The mesopontine rostromedial tegmental nucleus: A structure targeted by the lateral habenula that projects to the ventral tegmental area of tsai and substantia nigra compacta
Open accessAbstract
Prior studies revealed that aversive stimuli and psychostimulant drugs elicit Fos expression in neurons clustered above and behind the interpeduncular nucleus that project strongly to the ventral tegmental area (VTA) and substantia nigra (SN) compacta (C). Other reports suggest that these neurons modulate responses to aversive stimuli. We now designate the region containing them as the "mesopontine rostromedial tegmental nucleus" (RMTg) and report herein on its neuroanatomy. Dense micro-opioid receptor and somatostatin immunoreactivity characterize the RMTg, as do neurons projecting to the VTA/SNC that are enriched in GAD67 mRNA. Strong inputs to the RMTg arise in the lateral habenula (LHb) and, to a lesser extent, the SN. Other inputs come from the frontal cortex, ventral striatopallidum, extended amygdala, septum, preoptic region, lateral, paraventricular and posterior hypothalamus, zona incerta, periaqueductal gray, intermediate layers of the contralateral superior colliculus, dorsal raphe, mesencephalic, pontine and medullary reticular formation, and the following nuclei: parafascicular, supramammillary, mammillary, ventral lateral geniculate, deep mesencephalic, red, pedunculopontine and laterodorsal tegmental, cuneiform, parabrachial, and deep cerebellar. The RMTg has meager outputs to the forebrain, mainly to the ventral pallidum, preoptic-lateral hypothalamic continuum, and midline-intralaminar thalamus, but much heavier outputs to the brainstem, including, most prominently, the VTA/SNC, as noted above, and to medial tegmentum, pedunculopontine and laterodorsal tegmental nuclei, dorsal raphe, and locus ceruleus and subceruleus. The RMTg may integrate multiple forebrain and brainstem inputs in relation to a dominant LHb input. Its outputs to neuromodulatory projection systems likely converge with direct LHb projections to those structures.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
LHb has an inhibitory influence on dopaminergic neurons via GABAergic interneurons in RMTg, reflected by lesioning of habenula increasing cortical and striatal dopamine.
“It was shown that the LHb has an inhibitory influence on dopaminergic neurons (Matsumoto and Hikosaka, 2007) via GABAergic interneurons in the rostromedial tegmental nucleus (Ji and Shepard, 2007; Jhou et al., 2009), which is reflected by the fact that lesioning of the habenula leads to an increase of cortical and striatal dopamine levels (Nishikawa et al., 1986).”
From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as Jhou et al., 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Brain stem reticular formation and activation of the EEG
Moruzzi, G., & Magoun, H. W. (1949) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(49)90219-9 · Cited by 4,307 · see citing works
Hypothalamic regulation of sleep and circadian rhythms
Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804 · see citing works
Large-scale neurocognitive networks and distributed processing for attention, language, and memory
Mesulam, M. (1990) · Annals of Neurology · doi:10.1002/ana.410280502 · Cited by 2,684 · see citing works
Aston-Jones, G., & Bloom, F. (1981) · The Journal of Neuroscience · doi:10.1523/jneurosci.01-08-00876.1981 · Cited by 1,960 · see citing works
Histochemical mapping of nitric oxide synthase in the rat brain
Vincent, S. R., & Kimura, H. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90184-4 · Cited by 1,868 · see citing works
Mapping Patterns of c- fos Expression in the Central Nervous System After Seizure
Morgan, J. I., Cohén, D., Hempstead, J. L., & Curran, T. (1987) · Science · doi:10.1126/science.3037702 · Cited by 1,778 · see citing works
Pan, L., Gurevich, E. V., & Gurevich, V. V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209532200 · Cited by 1,758 · see citing works
Swanson, L. W. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90145-9 · Cited by 1,718 · see citing works
Differential expression of orexin receptors 1 and 2 in the rat brain
Marcus, J. N., Aschkenasi, C. J., Lee, C. E., Chemelli, R. M., Saper, C. B., Yanagisawa, M., & Elmquist, J. K. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1190 · Cited by 1,659 · see citing works
The sleep switch: hypothalamic control of sleep and wakefulness
Saper, C. B., Chou, T. C., & Scammell, T. E. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02002-6 · Cited by 1,656 · see citing works
Emson, P. C., Heffher, R. R., & Pearson, J. M. (1984) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198409000-00010 · Cited by 1,650 · see citing works
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477 · see citing works
Bredt, D. S., Glatt, C. E., Hwang, P. M., Fotuhi, M., Dawson, T. M., & Snyder, S. H. (1991) · Neuron · doi:10.1016/0896-6273(91)90374-9 · Cited by 1,359 · see citing works
Lateral habenula as a source of negative reward signals in dopamine neurons
Matsumoto, M., & Hikosaka, O. (2007) · Nature · doi:10.1038/nature05860 · Cited by 1,292 · see citing works
A putative flip–flop switch for control of REM sleep
Lu, J., Sherman, D. L., Devor, M. G., & Saper, C. B. (2006) · Nature · doi:10.1038/nature04767 · Cited by 1,219 · see citing works
Specificity in the projection patterns of accumbal core and shell in the rat
Heimer, L., Zahm, D. S., Churchill, L., Kalivas, P. W., & Wohltmann, C. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90202-y · Cited by 1,219 · see citing works
Alheid, G. F., & Heimer, L. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90217-5 · Cited by 1,217 · see citing works
Ascending Monoamine Neurons to the Telencephalon and Diencephalon
Andén, N. ‐., Dahlström, A. B., Fuxé, K., Larsson, K., Olson, L., & Ungerstedt, U. (1966) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1966.tb03318.x · Cited by 1,214 · see citing works
Two genes encode distinct glutamate decarboxylases
Erlander, M. G., Tillakaratne, N. J. K., Feldblum, S., Patel, N., & Tobin, A. J. (1991) · Neuron · doi:10.1016/0896-6273(91)90077-d · Cited by 1,213 · see citing works
Fallon, J. H., & Moore, R. Y. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901800310 · Cited by 1,172 · see citing works
Brog, J. S., Salyapongse, A., Deutch, A. Y., & Zahm, D. S. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903380209 · Cited by 1,102 · see citing works
Role of ion flux in the control of c-fos expression
Morgan, J. I., & Curran, T. (1986) · Nature · doi:10.1038/322552a0 · Cited by 998 · see citing works
Van der Werf, Y. D., Witter, M. P., & Groenewegen, H. J. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00181-9 · Cited by 994 · see citing works
Handbook of chemical neuroanatomy
(2005) · Handbook of chemical neuroanatomy · doi:10.1016/s0924-8196(05)80001-6 · Cited by 906 · see citing works
Kelley, A. E., Domesick, V. B., & Nauta, W. J. H. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90067-7 · Cited by 888 · see citing works
Fluoro-gold: a new fluorescent retrograde axonal tracer with numerous unique properties
Schmued, L. C., & Fallon, J. H. (1986) · Brain Research · doi:10.1016/0006-8993(86)91199-6 · Cited by 887 · see citing works
Simmons, D. M., Arriza, J. L., & Swanson, L. W. (1989) · Journal of Histotechnology · doi:10.1179/his.1989.12.3.169 · Cited by 872 · see citing works
Ferrier, D. (1876) · G P Putnam's Sons eBooks · doi:10.1037/12860-000 · Cited by 872 · see citing works
Amygdaloid projections to the mesencephalon, pons and medulla oblongata in the cat
Hopkins, D. A., & Holstege, G. (1978) · Experimental Brain Research · doi:10.1007/bf00239551 · Cited by 866 · see citing works
Efferent connections of the habenular nuclei in the rat
Herkenham, M. A., & Nauta, W. J. H. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901870103 · Cited by 855 · see citing works
A PHA-L analysis of ascending projections of the dorsal raphe nucleus in the rat
Vertes, R. P. (1991) · Journal of Comparative Neurology · doi:10.1002/cne.903130409 · Cited by 842 · see citing works
Demonstration and mapping out of nigro-neostriatal dopamine neurons
Andén, N. ‐., Carlsson, A., Dahlström, A. B., Fuxé, K., Hillarp, N. ‐., & Larsson, K. (1964) · Life Sciences · doi:10.1016/0024-3205(64)90161-4 · Cited by 812 · see citing works
Herkenham, M. A., & Nauta, W. J. H. (1977) · The Journal of Comparative Neurology · doi:10.1002/cne.901730107 · Cited by 798 · see citing works
Uniform Inhibition of Dopamine Neurons in the Ventral Tegmental Area by Aversive Stimuli
Ungless, M. A., Magill, P. J., & Bolam, J. P. (2004) · Science · doi:10.1126/science.1093360 · Cited by 782 · see citing works
Johansson, O., Hökfelt, T., & Elde, R. P. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90233-1 · Cited by 674 · see citing works
Hope, B. T., Nye, H. E., Kelz, M. B., Self, D. W., Iadarola, M. J., Nakabeppu, Y., Duman, R. S., & Nestler, E. J. (1994) · Neuron · doi:10.1016/0896-6273(94)90061-2 · Cited by 563 · see citing works
Rye, D. B., Saper, C. B., Lee, H. J., & Wainer, B. H. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902590403 · Cited by 545 · see citing works
Afferent regulation of locus coeruleus neurons: anatomy, physiology and pharmacology
Aston‐Jones, G., Shipley, M., Chouvet, G., Ennis, M. J., Bockstaele, E. V., Pieribone, V. A., Shiekhattar, R., Akaoka, H., Drolet, G., Astier, B., et al. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)63799-1 · Cited by 543 · see citing works
Fallon, J. H., Koziell, D. A., & Moore, R. Y. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901800308 · Cited by 497 · see citing works
Glutamatergic Afferents of the Ventral Tegmental Area in the Rat
Geisler, S., Derst, C., Veh, R. W., & Zahm, D. S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0012-07.2007 · Cited by 486 · see citing works
Hypothalamic Arousal Regions Are Activated during Modafinil-Induced Wakefulness
Scammell, T. E., Estabrooke, I. V., McCarthy, M. T., Chemelli, R. M., Yanagisawa, M., Miller, M. S., & Saper, C. B. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-22-08620.2000 · Cited by 484 · see citing works
Curran, T., & Morgan, J. I. (1985) · Science · doi:10.1126/science.4035354 · Cited by 479 · see citing works
Simmons, D. M., Arriza, J. L., & Swanson, L. W. (1989) · Journal of Histotechnology · doi:10.1179/014788889794651870 · Cited by 462 · see citing works
Christoph, G., Leonzio, R., & Wilcox, K. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-03-00613.1986 · Cited by 418 · see citing works
Locus coeruleus and regulation of behavioral flexibility and attention
(2000) · Progress in Brain Research · doi:10.1016/s0079-6123(00)26013-5 · Cited by 400 · see citing works
Ji, H., & Shepard, P. D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0958-07.2007 · Cited by 388 · see citing works
Afferents of the ventral tegmental area in the rat-anatomical substratum for integrative functions
Geisler, S., & Zahm, D. S. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20668 · Cited by 379 · see citing works
Self-citationChapter 1 The emotional motor system
Holstege, G., Bandler, R., & Saper, C. B. (1996) · Progress in Brain Research · doi:10.1016/s0079-6123(08)61855-5 · Cited by 379 · see citing works
Localization of nitric oxide synthase in the adult rat brain
Rodrigo, J., Springall, D. R., UTTENTHAL, L. O., Bentura, M. L., Abadía‐Molina, F., Riveros‐Moreno, V., Martínez‐Murillo, R., Polak, J. M., & Moncada, S. (1994) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1994.0096 · Cited by 378 · see citing works
Harrington, M. E. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00019-x · Cited by 367 · see citing works
Hallanger, A. E., & Wainer, B. H. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902740403 · Cited by 344 · see citing works
The pedunculopontine tegmental nucleus: Where the striatum meets the reticular formation
Inglis, W. L., & Winn, P. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(95)00013-l · Cited by 335 · see citing works
Chapter 14 Descending motor pathways and the spinal motor system: Limbic and non-limbic components
Holstege, G. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)63057-5 · Cited by 323 · see citing works
Afferent and efferent connections of the laterodorsal tegmental nucleus in the rat
Cornwall, J., Cooper, J. D., & Phillipson, O. T. (1990) · Brain Research Bulletin · doi:10.1016/0361-9230(90)90072-8 · Cited by 294 · see citing works
Steininger, T. L., Rye, D. B., & Wainer, B. H. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903210403 · Cited by 273 · see citing works
Kayama, Y., Ohta, M., & Jodo, E. (1992) · Brain Research · doi:10.1016/0006-8993(92)90632-j · Cited by 247 · see citing works
Afferent connections of the zona incerta: A horseradish peroxidase study in the rat
Shammah‐Lagnado, S. J., Negrão, N., & Ricardo, J. A. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90127-7 · Cited by 209 · see citing works
Telencephalic Projections of the A8 Dopamine Cell Group
Deutch, A. Y., Goldstein, M., Baldino, F., & Roth, R. H. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb42095.x · Cited by 209 · see citing works
Perrotti, L. I., Bolaños, C. A., Choi, K., Russo, S. J., Edwards, S., Ulery, P. G., Wallace, D. L., Self, D. W., Nestler, E. J., & Barrot, M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04110.x · Cited by 178 · see citing works
Andén, N., Dahlström, A. B., Fuxé, K., & Larsson, K. (1965) · Life Sciences · doi:10.1016/0024-3205(65)90076-7 · Cited by 178 · see citing works
Gritti, I., Manns, I. D., Mainville, L., & Jones, B. E. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10505 · Cited by 178 · see citing works
Devor, M. G., & Zalkind, V. I. (2001) · Pain · doi:10.1016/s0304-3959(01)00345-1 · Cited by 176 · see citing works
Topographical organization of GABAergic neurons within the ventral tegmental area of the rat
Olson, V. G., & Nestler, E. J. (2006) · Synapse · doi:10.1002/syn.20345 · Cited by 170 · see citing works
Araki, M., McGeer, P. L., & Kimura, H. (1988) · Brain Research · doi:10.1016/0006-8993(88)91410-2 · Cited by 163 · see citing works
Metabolic mapping with cellular resolution: c-fos vs. 2-deoxyglucose.
Sharp, F. R., Sagar, S. M., & Swanson, R. A. (1993) · PubMed · Cited by 157 · see citing works
The Lateral Habenula:No Longer Neglected
Geisler, S., & Trimble, M. (2008) · CNS Spectrums · doi:10.1017/s1092852900016710 · Cited by 149 · see citing works
Shepard, D. S., Holcomb, H. H., & Gold, J. M. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbj083 · Cited by 140 · see citing works
Shammah‐Lagnado, S. J., Costa, M. S. M. O., & Ricardo, J. A. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90433-3 · Cited by 138 · see citing works
The evolving theory of basal forebrain functional—anatomical ‘macrosystems’
Zahm, D. S. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.06.003 · Cited by 128 · see citing works
Smith, Y., Kieval, J. Z., Couceyro, P. R., & Kuhar, M. J. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990517)407:4 · Cited by 122 · see citing works
Direct comparison of projections from the central amygdaloid region and nucleus accumbens shell
Zahm, D. S., Jensen, S. L., Williams, E. S., & Martin, J. R. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00524.x · Cited by 121 · see citing works
(1996) · Progress in brain research · doi:10.1016/s0079-6123(08)x6058-3 · Cited by 121 · see citing works
Wu, M. ‐., John, J., Boehmer, L. N., Yau, D. M., Nguyen, G. B., & Siegel, J. M. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.052134 · Cited by 120 · see citing works
Chapter 28 Theories of basal forebrain organization and the “emotional motor system”
Alheid, G. F., & Heimer, L. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)61882-8 · Cited by 115 · see citing works
Evidence that Fluoro-Gold can be transported avidly through fibers of passage
Dado, R. J., Burstein, R., Cliffer, K. D., & Giesler, G. J. (1990) · Brain Research · doi:10.1016/0006-8993(90)91358-n · Cited by 112 · see citing works
The iontophoretic application of Fluoro-Gold for the study of afferents to deep brain nuclei
Pieribone, V. A., & Aston‐Jones, G. (1988) · Brain Research · doi:10.1016/0006-8993(88)90614-2 · Cited by 109 · see citing works
THE RÔLE OF THE HYPOTHALAMUS AND MESENCEPHALON IN LOCOMOTION
Hinsey, J. C. (1930) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1930.02220070004001 · Cited by 105 · see citing works
Holstege, G., Mouton, L. J., & Gerrits, P. O. (2004) · Elsevier eBooks · doi:10.1016/b978-012547626-3/50037-5 · Cited by 104 · see citing works
Carbachol models of REM sleep: recent developments and new directions.
Kubin, L. K. (2001) · PubMed · Cited by 101 · see citing works
Ferreira, J. G. P., Del-Fava, F., Hasue, R. H., & Shammah‐Lagnado, S. J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.003 · Cited by 101 · see citing works
Coizet, V., Dommett, E. J., Redgrave, P., & Overton, P. G. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.030 · Cited by 92 · see citing works
Geisler, S., & Zahm, D. S. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04928.x · Cited by 90 · see citing works
Prominent Activation of Brainstem and Pallidal Afferents of the Ventral Tegmental Area by Cocaine
Geisler, S., Marinelli, M., DeGarmo, B., Becker, M. L., Freiman, A. J., Beales, M., Meredith, G. E., & Zahm, D. S. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301650 · Cited by 84 · see citing works
Schulz, S., Schreff, M., Koch, T., Zimprich, A. A., Gramsch, C., Elde, R., & Höllt, V. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00288-1 · Cited by 83 · see citing works
Iontophoretic injection of fluoro-gold and other fluorescent tracers.
Schmued, L. C., & Heimer, L. (1990) · Journal of Histochemistry & Cytochemistry · doi:10.1177/38.5.2332627 · Cited by 80 · see citing works
Sukhotinsky, I., Zalkind, V. I., Lu, J., Hopkins, D. A., Saper, C. B., & Devor, M. G. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05399.x · Cited by 80 · see citing works
Colussi‐Mas, J., Geisler, S., Zimmer, L., Zahm, D. S., & Bérod, A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05738.x · Cited by 68 · see citing works
The Behaviour of Chronically Decerebrate Cats
Bard, P., & Macht, M. B. (1958) · Novartis Foundation symposium · doi:10.1002/9780470719091.ch4 · Cited by 61 · see citing works
Kowski, A. B., Geisler, S., Krauss, M. I., & Veh, R. W. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21610 · Cited by 58 · see citing works
Cellular-resolution activity mapping of the brain using immediate-early gene expression
Farivar, R. (2004) · Frontiers in bioscience · doi:10.2741/1198 · Cited by 58 · see citing works
Riveros‐Moreno, V., Beddell, C. R., & Moncada, S. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18095.x · Cited by 53 · see citing works
Neural mechanisms of freezing and passive aversive behaviors
Jhou, T. (2005) · The Journal of comparative neurology · doi:10.1002/cne.20734 · Cited by 51 · see citing works
Shammah‐Lagnado, S. J., Ricardo, J. A., Sakamoto, N., & ̃o, N. N. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90302-0 · Cited by 45 · see citing works
Sukhotinsky, I., Hopkins, D. A., Lu, J., Saper, C. B., & Devor, M. G. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20636 · Cited by 43 · see citing works
Reynolds, S. M., Geisler, S., Bérod, A., & Zahm, D. S. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04791.x · Cited by 31 · see citing works
Wirtshafter, D., Klitenick, M. A., & Asin, K. E. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90068-8 · Cited by 30 · see citing works
Voss, L. J., Young, B. J., Barnard, J. P. M., & Sleigh, J. W. (2005) · Anaesthesia and Intensive Care · doi:10.1177/0310057x0503300313 · Cited by 28 · see citing works
Arts, M. P. M., Groenewegen, H. J., Veening, J. G., & Cools, A. R. (1996) · Brain Research Bulletin · doi:10.1016/0361-9230(96)00048-2 · Cited by 26 · see citing works
Sukhov, R. R., Cayouette, M. H., Radeke, M. J., Feinstein, S. C., Blumberg, D., Rosenthal, A., Price, D. L., & Koliatsos, V. E. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970630)383:2 · Cited by 11 · see citing works
Harris, G. W. (1958) · Novartis Foundation symposium · doi:10.1002/9780470719091.ch1 · Cited by 5 · see citing works
Zahm (1996) · doi:10.1002/(sici)1096-9861(19960108)364:2
Flagged first, then by citations
1 of the 102 references couldn’t be matched to a known paper.
Research works printed but not linked: 5
- Heimer L Van Hoesen GW Trimble M Zahm DS Anatomy of Neuropsychiatry: The New Anatomy of the Basal Forebrain and its Implications for Neuropsychiatric Disease 2008 Elsevier Amsterdam- New York - San Diego
- Hökfelt T Mårtensson R Björklund A Kleinau S Goldstein M Björklund A Hökfelt T Distribution maps of tyrosine-hydroxylase-immunoreactive neurons in the rat brain Classical Transmitters in the CNS. Handbook of Chemical Neuroanatomy 1984 Volume 2 Part I 277 379 Elsevier Amsterdam
- Jakab RL Leranth C Paxinos G Septum The Rat Nervous System 1995 Volume 1 405 442 Academic Press Sydney Forebrain and Midbrain 2nd Edition
- Lindvall O Björklund A Emson PC Dopamine- and norepinephrine-containing neuron systems: Their anatomy in the rat brain Chemical Neuroanatomy 1983 229 256 Raven Press New York
- Paxinos G Watson C The rat brain in stereotaxic coordinates 1998 Academic Press San Diego, CA Fourth edition
Cited by
Sorted by citations
Dopamine in motivational control: rewarding, aversive, and alerting
Bromberg-Martin, E. S., Matsumoto, M., & Hikosaka, O. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.022 · Cited by 2,396 · see citing works
Input-specific control of reward and aversion in the ventral tegmental area
Lammel, S., Lim, B. K., Ran, C., Huang, K. W., Betley, M. J., Tye, K. M., Deisseroth, K., & Malenka, R. C. (2012) · Nature · doi:10.1038/nature11527 · Cited by 1,300 · see citing works
Mechanisms of ketamine action as an antidepressant
Zanos, P., & Gould, T. D. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.255 · Cited by 1,127 · see citing works
The habenula: from stress evasion to value-based decision-making
Hikosaka, O. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2866 · Cited by 955 · see citing works
Cortico-Basal Ganglia Reward Network: Microcircuitry
Sesack, S. R., & Grace, A. A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.93 · Cited by 985 · see citing works
Jhou, T. C., Fields, H. L., Baxter, M. G., Saper, C. B., & Holland, P. C. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.001 · Cited by 696 · see citing works
GABA Neurons of the VTA Drive Conditioned Place Aversion
Tan, K. R., Yvon, C., Turiault, M., Mirzabekov, J. J., Doehner, J., Labouèbe, G., Deisseroth, K. A., Tye, K. M., & Lüscher, C. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.015 · Cited by 635 · see citing works
How Addictive Drugs Disrupt Presynaptic Dopamine Neurotransmission
Sulzer, D. L. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.010 · Cited by 573 · see citing works
A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System
de Jong, J. W., Afjei, S. A., Dorocic, I. P., Peck, J. R., Liu, C. J., Kim, C. K., Tian, L., Deisseroth, K. A., & Lammel, S. (2018) · Neuron · doi:10.1016/j.neuron.2018.11.005 · Cited by 506 · see citing works
Circuits and functions of the lateral habenula in health and in disease
Hu, H., Cui, Y., & Yang, Y. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0292-4 · Cited by 471 · see citing works
Brain reward circuitry beyond the mesolimbic dopamine system: a neurobiological theory
Ikemoto, S. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.02.001 · Cited by 454 · see citing works
Hong, S., Jhou, T. C., Smith, M., Saleem, K. S., & Hikosaka, O. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1384-11.2011 · Cited by 390 · see citing works
Reward, addiction, withdrawal to nicotine
De Biasi, M., & Dani, J. A. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113734 · Cited by 366 · see citing works
“As in the LHb, RMTg neurons are phasically activated by aversive stimuli and inhibited by natural rewards such as food or reward-predictive stimuli, and conversely, RMTg neurons are stimulated by aversive stimuli (Jhou et al. 2009b).”
BackgroundStamatakis, A. M., Jennings, J. H., Ung, R. L., Blair, G. A., Weinberg, R. J., Neve, R. L., Boyce, F., Mattis, J., Ramakrishnan, C., Deisseroth, K., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.023 · Cited by 364 · see citing works
The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors
Root, D. H., Meléndez, R. I., Záborszky, L., & Napier, T. C. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.03.005 · Cited by 343 · see citing works
Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass
Menegas, W., Bergan, J. F., Ogawa, S. K., Isogai, Y., Venkataraju, K. U., Osten, P., Uchida, N., & Watabe‐Uchida, M. (2015) · eLife · doi:10.7554/elife.10032 · Cited by 323 · see citing works
Neuronal circuits underlying acute morphine action on dopamine neurons
Jalabert, M., Bourdy, R., Courtin, J., Veinante, P., Manzoni, O. J., Barrot, M., & Georges, F. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105418108 · Cited by 303 · see citing works
Molecular characterization of the subnuclei in rat habenula
Aizawa, H., Kobayashi, M. S., Tanaka, S., Fukai, T., & Okamoto, H. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23167 · Cited by 288 · see citing works
Lateral habenula in the pathophysiology of depression
Yang, Y., Wang, H., Hu, J., & Hu, H. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.10.024 · Cited by 254 · see citing works
Hu, H. (2016) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070815-014106 · Cited by 253 · see citing works
Circuit Mechanisms of Reward, Anhedonia, and Depression
Höflich, A., Michenthaler, P., Kasper, S., & Lanzenberger, R. (2019) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy081 · Cited by 253 · see citing works
Lateral habenula projections to dopamine and GABA neurons in the rat ventral tegmental area
Omelchenko, N., Bell, R., & Sesack, S. R. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06924.x · Cited by 253 · see citing works
Brinschwitz, K., Dittgen, A., Madai, V. I., Lommel, R., Geisler, S., & Veh, R. W. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.03.050 · Cited by 240 · see citing works
Identification of the Zebrafish Ventral Habenula As a Homolog of the Mammalian Lateral Habenula
Amo, R., Aizawa, H., Takahoko, M., Kobayashi, M. S., Takahashi, R., Aoki, T., & Okamoto, H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3690-09.2010 · Cited by 236 · see citing works
Topographical Organization of the Pedunculopontine Nucleus
Martinez‐Gonzalez, C., Bolam, J. P., & Mena‐Segovia, J. (2011) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2011.00022 · Cited by 240 · see citing works
Matsui, A., Jarvie, B. C., Robinson, B. G., Hentges, S. T., & Williams, J. T. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.030 · Cited by 237 · see citing works
Balcita‐Pedicino, J. J., Omelchenko, N., Bell, R., & Sesack, S. R. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22561 · Cited by 236 · see citing works
Basal ganglia circuit loops, dopamine and motivation: a review and enquiry
Ikemoto, S., Yang, C., & Tan, A. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.018 · Cited by 226 · see citing works
Distributed and Mixed Information in Monosynaptic Inputs to Dopamine Neurons
Tian, J., Huang, R., Cohen, J. Y., Osakada, F., Kobak, D., Machens, C. K., Callaway, E. M., Uchida, N., & Watabe-Uchida, M. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.018 · Cited by 224 · see citing works
VTA GABA Neurons at the Interface of Stress and Reward
Bouarab, C., Thompson, B. V., & Polter, A. M. (2019) · Frontiers in Neural Circuits · doi:10.3389/fncir.2019.00078 · Cited by 224 · see citing works
Braking Dopamine Systems: A New GABA Master Structure for Mesolimbic and Nigrostriatal Functions
Barrot, M., Sesack, S. R., Georges, F. E., Pistis, M., Hong, S., & Jhou, T. C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3370-12.2012 · Cited by 215 · see citing works
Amo, R., Fredes, F., Kinoshita, M., Aoki, R., Aizawa, H., Agetsuma, M., Aoki, T., Shiraki, T., Kakinuma, H., Matsuda, M., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.035 · Cited by 207 · see citing works
A new control center for dopaminergic systems: pulling the VTA by the tail
Bourdy, R., & Barrot, M. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.06.007 · Cited by 208 · see citing works
GABAergic and glutamatergic efferents of the mouse ventral tegmental area
Taylor, S. R., Badurek, S., Dileone, R., Nashmi, R., Minichiello, L., & Picciotto, M. R. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23603 · Cited by 209 · see citing works
Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb
Ma, S., Chen, M., Jiang, Y., Xiang, X., Wang, S., Wu, Z., Li, S., Cui, Y., Wang, J., Zhu, Y., et al. (2023) · Nature · doi:10.1038/s41586-023-06624-1 · Cited by 213 · see citing works
Dopamine and extinction: A convergence of theory with fear and reward circuitry
Abraham, A. D., Neve, K., & Lattal, K. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.11.007 · Cited by 211 · see citing works
Jhou, T. C., Good, C. H., Rowley, C. S., Xu, S., Wang, H., Burnham, N. W., Hoffman, A. F., Lupica, C. R., & Ikemoto, S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3634-12.2013 · Cited by 198 · see citing works
Identification of Rat Ventral Tegmental Area GABAergic Neurons
Margolis, E. B., Toy, B. C., Himmels, P., Morales, M., & Fields, H. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042365 · Cited by 202 · see citing works
Matsui, A., & Williams, J. T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4570-11.2011 · Cited by 191 · see citing works
Genetic dissection of medial habenula–interpeduncular nucleus pathway function in mice
Kobayashi, Y., Sano, Y., Vannoni, E., Goto, H., Suzuki, H., Oba, A., Kawasaki, H., Kanba, S., Lipp, H., Murphy, N. P., et al. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00017 · Cited by 189 · see citing works
Lecca, S., Melis, M., Luchicchi, A., Muntoni, A. L., & Pistis, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.302 · Cited by 185 · see citing works
An Update on the Role of Serotonin and its Interplay with Dopamine for Reward
Fischer, A. G., & Ullsperger, M. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00484 · Cited by 176 · see citing works
Stephenson‐Jones, M., Floros, O., Robertson, B., & Grillner, S. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119348109 · Cited by 167 · see citing works
An update on the connections of the ventral mesencephalic dopaminergic complex
Yetnikoff, L., Lavezzi, H. N., Reichard, R. A., & Zahm, D. S. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.010 · Cited by 172 · see citing works
Efferent Pathways of the Mouse Lateral Habenula
Quina, L. A., Tempest, L., Ng, L., Harris, J. A., Ferguson, S. M., Jhou, T. C., & Turner, E. E. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23662 · Cited by 165 · see citing works
Translating the habenula-from rodents to humans
Boulos, L.-J., Darcq, E., & Kieffer, B. L. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.06.003 · Cited by 164 · see citing works
Transcriptional and spatial resolution of cell types in the mammalian habenula
Hashikawa, Y., Hashikawa, K., Rossi, M. A., Basiri, M. L., Liu, Y., Johnston, N. L., Ahmad, O. R., & Stuber, G. D. (2020) · Neuron · doi:10.1016/j.neuron.2020.03.011 · Cited by 167 · see citing works
The Neural Circuits Underlying General Anesthesia and Sleep
Moody, O. A., Zhang, E. R., Vincent, K. F., Kato, R., Melonakos, E. D., Nehs, C. J., & Solt, K. (2021) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000005361 · Cited by 165 · see citing works
Deurwaerdère, P. D., & Giovanni, G. D. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.03.004 · Cited by 164 · see citing works
The Lateral Habenula Circuitry: Reward Processing and Cognitive Control
Baker, P. M., Jhou, T. C., Li, B., Matsumoto, M., Mizumori, S. J. Y., Stephenson‐Jones, M., & Vicentic, A. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2350-16.2016 · Cited by 156 · see citing works
Generating bursts (and pauses) in the dopamine midbrain neurons
Paladini, C. A., & Roeper, J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.032 · Cited by 158 · see citing works
Lecca, S., Melis, M., Luchicchi, A., Ennas, M. G., Castelli, M. P., Muntoni, A. L., & Pistis, M. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.190 · Cited by 158 · see citing works
Behavioral and neurobiological mechanisms of punishment: implications for psychiatric disorders
Jean-Richard-Dit-Bressel, P., Killcross, S., & McNally, G. P. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0047-3 · Cited by 160 · see citing works
Flagel, S. B., Cameron, C., Pickup, K. N., Watson, S. J., Akil, H., & Robinson, T. E. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.09.004 · Cited by 153 · see citing works
The role of the habenula in drug addiction
Velasquez, K. M., Molfese, D. L., & Salas, R. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00174 · Cited by 155 · see citing works
Morikawa, H., & Paladini, C. A. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.023 · Cited by 150 · see citing works
Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148 · see citing works
Zhao, H., Zhang, B., Yang, S., & Rusak, B. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.09.016 · Cited by 147 · see citing works
Okamoto, H., Agetsuma, M., & Aizawa, H. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20913 · Cited by 142 · see citing works
Mahler, S. V., & Aston‐Jones, G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2277-12.2012 · Cited by 143 · see citing works
Ethanol Action on Dopaminergic Neurons in the Ventral Tegmental Area
Morikawa, H., & Morrisett, R. A. (2010) · International review of neurobiology · doi:10.1016/s0074-7742(10)91008-8 · Cited by 139 · see citing works
Glial Dysfunction in the Mouse Habenula Causes Depressive-Like Behaviors and Sleep Disturbance
Cui, W., Mizukami, H., Yanagisawa, M., Aida, T., Nomura, M., Isomura, Y., Takayanagi, R., Ozawa, K., Tanaka, K., & Aizawa, H. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1465-14.2014 · Cited by 139 · see citing works
Kim, U., & Lee, T. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08030.x · Cited by 133 · see citing works
Overriding Phasic Dopamine Signals Redirects Action Selection during Risk/Reward Decision Making
Stopper, C. M., Tse, M. T. L., Montes, D. R., Wiedman, C. R., & Floresco, S. B. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.033 · Cited by 136 · see citing works
Gonçalves, L., Sego, C., & Metzger, M. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.22787 · Cited by 134 · see citing works
The medial habenula: still neglected
Viswanath, H., Carter, A. Q., Baldwin, P. R., Molfese, D. L., & Salas, R. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00931 · Cited by 133 · see citing works
What's better for me? Fundamental role for lateral habenula in promoting subjective decision biases
Stopper, C. M., & Floresco, S. (2013) · Nature Neuroscience · doi:10.1038/nn.3587 · Cited by 129 · see citing works
Liang, K. J., & Carlson, E. S. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.01.004 · Cited by 131 · see citing works
Optogenetic dissection of neural circuits underlying emotional valence and motivated behaviors
Nieh, E. H., Kim, S., Namburi, P., & Tye, K. M. (2012) · Brain Research · doi:10.1016/j.brainres.2012.11.001 · Cited by 129 · see citing works
α1-Adrenergic Receptors in Neurotransmission, Synaptic Plasticity, and Cognition
Perez, D. M. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.581098 · Cited by 131 · see citing works
Chartoff, E. H., & Connery, H. S. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00116 · Cited by 128 · see citing works
Kokane, S. S., & Perrotti, L. I. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00074 · Cited by 123 · see citing works
Sego, C., Gonçalves, L., Lima, L. B., Furigo, I. C., Donato, J., & Metzger, M. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23533 · Cited by 126 · see citing works
Defining the habenula in human neuroimaging studies
Lawson, R. P., Drevets, W. C., & Roiser, J. P. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.08.076 · Cited by 125 · see citing works
Wang, D. V., & Tsien, J. Z. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017047 · Cited by 116 · see citing works
Ikemoto, S., & Bonci, A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.031 · Cited by 122 · see citing works
The Evolving Understanding of Dopamine Neurons in the Substantia Nigra and Ventral Tegmental Area
Gantz, S. C., Ford, C., Morikawa, H., & Williams, J. T. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021317-121615 · Cited by 122 · see citing works
Phylogeny and Ontogeny of the Habenular Structure
eAizawa, H., Amo, R., & Okamoto, H. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00138 · Cited by 119 · see citing works
Neurobiological Mechanisms of Nicotine Reward and Aversion
Wills, L. P., Ables, J. L., Braunscheidel, K. M., Caligiuri, S. P. B., Elayouby, K. S., Fillinger, C., Ishikawa, M., Moen, J. K., & Kenny, P. J. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000299 · Cited by 126 · see citing works
Hahn, J. D., & Swanson, L. W. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.02.002 · Cited by 121 · see citing works
Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic Neurons
Evans, R. C., Twedell, E. L., Zhu, M., Ascencio, J., Zhang, R., & Khaliq, Z. M. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108156 · Cited by 117 · see citing works
Circadian oscillators in the epithalamus
Guilding, C., Hughes, A. T. L., & Piggins, H. D. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.015 · Cited by 112 · see citing works
Bourdy, R., Sánchez-Catalán, M. J., Kaufling, J., Balcita‐Pedicino, J. J., Freund‐Mercier, M. J., Veinante, P., Sesack, S. R., Georges, F. E., & Barrot, M. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.129 · Cited by 113 · see citing works
The antero-posterior heterogeneity of the ventral tegmental area
Sánchez-Catalán, M. J., Kaufling, J., Georges, F. E., Veinante, P., & Barrot, M. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.025 · Cited by 112 · see citing works
Optogenetic Modulation of Neural Circuits that Underlie Reward Seeking
Stuber, G. D., Britt, J. P., & Bonci, A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.11.010 · Cited by 110 · see citing works
Excitatory pathways from the lateral habenula enable propofol-induced sedation
Gelegen, C., Miracca, G., Ran, M. Z., Harding, E. C., Ye, Z., Yu, X., Tossell, K., Houston, C. M., Yustos, R., Hawkins, E. D., et al. (2018) · Current Biology · doi:10.1016/j.cub.2017.12.050 · Cited by 100 · see citing works
Opioid Modulation of Ventral Pallidal Afferents to Ventral Tegmental Area Neurons
Hjelmstad, G. O., Xia, Y., Margolis, E. B., & Fields, H. L. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0178-13.2013 · Cited by 106 · see citing works
Yetnikoff, L., Cheng, A. Y., Lavezzi, H. N., Parsley, K. P., & Zahm, D. S. (2015) · Journal of Comparative Neurology · doi:10.1002/cne.23797 · Cited by 101 · see citing works
Bernard, R., & Veh, R. W. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23080 · Cited by 103 · see citing works
The role of the habenula in the transition from reward to misery in substance use and mood disorders
Batalla, A., Homberg, J. R., Lipina, T. V., Sescousse, G., Luijten, M., Ivanova, S. А., Schellekens, A., & LOONEN, A. J. M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.03.019 · Cited by 100 · see citing works
Gardon, O., Faget, L. C., Chung, P. C. S., Matifas, A., Massotte, D., & Kieffer, B. L. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.053 · Cited by 101 · see citing works
Kawai, T., Yamada, H., Sato, N., Takada, M., & Matsumoto, M. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.030 · Cited by 98 · see citing works
Anxiety and Nicotine Dependence: Emerging Role of the Habenulo-Interpeduncular Axis
Molas, S., DeGroot, S. R., Zhao-Shea, R., & Tapper, A. R. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.11.001 · Cited by 100 · see citing works
Progress in understanding mood disorders: optogenetic dissection of neural circuits
Lammel, S., Tye, K. M., & Warden, M. R. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12049 · Cited by 98 · see citing works
Multiplexed neurochemical signaling by neurons of the ventral tegmental area
Barker, D. J., Root, D. H., Zhang, S., & Morales, M. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2015.12.016 · Cited by 99 · see citing works
Tsutsui‐Kimura, I., Matsumoto, H., Akiti, K., Yamada, M. M., Uchida, N., & Watabe‐Uchida, M. (2020) · eLife · doi:10.7554/elife.62390 · Cited by 91 · see citing works
Turning a Negative into a Positive: Ascending GABAergic Control of Cortical Activation and Arousal
Brown, R. E., & McKenna, J. T. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00135 · Cited by 89 · see citing works
Error-Related Functional Connectivity of the Habenula in Humans
Ide, J. S., & Li, C. R. (2011) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2011.00025 · Cited by 89 · see citing works
Cocaine Evokes Projection-Specific Synaptic Plasticity of Lateral Habenula Neurons
Maroteaux, M. J., & Mameli, M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2405-12.2012 · Cited by 92 · see citing works
Reward Prediction Error Coding in Dorsal Striatal Neurons
Oyama, K., Hernádi, I., Iijima, T., & Tsutsui, K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1719-10.2010 · Cited by 91 · see citing works
- Authors
- Jhou, T. C., Geisler, S., Marinelli, M., Degarmo, B. A., & Zahm, D. S.
- Affiliations
- National Institutes of Health (US)
- Saint Louis University (US)
- Rosalind Franklin University of Medicine and Science (US)
- Corresponding author
- Jhou, Thomas C.
- Zahm, Daniel S.
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 2009-02-20
- Volume
- 513
- Issue
- 6
- Pages
- 566-596
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- PMC
- PMC3116663
- OpenAlex
- W2085520758
- Cited by
- 503
- References
- 102
- Citations by year
- 2026: 16 · 2025: 15 · 2024: 35 · 2023: 13 · 2022: 17 · 2021: 39 · 2020: 48 · 2019: 39 · 2018: 34 · 2017: 27 · 2016: 34 · 2015: 26 · 2014: 38 · 2013: 36 · 2012: 28
- FWCI
- 11.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL 60292, P50HL060292)
- National Institute of Mental Health (MH-12370, F31MH012370)
- National Institute on Drug Abuse (DA020654, R01DA020654)
- National Institute of Neurological Disorders and Stroke (NS23805, R01NS023805)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- rostromedial tegmental nucleus, lateral habenula, ventral tegmental area, substantia nigra pars compacta, mesopontine tegmentum, interpeduncular nucleus, Fos expression, aversive stimuli, psychostimulants, mu-opioid receptor, somatostatin, GAD67, neuroanatomy, brainstem projections, neuromodulation, pedunculopontine nucleus, laterodorsal tegmentum, dorsal raphe nucleus, locus coeruleus
- MeSH terms
- Animals, Cocaine, Glutamate Decarboxylase, Male, Methamphetamine, Neural Pathways, RNA, Messenger, Self Administration, Somatostatin, Substantia Nigra, Sulfur Radioisotopes, Tegmentum Mesencephali, Gene Expression, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Receptors, Opioid, mu, Ventral Tegmental Area, Habenula, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
