The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism
Abstract
In recent years, the central nervous system (CNS) has emerged as a principle site of insulin action. This notion is supported by studies in animals relying on intracerebroventricular insulin infusion and by experiments in humans that make use of the intranasal pathway of insulin administration to the brain. Employing neurobehavioural and metabolic measurements as well as functional imaging techniques, these studies have provided insight into a broad range of central and peripheral effects of brain insulin. The present review focusses on CNS effects of insulin administered via the intranasal route on cognition, in particular memory function, and whole‐body energy homeostasis including glucose metabolism. Furthermore, evidence is reviewed that suggests a pathophysiological role of impaired brain insulin signaling in obesity and type 2 diabetes, which are hallmarked by peripheral and possibly central nervous insulin resistance, as well as in conditions such as Alzheimer's disease where CNS insulin resistance might contribute to cognitive dysfunction.
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“The direct manipulation of neuropeptidergic central nervous signaling pathways can be achieved via the intranasal administration of peptides, which is known to bypass the blood–brain barrier and result in significant cerebrospinal fluid elevations in substance levels within 40 min, without the need for systemic infusion (14,15).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [15]
In the citing paper
“Considering that impaired glucose tolerance as a result of diet-induced obesity abrogates the memory-improving and anxiolytic impact of insulin in mice, 152 impaired CNS insulin signalling might contribute to the association between metabolic disorders such as obesity and diabetes and cognitive impairments, as well dysthymia.156”
From Intranasal insulin (2021) · cites this paper as [156]
In the citing paper
“IN insulin administration (160 IU day -1 vs. diluent for 4 weeks) to patients with major depressive disorder failed to improve measures of emotional wellbeing,156”
From Intranasal insulin (2021) · cites this paper as [156]
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Metadata
- Authors
- Ott, V., Benedict, C., Schultes, B., Born, J., & Hallschmid, M.
- Affiliations
- University of Lübeck (DE)
- Uppsala University (SE)
- Kantonsspital St. Gallen (CH)
- Corresponding author
- Ott, V.
- Venue
- Diabetes, Obesity and Metabolism
- Publisher
- Wiley
- Published
- 2011-11-16
- Volume
- 14
- Issue
- 3
- Pages
- 214-221
- ISSN
- 1462-8902 (ISSN-L)
- 1463-1326
- OpenAlex
- W2124783702
- Cited by
- 139
- References
- 119
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 11 · 2023: 5 · 2022: 11 · 2021: 10 · 2020: 4 · 2019: 11 · 2018: 16 · 2017: 15 · 2016: 6 · 2015: 13 · 2014: 10 · 2013: 16 · 2012: 4
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Obesity and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- intranasal insulin, brain insulin signaling, cognitive function, memory, energy homeostasis, glucose metabolism, insulin resistance, obesity, type 2 diabetes, Alzheimer's disease
- MeSH terms
- Administration, Intranasal, Blood-Brain Barrier, Brain, Cognition Disorders, Diabetes Mellitus, Type 2, Female, Humans, Hypoglycemic Agents, Insulin, Insulin Resistance, Male, Obesity, Receptor, Insulin, Signal Transduction
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