Better efficacy for the osmotic release oral system methylphenidate among poor adherents to immediate‐release methylphenidate in the three ADHD subtypes
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Aims: To determine factors for switching to osmotic release oral system methylphenidate (OROS‐MPH) among poor adherents to immediate‐release methylphenidate (IR‐MPH); and to compare the efficacy of OROS‐MPH on the three attention‐deficit/hyperactivity disorder (ADHD) subtypes in a multi‐site prospective observational study in Taiwan. Methods: The sample included 240 children with ADHD, aged 6–16 years, who were poor adherents to IR‐MPH, 137 of whom were switched to OROS‐MPH. The child psychiatrists diagnosed the Diagnostic Statistical Manual of Mental Disorders (4th edition) ADHD subtypes and assessed the medical history, adherence, side‐effects, global ADHD severity, and family/school effectiveness. Parents reported their child's behavioral symptoms. Results: The determinants for an OROS‐MPH switch were higher dosage, shorter treatment and thrice‐daily administration of IR‐MPH, and more severe inattention symptoms. Hyperactivity and oppositional symptoms were greater in the ADHD combined and hyperactive‐impulsive subtypes than the inattentive subtype. Switching to OROS‐MPH significantly improved behavioral symptoms and family/school measures, and this was most evident in the ADHD‐combined group, followed by the ADHD‐inattentive group. Inattention influenced not only academic performance, but also overall classroom behaviors and the parent–child relationship, with the latter two also influenced by oppositional symptoms. Conclusions: This study suggests better efficacy for the OROS‐MPH among poor adherents to IR‐MPH; however, its effectiveness varied across the three ADHD subtypes (ClinicalTrials.gov number NCT00460720).
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OROS methylphenidate lessens ADHD symptoms throughout the day and has greater adherence, thought associated with convenience of once-daily dosing.
“Research has continued to suggest that osmotic-release oral system (OROS) methylphenidate lessens ADHD symptoms throughout the day and has greater adherence, thought to be associated with the convenience of once-daily dosing [39-41].”
From Advances in understanding and treating ADHD (2011) · cites this paper as [40]
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- Authors
- Chou, W., Chou, M., Tzang, R., Hsu, Y., Gau, S. S., Chen, S., Wu, Y., Huang, Y., Liang, H., & Cheng, H.
- Affiliations
- Chang Gung University (TW)
- Mackay Memorial Hospital (TW)
- Taichung Hospital (TW)
- National Taiwan University (TW)
- National Cheng Kung University Hospital (TW)
- Changhua Christian Hospital (TW)
- Corresponding author
- Gau, Susan Shur‐Fen
- Venue
- Psychiatry and Clinical Neurosciences
- Publisher
- Wiley
- Published
- 2009-03-20
- Volume
- 63
- Issue
- 2
- Pages
- 167-175
- ISSN
- 1323-1316 (ISSN-L)
- 1440-1819
- OpenAlex
- W2132430593
- Cited by
- 36
- References
- 25
- Citations by year
- 2026: 1 · 2024: 2 · 2021: 3 · 2020: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 2 · 2013: 5 · 2012: 7
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Psychiatry and Clinical Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health Research Institutes (NHRI-EX95, NHRI-EX95-9407PC)
- Cilag
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Keywords
- immediate-release methylphenidate, medication adherence, ADHD subtypes, children, inattentive symptoms, hyperactivity, behavioral symptoms, parent-child relationship, academic performance
- MeSH terms
- Adolescent, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Child, Child Behavior, Delayed-Action Preparations, Family Relations, Female, Humans, Male, Methylphenidate, Parents, Patient Compliance, Psychiatric Status Rating Scales, Psychomotor Performance, Schools, Treatment Outcome
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