The DOI matches its Crossref record; 59 of the 61 references it cites were found in a registry or an index.
ΔFosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment
Abstract
The transcription factor deltaFosB is induced in the nucleus accumbens and dorsal striatum by chronic exposure to several drugs of abuse, and increasing evidence supports the possibility that this induction is involved in the addiction process. However, to date there has been no report of deltaFosB induction by drugs of abuse in the ventral tegmental area (VTA), which is also a critical brain reward region. In the present study, we used immunohistochemistry to demonstrate that chronic forced administration of cocaine induces deltaFosB in the rat VTA. This induction occurs selectively in a gamma-aminobutyric acid (GABA) cell population within the posterior tail of the VTA. A similar effect is seen after chronic cocaine self-administration. Induction of deltaFosB in the VTA occurs after psychostimulant treatment only: it is seen with both chronic cocaine and amphetamine, but not with chronic opiates or stress. The expression of deltaFosB appears to be mediated by dopamine systems, as repeated administration of a dopamine uptake inhibitor induced deltaFosB in the VTA, while administration of serotonin or norepinephrine uptake inhibitors failed to produce this effect. Time course analysis showed that, following 14 days of cocaine administration, deltaFosB persists in the VTA for almost 2 weeks after cocaine withdrawal. This accumulation and persistence may account for some of the long-lasting changes in the brain associated with chronic drug use. These results provide the first evidence of deltaFosB induction in a discrete population of GABA cells in the VTA, which may regulate the functioning of the brain's reward mechanisms.
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“Furthermore, electrical stimulation of the LHb inhibits the vast majority of DA neurons [69, 71, 72]. Such inhibition is not direct, but rather occurs through the stimulation of neurons in the rostromedial tegmental nucleus (RMTg) [73].”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [73]
Citations
Cites
Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine
Ritz, M. C., Lamb, R. J., Goldberg, S. R., & Kuhar, M. J. (1987) · Science · doi:10.1126/science.2820058 · Cited by 2,180
Pan, L., Gurevich, E. V., & Gurevich, V. V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209532200 · Cited by 1,758
Swanson, L. W. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90145-9 · Cited by 1,718 · cited 4×
“There are two major neuronal cell types in the VTA, dopamine and GABA (Swanson, 1982).”
BackgroundInfluentialSingle cocaine exposure in vivo induces long-term potentiation in dopamine neurons
Ungless, M. A., Whistler, J. L., Malenka, R. C., & Bonci, A. (2001) · Nature · doi:10.1038/35079077 · Cited by 1,106
Wise, R. A. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80079-1 · Cited by 1,072
Koob, G. F., Sanna, P. P., & Bloom, F. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)80557-7 · Cited by 1,026
Graybiel, A. M., Moratalla, R., & Robertson, H. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.17.6912 · Cited by 957
The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior
McFarland, K., & Kalivas, P. W. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08655.2001 · Cited by 905
Carr, D. B., & Sesack, S. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03864.2000 · Cited by 880
Psychomotor stimulant addiction: a neural systems perspective
Everitt, B. J., & Wolf, M. E. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03312.2002 · Cited by 700
Research works printed but not linked: 5
- Alibhai I.N., 2004, In vivo and in vitro regulation of FosB mRNA isoforms, Soc. Neurosci. Abstr
- Carle T., 2004, Absence of conserved Fos family C‐terminal domain in DeltaFosB contributes to its unique stability, Soc. Neurosci. Abstr., 30, 692.3
- Perrotti L.I., 2004, Abstract Viewer/Itinerary Planner, Online
- Ulery P.G., 2004, Regulation of DeltaFosB stability by N‐terminus phosphorylation, Soc. Neurosci. Abstr., 30
- Winstanley C.W., 2004, Dissociable expression of DeltaFosB in the prelimbic and orbitofrontal cortex following contingent and non‐contingent cocaine, Soc. Neurosci. Abstr
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The habenula: from stress evasion to value-based decision-making
Hikosaka, O. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2866 · Cited by 955
“Chronic administration of cocaine also leads to long-term activity changes in GABA neurons in the VTA or the RMTg, which are the main targets of the LH”
BackgroundCortico-Basal Ganglia Reward Network: Microcircuitry
Sesack, S. R., & Grace, A. A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.93 · Cited by 985
“It receives afferents from many forebrain and brainstem structures (Jhou et al, 2009b), consists primarily of GABA cells (Perrotti et al, 2005; Olson and Nestler, 2007; Kaufling et al, 2009), and has extensive projections to the entire SNc–VTA complex (Figure 1; Colussi-Mas et al, 2007; Ferreira et…”
Jhou, T. C., Fields, H. L., Baxter, M. G., Saper, C. B., & Holland, P. C. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.001 · Cited by 696
“…enigmatic ‘‘ball-like nuclei’’ (Olson and Nestler, 2007) in the posterior VTA that exhibit psychostimulant-induced Fos expression (Scammell et al., 2000; Perrotti et al., 2005), high levels of GAD67 (Olson and Nestler, 2007), and projections to other dopaminergic neurons (Ferreira et al., 2008).”
BackgroundInfluentialActivation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance
Stamatakis, A. M., & Stuber, G. D. (2012) · Nature Neuroscience · doi:10.1038/nn.3145 · Cited by 564
Jhou, T. C., Geisler, S., Marinelli, M., Degarmo, B. A., & Zahm, D. S. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.21891 · Cited by 503
“D and shown in several previous publications following various experimental treatments (Scammell et al., 2000; Perrotti et al., 2005; Geisler et al., 2008).”
Background
Metadata
- Authors
- Perrotti, L. I., Bolaños, C. A., Choi, K., Russo, S. J., Edwards, S., Ulery, P. G., Wallace, D. L., Self, D. W., Nestler, E. J., & Barrot, M.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Florida State University (US)
- Centre National de la Recherche Scientifique (FR)
- ORCID
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2005-05
- Volume
- 21
- Issue
- 10
- Pages
- 2817-2824
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W1967616722
- Cited by
- 178
- References
- 61
- Citations by year
- 2025: 3 · 2024: 10 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 12 · 2019: 9 · 2018: 5 · 2017: 5 · 2016: 17 · 2015: 9 · 2014: 14 · 2013: 9 · 2012: 14
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- ΔFosB, ventral tegmental area, GABAergic neurons, cocaine, amphetamine, psychostimulants, drug addiction, dopamine, brain reward, cocaine self-administration, cocaine withdrawal, chronic drug exposure, transcription factor induction
- MeSH terms
- Animals, Cocaine, gamma-Aminobutyric Acid, Kinetics, Male, Morphine, Self Administration, Transcription Factors, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Ventral Tegmental Area, Cocaine-Related Disorders, Rats
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