Muscarinic receptor activation facilitates the induction of long-term potentiation (LTP) in the rat dentate gyrus

Burgard, Edward C.; Sarvey, John M.

doi:10.1016/0304-3940(90)90382-j

Cited by 188Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsReceptor Mechanisms and Signaling

Muscarinic receptor activation facilitates the induction of long-term potentiation (LTP) in the rat dentate gyrus

Burgard, Edward C., Sarvey, John M.·1990·Neuroscience Letters

DOI 10.1016/0304-3940(90)90382-j

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Abstract

Bath application of two different concentrations of muscarine produced two different effects on evoked responses in the dentate gyrus of rat hippocampal slices. A concentration of 1 microM muscarine did not affect the evoked population spike or excitatory postsynaptic potential (EPSP), but facilitated the induction of LTP. In contrast, a concentration of 10 microM muscarine depressed both the population spike and EPSP, but had no effect on LTP induction. The M1 muscarinic receptor antagonist pirenzepine (1 microM) blocked the muscarine-induced facilitation of LTP, but had no effect on the depression of evoked responses. These data suggest that activation of M1 receptors can facilitate the induction of LTP.

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The enhancement of long-term encoding could be at least partially mediated by the cholinergic enhancement of long-term potentiation in the hippocampus.
“The enhancement of long-term encoding could be at least partially mediated by the cholinergic enhancement of long-term potentiation in the hippocampus (Blitzer et al., 1990; Burgard and Sarvey, 1990; Auerbach and Segal, 1994; Isaac et al., 2009).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Burgard and Sarvey, 1990

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Muscarinic Cholinergic Modulation of Long-Lasting Synaptic Plasticity in the Rat Dentate Gyrus
Burgard, E. C. (1990)
Self-citation
SDZ ENS 163, a selective muscarinic M1 receptor agonist, facilitates the induction of long-term potentiation in rat hippocampal slices
Boddeke, E., Enz, A., & Shapiro, G. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90457-f · Cited by 38 · see citing works
Facilitatory but nonessential role of the muscarinic cholinergic system in the generation of long-term potentiation of population spikes in the dentate gyrus in vivo
Abe, K., Nakata, A., Mizutani, A., & Saitō, H. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90180-5 · Cited by 42 · see citing works
Muscarinic depression of synaptic transmission and blockade of norepinephrine-induced long-lasting potentiation in the dentate gyrus
Burgard, E. C., Cote, T. E., & Sarvey, J. M. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90259-i · Cited by 13 · see citing works
Self-citation
Activation of M1-like muscarinic receptors is required for the induction of corticostriatal LTP
Calabresi, P., Centonze, D., Gubellini, P., & Bernardi, G. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(98)00199-3 · Cited by 126 · see citing works

Authors: Burgard, E. C., & Sarvey, J. M.
Affiliations: Uniformed Services University of the Health Sciences (US)
Corresponding author: Sarvey, John M.
Venue: Neuroscience Letters
Publisher: Elsevier BV
Published: 1990-08
Volume: 116
Issue: 1-2
Pages: 34-39
ISSN: 0304-3940 (ISSN-L)
DOI: 10.1016/0304-3940(90)90382-j
OpenAlex: W2072926455
Cited by: 188
References: 24
Citations by year: 2026: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 5 · 2013: 1 · 2012: 10
FWCI: 2.97
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience Letters (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ns023865-07)
National Institute of Neurological Disorders and Stroke (NS-23865)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: muscarinic receptors, M1 muscarinic receptor, long-term potentiation, LTP induction, dentate gyrus, hippocampus, muscarine, pirenzepine, excitatory postsynaptic potentials, synaptic plasticity
MeSH terms: Animals, Electric Stimulation, Evoked Potentials, Hippocampus, Kinetics, Muscarine, Pirenzepine, Receptors, Muscarinic, Rats, In Vitro Techniques

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Muscarinic receptor activation facilitates the induction of long-term potentiation (LTP) in the rat dentate gyrus

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