Cited by 908T-cell and B-cell ImmunologyImmune responses and vaccinationsImmune Response and Inflammation

The DOI matches its Crossref record; 295 of the 295 references it cites were found in a registry or an index.

The aging of the immune system

Open access

Weiskopf, Daniela, Weinberger, Birgit, Grubeck-Loebenstein, Beatrix·2009·Transplant International

DOI 10.1111/j.1432-2277.2009.00927.x

Open this paper in CoChat — free account

Abstract

An age-related decline in immune functions, referred to as immunosenescence, is partially responsible for the increased prevalence and severity of infectious diseases, and the low efficacy of vaccination in elderly persons. Immunosenescence is characterized by a decrease in cell-mediated immune function as well as by reduced humoral immune responses. Age-dependent defects in T- and B-cell function coexist with age-related changes within the innate immune system. In this review, we discuss the mechanisms and consequences of age-associated immune alterations as well as their implications for health in old age.

Integrity signals

Registry

Crossref · 10.1111/j.1432-2277.2009.00927.x

Cites

295 of 295 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Items 201–295 of 295

Cytokine Antagonists in Aged Subjects and Their Relation With Cellular Immunity
Catania, A. P., Airaghi, L., Motta, P., Manfredi, M. G., Annoni, G., Pettenati, C., Brambilla, F., & Lipton, J. M. (1997) · The Journals of Gerontology Series A · doi:10.1093/gerona/52a.2.b93 · Cited by 85
Reference Intervals for Human Peripheral Blood Lymphocyte Subpopulations from ‘Healthy’ Young and Aged Subjects
Stulnig, T. M., Maczek, C., Böck, G., Majdic, O., & Wick, G. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000237155 · Cited by 81
Detection of T suppressor cells in patients with organ allografts
Ciubotariu, R., Vasilescu, E. R., Ho, E. K., Cinti, P., Cancedda, C., Poli, L., Late, M., Liu, Z., Berloco, P. B., Cortesini, R., et al. (2001) · Human Immunology · doi:10.1016/s0198-8859(00)00226-3 · Cited by 80
Costimulatory mechanisms in the elderly
Effros, R. B. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00503-4 · Cited by 79
Oligoclonality in the Human CD8+ T Cell Repertoire in Normal Subjects and Monozygotic Twins: Implications for Studies of Infectious and Autoimmune Diseases
Monteiro, J., Hingorani, R., Choi, I., et al. (1995) · Molecular Medicine · doi:10.1007/bf03401602 · Cited by 78
Cellular and substrate adhesion molecules (integrins) and their ligands in cerebral amyloid plaques in Alzheimer's disease
Eikelenboom, P., Zhan, S., Kamphorst, W., van der Valk, P., & Rozemüller, A. J. M. (1994) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00190565 · Cited by 78
Glucocorticoid production in the chicken bursa and thymus
Lechner, O., Dietrich, H., Wiegers, G. J., Vacchio, M. S., & Wick, G. (2001) · International Immunology · doi:10.1093/intimm/13.6.769 · Cited by 77
Bone Morphogenesis and Modeling: Soluble Signals Sculpt Osteosomes in the Solid State
Reddi, A. H. (1997) · Cell · doi:10.1016/s0092-8674(00)80193-2 · Cited by 77
Age-associated changes in CD8+ and CD16+ cell reactivity: clonal analysis
Mariani, E., Roda, P., Mariani, A. R., Vitale, M., Degrassi, A., Papa, S., & Facchini, A. (1990) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1990.tb05359.x · Cited by 74
T Lymphocytes and Aging
Globerson, A. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000237091 · Cited by 74
Biomarkers of Aging: Prediction of Longevity by Using Age-Sensitive T-Cell Subset Determinations in a Middle-Aged, Genetically Heterogeneous Mouse Population
Miller, R. A. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.4.b180 · Cited by 74
IL-4-Producing CD8+ T Cells with a CD62L++(bright) Phenotype Accumulate in a Subgroup of Older Adults and Are Associated with the Maintenance of Intact Humoral Immunity in Old Age
Schwaiger, S., Wolf, A. M., Robatscher, P., Jenewein, B., & Grubeck‐Loebenstein, B. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.1.613 · Cited by 73
Self-citation
Factors influencing serum neopterin and ?2-microglobulin levels in a healthy diverse population
Diamondstone, L. S., Tollerud, D. J., Fuchs, D., Wächter, H., Brown, L. M., Maloney, E. M., Kurman, C. C., Nelson, D. L., & Blattner, W. A. (1994) · Journal of Clinical Immunology · doi:10.1007/bf01546321 · Cited by 72
Age-related monoclonal gammapathies: clinical lessons from the aging C57BL mouse
Radl, J. (1990) · Immunology Today · doi:10.1016/0167-5699(90)90096-r · Cited by 71
AN IMBALANCE BETWEEN PRO- AND ANTI-INFLAMMATORY CYTOKINES, A CHARACTERISTIC FEATURE OF OLD AGE
Saurwein-Teissl, M., Blasko, I., Zisterer, K., Neuman, B., Lang, B., & Grubeck-Loebenstein, B. (2000) · Cytokine · doi:10.1006/cyto.2000.0679 · Cited by 69
Self-citation
Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes.
Miller, C., Štědra, J., Kelsoe, G. H., & Cerny, J. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.4.1319 · Cited by 69
Effect of age on lymphocyte proliferation
McCarron, M., Osborne, Y., Story, C. J., Dempsey, J. L., Turner, D. R., & Morley, A. A. (1987) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(87)90041-8 · Cited by 68
Surface markers and transendothelial migration of dendritic cells from elderly subjects
Pietschmann, P., Hahn, P., Kudlacek, S., Thomas, R., & Peterlik, M. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00089-3 · Cited by 68
Multidrug transporter p‐glycoprotein 170 as a differentiation antigen on normal human lymphocytes and thymocytes: Modulation with differentiation stage and during aging
Pilarski, L. M., Paine, D., McElhaney, J. E., Cass, C. E., & Belch, A. R. (1995) · American Journal of Hematology · doi:10.1002/ajh.2830490411 · Cited by 67
Heterogeneity and its biodemographic implications for longevity and mortality
Carnes, B. A., & Olshansky, S. J. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00254-0 · Cited by 66
Hematopoietic stem cells and aging
Globerson, A. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00069-2 · Cited by 66
Age-Related Decrease in Accessory Cell Function of Human Alveolar Macrophages
Zissel, G., Schlaak, M. W., & Müller-Quernheim, J. (1999) · Journal of Investigative Medicine · doi:10.1177/108155899904700108 · Cited by 66
Differential Tyrosine Phosphorylation of Zeta Chain Dimers in Mouse CD4 T Lymphocytes: Effect of Age
Garcia, G. G., & Miller, R. A. (1997) · Cellular Immunology · doi:10.1006/cimm.1996.1040 · Cited by 65
High Frequency of Cytomegalovirus‐Specific Cytotoxic T‐Effector Cells in HLA‐A*0201–Positive Subjects during Multiple Viral Coinfections
Jin, X., Demoitié, M., Donahoe, S. M., et al. (2000) · The Journal of Infectious Diseases · doi:10.1086/315201 · Cited by 65
Promotion of Lymphocyte Growth by High Density Lipoproteins (HDL)
Jürgens, G., Xu, Q., Huber, L. A., et al. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81826-9 · Cited by 64
Influence of aging on intracellular free calcium and proliferation of mouse T-cell subsets from various lymphoid organs
Grossmann, A., Maggio‐Price, L., Jinneman, J. C., et al. (1991) · Cellular Immunology · doi:10.1016/0008-8749(91)90259-e · Cited by 61
Age-associated changes in interferon-γ and interleukin-4 secretion by purified human CD4+ and CD8+ T cells
Yen, C., Lin, S., Huang, K.-T., & Lin, R. (2000) · Journal of Biomedical Science · doi:10.1007/bf02253251 · Cited by 61
Limiting dilution analysis of alloreactive cytotoxic precursor cells in aging mice.
Nordin, A. A., & Collins, G. D. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.131.5.2215 · Cited by 60
No immunity for the elderly
Grubeck‐Loebenstein, B., Berger, P., Saurwein-Teissl, M., Zisterer, K., & Wick, G. (1998) · Nature Medicine · doi:10.1038/nm0898-870b · Cited by 59
Self-citation
Oligoclonal expansions in the CD8+CD28− T cells largely explain the shorter telomeres detected in this subset:
Batliwalla, F., Rufer, N., Lansdorp, P. M., & Gregersen, P. K. (2000) · Human Immunology · doi:10.1016/s0198-8859(00)00157-9 · Cited by 59
Immunological studies of ageing. X. Impaired T lymphocytes and normal monocyte response from elderly humans to the mitogenic antibodies OKT3 and Leu 4.
Schwab, R., Hausman, P. B., Rinnooy-Kan, E., et al. (1985) · PubMed · Cited by 58
Atherosclerosis—An autoimmune disease! 11This paper is a modified version of an informal article that appeared in the February 1999 issue of Immunology News of the British Society for Immunology.
Wick, G., & Xu, Q. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00035-2 · Cited by 58
Long-Term in vitro Growth of Human T Cell Clones: Can Postmitotic ‘Senescent’ Cell Populations Be Defined?
Grubeck‐Loebenstein, B., Lechner, H., & Trieb, K. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000236671 · Cited by 58
Self-citation
Impairment of signal transduction in T cells from old mice
Utsuyama, M., Wakikawa, A., Tamura, T., et al. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01837-4 · Cited by 58
Diminished activation of the MAP kinase pathway in CD3-stimulated T lymphocytes from old mice
Gorgas, G., Butch, E. R., Guan, K., & Miller, R. A. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01857-x · Cited by 57
Influence of Age on Polymorphonuclear Leukocytes in vitro: Phagocytic Activity in Healthy Human Subjects
Emanuelli, G., Lanzio, M., Anfossi, T., Romano, S., Anfossi, G., & Calcamuggi, G. (2009) · Gerontology · doi:10.1159/000212809 · Cited by 57
Vaccination against tetanus in the elderly: do recommended vaccination strategies give sufficient protection?
Steger, M. M., Maczek, C., Berger, P., & Grubeck‐Loebenstein, B. (1996) · The Lancet · doi:10.1016/s0140-6736(05)65680-2 · Cited by 57
Self-citation
Genetics of longevity
Jazwinski, S. M. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00027-8 · Cited by 56
Diminished Influenza A Virus-Specific MHC Class I-Restricted Cytotoxic T Lymphocyte Activity among Elderly Persons
Mbawuike, I. N., LANGE, A. R., & Couch, R. B. (1993) · Viral Immunology · doi:10.1089/vim.1993.6.55 · Cited by 55
Immunosenescence, suppression and tumour progression
Pawelec, G., Koch, S. D., Griesemann, H., Rehbein, A., Hähnel, K., & Gouttefangeas, C. (2005) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-005-0109-3 · Cited by 54
The defects in effector generation associated with aging can be reversed by addition of IL-2 but not other related γc-receptor binding cytokines
Haynes, L., Eaton, S. M., & Swain, S. L. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00501-0 · Cited by 53
Senescence and functional failure in hematopoietic stem cells
Chen, J. (2004) · Experimental Hematology · doi:10.1016/j.exphem.2004.08.001 · Cited by 53
Membrane Signal Transduction in T Cells in Aging Humansa
Gupta, S. (1989) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1989.tb12517.x · Cited by 52
Lipoprotein interactions with T cells: an update
Traill, K. N., Huber, L. A., Wick, G., et al. (1990) · Immunology Today · doi:10.1016/0167-5699(90)90161-2 · Cited by 52
Functional Subsets within Clonally Expanded CD8+ Memory T Cells in Elderly Humans
Chamberlain, W., Falta, M. T., & Kotzin, B. L. (2000) · Clinical Immunology · doi:10.1006/clim.1999.4832 · Cited by 51
Dendritic cell responsiveness to stimulation with influenza vaccine is unimpaired in old age
Saurwein-Teissl, M., Schönitzer, D., & Grubeck-Loebenstein, B. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00026-6 · Cited by 51
Self-citation
TNF-α, leptin, and lymphocyte function in human aging
Brüünsgaard, H., Pedersen, B. K., Schroll, M., Skinhøj, P., & Pedersen, B. K. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00851-1 · Cited by 50
Activation of p21ras/MAPK Signal Transduction Molecules Decreases with Age in Mitogen-Stimulated T Cells from Rats
Pahlavani, M. A., Harris, M. D., & Richardson, A. G. (1998) · Cellular Immunology · doi:10.1006/cimm.1998.1274 · Cited by 50
ANTIGENS IN IMMUNITY. ANTIGEN LOCALIZATION IN CONGENITALLY ATHYMIC “NUDE” MICE
Mitchell, J., Pye, J., Holmes, M. C., et al. (1972) · Immunology and Cell Biology · doi:10.1038/icb.1972.56 · Cited by 49
Age-related changes of signal transduction in T cells
Hirokawa, K. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00067-9 · Cited by 49
Age-related decline in proliferative potential of purified stem cell candidates.
Lansdorp, P. M., Dragowska, W. H., Thomas, T. E., Little, M. T., & Mayani, H. (1994) · PubMed · Cited by 48
Aging and Impairment of Innate Immunity
Nomellini, V., Gómez, C. R., & Kovacs, E. J. (2008) · KARGER eBooks · doi:10.1159/000136358 · Cited by 47
Tumor necrosis factor α augments amyloid β protein (25–35) induced apoptosis in human cells
Blasko, I., Schmitt, T. L., Steiner, E., Trieb, K., & Grubeck‐Loebenstein, B. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00845-8 · Cited by 47
Self-citation
Decreased steady state c-myc mRNA in activated T cell cultures from old humans is caused by a smaller proportion of T cells that transcribe the c-myc gene.
Gamble, D., Schwab, R., Weksler, M. E., et al. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.9.3569 · Cited by 46
Age-Related Dysregulation of CD8+ T Cell Memory Specific for a Persistent Virus Is Independent of Viral Replication
Lang, A. M., Brien, J. D., Messaoudi, I., & Nikolich‐Žugich, J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4848 · Cited by 45
Cellular Basis of B Cell Clonal Populations in Old Mice
LeMaoult, J., Manavalan, J. S., Dyall, R., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.11.6384 · Cited by 45
In vitro senescence models for human T lymphocytes
Pawelec, G., Adibzadeh, M., Rehbein, A., Hähnel, K., Wagner, W., & Engel, A. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00504-6 · Cited by 45
Peripheral blood dendritic cells reinduce proliferation in in vitro aged T cell populations
Steger, M. M., Maczek, C., & Grubeck-Loebenstein, B. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01835-0 · Cited by 45
Self-citation
Effect of age on cytokine production in humans
Bernstein, E. D., & Murasko, D. M. (1998) · AGE · doi:10.1007/s11357-998-0024-6 · Cited by 42
Is atherosclerosis an autoimmune disease?
Wick, G., Kleindienst, R., Dietrich, H., et al. (1992) · Trends in Food Science & Technology · doi:10.1016/0924-2244(92)90154-o · Cited by 42
Reduced IFN-γ production in elderly people following in vitro stimulation with influenza vaccine and endotoxin
Ouyang, Q., Cicek, G., Westendorp, R. G. J., Cools, H. J. M., van der Klis, R. J., & Remarque, E. J. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00204-9 · Cited by 42
Early lymphocyte activation in elderly humans: impaired T and T-dependent B cell responses
Fernández‐Gutiérrez, B., Jovera, J. A., Miguela, S. D., Hernández‐García, C., Vidán, M. T., Riberab, J. M., Bañaresa, A., & Rexach, J. A. S. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00068-0 · Cited by 39
In Vitro Cellular Aging in T-Lymphocyte Cultures: Analysis of DNA Content and Cell Size
Perillo, N. L., Naeim, F., Walford, R. L., & Effros, R. B. (1993) · Experimental Cell Research · doi:10.1006/excr.1993.1171 · Cited by 39
Expression and catalytic activities of protein tyrosine kinases (PTKs) Fyn and Lck in peripheral blood T cells from elderly humans stimulated through the T cell receptor (TCR)/CD3 complex1This work was supported by United States Public Health Service Grant AG03763 from the National Institutes of Health.1
Whisler, R. L., Bagenstose, S. E., Newhouse, Y. G., & Carle, K. W. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00073-0 · Cited by 38
B cells and aging: gauging the interplay of generative, selective, and homeostatic events
Cancro, M. P. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00272.x · Cited by 37
Differential expression of the α- and β-isoforms of protein kinase C in peripheral blood T and B cells from young and elderly adults
Whisler, R. L., Newhouse, Y. G., Grants, I. S., & Hackshaw, K. V. (1995) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)01526-r · Cited by 33
Increased Zap-70 Association with CD3ζ in CD4 T Cells from Old Mice
Garcia, G. G., & Miller, R. A. (1998) · Cellular Immunology · doi:10.1006/cimm.1998.1394 · Cited by 33
In vitro T cell activation in elderly individuals: failure in CD69 and CD71 expression
Lio, D., Candore, G., Cigna, D., et al. (1996) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(96)01726-5 · Cited by 33
Age-related impairments in TCR/CD3 activation of ZAP-70 are associated with reduced tyrosine phosphorylations of ζ-chains and p59fyn/p56lck in human T cells
Whisler, R. L., Chen, M., Beiqing, L., & Newhouse, Y. G. (1999) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(99)00074-3 · Cited by 32
Lectin-induced cytotoxic activity in spleen cells from young and old mice. Age-related changes in types of effector cells, lymphokine production and response.
Saxena, R. K., Saxena, Q. B., & Adler, W. H. (1988) · PubMed · Cited by 32
Role of mRNA stability in the different patterns of cytokine production by CD4+ cells from young and old mice
Pioli, C., Pucci, S., Barile, S., Frasca, D., & Doria, G. (1998) · Immunology · doi:10.1046/j.1365-2567.1998.00523.x · Cited by 28
Vaccinating Elderly People
Stein, B. E. (1994) · Drugs & Aging · doi:10.2165/00002512-199405040-00002 · Cited by 26
Phosphorylation and coupling of ζ-chains to activated T-cell receptor (TCR)/CD3 complexes from peripheral blood T-cells of elderly humans
Whisler, R. L., Karanfilov, C. I., Newhouse, Y. G., Fox, C. C., Lakshmanan, R. R., & Beiqing, L. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00084-0 · Cited by 26
Effect of hydrogen peroxide administration on life span, superoxide dismutase, catalase, and glutathione in the adult housefly, Musca domestica
Sohal, R. S. (1988) · Experimental Gerontology · doi:10.1016/0531-5565(88)90008-3 · Cited by 26
Age-related decline in the lethal hit but not the binding stage of cytotoxic T-cell activity in mice
Bloom, E. T., Kubota, L. F., & Kawakami, K. (1988) · Cellular Immunology · doi:10.1016/0008-8749(88)90335-8 · Cited by 26
In Vivo LDL Receptor and HMG-CoA Reductase Regulation in Human Lymphocytes and Its Alterations During Aging
Stulnig, T. M., Klocker, H., Harwood, H. J., Jürgens, G., Schönitzer, D., Jarosch, E., Huber, L. A., Amberger, A., & Wick, G. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.7.872 · Cited by 25
Oligoclonal Expansions of Antigen‐Specific CD8+ T Cells in Aged Mice
Posnett, D. N., Yarilin, D. A., Valiando, J., Li, F., Liew, F. Y., Weksler, M. E., & Szabo, P. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb06061.x · Cited by 25
Decreased Association of p56lckwith CD4 May Account for Lowered Tyrosine Kinase Activity in Mitogen-Activated Human T Lymphocytes during Aging
Tinkle, C. W., Lipschitz, D. A., & Ponnappan, U. (1998) · Cellular Immunology · doi:10.1006/cimm.1998.1313 · Cited by 23
Immunodeficiency in Old Age1
WICK, G., Huber, L. A., Offner, F., et al. (2015) · Current problems in dermatology · doi:10.1159/000416847 · Cited by 23
Cluster Formation by Protein Kinase Cθ during Murine T Cell Activation: Effect of Age
Yang, D., & Miller, R. A. (1999) · Cellular Immunology · doi:10.1006/cimm.1999.1517 · Cited by 22
Non-regulatory CD8+CD45RO+CD25+ T-lymphocytes may compensate for the loss of antigen-inexperienced CD8+CD45RA+ T-cells in old age
Herndler‐Brandstetter, D., Veel, E. M., Laschober, G. T., Pfister, G., Brunner, S. M., Walcher, S., Parson, W., Lepperdinger, G., & Grubeck‐Loebenstein, B. (2008) · Biological Chemistry · doi:10.1515/bc.2008.052 · Cited by 21
Self-citation
IFN-γ production by CMV-specific CD8+ T cells is high in elderly donors
Almanzar, G., Schwaiger, S., Jenewein, B., Keller, M., Würzner, R., Schönitzer, D., & Grubeck‐Loebenstein, B. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.01.017 · Cited by 21
Self-citation
Post-thymic T-cell development in the rat.
Kampinga, J., Groen, H., Klatter, F., et al. (1997) · PubMed · Cited by 20
The Making and the Breaking of Senescence: Changes of Gene Expression During Cellular Aging and Immortalization
Jansen‐Dürr, P. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00006-0 · Cited by 19
Proliferative and cytotoxic immune functions in aging mice. IV. Effects of suppressor cell populations from aged and young mice.
Gottesman, S. R. S., Edington, J., & Thorbecke, G. J. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.6.1783 · Cited by 17
Induction of allograft tolerance through costimulatory blockade: first selection of drugs in vitro
Vierboom, M. (2003) · Transplant Immunology · doi:10.1016/s0966-3274(03)00009-1 · Cited by 15
The Localization of Antigen in Lymph Node Follicles of Congenitally Athymic Nude Rats
Mjaaland, S., & Fossum, S. (1987) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1987.tb02246.x · Cited by 15
Estimation of reference intervals from a senieur protocol compatible aged population for immunogerontological studies
Stulnig, T. M., Mair, A., Jarosch, E., Schober, M., Schönitzer, D., Wick, G., & Huber, L. A. (1993) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(93)90143-f · Cited by 14
GROWTH HORMONE BLOCKING ANTIBODIES IN A PATIENT WITH DELETION OF THE GH‐N GENE
Schwarz, S., BERGER, P., Frisch, H., et al. (1987) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1987.tb01147.x · Cited by 14
New Tools in Assessing Immune Reconstitution after Hematopoietic Stem Cell Transplantation
Toubert, A., Clave, E., Talvensaari, K. K., Douay, C., & Charron, D. J. (2000) · Vox Sanguinis · doi:10.1111/j.1423-0410.2000.tb00032.x · Cited by 12
Clinical immunology of aging
Fillit, H. M. (1994) · Reviews in Clinical Gerontology · doi:10.1017/s0959259800003816 · Cited by 11
[Immune reaction to tetanus in the elderly: what is the duration of vaccine protection?].
Steger, M. M., Maczek, C., Berger, P., et al. (1997) · PubMed · Cited by 10
Effect of CMV serology and CMV disease on AIDS morbidity and mortality
Laing, R. B. S., Brettle, R. P., & Leen, C. L. S. (1997) · Infection · doi:10.1007/bf01713158 · Cited by 2
Untitled work
(2002) · doi:10.1002/1521-4141(200206)32:6
Untitled work
(2001) · doi:10.1002/1521-4141(200108)31:8

Research works printed but not linked: 1

Pawelec, 1999, Immunosenescence: impact in the young as well as the old?, Mech Ageing Dev, 108, 1

Sorted by citations

Evolution of the immune system in humans from infancy to old age
Simon, A. K., Hollander, G. A., & McMichael, A. (2015) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2014.3085 · Cited by 1,796
Proinflammatory Cytokines, Aging, and Age-Related Diseases
Michaud, M., Balardy, L., Moulis, G., Gaudin, C., Peyrot, C., Vellas, B., Cesari, M., & Nourhashemi, F. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.009 · Cited by 1,094
The ageing haematopoietic stem cell compartment
Geiger, H., de Haan, G., & Florian, M. C. (2013) · Nature Reviews Immunology · doi:10.1038/nri3433 · Cited by 604
Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans
Solana, R., Tarazona, R., Gayoso, I., Lesur, O., Dupuis, G., & Fulop, T. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.008 · Cited by 567
Molecular and physiological manifestations and measurement of aging in humans
Khan, S. S., Singer, B. D., & Vaughan, D. E. (2017) · Aging Cell · doi:10.1111/acel.12601 · Cited by 530

See all 908

Authors: Weiskopf, D., Weinberger, B., & Grubeck-Loebenstein, B.
Affiliations: Universität Innsbruck (AT)
ORCID: Weiskopf, Daniela
Weinberger, Birgit
Venue: Transplant International
Publisher: Frontiers Media SA
Published: 2009-11
Volume: 22
Issue: 11
Pages: 1041-1050
ISSN: 0934-0874 (ISSN-L)
1432-2277
DOI: 10.1111/j.1432-2277.2009.00927.x
OpenAlex: W1981904722
Cited by: 908
References: 295
Citations by year: 2026: 35 · 2025: 43 · 2024: 63 · 2023: 62 · 2022: 77 · 2021: 81 · 2020: 74 · 2019: 41 · 2018: 43 · 2017: 49 · 2016: 38 · 2015: 42 · 2014: 33 · 2013: 62 · 2012: 51
FWCI: 3.13
Type: journal article
Language: en
Open access: green
epub.oeaw.ac.at
Licence: other-oa
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 2130 d)
Locations: Transplant International (publishedVersion)
PubMed (publishedVersion)
Oesterreichisches Musiklexikon online (Institut für kunst- und musikhistorische Forschungen der Österreichischen Akademie der Wissenschaften) (submittedVersion, other-oa)
Austrian Biographical Dictionary (Austrian Academy of Sciences) (submittedVersion, other-oa)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: immunosenescence, aging, immune system, cell-mediated immunity, humoral immunity, T cell function, B cell function, innate immunity
MeSH terms: Aged, Aged, 80 and over, Aging, Antibody Formation, Dendritic Cells, Disease Susceptibility, Hematopoietic Stem Cells, Humans, Immune System, Immunity, Cellular, Immunity, Innate, Infections, Macrophages, Neutrophils, Vaccination, Lymphocyte Subsets, Lymphopoiesis, Myelopoiesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The aging of the immune system

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks