Biofilm formation by the small colony variant phenotype of Pseudomonas aeruginosa
Abstract
Pseudomonas aeruginosa is an ubiquitous environmental bacterium and an opportunistic human pathogen. Not only in most natural habitats but also within the human host, e.g. within the chronically infected cystic fibrosis lung, P. aeruginosa is associated with surfaces in structures known as biofilms. These functional communities represent a unique mode of bacterial growth where bacteria display particular phenotypes that are fundamentally different from planktonic cells. In this review the issue of the molecular mechanisms underlying the emergence of small colony variant (SCV) P. aeruginosa morphotypes that are especially capable of forming biofilms is addressed. It is assumed that the expression of the chaperone usher pathway (cup) genes encoding putative fimbrial adhesins is responsible for the phenotypic switch to an autoaggregative SCV phenotype. The elucidation of phenotypic switching in response to environmental stimuli will significantly increase our understanding of regulatory processes during bacterial adaptation and might be the basis for the initiation of the development of new antimicrobial treatment strategies.
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P. aeruginosa isolates from single CF patients exhibit a number of growth phenotypes, including a small colony variant (SCV).
“Pseudomonas aeruginosa isolates from single CF patients exhibit a number of growth phenotypes, including a small colony variant (SCV) [132].”
From Bacterial autoaggregation (2018) · cites this paper as [132]
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Trunk, T., Bacterial Cell Surface Group, S. F. G. A. E. B., S. Khalil, H., & C. Leo, J. (2018) · AIMS Microbiology · doi:10.3934/microbiol.2018.1.140 · Cited by 444 · see citing works
“However, C-U pili have also been suggested to be responsible for the SCV autoaggregative phenotype [132].”
BackgroundInfluentialKlebensberger, J., Birkenmaier, A., Geffers, R., Kjelleberg, S., & Philipp, B. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.02012.x · Cited by 97 · see citing works
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- Authors
- Häußler, S.
- Affiliations
- Helmholtz Centre for Infection Research (DE)
- Corresponding author
- Häußler, Susanne
- ORCID
- Häußler, Susanne
- Venue
- Environmental Microbiology
- Publisher
- Wiley
- Published
- 2004-04-15
- Volume
- 6
- Issue
- 6
- Pages
- 546-551
- ISSN
- 1462-2912 (ISSN-L)
- 1462-2920
- OpenAlex
- W2143326957
- Cited by
- 143
- References
- 45
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 10 · 2013: 12 · 2012: 6
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Environmental Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Keywords
- Pseudomonas aeruginosa, small colony variants, biofilm formation, chaperone-usher pathway, fimbrial adhesins, phenotypic switching, self-aggregation, cystic fibrosis, bacterial surface colonization, bacterial adaptation, antimicrobial treatment strategies
- MeSH terms
- Environment, Cyclic GMP, Models, Biological, Phenotype, Pseudomonas aeruginosa, Species Specificity, Gene Expression, Biofilms, Adhesins, Bacterial
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