REACTIVE OXYGEN SPECIES IN CARDIAC SIGNALLING: FROM MITOCHONDRIA TO PLASMA MEMBRANE ION CHANNELS

Hool, Livia C

doi:10.1111/j.1440-1681.2006.04341.x

Cited by 83Redox biology and oxidative stressNitric Oxide and Endothelin EffectsCardiac Ischemia and Reperfusion

REACTIVE OXYGEN SPECIES IN CARDIAC SIGNALLING: FROM MITOCHONDRIA TO PLASMA MEMBRANE ION CHANNELS

Hool, Livia C·2006·Clinical and Experimental Pharmacology and Physiology

DOI 10.1111/j.1440-1681.2006.04341.x

Open this paper in CoChat — free account

Abstract

1. Reactive oxygen species (ROS) have been considered deleterious to cell function and there is good evidence to suggest that they play a role in the pathophysiology of a number of cardiac disease states. However, ROS are also now being recognized as important regulators of cell function by altering the redox state of proteins. 2. Possible sources of production of ROS in cardiac myocytes are the mitochondria and nicotinamide adenine dinucleotide phosphate-oxidase. The generation of ROS and anti-oxidant defence mechanisms in the heart are discussed. 3. The evidence for a role for ROS in the development of disease states, such as atherosclerosis, ischaemia, cardiac hypertrophy and hypertension, is presented. It is now recognized that cardiac ion channel function is regulated by ROS. Implications with respect to cardiac arrhythmia are discussed.

Integrity signals

Registry

Crossref · 10.1111/j.1440-1681.2006.04341.x

Cites

74 of 74 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Mitochondrial KCa channels can modulate ROS production up or down by altering ΔpH independent of ΔΨm.
“We have postulated that mitochondrial KCa channels can modulate ROS production up or down by altering ΔpH independent of ΔΨm (158, 159).”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [158]

Mitochondrial formation of reactive oxygen species
Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084 · see citing works
Reactive oxygen species in cell signaling
Thannickal, V. J., & Fanburg, B. L. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.6.l1005 · Cited by 2,936 · see citing works
Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.
Griendling, K. K., Minieri, C. A., Ollerenshaw, J. D., & Alexander, R. W. (1994) · Circulation Research · doi:10.1161/01.res.74.6.1141 · Cited by 2,735 · see citing works
ATP-regulated K+ channels in cardiac muscle
Noma, A. (1983) · Nature · doi:10.1038/305147a0 · Cited by 2,341 · see citing works
Role of oxidative stress in cardiovascular diseases
Dhalla, N. S., Temsah, R. M., & Netticadan, T. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018060-00002 · Cited by 1,467 · see citing works
Molecular and Cellular Mechanisms of Cardiac Arrhythmias
Keating, M. T., & Sanguinetti, M. C. (2001) · Cell · doi:10.1016/s0092-8674(01)00243-4 · Cited by 1,003 · see citing works
Modulation of Protein Kinase Activity and Gene Expression by Reactive Oxygen Species and Their Role in Vascular Physiology and Pathophysiology
Griendling, K. K., Sorescu, D., Lassegue, B. P., & Ushio‐Fukai, M. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.10.2175 · Cited by 955 · see citing works
Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate
Salmeen, A., Andersen, J. N., Myers, M. P., Meng, T.-C., Hinks, J. A., Tonks, N. K., & Barford, D. (2003) · Nature · doi:10.1038/nature01680 · Cited by 951 · see citing works
Superoxide production by the mitochondrial respiratory chain
Turrens, J. F. (1997) · Bioscience Reports · doi:10.1023/a:1027374931887 · Cited by 903 · see citing works
Does superoxide underlie the pathogenesis of hypertension?
Nakazono, K., Watanabe, N., Matsuno, K., Sasaki, J., Sato, T., & Inoue, M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10045 · Cited by 746 · see citing works
Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes
Vanden Hoek, T. L., Becker, L. B., Shao, Z., Li, C., & Schumacker, P. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18092 · Cited by 721 · see citing works
Superoxide and peroxynitrite inatherosclerosis.
White, C. R., Brock, T. A., Chang, L. Y., Crapo, J. D., BRISCOE, P. M., Ku, D. D., Bradley, W. A., Gianturco, S. H., Gore, J. Z., & Freeman, B. Α. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.3.1044 · Cited by 685 · see citing works
Reactive oxygen species and hormonal control of cell death
Overmyer, K., Brosché, M., & Kangasjärvi, J. (2003) · Trends in Plant Science · doi:10.1016/s1360-1385(03)00135-3 · Cited by 677 · see citing works
Early afterdepolarizations: mechanism of induction and block. A role for L-type Ca2+ current.
January, C. T., & Riddle, J. M. (1989) · Circulation Research · doi:10.1161/01.res.64.5.977 · Cited by 676 · see citing works
Hyperglycemia-Induced Apoptosis in Mouse Myocardium
Cai, L., Li, W., Wang, G., Guo, L., Jiang, Y., & Kang, Y. J. (2002) · Diabetes · doi:10.2337/diabetes.51.6.1938 · Cited by 663 · see citing works
Oxygen, Reactive Oxygen Species and Tissue Damage
Bergamini, C. M., Gambetti, S., Dondi, A., & Cervellati, C. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043384664 · Cited by 661 · see citing works
Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B
van Montfort, R. L. M., Congreve, M., Tisi, D., Carr, R. A. E., & Jhoti, H. (2003) · Nature · doi:10.1038/nature01681 · Cited by 642 · see citing works
Role of NADH/NADPH Oxidase–Derived H 2 O 2 in Angiotensin II–Induced Vascular Hypertrophy
Zafari, A. M., Ushio‐Fukai, M., Akers, M., Yin, Q., Shah, A. A., Harrison, D. G., Taylor, W. R., & Griendling, K. K. (1998) · Hypertension · doi:10.1161/01.hyp.32.3.488 · Cited by 610 · see citing works
Quick measurement of protein sulfhydryls with Ellman's reagent and with 4,4′-dithiodipyridine
Riener, C. K., Kada, G., & Gruber, H. J. (2002) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-002-1347-2 · Cited by 569 · see citing works
Reactive Oxygen Species Mediate the Activation of Akt/Protein Kinase B by Angiotensin II in Vascular Smooth Muscle Cells
Ushio‐Fukai, M., Alexander, R. W., Akers, M., Yin, Q., Fujio, Y., Walsh, K., & Griendling, K. K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22699 · Cited by 558 · see citing works
Methods of Detection of Vascular Reactive Species
Tarpey, M. M., & Fridovich, I. (2001) · Circulation Research · doi:10.1161/hh1501.094365 · Cited by 552 · see citing works
Activation of NADPH Oxidase During Progression of Cardiac Hypertrophy to Failure
Li, J., Gall, N. P., Grieve, D., Chen, M., & Shah, A. M. (2002) · Hypertension · doi:10.1161/01.hyp.0000032031.30374.32 · Cited by 517 · see citing works
Estimation of H 2 O 2 gradients across biomembranes
Antunes, F., & Cadenas, E. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01638-0 · Cited by 498 · see citing works
Regulation of brain mitochondrial H 2 O 2 production by membrane potential and NAD(P)H redox state
Starkov, A. A., & Fiskum, G. M. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01908.x · Cited by 491 · see citing works
Interactions of oxidants with vascular signaling systems
Wolin, M. S. (2000) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.20.6.1430 · Cited by 463 · see citing works
Increased Protein Kinase C Activity and Expression of Ca 2+ -Sensitive Isoforms in the Failing Human Heart
Bowling, N. L., Walsh, R. A., Song, G., Estridge, T. B., Sandusky, G. E., Fouts, R. L., Mintze, K., Pickard, T., Roden, R. L., Bristow, M. R., et al. (1999) · Circulation · doi:10.1161/01.cir.99.3.384 · Cited by 458 · see citing works
Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols.
Campbell, D. L., Stamler, J. S., & Strauss, H. C. (1996) · The Journal of general physiology · doi:10.1085/jgp.108.4.277 · Cited by 441 · see citing works
Contrasting Roles of NADPH Oxidase Isoforms in Pressure-Overload Versus Angiotensin II–Induced Cardiac Hypertrophy
Byrne, J., Grieve, D., Bendall, J. K., Li, J., Gove, C. D., Lambeth, J. D., Cave, A. C., & Shah, A. M. (2003) · Circulation Research · doi:10.1161/01.res.0000099504.30207.f5 · Cited by 411 · see citing works
The oxygen free radical system: from equations through membrane-protein interactions to cardiovascular injury and protection
Kukreja, R. C., & Hess, M. L. (1992) · Cardiovascular Research · doi:10.1093/cvr/26.7.641 · Cited by 396 · see citing works
Superoxide Mediates the Actions of Angiotensin II in the Central Nervous System
Zimmerman, M. C., Lazartigues, E. D., Lang, J., Sinnayah, P., Ahmad, I. M., Spitz, D. R., & Davisson, R. L. (2002) · Circulation Research · doi:10.1161/01.res.0000043501.47934.fa · Cited by 394 · see citing works
Cellular oxygen sensing by mitochondria: old questions, new insight
Chandel, N. S., & Schumacker, P. T. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.5.1880 · Cited by 389 · see citing works
Superoxide Dismutases
Beyer, W. F., Imlay, J. A., & Fridovich, I. (1991) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60843-0 · Cited by 347 · see citing works
Reperfusion injury: Experimental evidence and clinical implications
Ambrosio, G., & Tritto, I. (1999) · American Heart Journal · doi:10.1016/s0002-8703(99)70323-6 · Cited by 337 · see citing works
Localization of Protein Kinase C Isozymes in Cardiac Myocytes
Disatnik, M., Buraggi, G., & Mochly‐Rosen, D. (1994) · Experimental Cell Research · doi:10.1006/excr.1994.1041 · Cited by 335 · see citing works
The role of cysteine residues as redox-sensitive regulatory switches
Barford, D. (2004) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2004.09.012 · Cited by 331 · see citing works
Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle.
Marbán, E., Robinson, S., & Wier, W. G. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112701 · Cited by 318 · see citing works
Role of reactive oxygen species and NAD(P)H oxidase in α1-adrenoceptor signaling in adult rat cardiac myocytes
Xiao, L., Pimentel, D. R., Wang, J., Singh, K., Colucci, W. S., & Sawyer, D. B. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00254.2001 · Cited by 300 · see citing works
Determining Glutathione and Glutathione Disulfide Using the Fluorescence Probe o-Phthalaldehyde
Senft, A. P., Dalton, T. P., & Shertzer, H. G. (2000) · Analytical Biochemistry · doi:10.1006/abio.2000.4498 · Cited by 294 · see citing works
Hypoxia increases persistent sodium current in rat ventricular myocytes.
Ju, Y., Saint, D. A., & Gage, P. W. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021772 · Cited by 281 · see citing works
Detection of Superoxide in Vascular Tissue
Münzel, T. F., Afanasʹev, I. B., Kleschyov, A. L., & Harrison, D. G. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000034022.11764.ec · Cited by 281 · see citing works
HO 2 •: The Forgotten Radical
de Grey, A. D. N. J. (2002) · DNA and Cell Biology · doi:10.1089/104454902753759672 · Cited by 279 · see citing works
Catalase Protects Cardiomyocyte Function in Models of Type 1 and Type 2 Diabetes
Ye, G., Metreveli, N. S., Donthi, R. V., Shen, X., Xu, M., Carlson, E. C., & Epstein, P. N. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1336 · Cited by 278 · see citing works
The role of H2O2 generation in perfused rat liver and the reaction of catalase compound I and hydrogen donors
Oshino, N., Chance, B., Sies, H., & Bücher, T. (1973) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(73)90040-4 · Cited by 270 · see citing works
Overexpression of human copper,zinc-superoxide dismutase (SOD1) prevents postischemic injury
Wang, P., Chen, H., Qin, H., Sankarapandi, S., Bêcher, M. W., Wong, P. C., & Zweier, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4556 · Cited by 258 · see citing works
Transgenic Overexpression of Constitutively Active Protein Kinase C ε Causes Concentric Cardiac Hypertrophy
Takeishi, Y., Ping, P., Bolli, R., et al. (2000) · Circulation Research · doi:10.1161/01.res.86.12.1218 · Cited by 240 · see citing works
Myocardial reperfusion injury: Role of oxygen radicals and potential therapy with antioxidants
Jeroudi, M. O., Hartley, C. J., & Bolli, R. (1994) · The American Journal of Cardiology · doi:10.1016/0002-9149(94)90257-7 · Cited by 204 · see citing works
Measuring mitochondrial reactive oxygen species
Esposti, M. D. (2002) · Methods · doi:10.1016/s1046-2023(02)00039-7 · Cited by 190 · see citing works
Adhesion at a granular surface
Zhou, J., Rar, A., Otte, D., & Barnard, J. A. (2000) · Journal of Applied Physics · doi:10.1063/1.1303764 · Cited by 169 · see citing works
Functional Consequences of Sulfhydryl Modification in the Pore-Forming Subunits of Cardiovascular Ca 2+ and Na + Channels
Chiamvimonvat, N., O'Rourke, B. P., Kamp, T. J., Kallen, R. G., Hofmann, F. B., Flockerzi, V., & Marbán, E. (1995) · Circulation Research · doi:10.1161/01.res.76.3.325 · Cited by 160 · see citing works
Targeted Disruption of the Mouse Sod I Gene Makes the Hearts Vulnerable to Ischemic Reperfusion Injury
Yoshida, T., Maulik, N., Engelman, R. M., Ho, Y., & Das, D. K. (2000) · Circulation Research · doi:10.1161/01.res.86.3.264 · Cited by 135 · see citing works
Hypoxia and persistent sodium current
Hammarström, A., & Gage, P. W. (2002) · European Biophysics Journal · doi:10.1007/s00249-002-0218-2 · Cited by 120 · see citing works
Modulation of recombinant human cardiac L‐type Ca2+ channel α1C subunits by redox agents and hypoxia
Fearon, I. M., Palmer, A. C. V., Balmforth, A. J., et al. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.629ad.x · Cited by 120 · see citing works
Responses of Cardiac Protein Kinase C Isoforms to Distinct Pathological Stimuli Are Differentially Regulated
Takeishi, Y., Jalili, T., Ball, N. A., et al. (1999) · Circulation Research · doi:10.1161/01.res.85.3.264 · Cited by 110 · see citing works
Lucigenin as mediator of superoxide production: revisited
Liochev, S. I., & Fridovich, I. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00121-x · Cited by 101 · see citing works
Endogenous production of superoxide by rabbit lungs: effects of hypoxia or metabolic inhibitors
Paky, A., Michael, J. R., Burke-Wolin, T., Wolin, M. S., & Gurtner, G. H. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.74.6.2868 · Cited by 97 · see citing works
Endothelial dysfunction and inflammation: What is the link?
Galle, J., Quaschning, T., Seibold, S., & Wanner, C. (2003) · Kidney International · doi:10.1046/j.1523-1755.63.s84.12.x · Cited by 94 · see citing works
Hypoxia inhibits the recombinant alpha 1C subunit of the human cardiac L‐type Ca2+ channel.
Fearon, I. M., Palmer, A. C., Balmforth, A. J., et al. (1997) · The Journal of Physiology · doi:10.1113/jphysiol.1997.sp022041 · Cited by 81 · see citing works
Hypoxia Increases the Sensitivity of the L-Type Ca 2+ Current to β-Adrenergic Receptor Stimulation via a C2 Region–Containing Protein Kinase C Isoform
Hool, L. C. (2000) · Circulation Research · doi:10.1161/01.res.87.12.1164 · Cited by 78 · see citing works
Self-citation
Causative role of oxyradicals in myocardial stunning: A proven hypothesis
Bolli, R. (1998) · Basic Research in Cardiology · doi:10.1007/s003950050079 · Cited by 78 · see citing works
PKC translocation without changes in Gαqand PLC-β protein abundance in cardiac hypertrophy and failure
Jalili, T., Takeishi, Y., Song, G., et al. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.6.h2298 · Cited by 76 · see citing works
Splice Variants Reveal the Region Involved in Oxygen Sensing by Recombinant Human L-Type Ca 2+ Channels
Fearon, I. M., Váradi, G., Koch, S. E., et al. (2000) · Circulation Research · doi:10.1161/01.res.87.7.537 · Cited by 73 · see citing works
Mobilization of Antioxidant Vitamin Pools and Hemodynamic Function After Myocardial Infarction
Palace, V. P., Hill, M., Farahmand, F., et al. (1999) · Circulation · doi:10.1161/01.cir.99.1.121 · Cited by 71 · see citing works
Decreasing Cellular Hydrogen Peroxide With Catalase Mimics the Effects of Hypoxia on the Sensitivity of the L-Type Ca 2+ Channel to β-Adrenergic Receptor Stimulation in Cardiac Myocytes
Hool, L. C., & Arthur, P. G. (2002) · Circulation Research · doi:10.1161/01.res.0000035528.00678.d5 · Cited by 71 · see citing works
Self-citation
Role of H2O2and heme-containing O2 sensors in hypoxic regulation of tyrosine hydroxylase gene expression
Kroll, S. L., & Czyzyk-Krzeska, M. F. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.1.c167 · Cited by 69 · see citing works
Beneficial Effects of Vitamin E Treatment in Acute Myocardial Infarction
Sethi, R., Takeda, N., Nagano, M. C., et al. (2000) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/107424840000500107 · Cited by 68 · see citing works
Hypoxia Causes Downregulation of Protein and RNA Synthesis in Noncontracting Mammalian Cardiomyocytes
Casey, T. M., Pakay, J. L., Guppy, M., et al. (2002) · Circulation Research · doi:10.1161/01.res.0000015592.95986.03 · Cited by 64 · see citing works
NADPH oxidase, Nramp1 and nitric oxide synthase 2 in the host antimicrobial response.
Karupiah, G., Hunt, N. H., King, N. J. C., & Chaudhri, G. (2000) · PubMed · Cited by 52 · see citing works
Interaction between reactive oxygen metabolites and nitric oxide in oxidant tolerance1,2 1This article is part of a series of reviews on “Vascular Dysfunction and Free Radicals.” The full list of papers may be found on the homepage of the journal. 2Guest Editor: Toshikazu Yoshikawa
Cepinskas, G., Rui, T., & Kvietys, P. R. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00962-0 · Cited by 37 · see citing works
Hypoxia Alters the Sensitivity of the L-Type Ca 2+ Channel to α-Adrenergic Receptor Stimulation in the Presence of β-Adrenergic Receptor Stimulation
Hool, L. C. (2001) · Circulation Research · doi:10.1161/hh1001.090841 · Cited by 35 · see citing works
Self-citation
Inactivation-resistant channels underlying the persistent sodium current in rat ventricular myocytes
Ju, Y., Saint, D. A., & Gage, P. W. (1994) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1994.0065 · Cited by 33 · see citing works
Direct Evidence for Increased Hydroxyl Radicals in Angiotensin II-induced Cardiac Hypertrophy through Angiotensin II Type 1a Receptor
Kakishita, M., Nakamura, K., Asanuma, M., Morita, H., Saito, H., KUSANO, K. F., Nakamura, Y., Emori, T., Matsubara, H., Sugaya, T., et al. (2003) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200312001-00015 · Cited by 33 · see citing works
Differential regulation of the slow and rapid components of guinea‐pig cardiac delayed rectifier K+ channels by hypoxia
Hool, L. C. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.055442 · Cited by 22 · see citing works
Self-citation
Effect of Disopyramide on Left Ventricular Performance
Holt, G. W., Norris, R. L. G., Ravenscroft, P. J., et al. (1983) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-198301000-00007 · Cited by 21 · see citing works
When the KChIPs are down
Sanguinetti, M. C. (2002) · Nature Medicine · doi:10.1038/nm0102-18 · Cited by 17 · see citing works

Flagged first, then by citations

Sorted by citations

Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function
Stowe, D. F., & Camara, A. K. S. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2331 · Cited by 471 · see citing works
The role of mitochondria in protection of the heart by preconditioning
Halestrap, A. P., Clarke, S. J., & Khaliulin, I. (2007) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2007.05.008 · Cited by 390 · see citing works
The role of the mitochondrial permeability transition pore in heart disease
Halestrap, A. P., & Pasdois, P. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.12.017 · Cited by 362 · see citing works

The Nox Family of NADPH Oxidases: Friend or Foe of the Vascular System?
Takac, I., Schröder, K., & Brandes, R. P. (2011) · Current Hypertension Reports · doi:10.1007/s11906-011-0238-3 · Cited by 142 · see citing works
NADPH Oxidase as a Therapeutic Target for Oxalate Induced Injury in Kidneys
Joshi, S. K., Peck, A. B., & Khan, S. R. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/462361 · Cited by 69 · see citing works
Pathophysiology and Therapeutic Potential of NADPH Oxidases in Ischemic Stroke‐Induced Oxidative Stress
Duan, J., Gao, S., Tu, S., Lenahan, C., Shao, A., & Sheng, J. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6631805 · Cited by 76 · see citing works
Hemorrhagic Shock Activates Lung Endothelial Reduced Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase Via Neutrophil NADPH Oxidase
Xiang, M., Yin, L., Li, Y., Xiao, G., Yoram Vodovotz, B., Billiar, T. R., Wilson, M. A., & Fan, J. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0408oc · Cited by 25 · see citing works
NADPH treatment decreases C6 glioma cell survival by increasing oxidative stress
Ying, W. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/e325 · Cited by 4 · see citing works

Authors: Hool, L. C.
Affiliations: The University of Western Australia (AU)
Corresponding author: Hool, Livia C
ORCID: Hool, Livia C
Venue: Clinical and Experimental Pharmacology and Physiology
Publisher: Wiley
Published: 2006-01
Volume: 33
Issue: 1-2
Pages: 146-151
ISSN: 0305-1870 (ISSN-L)
1440-1681
DOI: 10.1111/j.1440-1681.2006.04341.x
OpenAlex: W1981822187
Cited by: 83
References: 74
Citations by year: 2025: 2 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 8 · 2012: 6
FWCI: 0.85
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 25 d)
Locations: Clinical and Experimental Pharmacology and Physiology (publishedVersion)
PubMed (publishedVersion)
UWA Profiles and Research Repository (UWA) (submittedVersion)
Funders: National Health and Medical Research Council
National Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
Keywords: reactive oxygen species, redox regulation, mitochondrial ROS production, NADPH oxidase, antioxidant defense, cardiomyocytes, atherosclerosis, ischemia, cardiac hypertrophy, hypertension, cardiac ion channels, cardiac arrhythmias
MeSH terms: Animals, Cell Membrane, Heart, Humans, Ion Channels, Mitochondria, Heart, Models, Biological, Myocardium, Oxidation-Reduction, Signal Transduction, Reactive Oxygen Species

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

REACTIVE OXYGEN SPECIES IN CARDIAC SIGNALLING: FROM MITOCHONDRIA TO PLASMA MEMBRANE ION CHANNELS

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks