The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Capsule and d-alanylated lipoteichoic acids protect Streptococcus pneumoniae against neutrophil extracellular traps
Open accessAbstract
Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide. Pneumococci can counteract the action of neutrophils with an antiphagocytic capsule and through electrochemical repulsion of antimicrobial peptides via addition of positive charge to the surface. Pneumococci are captured, but not killed in neutrophil extracellular traps (NETs). Here, we study the role of the polysaccharide capsule and lipoteichoic acid (LTA) modification on pneumococcal interaction with NETs. Expression of capsule (serotypes 1, 2, 4 and 9V) significantly reduced trapping by NETs, but was not required for resistance to NET-mediated killing. Pneumococci contain a dlt operon that mediates the incorporation of d-alanine residues into LTAs, thereby introducing positive charge. Genetic inactivation of dltA in non-encapsulated pneumococci rendered the organism sensitive to killing by antimicrobial components present in NETs. However, the encapsulated dltA mutant remained resistant to NET-mediated killing in vitro. Nevertheless, in a murine model of pneumococcal pneumonia, the encapsulated dltA-mutant strain was outcompeted by the wild-type upon invasion into the lungs and bloodstream. This suggests a non-redundant role for LTA alanylation in pneumococcal virulence at the early stage of invasive disease when capsule expression has been shown to be low.
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Cites
Neutrophil Extracellular Traps Kill Bacteria
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268
Self-citationNeutrophils and immunity: challenges and opportunities
Nathan, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1785 · Cited by 2,971
Diversity of antimicrobial peptides and their mechanisms of action
Epand, R. M., & Vogel, H. J. (1999) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(99)00198-4 · Cited by 1,358
Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae
Tettelin, H., Nelson, K. E., Paulsen, I. T., Eisen, J. A., Read, T. D., Peterson, S., Heidelberg, J., DeBoy, R. T., Haft, D. H., Dodson, R. J., et al. (2001) · Science · doi:10.1126/science.1061217 · Cited by 1,342
Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms
Urban, C. F., Reichard, U., Brinkmann, V., & Zychlinsky, A. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00659.x · Cited by 1,012
Self-citationGenome of the Bacterium Streptococcus pneumoniae Strain R6
Hoskins, J., Alborn, W. E., Arnold, J., Blaszczak, L. C., Burgett, S., DeHoff, B. S., Estrem, S. T., Fritz, L., Fu, D.-J., Fuller, W., et al. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.19.5709-5717.2001 · Cited by 725
Buchanan, J. T., Simpson, A. J., Aziz, R. K., Liu, G. Y., Kristian, S. A., Kotb, M., Feramisco, J., & Nizet, V. (2006) · Current Biology · doi:10.1016/j.cub.2005.12.039 · Cited by 682
Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors
Hava, D. L., & Camilli, A. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.t01-1-03106.x · Cited by 605
An Endonuclease Allows Streptococcus pneumoniae to Escape from Neutrophil Extracellular Traps
Beiter, K., Wartha, F., Albiger, B., Normark, S., Zychlinsky, A., & Henriques-Normark, B. (2006) · Current Biology · doi:10.1016/j.cub.2006.01.056 · Cited by 587
Self-citationA study of the genetic material determining an enzyme activity in Pneumococcus
Lacks, S., & Hotchkiss, R. D. (1960) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(60)90205-5 · Cited by 546
Cited by
Neutrophil extracellular traps in immunity and disease
Papayannopoulos, V. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.105 · Cited by 3,397
The multifaceted functions of neutrophils
Mayadas, T. N., Cullere, X., & Lowell, C. A. (2014) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-020712-164023 · Cited by 1,356
Neutrophil extracellular traps: Is immunity the second function of chromatin?
Brinkmann, V., & Zychlinsky, A. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201203170 · Cited by 1,021
Self-citationYipp, B. G., & Kubes, P. (2013) · Blood · doi:10.1182/blood-2013-04-457671 · Cited by 989
Beneficial suicide: why neutrophils die to make NETs
Brinkmann, V., & Zychlinsky, A. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1710 · Cited by 937
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Metadata
- Authors
- Wartha, F., Beiter, K., Albiger, B., Fernebro, J., Zychlinsky, A., Normark, S., & Henriques-Normark, B.
- Venue
- Cellular Microbiology
- Publisher
- Hindawi Limited
- Published
- 2007-05
- Volume
- 9
- Issue
- 5
- Pages
- 1162-1171
- ISSN
- 1462-5814 (ISSN-L)
- 1462-5822
- OpenAlex
- W2073623607
- Cited by
- 329
- References
- 48
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wartha, F., Beiter, K., Albiger, B., Fernebro, J., Zychlinsky, A., Normark, S., & Henriques-Normark, B. (2007). Capsule and d-alanylated lipoteichoic acids protect Streptococcus pneumoniae against neutrophil extracellular traps. Cellular Microbiology. https://doi.org/10.1111/j.1462-5822.2006.00857.x
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