Fungal morphogenesis and host invasion

Gow, Neil A.R; Brown, Alistair J.P; Odds, Frank C

doi:10.1016/s1369-5274(02)00338-7

Cited by 482Fungal and yeast genetics researchFungal Infections and StudiesAntifungal resistance and susceptibility

Fungal morphogenesis and host invasion

Gow, Neil A.R, Brown, Alistair J.P, Odds, Frank C·2002·Current Opinion in Microbiology

DOI 10.1016/s1369-5274(02)00338-7

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Abstract

Many fungal pathogens undergo morphological transformations during host invasion. However, the significance of this for fungal pathogenesis is not clear. Both yeast and hyphal cells have properties well suited to tissue invasion and evasion of the immune system. However, molecular control circuits that regulate morphogenesis also regulate the expression of other virulence traits. To establish the extent to which morphogenesis impacts on pathogenesis, it is necessary to characterise the morphology of the fungus at different stages and locations during the natural history of a disease and to untangle how gene expression is modulated at these stages. This review considers the role of morphogenesis in fungal infection and argues that no simple, universal relationship can be drawn between morphology and the invasive potential of a fungus.

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“Although morphogenesis is an important virulence trait in C. albicans and other fungal pathogens (40), the role of filamentous growth in C. auris is unclear.”
From Genetic Analysis of Candida auris Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance (2019) · cites this paper as [40]

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Authors: Gow, N. A. R., Brown, A. J. P., & Odds, F. C.
Affiliations: University of Aberdeen (GB)
Corresponding author: Gow, Neil A.R
ORCID: Gow, Neil A.R
Brown, Alistair J.P
Venue: Current Opinion in Microbiology
Publisher: Elsevier BV
Published: 2002-08
Volume: 5
Issue: 4
Pages: 366-371
ISSN: 1369-5274 (ISSN-L)
DOI: 10.1016/s1369-5274(02)00338-7
OpenAlex: W2044796416
Cited by: 482
References: 50
Citations by year: 2026: 5 · 2025: 10 · 2024: 11 · 2023: 14 · 2022: 19 · 2021: 14 · 2020: 22 · 2019: 17 · 2018: 11 · 2017: 23 · 2016: 18 · 2015: 25 · 2014: 30 · 2013: 25 · 2012: 23
FWCI: 1.35
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
European Commission
Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Keywords: fungal morphogenesis, host invasion, fungal pathogenesis, yeast-to-hypha transition, hyphal morphology, virulence factors, immune evasion, gene expression regulation, fungal infection
MeSH terms: Animals, Mitosporic Fungi, Fungal Proteins, Guinea Pigs, Humans, Morphogenesis, Mycoses, Virulence, Gene Expression Regulation, Fungal, Mice

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Fungal morphogenesis and host invasion

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