Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus
Abstract
In the rat hippocampus, nerve growth factor (NGF) and brain‐derived neurotrophic factor (BDNF) are synthesized by neurons in an activity‐dependent manner. Glutamate receptor activation increases whereas GABAergic stimulation decreases NGF and BDNF mRNA levels. Here we demonstrate that NGF and BDNF mRNA and NGF protein are up‐regulated in the rat hippocampus by the activation of muscarinic receptors. Conversely, NGF and BDNF enhance the release of acetylcholine (ACh) from rat hippocampal synaptosomes containing the nerve endings of the septal cholinergic neurons. NGF also rapidly increases the high‐affinity choline transport into synaptosomes. The reciprocal regulation of ACh, NGF and BDNF in the hippocampus suggests a novel molecular framework by which the neurotrophins might influence synaptic plasticity.
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The process of exercise increasing BDNF expression is largely mediated by neurotransmitter and neuroendocrine systems, with acetylcholine as a key regulator.
“This process is largely mediated by neurotransmitter and neuroendocrine systems, with extensive literature supporting acetylcholine (ACh) as a key regulator (Knipper et al., 1994).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Knipper et al., 1994
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- Authors
- Knipper, M., da Penha Berzaghi, M., Blöchl, A., Breer, H., Thoenen, H., & Lindholm, D.
- Affiliations
- University of Stuttgart (DE)
- Max Planck Institute of Psychiatry (DE)
- Corresponding author
- Lindholm, Dan
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 1994-04
- Volume
- 6
- Issue
- 4
- Pages
- 668-671
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2099452732
- Cited by
- 298
- References
- 2
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 6 · 2014: 6 · 2013: 9 · 2012: 5
- FWCI
- 6.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- acetylcholine, nerve growth factor, brain-derived neurotrophic factor, neurotrophins, muscarinic receptors, hippocampus, cholinergic synapses, septal cholinergic neurons, choline transport, synaptic plasticity, positive feedback, glutamate receptors, GABAergic inhibition
- MeSH terms
- Acetylcholine, Animals, Antibodies, Choline, Feedback, Hippocampus, Kinetics, Nerve Growth Factors, Nerve Tissue Proteins, Pilocarpine, RNA, Messenger, Synaptosomes, Brain-Derived Neurotrophic Factor, Rats
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