Mechanisms of transgenerational inheritance of addictive-like behaviors
Open accessAbstract
Genetic factors are implicated in the heritability of drug abuse. However, even with advances in current technology no specific genes have been identified that are critical for the transmission of drug-induced phenotypes to subsequent generations. It is now evident that epigenetic factors contribute to disease heritability and represent a link between genes and the environment. Recently, epigenetic mechanisms have been shown to underlie drug-induced structural, synaptic, and behavioral plasticity by coordinating the expression of gene networks within the brain. Therefore, the epigenome provides a direct mechanism for drugs of abuse to influence the genetic events involved in the development of addiction as well as its heritability to subsequent generations. In this review we discuss the mechanisms underlying intergenerational epigenetic transmission, highlight studies that demonstrate this phenomenon with particular attention to the field of addiction, and identify gaps for future studies.
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Transgenerational inheritance of addiction-like behavior appears supported by epigenetic mechanisms over genetic factors.
“Transgenerational inheritance of addiction-like behavior appears supported by epigenetic mechanisms (i.e., environmental exposure) over genetic factors (107).”
From A Biopsychosocial Overview of the Opioid Crisis: Considering Nutrition and Gastrointestinal Health (2019) · cites this paper as [107]
Epigenetic modifications acquired in one generation can be inherited by the next generation and can involve behavioral or social transmission, including the transmission of trauma.
“Furthermore, epigenetic modifications acquired in one generation can be inherited by the next generation and can involve behavioral or social transmission (107), including the transmission of trauma (216).”
From A Biopsychosocial Overview of the Opioid Crisis: Considering Nutrition and Gastrointestinal Health (2019) · cites this paper as [107]
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- Authors
- Vassoler, F. M., & Sadri-Vakili, G.
- Affiliations
- Tufts University (US)
- ORCID
- Vassoler, F.M.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 264
- Pages
- 198-206
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC3872494
- OpenAlex
- W2083871194
- Cited by
- 96
- References
- 93
- Citations by year
- 2026: 6 · 2025: 1 · 2024: 5 · 2023: 7 · 2022: 12 · 2021: 6 · 2020: 8 · 2019: 8 · 2018: 5 · 2017: 9 · 2016: 9 · 2015: 11 · 2014: 9
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (F32DA005589, K02DA018678, R01DA033641)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- transgenerational inheritance, epigenetic inheritance, addiction, drug abuse, gene-environment interaction, synaptic plasticity, behavioral plasticity, epigenome, heritability of addiction
- MeSH terms
- Animals, Female, Humans, Male, Behavior, Addictive, Inheritance Patterns, Epigenesis, Genetic, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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