Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism

Central nervous system control of food intake

Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451

The memory function of sleep

Diekelmann, S., & Born, J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2762 · Cited by 3,760

Central nervous system control of food intake and body weight

Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

Steen, E., Terry, B. M., J. Rivera, E., Cannon, J. L., Neely, T. R., Tavares, R., Xu, X. J., Wands, J. R., & de la Monte, S. M. (2005) · Journal of Alzheimer's Disease · doi:10.3233/jad-2005-7107 · Cited by 1,703

Sniffing neuropeptides: A transnasal approach to the human brain

Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356

Intranasal delivery to the central nervous system: Mechanisms and experimental considerations

Dhuria, S. V., Hanson, L. R., & Frey, W. H. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21924 · Cited by 1,239

Insulin receptors are widely distributed in the central nervous system of the rat

Havránková, J., Roth, J., & Brownstein, M. (1978) · Nature · doi:10.1038/272827a0 · Cited by 1,116

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

Woods, S. C., Lotter, E. C., McKay, L. D., & Porte, D. (1979) · Nature · doi:10.1038/282503a0 · Cited by 1,114

Ablation of Insulin-Producing Neurons in Flies: Growth and Diabetic Phenotypes

Rulifson, E. J., Kim, S. K., & Nusse, R. (2002) · Science · doi:10.1126/science.1070058 · Cited by 1,064

Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration

Thorne, R. G., Pronk, G. J., Padmanabhan, V., & Frey, W. H. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.029 · Cited by 958

Transport of drugs from the nasal cavity to the central nervous system

Illum, L. (2000) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(00)00087-7 · Cited by 907

Hypothalamic insulin signaling is required for inhibition of glucose production

Obici, S., Zhang, B. B., Karkanias, G., & Rossetti, L. (2002) · Nature Medicine · doi:10.1038/nm1202-798 · Cited by 904

Cognitive Dysfunction and Diabetes Mellitus

Kodl, C. T., & Seaquist, E. R. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0034 · Cited by 846

Diabetes, Obesity, and the Brain

Schwartz, M. W., & Porte, D. (2005) · Science · doi:10.1126/science.1104344 · Cited by 841

Intranasal insulin improves cognition and modulates β-amyloid in early AD

Reger, M. A., Watson, G. S., Green, P. S., Wilkinson, C. W., Baker, L. D., Cholerton, B., Fishel, M. A., Plymate, S. R., Breitner, J. C. S., DeGroodt, W., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000265401.62434.36 · Cited by 830

Insulin and neurodegenerative disease: shared and specific mechanisms

Craft, S., & Stennis Watson, G. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00681-7 · Cited by 830

Central obesity and increased risk of dementia more than three decades later

Whitmer, R. A., Gustafson, D. R., Barrett-Connor, E., Haan, M. N., Gunderson, E. P., & Yaffe, K. (2008) · Neurology · doi:10.1212/01.wnl.0000306313.89165.ef · Cited by 803

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

Obici, S., Feng, Z., Karkanias, G., Baskin, D. G., & Rossetti, L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-861 · Cited by 719

Synaptic mechanisms for plasticity in neocortex

Feldman, D. E. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135516 · Cited by 704

An Obesity-AssociatedFTOGene Variant and Increased Energy Intake in Children

Cecil, J. E., Tavendale, R., Watt, P., Hetherington, M. M., & Palmer, C. N. A. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0803839 · Cited by 702

Intranasal insulin improves memory in humans

Benedict, C., Hallschmid, M., Hatke, A., Schultes, B., Fehm, H. L., Born, J., & Kern, W. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.04.003 · Cited by 699

Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer’s disease

Risner, M. E., Saunders, A. M., Altman, J. F. B., Ormandy, G. C., Craft, S., Foley, I. M., Zvartau-Hind, M. E., Hosford, D. A., Roses, A. D., & for the Rosiglitazone in Alzheimer's Disease Study Group (2006) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500369 · Cited by 686

Hypothalamic KATP channels control hepatic glucose production

Pocai, A., Lam, T. K. T., Gutierrez-Juarez, R., Obici, S., Schwartz, G. J., Bryan, J., Aguilar-Bryan, L., & Rossetti, L. (2005) · Nature · doi:10.1038/nature03439 · Cited by 645

Effects of intranasal insulin on cognition in memory-impaired older adults: Modulation by APOE genotype

Reger, M. A., Watson, G. S., Frey, W. H., Baker, L. D., Cholerton, B., Keeling, M. L., Belongia, D., Fishel, M. A., Plymate, S. R., Schellenberg, G. D., et al. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.016 · Cited by 619

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

Mosconi, L., Pupi, A., & de Leon, M. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.007 · Cited by 616

Preserved Cognition in Patients With Early Alzheimer Disease and Amnestic Mild Cognitive Impairment During Treatment With Rosiglitazone

Watson, G. S., Cholerton, B. A., Reger, M. A., Baker, L. D., Plymate, S. R., Asthana, S., Fishel, M. A., Kulstad, J. J., Green, P. S., Cook, D. G., et al. (2005) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.13.11.950 · Cited by 614

ApoE genotype accounts for the vast majority of AD risk and AD pathology

Raber, J., Huang, Y., & Ashford, J. W. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.12.023 · Cited by 599

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

Obici, S., Feng, Z., Karkanias, G. B., et al. (2002) · Nature Neuroscience · doi:10.1038/nn861 · Cited by 572

Insulin‐associated weight gain in diabetes – causes, effects and coping strategies

Russell-Jones, D. L., & Khan, R. (2006) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2006.00686.x · Cited by 569

Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: Relationship to severity of dementia and apolipoprotein E genotype

Craft, S., Peskind, E., Schwartz, M. W., Schellenberg, G. D., Raskind, M., & Porte, D. (1998) · Neurology · doi:10.1212/wnl.50.1.164 · Cited by 560

Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction

Mitrakou, A., Ryan, C., Veneman, T., Mokan, M., Jenssen, T., Kiss, I., Durrant, J., Cryer, P., & Gerich, J. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.260.1.e67 · Cited by 558 · cited 1×

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

Reger, M. A., Watson, G. S., Green, P. S., Baker, L. D., Cholerton, B., Fishel, M. A., Plymate, S. R., Cherrier, M. M., Schellenberg, G. D., Frey, W. H., et al. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13309 · Cited by 524

Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo.

Cherrington, A. D. (1999) · Diabetes · doi:10.2337/diabetes.48.5.1198 · Cited by 500

Central Control of Body Weight and Appetite

Woods, S. C., & D’Alessio, D. A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1630 · Cited by 477

Localization of insulin receptor mRNA in rat brain by in situ hybridization

MARKS, J. L., PORTE, D., STAHL, W. L., & BASKIN, D. G. (1990) · Endocrinology · doi:10.1210/endo-127-6-3234 · Cited by 448

Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo

Chiu, S.-L., Chen, C.-M., & Cline, H. T. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.014 · Cited by 425

Insulin receptors in the central nervous system: Localization, signalling mechanisms and functional aspects

UNGER, J., Livingston, J. H., & Moss, A. (1991) · Progress in Neurobiology · doi:10.1016/0301-0082(91)90015-s · Cited by 399

Quantitative analysis of the olfactory pathway for drug delivery to the brain

Thorne, R. G., Emory, C. R., Ala, T. A., & Frey, W. H. (1995) · Brain Research · doi:10.1016/0006-8993(95)00637-6 · Cited by 352

Insulin Signaling in the Central Nervous System

Porte, D., Baskin, D. G., & Schwartz, M. W. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1264 · Cited by 339

Insulin gene expression and insulin synthesis in mammalian neuronal cells.

Devaskar, S. U., Giddings, S. J., Rajakumar, P. A., Carnaghi, L. R., Menon, R. K., & Zahm, D. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37214-9 · Cited by 333

Differential Sensitivity to Central Leptin and Insulin in Male and Female Rats

Clegg, D. J., Riedy, C. A., Smith, K. A. B., Benoit, S. C., & Woods, S. C. (2003) · Diabetes · doi:10.2337/diabetes.52.3.682 · Cited by 332

Polymorphisms of the FTO Gene Are Associated With Variation in Energy Intake, but not Energy Expenditure

Speakman, J. R., Rance, K. A., & Johnstone, A. M. (2008) · Obesity · doi:10.1038/oby.2008.318 · Cited by 331

Insulin and the Blood-Brain Barrier

Woods, S. C., Seeley, R. J., Baskin, D. G., & Schwartz, M. W. (2003) · Current Pharmaceutical Design · doi:10.2174/1381612033455323 · Cited by 321

Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like changes

Gupta, A., Bisht, B., & Dey, C. S. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.033 · Cited by 302

Intranasal Insulin Improves Memory in Humans: Superiority of Insulin Aspart

Benedict, C., Hallschmid, M., Schmitz, K., Schultes, B., Ratter, F., Fehm, H. L., Born, J., & Kern, W. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301193 · Cited by 302

Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin

Benedict, C., Kern, W., Schultes, B., Born, J., & Hallschmid, M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2606 · Cited by 296 · cited 4×

PPARγ Agonists as Therapeutics for the Treatment of Alzheimer's Disease

Landreth, G. E., Jiang, Q., Mandrekar, S., & Heneka, M. T. (2008) · Neurotherapeutics · doi:10.1016/j.nurt.2008.05.003 · Cited by 283

Intranasal Insulin Reduces Body Fat in Men but not in Women

Hallschmid, M., Benedict, C., Schultes, B., Fehm, H.-L., Born, J., & Kern, W. (2004) · Diabetes · doi:10.2337/diabetes.53.11.3024 · Cited by 281 · cited 3×

Central insulin action regulates peripheral glucose and fat metabolism in mice

Koch, L., Wunderlich, F. T., Seibler, J., Könner, A. C., Hampel, B., Irlenbusch, S., Brabant, G. E., Kahn, C. R., Schwenk, F., & Brüning, J. C. (2008) · Journal of Clinical Investigation · doi:10.1172/jci31073 · Cited by 278

Brain Insulin Controls Adipose Tissue Lipolysis and Lipogenesis

Scherer, T., O’Hare, J., Diggs‐Andrews, K. A., Schweiger, M., Cheng, B., Lindtner, C., Zieliński, E., Vempati, P., Su, K., Dighe, S. V., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.008 · Cited by 270

Cerebrospinal Fluid Insulin Levels Increase During Intravenous Insulin Infusions in Man*

Wallum, B. J., Taborsky, G. J., Porte, D., Figlewicz, D. P., Jacobson, L., Beard, J. C., Ward, W. K., & Dorsa, D. M. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-1-190 · Cited by 254

Awake Intranasal Insulin Delivery Modifies Protein Complexes and Alters Memory, Anxiety, and Olfactory Behaviors

Marks, D. R., Tucker, K., Cavallin, M. A., Mast, T. G., & Fadool, D. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1350-09.2009 · Cited by 242

Hormonal regulation of hormone-sensitive lipase in intact adipocytes: identification of phosphorylated sites and effects on the phosphorylation by lipolytic hormones and insulin.

Strålfors, P., Björgell, P., & Belfrage, P. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.11.3317 · Cited by 233

Monitoring of stored and available fuel by the CNS: implications for obesity

Seeley, R. J., & Woods, S. C. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1245 · Cited by 233

Insulin receptor signaling in the development of neuronal structure and function

Chiu, S., & Cline, H. T. (2010) · Neural Development · doi:10.1186/1749-8104-5-7 · Cited by 231

Control of energy homeostasis by insulin and leptin: Targeting the arcuate nucleus and beyond

Könner, A. C., Klöckener, T., & Brüning, J. C. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.03.027 · Cited by 230

The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: A magnetoencephalographic study

Tschritter, O., Preissl, H., Hennige, A. M., Stumvoll, M., Porubska, K., Frost, R., Marx, H., Klösel, B., Lutzenberger, W., Birbaumer, N., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604404103 · Cited by 223

Hyperinsulinemia Provokes Synchronous Increases in Central Inflammation and β-Amyloid in Normal Adults

Fishel, M. A., Watson, G. S., Montine, T. J., Wang, Q., Green, P. S., Kulstad, J. J., Cook, D. G., Peskind, E. R., Baker, L. D., Goldgaber, D., et al. (2005) · Archives of Neurology · doi:10.1001/archneur.62.10.noc50112 · Cited by 222

Selective, Physiological Transport of Insulin Across the Blood-Brain Barrier: Novel Demonstration by Species-Specific Radioimmunoassays

Banks, W. A., Jaspan, J. B., & Kastin, A. J. (1997) · Peptides · doi:10.1016/s0196-9781(97)00198-8 · Cited by 219

Glucocorticoids, chronic stress, and obesity

Dallman, M. F., Pecoraro, N. C., La Fleur, S. E., Warne, J. P., Ginsberg, A. B., Akana, S. F., Laugero, K. C., Houshyar, H., Strack, A. M., Bhatnagar, S., et al. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)53004-3 · Cited by 198

Untitled work

Anthony (2006) · doi:10.2337/db06-0376 · Cited by 195

Insulin's direct effects on the liver dominate the control of hepatic glucose production

Edgerton, D. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27073 · Cited by 194

Central nervous system effects of intranasally administered insulin during euglycemia in men.

Kern, W., Jan Born, A., Schreiber, H., & Fehm, H. (1999) · Diabetes · doi:10.2337/diabetes.48.3.557 · Cited by 192

Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease

Mosconi, L., Mistur, R., Switalski, R., Brys, M., Glodzik, L., Rich, K., Pirraglia, E., Tsui, W., De Santi, S., & de Leon, M. J. (2009) · Neurology · doi:10.1212/01.wnl.0000333247.51383.43 · Cited by 188

The Effect of Insulin on In Vivo Cerebral Glucose Concentrations and Rates of Glucose Transport/Metabolism in Humans

Seaquist, E. R., Damberg, G., Tkáč, I., & Rolf Gruetter, A. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2203 · Cited by 185

Evidence for entry of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs. Quantitative aspects and implications for transport.

Schwartz, M. W., Bergman, R. N., Kahn, S. E., Taborsky, G. J., Fisher, L. D., Sipols, A. J., Woods, S. C., Steil, G. M., & Porte, D. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115431 · Cited by 183

Hippocampal synaptic plasticity and glutamate receptor regulation: influences of diabetes mellitus

Trudeau, F., Gagnon, S., & Massicotte, G. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.055 · Cited by 182

Leçons de physiologie expérimentale appliquée à la médecine, faites au Collège de France,

Bernard, C. (1855) · doi:10.5962/bhl.title.1818 · Cited by 174

No effect of insulin on glucose blood-brain barrier transport and cerebral metabolism in humans.

Hasselbalch, S. G., Knudsen, G. M., Videbæk, C. S., Pinborg, L. H., Schmidt, J. F., Holm, S., & Paulson, O. B. (1999) · Diabetes · doi:10.2337/diabetes.48.10.1915 · Cited by 172

Obese men respond to cognitive but not to catabolic brain insulin signaling

Hallschmid, M., Benedict, C., Schultes, B., Born, J., & Kern, W. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803722 · Cited by 165

Intranasal delivery of neurotrophic factors BDNF, CNTF, EPO, and NT-4 to the CNS

Alcala, S. R., Lee, M. S., Hanson, L. R., McDonald, A. A., Frey, W. H., & McLoon, L. K. (2009) · Journal of drug targeting · doi:10.3109/10611860903318134 · Cited by 165

Neuroendocrine responses to hypoglycemia

Tesfaye, N., & Seaquist, E. R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05820.x · Cited by 164 · cited 1×

Evidence for the presence of specific receptors for insulin-like growth factors 1 (IGF-1) and 2 (IGF-2) and insulin throughout the adult human brain

Saka, V. R., Hall, K. E., Holtz, H. V., HUMBEL, R. E., Sjören, B., & Wetterberg, L. (1982) · Neuroscience Letters · doi:10.1016/0304-3940(82)90089-1 · Cited by 164

Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons

Lin, H. V., Plum, L., Ono, H., Juárez, R. G., Shanabrough, M., Borók, E., Horváth, T. L., Rossetti, L., & Accili, D. (2009) · Diabetes · doi:10.2337/db09-1303 · Cited by 162

Insulin Modulates Food-Related Activity in the Central Nervous System

Guthoff, M., Grichisch, Y., Canova, C., Tschritter, O., Veit, R., Hallschmid, M., Häring, H., Preissl, H. T., Hennige, A. M., & Fritsche, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1677 · Cited by 157

Low cerebrospinal fluid insulin levels in obese humans

Kern, W., Benedict, C., Schultes, B., Plohr, F., Moser, A., Jan Born, A., Fehm, H. L., & Hallschmid, M. (2006) · Diabetologia · doi:10.1007/s00125-006-0409-y · Cited by 143

Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice

Brown, L. M., Clegg, D. J., Benoit, S. C., & Woods, S. C. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.08.008 · Cited by 139

The direct and indirect effects of insulin on hepatic glucose production in vivo

Cherrington, A. D., Edgerton, D. S., & Sindelar, D. K. (1998) · Diabetologia · doi:10.1007/s001250051021 · Cited by 137

Insulin and Leptin Combine Additively to Reduce Food Intake and Body Weight in Rats

Air, E. L., Benoit, S. C., Clegg, D. J., Seeley, R. J., & Woods, S. C. (2002) · Endocrinology · doi:10.1210/endo.143.6.8948 · Cited by 131

Intranasal Insulin Enhances Postprandial Thermogenesis and Lowers Postprandial Serum Insulin Levels in Healthy Men

Benedict, C., Brede, S., Schiöth, H. B., Lehnert, H., Schultes, B., Born, J., & Hallschmid, M. (2011) · Diabetes · doi:10.2337/db10-0329 · Cited by 129

Central insulin and leptin-mediated autonomic control of glucose homeostasis

Marino, J. S., Xu, Y., & Hill, J. W. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.03.001 · Cited by 129

Metabolic syndrome and cognitive decline in French elders

Raffaitin, C., Féart, C., Goff, M. L., Amieva, H., Helmer, C., Akbaraly, T. N., Tzourio, C., Gin, H., & Barberger‐Gateau, P. (2011) · Neurology · doi:10.1212/wnl.0b013e31820b7656 · Cited by 125

Orchestration of Glucose Homeostasis

Bergman, R. N. (2007) · Diabetes · doi:10.2337/db07-9903 · Cited by 115

Variation in the FTO gene locus is associated with cerebrocortical insulin resistance in humans

Tschritter, O., Preissl, H. T., Yokoyama, Y., Machicao, F. E., Häring, H., & Fritsche, A. (2007) · Diabetologia · doi:10.1007/s00125-007-0839-1 · Cited by 114

Rosiglitazone attenuates the cognitive deficits induced by high fat diet feeding in rats

Pathan, A. R., Gaikwad, A. B., Viswanad, B., & Ramarao, P. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.06.016 · Cited by 105

Downregulation of hypothalamic insulin receptor expression elicits depressive-like behaviors in rats

Grillo, C. A., Piroli, G. G., Kaigler, K. F., Wilson, S. P., Wilson, M. A., & Reagan, L. P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.052 · Cited by 104

Glucocorticoids and the ageing hippocampus

Hibberd, C. J., Yau, J. L. W., & Seckl, J. R. (2000) · Journal of Anatomy · doi:10.1046/j.1469-7580.2000.19740553.x · Cited by 100

New strategies to improve the intranasal absorption of insulin

Duan, X., & Mao, S. (2010) · Drug Discovery Today · doi:10.1016/j.drudis.2010.03.011 · Cited by 96

Insulin Causes Hyperthermia by Direct Inhibition of Warm-Sensitive Neurons

Sánchez-Alavez, M., Tabarean, I. V., Osborn, O., Mitsukawa, K., Schaefer, J. F., Dubins, J. S., Holmberg, K. H., Klein, I., Klaus, J., Gomez, L. F., et al. (2009) · Diabetes · doi:10.2337/db09-1128 · Cited by 93

Central nervous insulin resistance: a promising target in the treatment of metabolic and cognitive disorders?

Hallschmid, M., & Schultes, B. (2009) · Diabetologia · doi:10.1007/s00125-009-1501-x · Cited by 90

Insulin enhances glucose-stimulated insulin secretion in healthy humans

Bouché, C., López, X., Fleischman, A., Cypess, A. M., O'Shea, S., Stefanovski, D., Bergman, R. N., Rogatsky, E., Stein, D. T., Kahn, C. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000002107 · Cited by 90

Intranasal insulin attenuates the hypothalamic–pituitary–adrenal axis response to psychosocial stress

Bohringer, A., Schwabe, L., Richter, S., & Schachinger, H. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.08.002 · Cited by 89

Various phosphodiesterase subtypes mediate the in vivo antilipolytic effect of insulin on adipose tissue and skeletal muscle in man

Enoksson, S., Degerman, E., Toft, E., Large, V., & Arner, P. (1998) · Diabetologia · doi:10.1007/s001250050947 · Cited by 88

Insulin and Hippocampus Activation in Response to Images of High‐Calorie Food in Normal Weight and Obese Adolescents

Wallner-Liebmann, S., Koschutnig, K., Reishofer, G., Sorantin, E., Blaschitz, B., Kruschitz, R., Unterrainer, H., Gasser, R., Freytag, F., Bauer-Denk, C., et al. (2010) · Obesity · doi:10.1038/oby.2010.26 · Cited by 87

Central Insulin Signaling Is Attenuated by Long-Term Insulin Exposure via Insulin Receptor Substrate-1 Serine Phosphorylation, Proteasomal Degradation, and Lysosomal Insulin Receptor Degradation

Mayer, C., & Belsham, D. D. (2009) · Endocrinology · doi:10.1210/en.2009-0838 · Cited by 84

Central administration of insulin suppresses food intake in chicks

Honda, K., Kamisoyama, H., Saneyasu, T., Sugahara, K., & Hasegawa, S. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.07.004 · Cited by 81

Brain Uptake of Intranasally Applied Radioiodinated Leptin in Wistar Rats

Fliedner, S. M. J., Schulz, C., & Lehnert, H. (2006) · Endocrinology · doi:10.1210/en.2005-1016 · Cited by 81

Effect of Intracisternal Insulin on Plasma Glucose and Insulin in the Dog

Woods, S. C., & Porte, D. (1975) · Diabetes · doi:10.2337/diab.24.10.905 · Cited by 80

Effect of Cerebral Intraventricular Insulin on Pancreatic Insulin Secretion in the Dog

Chen, M., Woods, S. C., & Porte, D. (1975) · Diabetes · doi:10.2337/diab.24.10.910 · Cited by 79

Age at Onset and Regional Cerebral Glucose Metabolism in Alzheimer’s Disease

Yasuno, F., Imamura, T., Hirono, N., Ishii, K., Sasaki, M., Ikejiri, Y., Hashimoto, M., Shimomura, T., Yamashita, H., & Mori, E. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017024 · Cited by 75

Hormonal regulation of hippocampal dendritic morphology and synaptic plasticity

Moult, P. R., & Harvey, J. (2008) · Cell Adhesion & Migration · doi:10.4161/cam.2.4.6354 · Cited by 72

Blood-to-brain glucose transport and cerebral glucose metabolism are not reduced in poorly controlled type 1 diabetes.

Fanelli, C. G., Dence, C. S., Markham, J., Videen, T. O., Paramore, D. S., Cryer, P. E., & Powers, W. J. (1998) · Diabetes · doi:10.2337/diabetes.47.9.1444 · Cited by 69

The role of insulin receptor signaling in synaptic plasticity and cognitive function.

Huang, C. C., Lee, C. C., & Hsu, K. (2010) · PubMed · Cited by 66

Inhaled insulin—Intrapulmonary, intranasal, and other routes of administration: Mechanisms of action

Henkin, R. I. (2009) · Nutrition · doi:10.1016/j.nut.2009.08.001 · Cited by 62

The Insulin-Mediated Modulation of Visually Evoked Magnetic Fields Is Reduced in Obese Subjects

Guthoff, M., Stingl, K. T., Tschritter, O., Vidaković, M. R., Heni, M., Štingl, K., Hallschmid, M., Häring, H., Fritsche, A., Preissl, H. T., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019482 · Cited by 59

The role of hepatic insulin receptors in the regulation of glucose production

Cherrington, A. D. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25152 · Cited by 57

Insulin Therapy and Type 2 Diabetes: Management of Weight Gain

McFarlane, S. I. (2009) · Journal of Clinical Hypertension · doi:10.1111/j.1751-7176.2009.00063.x · Cited by 52

Transcortical Direct Current Potential Shift Reflects Immediate Signaling of Systemic Insulin to the Human Brain

Hallschmid, M., Schultes, B., Marshall, L., Mölle, M., Kern, W., Bredthauer, J., Fehm, H. L., & Jan Born, A. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2202 · Cited by 50

Central insulin action regulates peripheral glucose and fat metabolism in mice

Schinner, S. (2009) · Yearbook of Endocrinology · doi:10.1016/s0084-3741(09)79310-2 · Cited by 48

The role of hepatic insulin receptors in the regulation of glucose production

Cherrington, A. D. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200525152 · Cited by 47

Four-day hyperinsulinemia in euglycemic conditions alters local cerebral glucose utilization in specific brain nuclei of freely moving rats

Doyle, P., Cusin, I., Rohner‐Jeanrenaud, F., & Jeanrenaud, B. (1995) · Brain Research · doi:10.1016/0006-8993(95)00402-c · Cited by 46

The Insulin Effect on Cerebrocortical Theta Activity Is Associated with Serum Concentrations of Saturated Nonesterified Fatty Acids

Tschritter, O., Preissl, H., Hennige, A. M., Sartorius, T., Grichisch, Y., Stefan, N., Guthoff, M., Düsing, S., Machann, J., Schleicher, E., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0469 · Cited by 42

Analysis of Insulin Sensitivity in Adipose Tissue of Patients with Primary Aldosteronism

Urbanet, R., Pilon, C., Calcagno, A., Peschechera, A., Hubert, E.-L., Giacchetti, G., Gomez-Sanchez, C., Mulatero, P., Toffanin, M., Sonino, N., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0097 · Cited by 38

Ontogenesis of insulin receptors in human cerebral cortex

Potau, N., Escofet, M. A., & Martı́nez, M. C. (1991) · Journal of Endocrinological Investigation · doi:10.1007/bf03350263 · Cited by 37

Unconditioned and conditioned effects of intranasally administered insulin vs placebo in healthy men: a randomised controlled trial

Stockhorst, U., de Fries, D., Steingrüber, H.-J., & Scherbaum, W. A. (2011) · Diabetologia · doi:10.1007/s00125-011-2111-y · Cited by 33

Insulin expression in the brain and pituitary cells of tilapia (Oreochromis niloticus)

Hrytsenko, О., Wright, J. R., Morrison, C. M., & Pohajdak, B. (2007) · Brain Research · doi:10.1016/j.brainres.2006.12.009 · Cited by 32

The role of metabolic derangements and glucocorticoid excess in the aetiology of cognitive impairment in type 2 diabetes. Implications for future therapeutic strategies

Strachan, M. W. J., Reynolds, R. M., Frier, B. M., Mitchell, R. J., & Price, J. F. (2009) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00963.x · Cited by 30

Full length article

van Dijk, G., de Groote, C., Chavez, M., van der Werf, Y. D., Steffens, A. B., & Strubbe, J. H. (1997) · Brain Research · doi:10.1016/s0006-8993(97)01103-7 · Cited by 28

Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans

Kullmann, S., Heni, M., Hallschmid, M., Fritsche, A., Preissl, H. T., & Häring, H. (2016) · Physiological Reviews · doi:10.1152/physrev.00032.2015 · Cited by 654

Insulin in the Brain: Its Pathophysiological Implications for States Related with Central Insulin Resistance, Type 2 Diabetes and Alzheimer’s Disease

Blázquez, E., Velázquez, E., Hurtado-Carneiro, V., & Ruiz‐Albusac, J. M. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00161 · Cited by 523

Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

Freiherr, J., Hallschmid, M., Frey, W. H., Brünner, Y. F., Chapman, C. D., Hölscher, C., Craft, S., Felice, F. G. D., & Benedict, C. (2013) · CNS Drugs · doi:10.1007/s40263-013-0076-8 · Cited by 477

Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

Felice, F. G. D. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64595 · Cited by 336

Olfaction and Aging: A Mini-Review

Attems, J., Walker, L., & Jellinger, K. A. (2015) · Gerontology · doi:10.1159/000381619 · Cited by 324

Outcomes and clinical implications of intranasal insulin administration to the central nervous system

Santiago, J. C. P., & Hallschmid, M. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.03.007 · Cited by 37

Intranasal insulin

Hallschmid, M. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12934 · Cited by 113

Prospects of intranasal insulin for correction of cognitive impairments, in particular those associated with diabetes mellitus

Surkova, E. V., Derkach, K. V., Bespalov, A. I., & Shpakov, A. O. (2019) · Problems of Endocrinology · doi:10.14341/probl9755 · Cited by 5

Insulin and the CNS: effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans

Stockhorst, U., de Fries, D., Steingrüber, H.-J., & Scherbaum, W. A. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.07.022 · Cited by 191

Targeting metabolic and cognitive pathways of the CNS by intranasal insulin administration

Hallschmid, M., Benedict, C., Jan Born, A., & Kern, W. (2007) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.4.4.319 · Cited by 22