Progressive deterioration of β-cell function in obese youth with type 2 diabetes: β-Cell function in youth T2DM

Bacha, Fida; Gungor, Neslihan; Lee, SoJung; Arslanian, Silva A

doi:10.1111/j.1399-5448.2012.00915.x

Cited by 106Pancreatic function and diabetesDiabetes Treatment and ManagementDiabetes and associated disorders

Progressive deterioration of β-cell function in obese youth with type 2 diabetes: β-Cell function in youth T2DM

Open access

Bacha, Fida, Gungor, Neslihan, Lee, SoJung, Arslanian, Silva A·2013·Pediatric Diabetes

DOI 10.1111/j.1399-5448.2012.00915.xPMC PMC3648791

Open this paper in CoChat — free account Open PDF

Abstract

OBJECTIVE: In adults, type 2 diabetes (T2DM) is characterized with progressive deterioration in insulin secretion. Data are scanty in youth. We investigated prospectively the change in β-cell function and in insulin sensitivity in youth with T2DM. RESEARCH DESIGN AND METHODS: Six adolescents with T2DM [hemoglobin A1c (HbA1c) 6.6 ± 1.0%] underwent evaluation of hepatic glucose production (HGP; [6,6-²H₂] glucose), insulin-stimulated glucose disposal (Rd; hyperinsulinemic-euglycemic clamp), first- and second-phase insulin/C-peptide secretion (hyperglycemic clamp), body composition dual energy X-ray absorptiometry (DEXA), and abdominal adiposity (computed tomography) within 3 yr of the diagnosis of diabetes and after 12-16 months of follow-up. RESULTS: Weight, body mass index (37.1 ± 6.9), HbA1c (6.3 ± 0.7%), HGP (2.8 ± 1.2 mg/kg/min), and Rd (4.9 ± 3.4 mg/kg/min) did not change significantly from baseline. However, first-phase insulin and C-peptide declined (152.6 ± 261.2 vs. 75.9 ± 108.5 μU/mL, p = 0.028; 8.0 ± 6.3 vs. 5.9 ± 4.4 ng/mL, p = 0.048, respectively) with no significant change in second-phase insulin/C-peptide. The rate of decline in β-cell function was ∼20% per year. CONCLUSIONS: After a median duration of 20 months of diabetes, youth with T2DM manifest a rapid decline in β-cell function with no significant changes in peripheral or hepatic insulin sensitivity. Interventions to retard this deterioration in β-cell function should be investigated.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1399-5448.2012.00915.x

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Younger people with type 2 diabetes can have up to three times more liver fat than BMI-matched non-diabetic controls and than middle-aged or older type 2 diabetes presentations.
“and younger people with T2DM can have much higher (up to 3 times) amounts of liver fat compared with BMI-matched non-diabetic controls and compared with presentations of T2DM in middle and later life 24,”
From Type 2 diabetes in adolescents and young adults (2018) · cites this paper as [24]
The Results section (‘Study subjects and fasting metabolic profile’; page unavailable) reports abdominal fat and hepatic insulin sensitivity, but not liver-fat amounts. Searches for liver fat, intrahepatic fat, and a threefold difference found no comparison with BMI-matched non-diabetic controls or older people with type 2 diabetes in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

10-year follow-up of intensive glucose control in type 2 diabetes
Holman, R. R., Paul, S. K., Bethel, M. A., Matthews, D. R., & Neil, H. A. W. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0806470 · Cited by 7,751 · see citing works
The Importance of -Cell Failure in the Development and Progression of Type 2 Diabetes
Kahn, S. E. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7713 · Cited by 694 · see citing works
Prevalence of Diabetes Complications in Adolescents With Type 2 Compared With Type 1 Diabetes
Eppens, M. C., Craig, M. E., Cusumano, J. M., Hing, S. J., Chan, A. K. F., Howard, N. J., Silink, M., & Donaghue, K. C. (2006) · Diabetes Care · doi:10.2337/dc05-2470 · Cited by 468 · see citing works
Acute and chronic complications of type 2 diabetes mellitus in children and adolescents
Pinhas‐Hamiel, O., & Zeitler, P. S. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60821-6 · Cited by 386 · see citing works
Adiponectin in Youth
Bacha, F. F., Saad, R. J., Gungor, N., & Arslanian, S. A. (2004) · Diabetes Care · doi:10.2337/diacare.27.2.547 · Cited by 278 · see citing works
Self-citation
Treatment options for type 2 diabetes in adolescents and youth: a study of the comparative efficacy of metformin alone or in combination with rosiglitazone or lifestyle intervention in adolescents with type 2 diabetes
The TODAY Study Group (2007) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2007.00237.x · Cited by 260 · see citing works
Effects of rosiglitazone, glyburide, and metformin on β-cell function and insulin sensitivity in ADOPT
Kahn, S. E., Lachin, J. M., Zinman, B., Haffner, S. M., Aftring, R. P., Paul, G., Kravitz, B. G., Herman, W. H., Viberti, G., Holman, R. R., et al. (2011) · Diabetes · doi:10.2337/db10-1392 · Cited by 249 · see citing works
Youth Type 2 Diabetes
Gungor, N., Bacha, F., Saad, R., Janosky, J., & Arslanian, S. (2005) · Diabetes Care · doi:10.2337/diacare.28.3.638 · Cited by 186 · see citing works
Self-citation
A 12-Year Prospective Study of the Relationship Between Islet Antibodies and β-Cell Function At and After the Diagnosis in Patients With Adult-Onset Diabetes
Borg, H., Gottsäter, A., Fernlund, P., & Sundkvist, G. (2002) · Diabetes · doi:10.2337/diabetes.51.6.1754 · Cited by 168 · see citing works
Characterization of insulin secretion and resistance in type 2 diabetes of adolescents
Druet, C., Tubiana-Rufi, N., Chevenne, D., Rigal, O., Polak, M., & Levy-Marchal, C. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1672 · Cited by 93 · see citing works
Progressive beta cell failure in type 2 diabetes mellitus of youth
Gungor, N., & Arslanian, S. A. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2003.12.045 · Cited by 90 · see citing works
Self-citation
In Vivo Insulin Sensitivity and Secretion in Obese Youth
Bacha, F., Gungor, N., Lee, S., & Arslanian, S. A. (2009) · Diabetes Care · doi:10.2337/dc08-1030 · Cited by 90 · see citing works
Self-citation
Phenotypic Type 2 Diabetes in Obese Youth
Tfayli, H. M., Bacha, F. F., Gungor, N., & Arslanian, S. A. (2008) · Diabetes · doi:10.2337/db08-1372 · Cited by 88 · see citing works
Self-citation
β-Cell Function, Insulin Sensitivity, and Glucose Tolerance in Obese Diabetic and Nondiabetic Adolescents and Young Adults
Elder, D. A., Prigeon, R. L., Wadwa, R. P., Dolan, L. M., & D’Alessio, D. A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0853 · Cited by 78 · see citing works
Determinants of glycemic control in youth with type 2 diabetes at randomization in the TODAY study
Bacha, F. F., Pyle, L., Nadeau, K. J., Cuttler, L., Goland, R., Haymond, M. W., Levitsky, L. L., Lynch, J. L., Weinstock, R. S., White, N. H., et al. (2012) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2011.00841.x · Cited by 52 · see citing works
Self-citation
Progression from normal glucose tolerance to type 2 diabetes in a young girl: longitudinal changes in insulin sensitivity and secretion assessed by the clamp technique and surrogate estimates
Saad, R. J., Gungor, N., & Arslanian, S. A. (2005) · Pediatric Diabetes · doi:10.1111/j.1399-543x.2005.00097.x · Cited by 47 · see citing works
Self-citation
Type 2 diabetes in youth: are there racial differences in β-cell responsiveness relative to insulin sensitivity?
Bacha, F. F., Gungor, N., Lee, S., & Arslanian, S. A. (2011) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2011.00820.x · Cited by 43 · see citing works
Self-citation
Glycemic Control in Youth with Type 2 Diabetes Declines as Early as Two Years after Diagnosis
Katz, L. E. L., Magge, S. N., Hernandez, M. L., Murphy, K. M., McKnight, H., & Lipman, T. H. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.07.011 · Cited by 35 · see citing works
No signs of progressive beta cell damage during 20 years of prospective follow-up of autoantibody-negative diabetes
Ekholm, E., Gottsäter, A., Dahlin, L. B., & Sundkvist, G. (2011) · Acta Diabetologica · doi:10.1007/s00592-011-0273-1 · Cited by 15 · see citing works
An observational study of type 2 diabetes within a large Australian tertiary hospital pediatric diabetes service
Ruhayel, S. D., James, R., Ehtisham, S., Cameron, F. J., Werther, G. A., & Sabin, M. A. (2010) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2010.00647.x · Cited by 11 · see citing works
UKPDS 26: sulphonylurea failure in non-insulin-dependent diabetic patients over six years
UK Prospective Diabetes Study (UKPDS) Group, Matthews, D. R., Cull, C. A., Stratton, I. M., Holman, R. R., & Turner, R. C. (1998) · Diabetic Medicine · doi:10.1002/(sici)1096-9136(199804)15:4

Flagged first, then by citations

2 of the 23 references couldn’t be matched to a known paper.

Sorted by citations

Clinical Practice Guideline for the Evaluation and Treatment of Children and Adolescents With Obesity
Hampl, S. E., Hassink, S. G., Skinner, A. C., Armstrong, S. C., Barlow, S. E., Bolling, C. F., Avila Edwards, K. C., Eneli, I., Hamre, R., Joseph, M. M., et al. (2023) · Pediatrics · doi:10.1542/peds.2022-060640 · Cited by 1,389 · see citing works
Type 2 diabetes in adolescents and young adults
Lascar, N., Brown, J., Pattison, H., Barnett, A. H., Bailey, C. J., & Bellary, S. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30186-9 · Cited by 824 · see citing works
Hyperglycemia and adverse pregnancy outcome follow-up study (HAPO FUS): maternal gestational diabetes mellitus and childhood glucose metabolism
Lowe, W. L., Scholtens, D. M., Kuang, A., Linder, B., Lawrence, J. M., Lebenthal, Y., McCance, D., Hamilton, J., Nodzenski, M., Talbot, O., et al. (2019) · Diabetes Care · doi:10.2337/dc18-1646 · Cited by 574 · see citing works
Young-onset type 2 diabetes mellitus — implications for morbidity and mortality
Magliano, D. J., Sacre, J. W., Harding, J. L., Gregg, E. W., Zimmet, P. Z., & Shaw, J. E. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0334-z · Cited by 483 · see citing works
Effects of metformin, metformin plus rosiglitazone, and metformin plus lifestyle on insulin sensitivity and β-cell function in TODAY
TODAY Study Group (2013) · Diabetes Care · doi:10.2337/dc12-2393 · Cited by 288 · see citing works
Adolescent and Childhood Obesity and Excess Morbidity and Mortality in Young Adulthood—a Systematic Review
Horesh, A., Tsur, A. M., Bardugo, A., & Twig, G. (2021) · Current Obesity Reports · doi:10.1007/s13679-021-00439-9 · Cited by 242 · see citing works
ISPAD Clinical Practice Consensus Guidelines 2018: Type 2 diabetes mellitus in youth
Zeitler, P. S., Arslanian, S. A., Fu, J., Pinhas‐Hamiel, O., Reinehr, T., Tandon, N., Urakami, T., Wong, J., & Maahs, D. M. (2018) · Pediatric Diabetes · doi:10.1111/pedi.12719 · Cited by 225 · see citing works
Self-citation
Resilience of patients with chronic diseases: A systematic review
Kim, G. M., Lim, J. Y., Kim, E. J., & Park, S. (2019) · Health & Social Care in the Community · doi:10.1111/hsc.12620 · Cited by 219 · see citing works
Early beta cell dysfunction vs insulin hypersecretion as the primary event in the pathogenesis of dysglycaemia
Esser, N., Utzschneider, K. M., & Kahn, S. E. (2020) · Diabetologia · doi:10.1007/s00125-020-05245-x · Cited by 199 · see citing works
ISPAD Clinical Practice Consensus Guidelines 2022: Type 2 diabetes in children and adolescents
SHAH, A. S., Zeitler, P. S., Wong, J., Peña, A. S., Wicklow, B. A., Arslanian, S. A., CHANG, N. T., Fu, J., Dabadghao, P., Pinhas‐Hamiel, O., et al. (2022) · Pediatric Diabetes · doi:10.1111/pedi.13409 · Cited by 171 · see citing works
Self-citation
The changing face of diabetes in youth: lessons learned from studies of type 2 diabetes
Hannon, T. S., & Arslanian, S. A. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12939 · Cited by 137 · see citing works
Self-citation
Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity
Luo, X., Wu, J., Jing, S., & Yan, L. (2016) · Aging and Disease · doi:10.14336/ad.2015.0702 · Cited by 136 · see citing works
Pathophysiology of Type 2 Diabetes in Children and Adolescents
Valaiyapathi, B., Gower, B. A., & Ashraf, A. P. (2019) · Current Diabetes Reviews · doi:10.2174/1573399814666180608074510 · Cited by 151 · see citing works
The regulation of PKA signaling in obesity and in the maintenance of metabolic health
London, E., & Stratakis, C. A. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108113 · Cited by 95 · see citing works
β-Cell Function, Incretin Effect, and Incretin Hormones in Obese Youth Along the Span of Glucose Tolerance From Normal to Prediabetes to Type 2 Diabetes
Michaliszyn, S. F., Mari, A., Lee, S., Bacha, F. F., Tfayli, H. M., Farchoukh, L. O., Ferrannini, E., & Arslanian, S. A. (2014) · Diabetes · doi:10.2337/db13-1951 · Cited by 93 · see citing works
Self-citation
Review of methods for measuring β‐cell function: D esign considerations from the R estoring I nsulin S ecretion ( RISE ) C onsortium
Hannon, T. S., Kahn, S. E., Utzschneider, K. M., Buchanan, T. A., Nadeau, K. J., Zeitler, P. S., Ehrmann, D. A., Arslanian, S. A., Caprio, S., Edelstein, S. L., et al. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13005 · Cited by 88 · see citing works
Self-citation
Insulin sensitivity across the lifespan from obese adolescents to obese adults with impaired glucose tolerance: Who is worse off?
Arslanian, S., Kim, J., Nasr, A., Bacha, F., Tfayli, H., Lee, S., & Toledo, F. (2018) · Pediatric Diabetes · doi:10.1111/pedi.12562 · Cited by 69 · see citing works
Self-citation
Rapid progression of type 2 diabetes and related complications in children and young people—A literature review
Barrett, T. G., Jalaludin, M. Y., Turan, S., Hafez, M., Shehadeh, N., & Panel, O. B. O. T. N. N. P. T. 2. D. G. E. (2019) · Pediatric Diabetes · doi:10.1111/pedi.12953 · Cited by 72 · see citing works
Modulation of type 1 and type 2 diabetes risk by the intestinal microbiome: Role of gut microbiome in diabetes
Paun, A., & Danska, J. S. (2016) · Pediatric Diabetes · doi:10.1111/pedi.12424 · Cited by 67 · see citing works
Estimation of insulin sensitivity in children: methods, measures and controversies
Brown, R. J., & Yanovski, J. (2014) · Pediatric Diabetes · doi:10.1111/pedi.12146 · Cited by 65 · see citing works
Presentation and effectiveness of early treatment of type 2 diabetes in youth: lessons from the TODAY study
Kelsey, M. M., Geffner, M. E., Guandalini, C., Pyle, L., Tamborlane, W. V., Zeitler, P. S., White, N. H., & for the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study Group (2015) · Pediatric Diabetes · doi:10.1111/pedi.12264 · Cited by 60 · see citing works
The Impact of Diabetes Mellitus on Cardiovascular Risk Onset in Children and Adolescents
Pastore, I., Bolla, A. M., Montefusco, L. B., Lunati, M. E., Rossi, A., Assi, E., Zuccotti, G., & Fiorina, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144928 · Cited by 56 · see citing works
Pathophysiology and Treatment of Prediabetes and Type 2 Diabetes in Youth
Bacha, F. F., Hannon, T. S., Tosur, M., Pike, J. M., Butler, A. M., Tommerdahl, K. L., & Zeitler, P. S. (2024) · Diabetes Care · doi:10.2337/dci24-0029 · Cited by 59 · see citing works
Self-citation
Addressing Prediabetes in Childhood Obesity Treatment Programs: Support from Research and Current Practice
Haemer, M. A., Grow, H. M., Fernandez, C., Lukasiewicz, G., Rhodes, E. T., Shaffer, L. A., Sweeney, B. R., Woolford, S. J., & Estrada, E. (2014) · Childhood Obesity · doi:10.1089/chi.2013.0158 · Cited by 50 · see citing works
A cross-sectional view of the current state of treatment of youth with type 2 diabetes in the USA: enrollment data from the Pediatric Diabetes Consortium Type 2 Diabetes Registry
Nambam, B., Silverstein, J. H., Cheng, P., Ruedy, K. J., Beck, R. W., Wadwa, R. P., KLINGENSMITH, G. J., Willi, S. M., Wood, J., Bacha, F. F., et al. (2016) · Pediatric Diabetes · doi:10.1111/pedi.12377 · Cited by 44 · see citing works
Self-citation
Efficacy and safety of tirzepatide in children and adolescents with type 2 diabetes (SURPASS-PEDS): a randomised, double-blind, placebo-controlled, phase 3 trial
Hannon, T. S., Chao, L. C., Pérez, M. B., Pamidipati, K. C., Landó, L. F., Lee, C. J., Patel, H., & Bergman, B. K. (2025) · The Lancet · doi:10.1016/s0140-6736(25)01774-x · Cited by 39 · see citing works
Type 2 diabetes in prepubertal children
Astudillo, M., Tosur, M., Castillo, B., Rafaey, A., Siller, A. F., Nieto, J., Sisley, S. R., McKay, S. V., Nella, A. A., Balasubramanyam, A., et al. (2021) · Pediatric Diabetes · doi:10.1111/pedi.13254 · Cited by 38 · see citing works
Self-citation
Ethnic Minorities Are at Greater Risk for Childhood-Onset Type 2 Diabetes and Poorer Glycemic Control in England and Wales
Khanolkar, A. R., Amin, R., Taylor-Robinson, D. C., Viner, R., Warner, J., & Stephenson, T. J. (2016) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2016.05.012 · Cited by 36 · see citing works
Prevalence and risk of diabetic complications in young-onset versus late-onset type 2 diabetes mellitus
Cho, Y., Park, H. S., Huh, B. W., Seo, S., Seo, D. H., Ahn, S. H., Hong, S., Suh, Y. J., & Kim, S. H. (2022) · Diabetes & Metabolism · doi:10.1016/j.diabet.2022.101389 · Cited by 37 · see citing works
Beta Cell Dysfunction in Youth- and Adult-Onset Type 2 Diabetes: An Extensive Narrative Review with a Special Focus on the Role of Nutrients
Serbis, A., Giapros, V. I., Tsamis, K. I., Balomenou, F., Galli‐Τsinopoulou, A., & Siomou, E. C. (2023) · Nutrients · doi:10.3390/nu15092217 · Cited by 40 · see citing works
The changing face of paediatric diabetes
SHAH, A. S., & Nadeau, K. J. (2020) · Diabetologia · doi:10.1007/s00125-019-05075-6 · Cited by 33 · see citing works
Bariatric Surgery: A Potential Treatment for Type 2 Diabetes in Youth
SHAH, A. S., D’Alessio, D. A., Ford‐Adams, M., Desai, A. P., & Inge, T. H. (2016) · Diabetes Care · doi:10.2337/dc16-0067 · Cited by 33 · see citing works
Trends of Diabetes and Prediabetes Prevalence among Korean Adolescents From 2007 to 2018
Kim, J. H., & Lim, J. S. (2021) · Journal of Korean Medical Science · doi:10.3346/jkms.2021.36.e112 · Cited by 26 · see citing works
Preserved glucagon-like peptide-1 responses to oral glucose, but reduced incretin effect, insulin secretion and sensitivity in young Asians with type 2 diabetes mellitus
Yeow, T. P., Pacini, G., Tura, A., Hor, C. P., Lim, S. L., Tan, F. H. S., Tong, C. V., Hong, J. Y. H., Zain, F. M., Holst, J. J., et al. (2017) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2016-000352 · Cited by 26 · see citing works
Youth prediabetes and type 2 diabetes: Risk factors and prevalence of dysglycaemia
Saleh, M. W., Kim, J. Y., March, C. A., Gebara, N. Y., & Arslanian, S. A. (2021) · Pediatric Obesity · doi:10.1111/ijpo.12841 · Cited by 26 · see citing works
Self-citation
Comparison of beta-cell function between Hong Kong Chinese with young-onset type 2 diabetes and late-onset type 2 diabetes
Fan, Y., Fan, B., Lau, E. S. H., Lim, C. K. P., Wu, H., Ronald, C. W., Ozaki, R., Kong, A. P. S., Chow, E., Luk, A. O. Y., et al. (2023) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2023.110954 · Cited by 27 · see citing works
Initial Presentation of Type 2 Diabetes in Adolescents Predicts Durability of Successful Treatment with Metformin Monotherapy: Insights from the Pediatric Diabetes Consortium T2D Registry
Bacha, F. F., Cheng, P., Gal, R. L., Kollman, C., Tamborlane, W. V., KLINGENSMITH, G. J., Manseau, K., Wood, J., & Beck, R. W. (2017) · Hormone Research in Paediatrics · doi:10.1159/000481687 · Cited by 25 · see citing works
Self-citation
Youth with type 2 diabetes have hepatic, peripheral, and adipose insulin resistance
Cree‐Green, M., Wiromrat, P., Stuppy, J. J., Thurston, J. E., Bergman, B. C., Baumgartner, A., Bacon, S. D., Scherzinger, A. L., Pyle, L. L., & Nadeau, K. J. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00258.2018 · Cited by 25 · see citing works
Impaired fasting glucose and the metabolic profile in Danish children and adolescents with normal weight, overweight, or obesity
Kloppenborg, J. T., Fonvig, C., Nielsen, T. R. H., Mollerup, P., Bøjsøe, C., Pedersen, O., Johannesen, J., Hansen, T., & Holm, J. (2018) · Pediatric Diabetes · doi:10.1111/pedi.12604 · Cited by 28 · see citing works
Redox Imbalance and Methylation Disturbances in Early Childhood Obesity
Barbosa, P., Melnyk, S., Bennuri, S. C., Delhey, L. M., Reis, A., Moura, G., Børsheim, E., Rose, S., & Carvalho, E. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/2207125 · Cited by 22 · see citing works
Phenotypic characteristics and risk factors in a multi-ethnic cohort of young adults with type 2 diabetes
Lascar, N., Altaf, Q., Raymond, N. T., Brown, J. E. P., Pattison, H. M., Barnett, A. H., Bailey, C. J., & Bellary, S. (2019) · Current Medical Research and Opinion · doi:10.1080/03007995.2019.1638239 · Cited by 21 · see citing works
Outpatient Management of Pediatric Type 1 Diabetes
Beck, J. K., & Cogen, F. R. (2015) · The Journal of Pediatric Pharmacology and Therapeutics · doi:10.5863/1551-6776-20.5.344 · Cited by 21 · see citing works
Prevalences and Management of Diabetes and Pre-diabetes among Korean Teenagers and Young Adults: Results from the Korea National Health and Nutrition Examination Survey 2005–2014
Cho, E.-H., Shin, D., Cho, K.-H., & Hur, J. (2017) · Journal of Korean Medical Science · doi:10.3346/jkms.2017.32.12.1984 · Cited by 20 · see citing works
C-peptide levels in pediatric type 2 diabetes in the Pediatric Diabetes Consortium T2D Clinic Registry
Gregg, B. E., Connor, C. G., Cheng, P., Ruedy, K. J., Beck, R. W., Kollman, C., Schatz, D., Cengiz, E., Tamborlane, W. V., KLINGENSMITH, G. J., et al. (2015) · Pediatric Diabetes · doi:10.1111/pedi.12280 · Cited by 18 · see citing works
Obesity and Diabetes: Pathophysiology of Obesity-Induced Hyperglycemia and Insulin Resistance
Gupta, G., Wadhwa, R., Pandey, P., Singh, S. K., Gulati, M., Sajita, S., Mehta, M., Singh, A. K., Dureja, H., Collet, T., et al. (2020) · Springer eBooks · doi:10.1007/978-3-030-35358-2_5 · Cited by 17 · see citing works
Metabolic flexibility across the spectrum of glycemic regulation in youth
Bacha, F. F., Bartz, S. K., Puyau, M. R., Adolph, A. L., & Sharma, S. (2021) · JCI Insight · doi:10.1172/jci.insight.146000 · Cited by 17 · see citing works
Self-citation
Integrative analysis reveals novel associations between DNA methylation and the serum metabolome of adolescents with type 2 diabetes: A cross-sectional study
Agarwal, P., Wicklow, B. A., Dart, A. B., Hizon, N. A., Sellers, E. A. C., McGavock, J., Talbot, C. P. J., Fonseca, M. A., Xu, W. W., Davie, J., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.934706 · Cited by 17 · see citing works
Risk of progression from pre‐diabetes to type 2 diabetes in a large UK adult cohort
Gardner, M. P., Wang, J., Hazlehurst, J., Sainsbury, C. A. R., Blissett, J. M., Nirantharakumar, K., Thomas, G. N., & Bellary, S. (2022) · Diabetic Medicine · doi:10.1111/dme.14996 · Cited by 18 · see citing works
Progression from prediabetes to type 2 diabetes mellitus in adolescents: a real world experience
Weiner, A., Zhang, M., Ren, S., Tchang, B. G., Gandica, R., & Murillo, J. E. (2023) · Frontiers in Clinical Diabetes and Healthcare · doi:10.3389/fcdhc.2023.1181729 · Cited by 17 · see citing works
Trends of clinical parameters and incidences of diabetes mellitus complications among patients with type 2 diabetes mellitus in Hong Kong, 2010–2019: a retrospective cohort study
Wang, Y., Xu, W., Mak, I. L., Chin, W. Y., Yu, E. Y. T., Lam, C. L. K., & Wan, E. Y. F. (2023) · EClinicalMedicine · doi:10.1016/j.eclinm.2023.101999 · Cited by 15 · see citing works
Type 2 diabetes in children and adolescents: distinct characteristics and evidence-based management
Karavanaki, K., Paschou, S. Α., Tentolouris, N., Karachaliou, F., & Soldatou, A. (2022) · Endocrine · doi:10.1007/s12020-022-03172-y · Cited by 16 · see citing works
β-Cell Function Over Time in Adolescents With New Type 2 Diabetes and Obese Adolescents Without Diabetes
Elder, D. A., Hornung, L. N., Khoury, J. C., & D’Alessio, D. A. (2017) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2017.06.007 · Cited by 15 · see citing works
Distinct Amino Acid Profile Characterizes Youth With or at Risk for Type 2 Diabetes
Bacha, F. F., El‐Ayash, H., Mohamad, M., Sharma, S., Puyau, M. R., Kanchi, R. S., & Coarfa, C. (2024) · Diabetes · doi:10.2337/db23-0375 · Cited by 14 · see citing works
Self-citation
Clinical characteristics and beta-cell function of Chinese children and adolescents with type 2 diabetes from 2009 to 2018
Xu, Z., Zhang, M.-Y., Ni, J., Cheng, R., Zheng, Z., Li, X., & Luo, F. (2019) · World Journal of Pediatrics · doi:10.1007/s12519-019-00243-5 · Cited by 14 · see citing works
Diabetes mellitus
Sperling, M. A., Tamborlane, W. V., Battelino, T., WEINZIMER, S. A., & Phillip, M. (2014) · Elsevier eBooks · doi:10.1016/b978-1-4557-4858-7.00028-7 · Cited by 14 · see citing works
Assessing Dysglycemia Risk Among Younger Adults: A Validation of the Canadian Diabetes Risk Questionnaire
Srugo, S. A., MORRISON, H. I., Villeneuve, P. J., de Groh, M., & Jiang, Y. (2019) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2019.11.002 · Cited by 13 · see citing works
Postintervention Effects of Varying Treatment Arms on Glycemic Failure and β-Cell Function in the TODAY Trial
The TODAY Study Group (2020) · Diabetes Care · doi:10.2337/dc20-0622 · Cited by 13 · see citing works
Young‐onset type 2 diabetes—Epidemiology, pathophysiology, and management
Luk, A. O. Y., Wu, H., Fan, Y., Fan, B., Chun Kwan, O., & Chan, J. C.-N. (2025) · Journal of Diabetes Investigation · doi:10.1111/jdi.70081 · Cited by 10 · see citing works
Association of β-cell function and insulin resistance with pediatric type 2 diabetes among Chinese children
Xu, Z., Du, H., Cui, L., Zheng, R., Li, G., Wei, H., Lu, F., Chen, L.-L., Wu, C., Zhang, S.-X., et al. (2021) · World Journal of Diabetes · doi:10.4239/wjd.v12.i8.1292 · Cited by 11 · see citing works
Treatment of type 2 diabetes in children: what are the specific considerations?
Grøndahl, M. F. G., Johannesen, J., Kristensen, K., & Knop, F. K. (2021) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2021.1954160 · Cited by 12 · see citing works
Liraglutide protects β-cell function by reversing histone modification of Pdx-1 proximal promoter in catch-up growth male rats
Gao, M., Deng, X., Liu, Z., Song, H.-J., Zheng, J., Cui, Z., Xiao, K., Chen, L., & Li, H. (2018) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2018.08.002 · Cited by 10 · see citing works
Impact of disease duration and β‐cell reserve on the efficacy of switching to iGlarLixi in adults with type 2 diabetes on glucagon‐like peptide‐1 receptor agonist therapy: Exploratory analyses from the LixiLan‐G trial
Prato, S. D., Frías, J. P., Blonde, L., Aroda, V. R., Shehadeh, N., Saremi, A., DEX, T. A., Niemoeller, E., Souhami, E., Liu, M., et al. (2020) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14068 · Cited by 10 · see citing works
Association Analysis Between Different Diabetic Family History and Gender with Diagnosed Age of Type 2 Diabetes Mellitus: A Cross-Sectional Study in Tianjin, China
Hao, Z., Huang, X. D., Liu, X., Xu, R., Yao, J., He, F., & Shao, H. (2022) · INQUIRY The Journal of Health Care Organization Provision and Financing · doi:10.1177/00469580221086364 · Cited by 9 · see citing works
Management of Early-Onset Type 2 Diabetes in Adults: Current Evidence and Future Directions
Savage, M. J., Goldney, J., Slater, T., Sarkar, P., Sargeant, J. A., Wilmot, E. G., & Davies, M. J. (2025) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2025.0561 · Cited by 10 · see citing works
Diabetes Mellitus
Sperling, M. A., Wolfsdorf, J. I., Menon, R. K., Tamborlane, W. V., Maahs, D. M., Battelino, T., & Phillip, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-62520-3.00021-x · Cited by 9 · see citing works
Treatment Options for Type 2 Diabetes in Youth Remain Limited
Meehan, C., & Silverstein, J. H. (2015) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2015.11.015 · Cited by 8 · see citing works
Commentary on the Impact of Obesity on Pediatric Diabetes
Agrawal, S., & Gensure, R. C. (2018) · Clinical Therapeutics · doi:10.1016/j.clinthera.2018.08.006 · Cited by 8 · see citing works
Insulin Dynamics and Pathophysiology in Youth-Onset Type 2 Diabetes
Abu-Nejem, R., & Hannon, T. S. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae463 · Cited by 7 · see citing works
Intervention with Therapeutic Agents, Understanding the Path to Remission in Type 2 Diabetes
Hao, S., Umpierrez, G. E., Daley, T. C., & Vellanki, P. (2022) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2022.07.003 · Cited by 7 · see citing works
Overview of Pediatric Obesity as a Disease
Waldrop, S. W., Ibrahim, A. A., Maya, J., Monthe-Dreze, C., & Stanford, F. C. (2024) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2024.06.003 · Cited by 6 · see citing works
Youth with type 2 diabetes have a high rate of treatment failure after discontinuation of insulin: A Pediatric Diabetes Consortium study
Wolf, R. M., Cheng, P., Gal, R. L., Beaulieu, L. C., Kollman, C., ISGANAITIS, E. M., Magge, S. N., Mastrandrea, L. D., KLINGENSMITH, G. J., Tamborlane, W. V., et al. (2022) · Pediatric Diabetes · doi:10.1111/pedi.13325 · Cited by 6 · see citing works
Type 2 diabetes in pediatrics
Fornari, E., Barbetti, F., Iafusco, D., Lombardo, F., GIUDICE, E. M. D., Rabbone, I., & Mozzillo, E. (2021) · Minerva Pediatrics · doi:10.23736/s2724-5276.21.06530-7 · Cited by 5 · see citing works
Beta-Cell Function, Insulin Sensitivity, and Metabolic Characteristics in Young-Onset Type 2 Diabetes Mellitus: Findings from Anam Diabetes Observational Study
Kim, J. Y., Lee, J., Kim, S. G., & Kim, N. H. (2025) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2024.0601 · Cited by 4 · see citing works
β ‐ Cell function in obese children and adolescents with metabolic syndrome compared to isolated obesity
Li, G., Chen, X., Liang, X., Hu, L., Zhang, L., Xu, X., Wu, W., Huang, K., Dong, G., Zhang, J., et al. (2019) · Pediatric Diabetes · doi:10.1111/pedi.12905 · Cited by 4 · see citing works
Trajectory of haemoglobin A1c and incidence of cardiovascular disease in patients with type 2 diabetes mellitus
Wang, Y., Chin, W. Y., Lam, C. L. K., & Wan, E. Y. F. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15856 · Cited by 4 · see citing works
Role of Psychologists in Pediatric Endocrinology
Feldman, M. A., Yardley, H. L., Bulan, A., & Kamboj, M. K. (2022) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2022.05.005 · Cited by 5 · see citing works
Changes in Pediatric Type 2 Diabetes During the COVID-19 Pandemic
Hani, N. S., & Thomas, I. H. (2024) · Pediatric Annals · doi:10.3928/19382359-20240502-03 · Cited by 4 · see citing works
Prevalence, Demographic and Clinical Characteristics of Individuals with Early Onset Type 2 Diabetes in the USA: an NHANES Analysis 1999–2020
Lee, C. J., Bergman, B. K., Gou, R. Y., WILLIAMSON, S. E., & Boye, K. S. (2025) · Diabetes Therapy · doi:10.1007/s13300-025-01788-7 · Cited by 5 · see citing works
Navigating the complexities of end-stage kidney disease (ESKD) from risk factors to outcome: insights from the UK Biobank cohort
Kar, D., Byng, R., Sheikh, A., Nath, M., Zabeen, B., Kar, S., Banu, S., Sarker, M. H. R., Khan, N., Acharjee, D., et al. (2025) · BMC Nephrology · doi:10.1186/s12882-025-04090-7 · Cited by 3 · see citing works
Pregnancy outcomes in women with young‐onset type 2 diabetes: the impact of age of diabetes diagnosis and duration of diabetes
Zhen, X. M., Ross, G. P., Gauld, A., Nettel‐Aguirre, A., Noonan, S., Constantino, M., Sweeting, A., Harding, A., Mackie, A., Chatila, H., et al. (2025) · Diabetic Medicine · doi:10.1111/dme.70049 · Cited by 3 · see citing works
Beta-cell function and insulin resistance among Peruvian adolescents with type 2 diabetes
Zelada, H., Carnero, A. M., Hurtado, C. J. M., Aliaga, D. I. C., Munarriz, C. A. L., Aro, P., & Manrique, H. A. (2016) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2016.05.003 · Cited by 3 · see citing works
Association between age at diagnosis and all-cause mortality in type 2 diabetes: the Renal Insufficiency and Cardiovascular Events (RIACE) Italian Multicenter Study
Vitale, M., Orsi, E., Solini, A., Garofolo, M., Grancini, V., Bonora, E., Fondelli, C., Trevisan, R., Vedovato, M., Penno, G., et al. (2024) · Acta Diabetologica · doi:10.1007/s00592-024-02294-1 · Cited by 3 · see citing works
Le diabète de type 2 chez l’enfant et l’adolescent
Bismuth, É. (2020) · Médecine des Maladies Métaboliques · doi:10.1016/j.mmm.2020.06.007 · Cited by 3 · see citing works
Cardiovascular and metabolic complications of childhood obesity
Malíková, J. K., Čepová, J., Doušová, T., Durilová, M., Konopásek, P., Šumnı́k, Z., & Lebl, J. (2024) · Česko-slovenská pediatrie · doi:10.55095/cspediatrie2024/007 · Cited by 2 · see citing works
Outcomes in youth-onset type 2 diabetes during the transition period: glycemic control, microvascular complications, and effects of second-line agents
Yoo, J., Lee, Y. J., Shin, C. H., & Lee, Y. A. (2026) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2550068.034 · Cited by 2 · see citing works
Diabetes in Children and Adolescents
Šumnı́k, Z., & Průhová, Š. (2024) · Endocrinology · doi:10.1007/978-3-030-23709-7_10 · Cited by 2 · see citing works
Undiagnosed pediatric type 2 diabetes mellitus: the giant hidden iceberg
Pu, J. Q., & Fu, J. (2025) · World Journal of Pediatrics · doi:10.1007/s12519-025-00917-3 · Cited by 2 · see citing works
Pediatric type 2 diabetes mellitus complications: a systematic review of the literature
Jordan, D. N., & Jordan, J. L. (2012) · journal of Diabetes Research and Clinical Metabolism · doi:10.7243/2050-0866-1-24 · Cited by 2 · see citing works
Diabetic Ketoacidosis and Long-term Insulin Requirements in Youths with Newly Diagnosed Type 2 Diabetes During the SARS-CoV-2 Pandemic
Hao, S., Cossen, K., Westbrook, A. L., Umpierrez, G. E., & Vellanki, P. (2023) · Endocrine Practice · doi:10.1016/j.eprac.2023.07.002 · Cited by 2 · see citing works
Reduced Blood to Brain Glucose Transport as the Cause for Hyperglycemia: A Model That Resolves Multiple Anomalies in Type 2 DiabetesPreprint
Ojha, A., & Watve, M. (2024) · Qeios · doi:10.32388/gl52db · Cited by 3 · see citing works
Diagnostic and Therapeutic Strategies of Type 2 Diabetes Mellitus in Youth
Kim, H. Y., & Kim, J. H. (2022) · Ewha Medical Journal · doi:10.12771/emj.2022.e3 · Cited by 1 · see citing works
Validation of Fat Mass Metrics in Pediatric Obesity
Lischka, J., Pixner, T., Mörwald, K., Lauth, W., Furthner, D., Weghuber, D., Gomahr, J., Thivel, D., Brandtner, H., Bergauer, M., et al. (2024) · Annals of Nutrition and Metabolism · doi:10.1159/000542029 · Cited by 1 · see citing works
Self-Management Experiences of Adolescents With Diabetes Mellitus After Participating in a Structured Diabetes Education Program: A Qualitative Systematic Review and Thematic Synthesis
Saard, P., Farré, A., Boehnke, J. R., & Malcolm, C. A. (2026) · The Science of Diabetes Self-Management and Care · doi:10.1177/26350106261422691 · Cited by 1 · see citing works
Type 2 Diabetes Mellitus in Adolescents: Should We Reconsider Screening?
Reinehr, T. (2017) · Hormone Research in Paediatrics · doi:10.1159/000481912 · Cited by 1 · see citing works
Nothing Ventured, Nothing Gained: Does This Apply to Obesity in Young People?
Sudlow, A. C., & le Roux, C. W. (2021) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2021.08.683 · Cited by 1 · see citing works
Why are adolescents with obesity and diabetes not having bariatric surgery earlier?
Sudlow, A. C., & le Roux, C. W. (2020) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2020.10.005 · Cited by 1 · see citing works
Metabolic Issues in Adolescence
Morandi, A., & Maffeis, C. (2013) · Current Obesity Reports · doi:10.1007/s13679-013-0069-4
Supporting children and young people diagnosed with type 2 diabetes in school
Bacon, C. (2013) · British Journal of School Nursing · doi:10.12968/bjsn.2013.8.5.222
Bariatric Surgery and Adolescent Type 2 Diabetes
SHAH, A. S., & Inge, T. H. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-55138-0.00013-9
Reduced blood to brain glucose transport as the cause for hyperglycemia in a model resolves multiple anomalies in type 2 diabetesPreprint
Ojha, A., & Watve, M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.19.477014

Decline in Beta-Cell Function among Adolescents with Type 2 Diabetes Mellitus
Masoodi, S. R. (2017) · J Med Sci · doi:10.33883/jms.v20i2.211
β-Cell Function Over Time in Adolescents With New Type 2 Diabetes and Obese Adolescents Without Diabetes
Elder, D. A., Hornung, L. N., Khoury, J. C., & D’Alessio, D. A. (2017) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2017.06.007 · Cited by 15 · see citing works
Progressive beta cell failure in type 2 diabetes mellitus of youth*1
Gungor, N. (2004) · The Journal of Pediatrics · doi:10.1016/s0022-3476(04)00042-3 · Cited by 3 · see citing works
Self-citation
Progressive beta cell failure in type 2 diabetes mellitus of youth
Gungor, N., & Arslanian, S. A. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2003.12.045 · Cited by 90 · see citing works
Self-citation
β-Cell Dysfunction in Adolescents and Adults with Newly Diagnosed Type 2 Diabetes Mellitus
Elder, D. A., Herbers, P. M., Weis, T., Standiford, D. A., Woo, J. G., & D’Alessio, D. A. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2011.12.002 · Cited by 21 · see citing works

Authors: Bacha, F., Gungor, N., Lee, S., & Arslanian, S. A.
Affiliations: University of Pittsburgh (US)
Louisiana State University Health Sciences Center Shreveport (US)
Corresponding author: Bacha, Fida
ORCID: Bacha, Fida
Lee, SoJung
Arslanian, Silva A
Venue: Pediatric Diabetes
Publisher: Hindawi Limited
Published: 2012-08-23
Volume: 14
Issue: 2
Pages: 106-111
ISSN: 1399-543X (ISSN-L)
DOI: 10.1111/j.1399-5448.2012.00915.x
PMC: PMC3648791
OpenAlex: W1598677707
Cited by: 106
References: 23
Citations by year: 2026: 5 · 2025: 9 · 2024: 12 · 2023: 8 · 2022: 12 · 2021: 11 · 2020: 9 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 2 · 2012: 1
FWCI: 3.89
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1104 d)
Locations: Pediatric Diabetes (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Defense (UL1 RR024153, K24 HD01357, MO1 RR00084, UL1TR000005)
Deutsches Krebsforschungszentrum
National Institutes of Health (UL1TR000005)
U.S. Public Health Service (UL1TR000005, K24 HD01357, UL1 RR024153)
National Center for Research Resources (MO-1-RR-00084, UL1RR024153, M01RR000084)
National Center for Advancing Translational Sciences
Eunice Kennedy Shriver National Institute of Child Health and Human Development (K24HD001357)
Children's Hospital of Pittsburgh
Topics: Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords: type 2 diabetes, adolescents, beta-cell function, insulin secretion, first-phase insulin secretion, C-peptide, insulin sensitivity, hepatic glucose production, insulin-stimulated glucose disposal, obesity, disease progression, abdominal fat
MeSH terms: Adolescent, Blood Glucose, Body Composition, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Insulin Resistance, Male, Glucose Clamp Technique, Absorptiometry, Photon, Body Mass Index, Insulin-Secreting Cells, Obesity, Abdominal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Progressive deterioration of β-cell function in obese youth with type 2 diabetes: β-Cell function in youth T2DM

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks