Cited by 139Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesDiabetes Management and Research

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Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism

Ott, V., Benedict, C., Schultes, B., Born, J., Hallschmid, M.·2012·Diabetes, Obesity and Metabolism

DOI 10.1111/j.1463-1326.2011.01490.x

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Abstract

In recent years, the central nervous system (CNS) has emerged as a principle site of insulin action. This notion is supported by studies in animals relying on intracerebroventricular insulin infusion and by experiments in humans that make use of the intranasal pathway of insulin administration to the brain. Employing neurobehavioural and metabolic measurements as well as functional imaging techniques, these studies have provided insight into a broad range of central and peripheral effects of brain insulin. The present review focusses on CNS effects of insulin administered via the intranasal route on cognition, in particular memory function, and whole‐body energy homeostasis including glucose metabolism. Furthermore, evidence is reviewed that suggests a pathophysiological role of impaired brain insulin signaling in obesity and type 2 diabetes, which are hallmarked by peripheral and possibly central nervous insulin resistance, as well as in conditions such as Alzheimer's disease where CNS insulin resistance might contribute to cognitive dysfunction.

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Authors: Ott, V., Benedict, C., Schultes, B., Born, J., & Hallschmid, M.
Affiliations: University of Lübeck (DE)
Uppsala University (SE)
Kantonsspital St. Gallen (CH)
Corresponding author: Ott, V.
ORCID: Benedict, C.
Schultes, B.
Hallschmid, M.
Venue: Diabetes, Obesity and Metabolism
Publisher: Wiley
Published: 2011-11-16
Volume: 14
Issue: 3
Pages: 214-221
ISSN: 1462-8902 (ISSN-L)
1463-1326
DOI: 10.1111/j.1463-1326.2011.01490.x
OpenAlex: W2124783702
Cited by: 139
References: 119
Citations by year: 2026: 1 · 2025: 5 · 2024: 11 · 2023: 5 · 2022: 11 · 2021: 10 · 2020: 4 · 2019: 11 · 2018: 16 · 2017: 15 · 2016: 6 · 2015: 13 · 2014: 10 · 2013: 16 · 2012: 4
FWCI: 1.00
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Diabetes Obesity and Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: intranasal insulin, brain insulin signaling, cognitive function, memory, energy homeostasis, glucose metabolism, insulin resistance, obesity, type 2 diabetes, Alzheimer's disease
MeSH terms: Administration, Intranasal, Blood-Brain Barrier, Brain, Cognition Disorders, Diabetes Mellitus, Type 2, Female, Humans, Hypoglycemic Agents, Insulin, Insulin Resistance, Male, Obesity, Receptor, Insulin, Signal Transduction

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Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism

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