Cited by 143Bacterial biofilms and quorum sensingBacterial Genetics and BiotechnologyEscherichia coli research studies

Biofilm formation by the small colony variant phenotype of Pseudomonas aeruginosa

Häußler, Susanne·2004·Environmental Microbiology

Abstract

Pseudomonas aeruginosa is an ubiquitous environmental bacterium and an opportunistic human pathogen. Not only in most natural habitats but also within the human host, e.g. within the chronically infected cystic fibrosis lung, P. aeruginosa is associated with surfaces in structures known as biofilms. These functional communities represent a unique mode of bacterial growth where bacteria display particular phenotypes that are fundamentally different from planktonic cells. In this review the issue of the molecular mechanisms underlying the emergence of small colony variant (SCV) P. aeruginosa morphotypes that are especially capable of forming biofilms is addressed. It is assumed that the expression of the chaperone usher pathway (cup) genes encoding putative fimbrial adhesins is responsible for the phenotypic switch to an autoaggregative SCV phenotype. The elucidation of phenotypic switching in response to environmental stimuli will significantly increase our understanding of regulatory processes during bacterial adaptation and might be the basis for the initiation of the development of new antimicrobial treatment strategies.

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Crossref · 10.1111/j.1462-2920.2004.00618.x

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  • P. aeruginosa isolates from single CF patients exhibit a number of growth phenotypes, including a small colony variant (SCV).

    “Pseudomonas aeruginosa isolates from single CF patients exhibit a number of growth phenotypes, including a small colony variant (SCV) [132].”

    From Bacterial autoaggregation (2018) · cites this paper as [132]

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Authors
Häußler, S.
Affiliations
Helmholtz Centre for Infection Research (DE)
Corresponding author
Häußler, Susanne
Venue
Environmental Microbiology
Publisher
Wiley
Published
2004-04-15
Volume
6
Issue
6
Pages
546-551
ISSN
  • 1462-2912 (ISSN-L)
  • 1462-2920
OpenAlex
W2143326957
Cited by
143
References
45
Citations by year
2026: 3 · 2025: 5 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 10 · 2013: 12 · 2012: 6
FWCI
2.94
Type
journal article
Language
en
Open access
closed
Locations
  • Environmental Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Keywords
Pseudomonas aeruginosa, small colony variants, biofilm formation, chaperone-usher pathway, fimbrial adhesins, phenotypic switching, self-aggregation, cystic fibrosis, bacterial surface colonization, bacterial adaptation, antimicrobial treatment strategies
MeSH terms
Environment, Cyclic GMP, Models, Biological, Phenotype, Pseudomonas aeruginosa, Species Specificity, Gene Expression, Biofilms, Adhesins, Bacterial

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