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The molecular biology of chronic wounds and delayed healing in diabetes
Abstract
Wound healing is a complicated and integrated process. Although there is some tolerance in terms of redundancy and interrelated control mechanisms, pushing beyond such limits may contribute to delayed wound healing, and in extreme cases lead to chronic wounds/ulcers and thus potentially to lower extremity amputation. Diabetes is associated with such disruption in wound healing. Research in humans and in animal models has identified a large number of changes associated with diabetes at the molecular level in delayed wound healing and to a lesser extent in chronic diabetic ulcers. Better overall understanding of these changes and how they are interrelated would allow for specifically targeted treatment, thus ensuring improved quality of life for patients and providing savings to the high costs that are associated with all aspects of chronic diabetic ulcers. This review examines the work done at the molecular level on chronic diabetic ulcers, as well as considering changes seen in diabetes in general, both in humans and animal models, that may in turn contribute to ulcer formation.
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“Diabetics typically suffer from delayed and diminished wound healing.127”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [127]
In the citing paper
“During impaired healing associated with diabetes, wounds exhibit prolonged accumulation of Mp associated with elevated levels of proinflammatory cytokines and proteases and reduced levels of various growth factors (2,12,13).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [2]
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Animal Models of Type 2 Diabetes Complications: A Review
Sun, Z., Liu, Y., Zhao, Y., & Xu, Y. (2023) · Endocrine Research · doi:10.1080/07435800.2023.2278049 · Cited by 14
Nitric Oxide-Releasing Nanomaterials and Skin Care
Seabra, A. B. (2011) · Springer eBooks · doi:10.1007/978-3-642-19792-5_13 · Cited by 11
Şener, A., Çevik, Ö. D., Doğan, Ö., ALTINDİŞ, N. G., Aksoy, H., & Okuyan, B. (2015) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-1502-68 · Cited by 11
Diabetes and hyperglycemia as risk factors for postoperative outcome in maxillofacial surgery
Rahimi-Nedjat, R. K., Sagheb, K., Pabst, A. M., Foersch, M., Jacobs, C., Vollandt, L., Al‐Nawas, B., & Walter, C. (2017) · Journal of Surgical Research · doi:10.1016/j.jss.2017.05.021 · Cited by 11
A REVIEW ON CURCUMIN: WOUND HEALING PROPERTIES AND BIOMARKERS OF WOUND HEALING
Choudhary, V. T., & Shivakumar, H. G. (2018) · International Research Journal of Pharmacy · doi:10.7897/2230-8407.099179 · Cited by 11
Guetta, O., Vakhrushev, A., Dukhno, O., Ovnat, A., & Sebbag, G. (2019) · World Journal of Diabetes · doi:10.4239/wjd.v10.i2.78 · Cited by 11
Kupczyk, D., Bilski, R., Studzińska, R., & Woźniak, A. (2021) · Advances in Dermatology and Allergology · doi:10.5114/ada.2020.100737 · Cited by 11
Foot Care for Patients With Diabetes
Heitzman, J. (2010) · Topics in Geriatric Rehabilitation · doi:10.1097/tgr.0b013e3181ef31c9 · Cited by 11
Bioengineering Scaffolds for Regenerative Engineering
Qian, Z., Radke, D., Jia, W., Tahtinen, M., Wang, G., & Zhao, F. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.99891-x · Cited by 12
Metadata
- Authors
- Blakytny, R., & Jude, E.
- Affiliations
- Fachklinik Hornheide (DE)
- Tameside Hospital (GB)
- Corresponding author
- Jude, E.
- ORCID
- Jude, E.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 2006-02-13
- Volume
- 23
- Issue
- 6
- Pages
- 594-608
- ISSN
- 0742-3071 (ISSN-L)
- 1464-5491
- OpenAlex
- W1967162280
- Cited by
- 632
- References
- 224
- Citations by year
- 2026: 13 · 2025: 32 · 2024: 34 · 2023: 50 · 2022: 38 · 2021: 65 · 2020: 41 · 2019: 36 · 2018: 32 · 2017: 38 · 2016: 43 · 2015: 37 · 2014: 40 · 2013: 31 · 2012: 22
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Keywords
- chronic wounds, diabetic ulcers, delayed wound healing, diabetes mellitus, molecular mechanisms, lower limb amputation, animal models of diabetes
- MeSH terms
- Animals, Diabetes Mellitus, Experimental, Extracellular Matrix, Glucose, Humans, Nitric Oxide, Oxidation-Reduction, Skin, Wound Healing, Cytokines, Intercellular Signaling Peptides and Proteins, Diabetes Complications
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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