The aging of the immune system

Oxidants, oxidative stress and the biology of ageing

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Telomeres shorten during ageing of human fibroblasts

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Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.

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Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

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Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.

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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.

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Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

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Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.

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Changes in thymic function with age and during the treatment of HIV infection

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Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.

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Reconstitution of Cellular Immunity against Cytomegalovirus in Recipients of Allogeneic Bone Marrow by Transfer of T-Cell Clones from the Donor

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Gene expression profile of aging and its retardation by caloric restriction

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Cells in Stress: Transcriptional Activation of Heat Shock Genes

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Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies

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Phenotypic and functional separation of memory and effector human CD8+ T cells

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Activation of microglial cells by β-amyloid protein and interferon-γ

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Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty

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Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

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Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease

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The aging immune system: primer and prospectus

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Aminoguanidine Prevents Diabetes-Induced Arterial Wall Protein Cross-Linking

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Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

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The Efficacy of Influenza Vaccine in Elderly Persons: A Meta-Analysis and Review of the Literature

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Age, Thymopoiesis, and CD4+ T-Lymphocyte Regeneration after Intensive Chemotherapy

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Skewed maturation of memory HIV-specific CD8 T lymphocytes

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The Efficacy and Cost Effectiveness of Vaccination against Influenza among Elderly Persons Living in the Community

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Ageing and infection

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Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease

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NKT cells: facts, functions and fallacies

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The aging of hematopoietic stem cells

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Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

Gao, H., & Hong, J. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.05.002 · Cited by 852

Glucocorticoids in T Cell Development and Function

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Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy".

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Admission criteria for immunogerontological studies in man: The senieur protocol

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Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals

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RANK Is the Essential Signaling Receptor for Osteoclast Differentiation Factor in Osteoclastogenesis

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Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species

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Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes

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Aging and proinflammatory cytokines

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The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts.

Burgess, T. L., Qian, Y.-X., Kaufman, S., Ring, B. D., Van, G., Capparelli, C., Kelley, M., Hsu, H., Boyle, W. J., Dunstan, C. R., et al. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.3.527 · Cited by 689

Cytotoxic T-lymphocyte response to cytomegalovirus after human allogeneic bone marrow transplantation: pattern of recovery and correlation with cytomegalovirus infection and disease

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Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor

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Epidemiology of Invasive Streptococcus pneumoniae Infections in the United States, 1995-1998 Opportunities for Prevention in the Conjugate Vaccine Era

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Immunology Taught by Viruses

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Caloric restriction and aging: an update

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Microglia in degenerative neurological disease

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Hazzard’s Geriatric Medicine and Gerontology

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Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging

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Chronic Infections and the Risk of Carotid Atherosclerosis

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Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines

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Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space

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Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections.

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Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1.

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Effect of age on human neutrophil function

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CD28 extinction in human T cells: altered functions and the program of T‐cell senescence

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Anti-inflammatory drugs and Alzheimer disease

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Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans

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Serum Soluble Heat Shock Protein 60 Is Elevated in Subjects With Atherosclerosis in a General Population

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Innate immunity in aging: impact on macrophage function

Plowden, J., Renshaw‐Hoelscher, M., Engleman, C., Katz, J. M., & Sambhara, S. R. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00102.x · Cited by 430

Functional Heterogeneity and High Frequencies of Cytomegalovirus-Specific CD8+T Lymphocytes in Healthy Seropositive Donors

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Osteoporosis, inflammation and ageing

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Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals

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Is atherosclerosis an immunologically mediated disease?

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Age-Related Alterations in the Inflammatory Response to Dermal Injury

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CD28- T lymphocytes. Antigenic and functional properties

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Biology of Immune Responses to Vaccines in Elderly Persons

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Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts

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Generation of Functional Thymocytes in the Human Adult

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Thymic involution with ageing: obsolescence or good housekeeping?

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Long-Term Cytomegalovirus Infection Leads to Significant Changes in the Composition of the CD8+T-Cell Repertoire, Which May Be the Basis for an Imbalance in the Cytokine Production Profile in Elderly Persons

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Aging and innate immune cells

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Herpesvirus-Specific CD8 T Cell Immunity in Old Age: Cytomegalovirus Impairs the Response to a Coresident EBV Infection

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Changes in the Human Thymus During Aging

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Increased transplant-related morbidity and mortality in CMV-seropositive patients despite highly effective prevention of CMV disease after allogeneic T-cell–depleted stem cell transplantation

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The network and the remodeling theories of aging: historical background and new perspectives

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Thymic Involution in Aging

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Elevated levels of tumor necrosis factor alpha and mortality in centenarians

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Constraints on CD4 Recovery Postchemotherapy in Adults: Thymic Insufficiency and Apoptotic Decline of Expanded Peripheral CD4 Cells

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The aging innate immune system

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Infections, Immunity, and Atherosclerosis

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Normal Variations with Aging of the Amount of Hematopoietic Tissue in Bone Marrow from the Anterior Iliac Crest: A Study Made from 177 Cases of Sudden Death Examined by Necropsy

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Expanded CD4+ and CD8+ T cell clones in elderly humans

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Autoantibodies against heat shock protein 60 mediate endothelial cytotoxicity.

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Clonal predominance of T cell receptors within the CD8+ CD45RO+ subset in normal human subjects.

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Chronic herpesvirus reactivation occurs in aging

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NK and NK/T cells in human senescence

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TNFα plus IFNγ induce the production of Alzheimer β‐amyloid peptides and decrease the secretion of APPs

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T cell development and receptor diversity during aging

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NK phenotypic markers and IL2 response in NK cells from elderly people

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Cytomegalovirus (CMV) Phosphoprotein 65 Makes a Large Contribution to Shaping the T Cell Repertoire in CMV‐Exposed Individuals

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Pgp‐1hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A

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