Voxel-based morphometry (VBM) is suitable for studying whole brain-wise structural brain changes in opiate-dependent subjects.Objectives The objective of the current study is to explore gray matter density in opiate-dependent subjects.Methods Gray matter density in 63 opiate-dependent subjects and 46 age- and sex-matched healthy comparison subjects was compared using VBM.Results Relative to healthy comparison subjects, opiate-dependent subjects exhibited decreased gray matter density in bilateral prefrontal cortex [Brodmann areas (BA) 8, 9, 10, 11, and 47], bilateral insula (BA 13), bilateral superior temporal cortex (BA 21 and 38), left fusiform cortex (BA 37), and right uncus (BA 28).Conclusions This study reports that opiate-dependent subjects have gray matter density decreases in prefrontal and temporal cortex, which may be associated with behavioral and neuropsychological dysfunction in opiate-dependent subjects.

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Crossref · 10.1007/s00213-005-0198-x

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Authors
Lyoo, I. K., Pollack, M. H., Silveri, M. M., Ahn, K. H., Diaz, C. I., Hwang, J., Kim, S. J., Yurgelun-Todd, D. A., Kaufman, M. J., & Renshaw, P. F.
Affiliations
  • Harvard University (US)
  • Massachusetts General Hospital (US)
  • Seoul National University (KR)
  • Gachon University Gil Medical Center (KR)
Corresponding author
Lyoo, In Kyoon
Venue
Psychopharmacology
Published
2005-12-21
Volume
184
Issue
2
Pages
139-144
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
OpenAlex
W2058459387
Cited by
178
References
25
Citations by year
2026: 3 · 2025: 3 · 2024: 5 · 2023: 7 · 2022: 8 · 2021: 15 · 2020: 13 · 2019: 7 · 2018: 10 · 2017: 11 · 2016: 12 · 2015: 9 · 2014: 9 · 2013: 13 · 2012: 13
FWCI
5.94
Type
journal article
Language
en
Open access
closed
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Seoul National University Open Repository (Seoul National University) (submittedVersion)
Funders
  • National Institutes of Health (5r01da011231-05)
  • National Institute on Drug Abuse (K24DA015116, DA15116, DA-09448, R01DA009448, K02DA017324, DA017324, DA11231)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
opioid use disorder, gray matter density, prefrontal cortex, temporal cortex, insula, superior temporal cortex, fusiform cortex, uncus, brain structural changes, addiction
MeSH terms
Adult, Axons, Female, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Opioid-Related Disorders, Psychiatric Status Rating Scales, Temporal Lobe, Prefrontal Cortex

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