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Cited by 334Transcranial Magnetic Stimulation StudiesMuscle activation and electromyography studiesSports Performance and Training

Improved isometric force endurance after transcranial direct current stimulation over the human motor cortical areas

Cogiamanian, F., Marceglia, S., Ardolino, G., Barbieri, S., Priori, A.·2007·European Journal of Neuroscience
DOI 10.1111/j.1460-9568.2007.05633.x
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Abstract

Neuromuscular fatigue is the exercise‐dependent decrease in the ability of muscle fibres to generate force. To investigate whether manipulation of brain excitability by transcranial direct current stimulation (tDCS; 1.5 mA, 10 min, 0.026 C/cm 2 ) modulates neuromuscular fatigue, we evaluated the effect of brain polarization over the right motor areas of the cerebral cortex of healthy subjects on the endurance time for a submaximal isometric contraction of left elbow flexors. In 24 healthy volunteers the study protocol comprised an assessment of the maximum voluntary contraction (MVC) for the left elbow flexors and a fatiguing isometric contraction (35% of MVC), before and immediately after brain polarization. One hour elapsed between baseline (T0) and postconditioning (T1) evaluation. After tDCS, MVC remained unchanged from baseline (mean ± SEM; anodal tDCS: T0, 154.4 ± 18.07; T1, 142.8 ± 16.62 N; cathodal tDCS: T0, 156 ± 18.75; T1, 141.86 ± 17.53 N; controls: T0, 148.8 ± 6.64; T1, 137.6 ± 7.36 N; P > 0.1). Conversely, endurance time decreased significantly less after anodal than after cathodal tDCS or no stimulation (−21.1 ± 5.5%, −35.7 ± 3.3% and −39.3 ± 3.3%, respectively; P < 0.05). None of the evaluated electromyographic variables changed after tDCS. Anodal tDCS could improve endurance time by directly modulating motor cortical excitability, modulating premotor areas, decreasing fatigue‐related muscle pain, increasing motivation and improving synergist muscle coupling. Our findings, showing that anodal tDCS over the motor areas of the cerebral cortex improves muscle endurance, open the way to increasing muscle endurance and decreasing muscle fatigue in normal (i.e. sports medicine) and pathological conditions.

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  • Transcranial direct current stimulation at low currents (e.g., <2 mA) applied over the scalp induced changes in brain excitability for an extended duration to result in synaptic and nonsynaptic functional changes.

    “Research showed that transcranial direct current stimulation at low currents (e.g., <2 mA) applied over the scalp induced changes in brain excitability for an extended duration to result in synaptic and nonsynaptic functional changes.121,122”

    From Wearable sensors for monitoring the physiological and biochemical profile of the athlete (2019) · cites this paper as [122]

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Authors
Cogiamanian, F., Marceglia, S., Ardolino, G., Barbieri, S., & Priori, A.
Affiliations
  • University of Milan (IT)
  • IRCCS Humanitas Research Hospital (IT)
Corresponding author
Priori, A.
ORCID
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2007-07
Volume
26
Issue
1
Pages
242-249
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
DOI
10.1111/j.1460-9568.2007.05633.x
OpenAlex
W1963381691
Cited by
334
References
35
Citations by year
2026: 11 · 2025: 12 · 2024: 14 · 2023: 15 · 2022: 18 · 2021: 24 · 2020: 33 · 2019: 37 · 2018: 18 · 2017: 23 · 2016: 21 · 2015: 14 · 2014: 20 · 2013: 25 · 2012: 15
FWCI
4.68
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2 d)
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion)
  • Virtual Community of Pathological Anatomy (University of Castilla La Mancha) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
transcranial direct current stimulation, neuromuscular fatigue, muscular endurance, isometric contraction, motor cortex excitability, anodal tDCS, cathodal tDCS, elbow flexors, maximal voluntary contraction, myalgia
MeSH terms
Adult, Elbow, Electric Stimulation, Electromyography, Female, Humans, Isometric Contraction, Male, Motor Cortex, Physical Endurance, Muscle Fatigue, Evoked Potentials, Motor, Transcranial Magnetic Stimulation

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