The DOI matches its Crossref record; 224 of the 224 references it cites were found in a registry or an index.
The molecular biology of chronic wounds and delayed healing in diabetes
Abstract
Wound healing is a complicated and integrated process. Although there is some tolerance in terms of redundancy and interrelated control mechanisms, pushing beyond such limits may contribute to delayed wound healing, and in extreme cases lead to chronic wounds/ulcers and thus potentially to lower extremity amputation. Diabetes is associated with such disruption in wound healing. Research in humans and in animal models has identified a large number of changes associated with diabetes at the molecular level in delayed wound healing and to a lesser extent in chronic diabetic ulcers. Better overall understanding of these changes and how they are interrelated would allow for specifically targeted treatment, thus ensuring improved quality of life for patients and providing savings to the high costs that are associated with all aspects of chronic diabetic ulcers. This review examines the work done at the molecular level on chronic diabetic ulcers, as well as considering changes seen in diabetes in general, both in humans and animal models, that may in turn contribute to ulcer formation.
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In the citing paper
“Diabetics typically suffer from delayed and diminished wound healing.127”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [127]
In the citing paper
“During impaired healing associated with diabetes, wounds exhibit prolonged accumulation of Mp associated with elevated levels of proinflammatory cytokines and proteases and reduced levels of various growth factors (2,12,13).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [2]
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Cites
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
Global Burden of Diabetes, 1995–2025: Prevalence, numerical estimates, and projections
King, H. O. M., Aubert, R. E., & Herman, W. H. (1998) · Diabetes Care · doi:10.2337/diacare.21.9.1414 · Cited by 6,294
Singer, A. J., & Clark, R. A. F. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411006 · Cited by 6,106
Diabetes, oxidative stress, and antioxidants: A review
Maritim, A. C., Sanders, R. A., & Watkins, J. B. (2003) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.10058 · Cited by 3,167
Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor
Heldin, C., & Westermark, B. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1283 · Cited by 2,521
Peroxynitrite oxidation of sulfhydryls.
Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,492
DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systems
Halliwell, B. B., & Aruoma, O. I. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80347-6 · Cited by 1,537
Advanced glycation endproducts—role in pathology of diabetic complications
Ahmed, N. (2004) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.09.004 · Cited by 1,457
Edwards, D. R., Murphy, G., Reynolds, J. J., Whitham, S. E., Docherty, A. J., Angel, P., & Heath, J. K. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02449.x · Cited by 1,221
Shah, M., Foreman, D. M., & Ferguson, M. W. J. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.3.985 · Cited by 1,168
Flagged first, then by citations
Research works printed but not linked: 5
- Jude EB, 1999, End‐stage complications of diabetic neuropathy, Diabet Rev, 7, 395
- 10.1002/1520-7560(200009/10)16:1 <::AID-DMRR142>3.0.CO;2-S · DOI
- Wierusz‐Wysocka B, 1985, Phagocytosis, bactericidal capacity, and superoxide anion (02–) production by polymorphonuclear neutrophils from patients with diabetes mellitus, Folia Haematol Int Mag Klin Morph Blutforsch, 112, 658
- 10.1210/jc.74.6.1352 · DOI
- Williams DRR., 1994, The Foot in Diabetes, 15
Cited by
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Ulima, A. T., & Fawzy, A. (2023) · International Journal of Medical Science and Clinical Research Studies · doi:10.47191/ijmscrs/v3-i3-38
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Versey, Z. (2023) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2023-15377
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Zgheib, C., Niemiec, S. M., Louiselle, A. E., Liechty, K. W., & Xu, J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-820719-2.00004-1
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Growth factors and their receptors in neuropathic diabetic foot ulcers of different durations
Komelyagina, E., Antsiferov, M. B., Коган, Е. А., & Zharkov, N. V. (2023) · Diabetes Mellitus · doi:10.14341/dm13009
Deprogramming senescence by genomic stabilizing molecules in vivo
Yasom, S. (2021) · Chula Digiverse · doi:10.58837/chula.the.2021.21
Bacca, L., Estevez, M. A., Acevedo, D., Castillo, S., Arias, A. F., Dulcey, L., Gomez, J., Hernandez, C., Therán, J. S., Caltagirone, R., et al. (2023) · doi:10.33774/coe-2023-5rfb9
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-, M. R. P., -, V. S. G., & -, K. S. K. (2023) · International Journal For Multidisciplinary Research · doi:10.36948/ijfmr.2023.v05i06.10199
Sedeh, S. S., Fatemi, M., & Ghandehari, F. (2023) · Avicenna Journal of Clinical Microbiology and Infection · doi:10.34172/ajcmi.3496
Signaling pathway and pharmacology
Li, X. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15793-6.00005-6
Revision Total Hip Arthroplasty: Postoperative Wound Complications
Son, S. J., Andrawis, J. P., & Wassef, A. J. (2025) · Springer eBooks · doi:10.1007/978-3-031-83959-7_65
New advances in pressure ulcer treatment − the promoting effect of biomaterials on drugs
Song, L., Luo, J., Xu, Y., Zhang, Y., Gao, J., Yang, G., & Luo, Y. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126500
Fibrin Mediated Proangiogenic and Secretory Control Gene Therapy for Compromised Wound Healing
Kulkarni, M. (2012) · Arrow@dit (Dublin Institute of Technology) · doi:10.13025/16055
Local administration of low-intensity vibration improves wound healing in diabetic mice
Roberts, R. E., Silva, J. C., Bilgen, O., Kineman, R. D., & Koh, T. J. (2026) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2026.1731310
Emmerich, K., Suri, R., Yang, D., Liu, D., Huffstutler, R. D., Dmitrieva, N. I., Cudrici, C. D., Schwartzbeck, R., Ferrante, E. A., Hsu, I., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.24.707845
Rojczyk, E., Spyrka, K., SIEROŃ, A., Bazaliński, D., & Kucharzewski, M. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1790277 · Cited by 1
Begey, A.-L. (2018) · theses.fr (ABES) · doi:10.70675/d27994bbz9ea0z4727za8f5zbb789d22105d
Yang, S., Song, N., Wei, H., Zhang, Y., & Chu, Y. (2026) · Applied Materials Today · doi:10.1016/j.apmt.2026.103241
Lukas, B., Pang, J., Dai, Y., & Koh, T. J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.21.719960
Advances in electroactive materials-based strategies for promoting skin wound healing
Ge, H., Ren, X., & Lei, Z. (2026) · Frontiers in Medical Technology · doi:10.3389/fmedt.2026.1919503
Liu, L., Guo, X., Dai, Y., Zhang, Q., Yang, J., Gu, R., Tang, M., Tan, M., & Nie, X. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102567
The role of ARNT in liver and myeloid cell function
Scott, C. H. (2013) · The Sydney eScholarship Repository (The University of Sydney)
Metadata
- Authors
- Blakytny, R., & Jude, E.
- Affiliations
- Fachklinik Hornheide (DE)
- Tameside Hospital (GB)
- Corresponding author
- Jude, E.
- ORCID
- Jude, E.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 2006-02-13
- Volume
- 23
- Issue
- 6
- Pages
- 594-608
- ISSN
- 0742-3071 (ISSN-L)
- 1464-5491
- OpenAlex
- W1967162280
- Cited by
- 632
- References
- 224
- Citations by year
- 2026: 13 · 2025: 32 · 2024: 34 · 2023: 50 · 2022: 38 · 2021: 65 · 2020: 41 · 2019: 36 · 2018: 32 · 2017: 38 · 2016: 43 · 2015: 37 · 2014: 40 · 2013: 31 · 2012: 22
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Keywords
- chronic wounds, diabetic ulcers, delayed wound healing, diabetes mellitus, molecular mechanisms, lower limb amputation, animal models of diabetes
- MeSH terms
- Animals, Diabetes Mellitus, Experimental, Extracellular Matrix, Glucose, Humans, Nitric Oxide, Oxidation-Reduction, Skin, Wound Healing, Cytokines, Intercellular Signaling Peptides and Proteins, Diabetes Complications
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