Cited by 187Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeural and Behavioral Psychology Studies

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A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in rats

Berglind, William J., See, Ronald E., Fuchs, Rita A., Ghee, Shannon M., Whitfield, Timothy W., Miller, Scott W., McGinty, Jacqueline F.·2007·European Journal of Neuroscience

DOI 10.1111/j.1460-9568.2007.05692.x

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Abstract

The medial prefrontal cortex (mPFC) is critical for reinstatement of cocaine seeking and is the main source of brain‐derived neurotrophic factor (BDNF) to striatal regions of the brain relapse circuitry. To test the hypothesis that BDNF in the mPFC regulates cocaine‐seeking behavior, rats were trained to press a lever for cocaine infusions (0.2 mg/inf, 2 h/day) paired with light + tone conditioned stimulus (CS) presentations on 10 consecutive days. After the last self‐administration session, rats received a single infusion of BDNF (0.75 µg/0.5 µL/side) into the mPFC; this manipulation produced protracted effects on cocaine‐seeking behavior (non‐reinforced lever pressing). BDNF pretreatment administered after the last session attenuated cocaine seeking 22 h later and, remarkably, it also blocked cocaine‐induced suppression of phospho‐extracellular‐regulated kinase and elevated BDNF immunoreactivity in the nucleus accumbens. The same pretreatment also suppressed cocaine‐seeking behavior elicited by response‐contingent CS presentations after 6 days of forced abstinence or extinction training, as well as a cocaine challenge injection (10 mg/kg, i.p.) after extinction training. However, BDNF infused into the mPFC had no effect on food‐seeking behavior. Furthermore, BDNF infused on the sixth day of abstinence failed to alter responding, suggesting that the regulatory influence of BDNF is time limited. The suppressive effects of BDNF infused into the mPFC on cocaine seeking indicate that BDNF regulates cortical pathways implicated in relapse to drug seeking and that corticostriatal BDNF adaptations during early abstinence diminish compulsive drug seeking.

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Longitudinal data analysis using generalized linear models
LIANG, K.-Y., & ZEGER, S. L. (1986) · Biometrika · doi:10.1093/biomet/73.1.13 · Cited by 18,550
Categorical Data Analysis
Agresti, A. (2002) · Wiley Series in Probability and Statistics · doi:10.1002/0471249688 · Cited by 6,746
The Neural Basis of Addiction: A Pathology of Motivation and Choice
Kalivas, P. W., & Volkow, N. D. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1403 · Cited by 2,757
Homeostatic plasticity in the developing nervous system
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The Nature of the Arrestin·Receptor Complex Determines the Ultimate Fate of the Internalized Receptor
Pan, L., Gurevich, E. V., & Gurevich, V. V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209532200 · Cited by 1,758
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654
Behavioral Theories and the Neurophysiology of Reward
Schultz, W. (2006) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070229 · Cited by 1,637
The reinstatement model of drug relapse: history, methodology and major findings
Shaham, Y., Shalev, U., Lu, L., de Wit, H., & Stewart, J. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1224-x · Cited by 1,615
New approaches to antidepressant drug discovery: beyond monoamines
Berton, O., & Nestler, E. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1846 · Cited by 1,589
Differential projections of the infralimbic and prelimbic cortex in the rat
Vertes, R. P. (2004) · Synapse · doi:10.1002/syn.10279 · Cited by 1,550

Show all 50 references

Research works printed but not linked: 3

Graham D.L., 2004, Program No. 465.2 2004 Abstract Viewer/Itinerary Planner
Grimm J.W., 2003, Time‐dependent increases in brain‐derived neurotrophic factor levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving, J. Neurosci., 3, 342
Litrell R.C., 2002, SAS for Linear Models

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Self-citation
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Self-citation
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Gene expression changes following extinction testing in a heroin behavioral incubation model
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Self-citation
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Self-citation
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Muhammad, A., Hossain, S., Pellis, S. M., & Kolb, B. E. (2011) · Behavioral Neuroscience · doi:10.1037/a0022628 · Cited by 47
Region-specific effects on BDNF expression after contingent or non-contingent cocaine i.v. self-administration in rats
Fumagalli, F., Moro, F., Caffino, L., Orrù, A., Cassina, C., Giannotti, G., Clemente, A. D., Racagni, G., Riva, M. A., & Cervo, L. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114571200096x · Cited by 51
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Authors: Berglind, W. J., See, R. E., Fuchs, R. A., Ghee, S. M., Whitfield, T. W., Miller, S. W., & McGinty, J. F.
Affiliations: Medical University of South Carolina (US)
University of North Carolina at Chapel Hill (US)
ORCID: Fuchs, Rita A.
Miller, Scott W.
McGinty, Jacqueline F.
Venue: European Journal of Neuroscience
Publisher: Wiley
Published: 2007-08
Volume: 26
Issue: 3
Pages: 757-766
ISSN: 0953-816X (ISSN-L)
1460-9568
DOI: 10.1111/j.1460-9568.2007.05692.x
OpenAlex: W1917605014
Cited by: 187
References: 50
Citations by year: 2026: 1 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 11 · 2018: 16 · 2017: 7 · 2016: 16 · 2015: 8 · 2014: 16 · 2013: 20 · 2012: 19
FWCI: 4.91
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: European Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1c06rr015455-01a1)
National Institute on Drug Abuse (P50DA015369, P50 DA15369)
National Center for Research Resources (C06 RR-015455)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: brain-derived neurotrophic factor, medial prefrontal cortex, cocaine seeking, reinstatement, relapse, cocaine self-administration, conditioned stimulus, nucleus accumbens, extracellular signal-regulated kinase, forced abstinence, extinction, cocaine challenge, compulsive drug seeking, corticostriatal circuits
MeSH terms: Animals, Behavior, Animal, Cocaine, Conditioning, Psychological, Drug Administration Routes, Male, Neural Pathways, Nucleus Accumbens, Self Administration, Substance Withdrawal Syndrome, Time Factors, Rats, Sprague-Dawley, Prefrontal Cortex, Dopamine Uptake Inhibitors, Brain-Derived Neurotrophic Factor, Cocaine-Related Disorders, Extracellular Signal-Regulated MAP Kinases, Rats, Secondary Prevention

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A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in rats

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