The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA‐mediated down‐regulation of the glucocorticoid receptor
Abstract
In the present study, we established and characterized an animal model of vulnerability to repeated stress. We found that control Sprague–Dawley (SD) rats showed a gradual decrease in the HPA axis response following 14 days of repeated restraint stress, whereas Fischer 344 (F344) rats did not show such HPA axis habituation. Similar habituation was observed in the expression of c‐fos mRNA, corticotropin‐releasing hormone hnRNA, and phospho‐CREB and phospho‐ERK proteins in the hypothalamic paraventricular nucleus (PVN) of SD rats, but not in the F344 rats. In addition, repeatedly restrained F344 rats exhibited decreased cell proliferation in the dentate gyrus of the hippocampus and increased anxiety‐related behaviours, while repeatedly restrained SD rats exhibited a selective enhancement of hippocampal cell proliferation in the ventral area. Moreover, we found a lower expression of glucocorticoid receptor (GR) protein, but not mRNA, in the PVN of F344 rats compared to SD rats. We also identified that microRNA (miR)‐18a inhibited translation of GR mRNA in cultured neuronal cells and that increased expression of miR‐18a in the PVN was observed in F344 rats compared with SD rats. These strain differences in GR protein levels were not found in the hippocampus and prefrontal cortex, and the expression of miR‐18a was much lower in these brain regions than in the PVN. Our results suggest that F344 rats could be a useful animal model for studying vulnerability to repeated stress, and that miR‐18a‐mediated down‐regulation of GR translation may be an important factor to be considered in susceptibility to stress‐related disorders.
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“We recently demonstrated that miRNA mediate behavioral responses to chronic stress in rodents by regulating gene expression and synapse number”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [146]
In the citing paper
“In contrast, reduced miR-124 expression enhances behavioral susceptibility to a subthreshold stress episode.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [146]
In the citing paper
“miR-124 targets Hdac4, Hdac5, and Gsk3b.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [146]
In the citing paper
“Drugs that inhibit HDAC4/5 and GSK3 have antidepressant-like effects on behavior.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [146]
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Metadata
- Authors
- Uchida, S., Nishida, A., Hara, K., Kamemoto, T., Suetsugi, M., Fujimoto, M., Watanuki, T., Wakabayashi, Y., Otsuki, K., McEwen, B. S., & Watanabe, Y.
- Affiliations
- Yamaguchi University (JP)
- Rockefeller University (US)
- Corresponding author
- Watanabe, Yoshifumi
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2008-04-25
- Volume
- 27
- Issue
- 9
- Pages
- 2250-2261
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2028776429
- Cited by
- 203
- References
- 63
- Citations by year
- 2024: 3 · 2023: 5 · 2022: 8 · 2021: 9 · 2020: 9 · 2019: 11 · 2018: 14 · 2017: 12 · 2016: 25 · 2015: 18 · 2014: 21 · 2013: 11 · 2012: 12
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- restraint stress, glucocorticoid receptor, microRNA-18a, hypothalamic paraventricular nucleus, hippocampal cell proliferation, anxiety-like behavior, strain differences, F344 rats, stress-related disorders, c-fos, CREB, ERK, corticotropin-releasing factor
- MeSH terms
- Animals, Anxiety, Body Weight, Brain, Corticosterone, Corticotropin-Releasing Hormone, Disease Models, Animal, Habituation, Psychophysiologic, Humans, Hypothalamo-Hypophyseal System, Immunohistochemistry, Male, Pituitary-Adrenal System, Rats, Inbred F344, Receptors, Glucocorticoid, Restraint, Physical, RNA, Messenger, Stress, Psychological, Blotting, Northern, Blotting, Western, Down-Regulation, Genes, fos, Rats, Sprague-Dawley, Cyclic AMP Response Element-Binding Protein, In Situ Hybridization, Receptors, Mineralocorticoid, Reverse Transcriptase Polymerase Chain Reaction, MicroRNAs, Extracellular Signal-Regulated MAP Kinases, Cell Proliferation, Rats
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