Cited by 632Wound Healing and TreatmentsDiabetic Foot Ulcer Assessment and ManagementSkin Diseases and Diabetes

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The molecular biology of chronic wounds and delayed healing in diabetes

Blakytny, R., Jude, E.·2006·Diabetic Medicine

DOI 10.1111/j.1464-5491.2006.01773.x

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Abstract

Wound healing is a complicated and integrated process. Although there is some tolerance in terms of redundancy and interrelated control mechanisms, pushing beyond such limits may contribute to delayed wound healing, and in extreme cases lead to chronic wounds/ulcers and thus potentially to lower extremity amputation. Diabetes is associated with such disruption in wound healing. Research in humans and in animal models has identified a large number of changes associated with diabetes at the molecular level in delayed wound healing and to a lesser extent in chronic diabetic ulcers. Better overall understanding of these changes and how they are interrelated would allow for specifically targeted treatment, thus ensuring improved quality of life for patients and providing savings to the high costs that are associated with all aspects of chronic diabetic ulcers. This review examines the work done at the molecular level on chronic diabetic ulcers, as well as considering changes seen in diabetes in general, both in humans and animal models, that may in turn contribute to ulcer formation.

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Authors: Blakytny, R., & Jude, E.
Affiliations: Fachklinik Hornheide (DE)
Tameside Hospital (GB)
Corresponding author: Jude, E.
ORCID: Jude, E.
Venue: Diabetic Medicine
Publisher: Wiley
Published: 2006-02-13
Volume: 23
Issue: 6
Pages: 594-608
ISSN: 0742-3071 (ISSN-L)
1464-5491
DOI: 10.1111/j.1464-5491.2006.01773.x
OpenAlex: W1967162280
Cited by: 632
References: 224
Citations by year: 2026: 13 · 2025: 32 · 2024: 34 · 2023: 50 · 2022: 38 · 2021: 65 · 2020: 41 · 2019: 36 · 2018: 32 · 2017: 38 · 2016: 43 · 2015: 37 · 2014: 40 · 2013: 31 · 2012: 22
FWCI: 2.23
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Diabetic Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
Keywords: chronic wounds, diabetic ulcers, delayed wound healing, diabetes mellitus, molecular mechanisms, lower limb amputation, animal models of diabetes
MeSH terms: Animals, Diabetes Mellitus, Experimental, Extracellular Matrix, Glucose, Humans, Nitric Oxide, Oxidation-Reduction, Skin, Wound Healing, Cytokines, Intercellular Signaling Peptides and Proteins, Diabetes Complications

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The molecular biology of chronic wounds and delayed healing in diabetes

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