Cited by 632Wound Healing and TreatmentsDiabetic Foot Ulcer Assessment and ManagementSkin Diseases and Diabetes

The DOI matches its Crossref record; 224 of the 224 references it cites were found in a registry or an index.

The molecular biology of chronic wounds and delayed healing in diabetes

Blakytny, R., Jude, E.·2006·Diabetic Medicine

DOI 10.1111/j.1464-5491.2006.01773.x

Open this paper in CoChat — free account

Abstract

Wound healing is a complicated and integrated process. Although there is some tolerance in terms of redundancy and interrelated control mechanisms, pushing beyond such limits may contribute to delayed wound healing, and in extreme cases lead to chronic wounds/ulcers and thus potentially to lower extremity amputation. Diabetes is associated with such disruption in wound healing. Research in humans and in animal models has identified a large number of changes associated with diabetes at the molecular level in delayed wound healing and to a lesser extent in chronic diabetic ulcers. Better overall understanding of these changes and how they are interrelated would allow for specifically targeted treatment, thus ensuring improved quality of life for patients and providing savings to the high costs that are associated with all aspects of chronic diabetic ulcers. This review examines the work done at the molecular level on chronic diabetic ulcers, as well as considering changes seen in diabetes in general, both in humans and animal models, that may in turn contribute to ulcer formation.

Integrity signals

Registry

Crossref · 10.1111/j.1464-5491.2006.01773.x

Cites

224 of 224 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
Global Burden of Diabetes, 1995–2025: Prevalence, numerical estimates, and projections
King, H. O. M., Aubert, R. E., & Herman, W. H. (1998) · Diabetes Care · doi:10.2337/diacare.21.9.1414 · Cited by 6,294
Cutaneous Wound Healing
Singer, A. J., & Clark, R. A. F. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411006 · Cited by 6,106
Diabetes, oxidative stress, and antioxidants: A review
Maritim, A. C., Sanders, R. A., & Watkins, J. B. (2003) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.10058 · Cited by 3,167
Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor
Heldin, C., & Westermark, B. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1283 · Cited by 2,521
Peroxynitrite oxidation of sulfhydryls.
Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,492
DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systems
Halliwell, B. B., & Aruoma, O. I. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80347-6 · Cited by 1,537
Advanced glycation endproducts—role in pathology of diabetic complications
Ahmed, N. (2004) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.09.004 · Cited by 1,457
Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.
Edwards, D. R., Murphy, G., Reynolds, J. J., Whitham, S. E., Docherty, A. J., Angel, P., & Heath, J. K. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02449.x · Cited by 1,221
Neutralisation of TGF-β1 and TGF-β2 or exogenous addition of TGF-β3 to cutaneous rat wounds reduces scarring
Shah, M., Foreman, D. M., & Ferguson, M. W. J. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.3.985 · Cited by 1,168

Flagged first, then by citations

Show all 224 references

Research works printed but not linked: 5

Jude EB, 1999, End‐stage complications of diabetic neuropathy, Diabet Rev, 7, 395
10.1002/1520-7560(200009/10)16:1 <::AID-DMRR142>3.0.CO;2-S · DOI
Wierusz‐Wysocka B, 1985, Phagocytosis, bactericidal capacity, and superoxide anion (02–) production by polymorphonuclear neutrophils from patients with diabetes mellitus, Folia Haematol Int Mag Klin Morph Blutforsch, 112, 658
10.1210/jc.74.6.1352 · DOI
Williams DRR., 1994, The Foot in Diabetes, 15

Sorted by citations

Items 201–300 of 631

Intracellular delivery of adenosine triphosphate enhanced healing process in full-thickness skin wounds in diabetic rabbits
Wang, J., Wan, R., Mo, Y., Li, M., Zhang, Q., & Chien, S. (2010) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2009.05.040 · Cited by 44
Diabetic retinopathy: Proteomic approaches to help the differential diagnosis and to understand the underlying molecular mechanisms
Csősz, É., Deák, E., Kalló, G., Csutak, A., & Tőzsér, J. (2016) · Journal of Proteomics · doi:10.1016/j.jprot.2016.06.034 · Cited by 45
Topical insulin accelerates cutaneous wound healing in insulin-resistant diabetic rats.
Yu, T., Gao, M., Yang, P., Pei, Q., Liu, D., Wang, D., Zhang, X., & Liu, Y. (2017) · PubMed Central · Cited by 43
Overview of in situ gelling injectable hydrogels for diabetic wounds
Mude, L., Sanapalli, B. K. R., Vadakkepushpakath, A. N., Singh, S. K., & Karri, V. V. S. R. (2021) · Drug Development Research · doi:10.1002/ddr.21788 · Cited by 43
Amniotic Epithelial Cells Accelerate Diabetic Wound Healing by Modulating Inflammation and Promoting Neovascularization
Zheng, Y., Zheng, S., Fan, X., Li, L., Xiao, Y., Luo, P., Liu, Y., Wang, L., Cui, Z., He, F., et al. (2018) · Stem Cells International · doi:10.1155/2018/1082076 · Cited by 42
Anti-inflammatory and wound healing potential of kirenol in diabetic rats through the suppression of inflammatory markers and matrix metalloproteinase expressions
Ren, J., Yang, M., Chen, J., Ma, S., & Wang, N. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110475 · Cited by 42
A nano phototheranostic approach of toluidine blue conjugated gold silver core shells mediated photodynamic therapy to treat diabetic foot ulcer
Akhtar, F., Khan, A. U., Qazi, B., Kulanthaivel, S., Mishra, P., Akhtar, K., & Ali, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-04008-x · Cited by 44
Oxygen releasing patches based on carbohydrate polymer and protein hydrogels for diabetic wound healing: A review
Mamun, A. A., Ullah, A., Chowdhury, M. E. H., Marei, H. E. S., Madappura, A. P., Hassan, M., Rizwan, M., Gomes, V. G., Amirfazli, A., & Hasan, A. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126174 · Cited by 41
The role of micro RNA ‐15 b in the impaired angiogenesis in diabetic wounds
Xu, J., Zgheib, C., Hu, J., Wu, W., Zhang, L., & Liechty, K. W. (2014) · Wound Repair and Regeneration · doi:10.1111/wrr.12217 · Cited by 41
The Anti-Inflammatory and Antibacterial Action of Nanocrystalline Silver and Manuka Honey on the Molecular Alternation of Diabetic Foot Ulcer: A Comprehensive Literature Review
Tsang, K.-K., Kwong, E. W. Y., Woo, K. Y., To, S. S. T., Chung, J. W. Y., & Wong, T. K.-S. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/218283 · Cited by 40
Higher Biostability of rh-aFGF-Carbomer 940 Hydrogel and Its Effect on Wound Healing in a Diabetic Rat Model
Hui, Q., Zhang, L., Yang, X., Yu, B., Huang, Z., Pang, S., Zhou, Q., Yang, R., Li, W., Hu, L., et al. (2018) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b00011 · Cited by 41
Simvastatin accelerates the healing process of burn wound in Wistar rats through Akt/mTOR signaling pathway
Ramhormozi, P., Ansari, J. M., Simorgh, S., Asgari, H. R., Najafi, M., Barati, M., Babakhani, A., & Nobakht, M. (2020) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2020.151652 · Cited by 40
Immune cell-derived extracellular vesicles for precision therapy of inflammatory-related diseases
Li, S., Li, W., Wu, X., Zhang, B., Liu, L., & Yin, L. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.03.007 · Cited by 41
Tissue‐engineered provisional matrix as a novel approach to enhance diabetic wound healing
Balaji, S., Vaikunth, S. S., Tanadini‐Lang, S., Sheikh, A. Q., Lim, F. Y., Crombleholme, T. M., & Narmoneva, D. A. (2011) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2011.00750.x · Cited by 39
The regenerative potential of fibroblasts in a new diabetes‐induced delayed humanised wound healing model
Martínez‐Santamaría, L., Conti, C. J., Llames, S. G., García, E., Retamosa, L., Holguín, A., Illera, N., Duarte, B., Camblor, L., Llaneza, J. M., et al. (2013) · Experimental Dermatology · doi:10.1111/exd.12097 · Cited by 39
Wound healing effects of dipeptidyl peptidase-4 inhibitors: An emerging concept in management of diabetic foot ulcer—A review
Saboo, A., Rathnayake, A., Vangaveti, V., & Malabu, U. H. (2015) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2015.04.006 · Cited by 39
Immunomodulation at epithelial sites by obesity and metabolic disease
Cheung, K. P., Taylor, K. R., & Jameson, J. (2011) · Immunologic Research · doi:10.1007/s12026-011-8261-7 · Cited by 40
Chronic Wound Dressings Based on Collagen-Mimetic Proteins
Cereceres, S., Touchet, T. J., Browning, M. B., Smith, C., Rivera, J., Höök, M., Whitfield-Cargile, C., Russell, B. H., & Cosgriff‐Hernandez, E. (2015) · Advances in Wound Care · doi:10.1089/wound.2014.0614 · Cited by 39
THE DIABETIC FOOT: ESTABLISHED AND EMERGING TREATMENTS
Παπάνας, Ν., & Maltezos, E. S. (2007) · Acta Clinica Belgica · doi:10.1179/acb.2007.037 · Cited by 39
Association Between Preoperative HbA1c Levels and Complications after Esophagectomy
Okamura, A., Yamamoto, H., Watanabe, M., Miyata, H., Kanaji, S., Kamiya, K., Kakeji, Y., Doki, Y., & Kitagawa, Y. (2020) · Annals of Surgery · doi:10.1097/sla.0000000000004547 · Cited by 38
Regenerative Medicine Approaches for Skin Wound Healing: from Allografts to Engineered Skin Substitutes
Mahajan, N., Söker, S., & Murphy, S. V. (2024) · Current Transplantation Reports · doi:10.1007/s40472-024-00453-5 · Cited by 44
The Biomechanical and Histological Effects of Diabetes on Tendon Healing: Experimental Study in Rats
Egemen, O., Özkaya, Ö., Öztürk, M. B., Şen, E. H., Akan, M., Sakız, D., & Aygıt, C. (2012) · Journal of Hand and Microsurgery · doi:10.1007/s12593-012-0074-y · Cited by 37
Diabetes as a risk factor to cancer: Functional role of fermented papaya preparation as phytonutraceutical adjunct in the treatment of diabetes and cancer
Aruoma, O. I., Somanah, J., Bourdon, E., Rondeau, P., & Bahorun, T. (2014) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2014.04.007 · Cited by 38
Combination Growth Factor Therapy via Electrostatically Assembled Wound Dressings Improves Diabetic Ulcer Healing In Vivo
Almquist, B. D., Castleberry, S. A., Sun, J. B., Lu, A. Y., & Hammond, P. T. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500403 · Cited by 36
Microvesicles enhance the mobility of human diabetic adipose tissue-derived mesenchymal stem cells in vitro and improve wound healing in vivo
Trinh, N., Yamashita, T., Tu, T. C., Kato, T., Ohneda, K., Sato, F., & Ohneda, O. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.04.025 · Cited by 37
Perioperative Management of Patients with Diabetes
Leung, V., & Ragbir-Toolsie, K. (2017) · Health Services Insights · doi:10.1177/1178632917735075 · Cited by 36
Dysregulation of collagen production in diabetes following recurrent skin injury: Contribution to the development of a chronic wound
Caskey, R. C., Zgheib, C., Morris, M., Allukian, M., Dorsett‐Martin, W., Xu, J., Wu, W., & Liechty, K. W. (2014) · Wound Repair and Regeneration · doi:10.1111/wrr.12199 · Cited by 36
Advances in Metal and Metal Oxide Nanomaterials for Topical Antimicrobial Applications: Insights and Future Perspectives
Medić, B. Š., Tomić, N., Lаgopati, N., Gazouli, M., & Pojskić, L. (2024) · Molecules · doi:10.3390/molecules29235551 · Cited by 35
Tissue Engineering-Based Strategies for Diabetic Foot Ulcer Management
Chiu, A., Sharma, D., & Zhao, F. (2021) · Advances in Wound Care · doi:10.1089/wound.2021.0081 · Cited by 34
Larval Therapy and Larval Excretions/Secretions: A Potential Treatment for Biofilm in Chronic Wounds? A Systematic Review
Morris, D., Flores, M., Harris, L. G., Gammon, J., & Nigam, Y. (2023) · Microorganisms · doi:10.3390/microorganisms11020457 · Cited by 34
Heme Oxygenase-1 as Therapeutic Target for Diabetic Foot Ulcers
Leal, E. C., & Carvalho, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231912043 · Cited by 36
The Effect of Captopril on Impaired Wound Healing in Experimental Diabetes
Zandifar, E., Beheshti, S. S., Zandifar, A., & Javanmard, S. H. (2012) · International Journal of Endocrinology · doi:10.1155/2012/785247 · Cited by 34
Assessing the efficacy of curcumin-loaded alginate hydrogel on skin wound healing: A gene expression analysis
Zamani, S., Salehi, M., Ehterami, A., Fauzi, M. B., & Abbaszadeh‐Goudarzi, G. (2024) · Journal of Biomaterials Applications · doi:10.1177/08853282241238581 · Cited by 33
Host–Microbiome Crosstalk in Chronic Wound Healing
Mihai, M. M., Bălăceanu-Gurău, B., Ion, A., Holban, A. M., Gurău, C.-D., Popescu, M. N., Beiu, C., Popa, L. G., Popa, M. I., Dragomirescu, C. C., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094629 · Cited by 36
Low-Magnitude High-Frequency Vibration Accelerated the Foot Wound Healing of n5-streptozotocin-induced Diabetic Rats by Enhancing Glucose Transporter 4 and Blood Microcirculation
Yu, C. O.-L., Leung, K., Jiang, J. L., Wang, T. B.-Y., Chow, S. K., & Cheung, W. (2017) · Scientific Reports · doi:10.1038/s41598-017-11934-2 · Cited by 34
Metal nanoparticles and biomaterials: The multipronged approach for potential diabetic wound therapy
Azlan, A. Y. H. N., Katas, H., Busra, M. F. M., Salleh, N. A. M., & Smandri, A. (2021) · Nanotechnology Reviews · doi:10.1515/ntrev-2021-0046 · Cited by 33
RETRACTED: Cold atmospheric plasma induces the curing mechanism of diabetic wounds by regulating the oxidative stress mediators iNOS and NO, the pyroptotic mediators NLRP-3, Caspase-1 and IL-1β and the angiogenesis mediators VEGF and Ang-1
Badr, G., El-Hossary, F. M., Lashein, F. E.-D. M., Negm, N. Z., Khalaf, M., Salah, M., Sayed, L. H., Abdel-Maksoud, M. A., & Elminshawy, A. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115934 · Cited by 33
Retracted
Contrasting host immuno‐inflammatory responses to bacterial challenge within venous and diabetic ulcers
McInnes, R. L., Cullen, B. M., Hill, K. E., Price, P., Harding, K. G., Thomas, D. W., Stephens, P., & Moseley, R. (2013) · Wound Repair and Regeneration · doi:10.1111/wrr.12133 · Cited by 35
Mechanisms of mesenchymal stem cell correction of the impaired biomechanical properties of diabetic skin: The role of miR‐29a
Zgheib, C., Hodges, M. M., Hu, J., Beason, D. P., Soslowsky, L. J., Liechty, K. W., & Xu, J. (2016) · Wound Repair and Regeneration · doi:10.1111/wrr.12412 · Cited by 33
Orchestration of Macrophage Polarization Dynamics by Fibroblast-Secreted Exosomes during Skin Wound Healing
Chen, C., Yang, J., Shang, R., Tang, Y., Cai, X., Chen, Y., Liu, Z., Hu, W., Zhang, W., Zhang, X., et al. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2024.05.007 · Cited by 34
The effect of Hypericum Perforatum on wound healing of oral mucosa in diabetic rats
Altan, A., Aras, M. H., Damlar, İ., Gökçe, H., Özcan, O., & Alpaslan, C. (2018) · European Oral Research · doi:10.26650/eor.2018.505 · Cited by 31
Targeting the NOD-Like Receptor Pyrin Domain Containing 3 Inflammasome to Improve Healing of Diabetic Wounds
Silva, J. C., & Koh, T. J. (2021) · Advances in Wound Care · doi:10.1089/wound.2021.0148 · Cited by 30
Cell Interactions with Vascular Regenerative MAA‐Based Materials in the Context of Wound Healing
Lisovsky, A., Chamberlain, M. D., Wells, L. A., & Sefton, M. V. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500192 · Cited by 30
Loss of Innervation and Axon Plasticity Accompanies Impaired Diabetic Wound Healing
Cheng, C., Singh, V., Krishnan, A., Kan, M., Martinez, J. A., & Zochodne, D. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075877 · Cited by 30
Vasculoprotective Effects of Combined Endothelial Progenitor Cells and Mesenchymal Stem Cells in Diabetic Wound Care: Their Potential Role in Decreasing Wound-Oxidative Stress
Sukpat, S., Isarasena, N., Wongphoom, J., & Patumraj, S. (2013) · BioMed Research International · doi:10.1155/2013/459196 · Cited by 30
Enhanced healing of full-thickness diabetic wounds using bioactive glass and Yunnan baiyao ointments
Mao, C., Lin, C., & Chen, X. (2014) · Journal of Wuhan University of Technology-Mater Sci Ed · doi:10.1007/s11595-014-1044-y · Cited by 29
The Discovery and Development of Natural-Based Biomaterials with Demonstrated Wound Healing Properties: A Reliable Approach in Clinical Trials
Fadilah, N. I. M., Maarof, M., Motta, A., Tabata, Y., & Fauzi, M. B. (2022) · Biomedicines · doi:10.3390/biomedicines10092226 · Cited by 31
Acceleration of Diabetic Wound Healing by Low-Dose Radiation is Associated with Peripheral Mobilization of Bone Marrow Stem Cells
Guo, W., Wang, G., Wang, P., Chen, Q., Tan, Y., & Cai, L. (2010) · Radiation Research · doi:10.1667/rr1980.1 · Cited by 29
Obesity-Induced Immunological Effects on the Skin
Palanivel, J. A., & Millington, G. W. M. (2023) · Skin Health and Disease · doi:10.1002/ski2.160 · Cited by 30
Effects of pulsed infra-red low level-laser irradiation on mast cells number and degranulation in open skin wound healing of healthy and streptozotocin-induced diabetic rats
Fathabadie, F. F., Bayat, M., Amini, A., Bayat, M., & Rezaie, F. (2013) · Journal of Cosmetic and Laser Therapy · doi:10.3109/14764172.2013.764435 · Cited by 28
Emerging Trends in Curcumin Embedded Electrospun Nanofibers for Impaired Diabetic Wound Healing
Tamilarasi, G. P., Krishnan, M., Sabarees, G., Gouthaman, S., Alagarsamy, V., & Solomon, V. R. (2022) · Applied Nano · doi:10.3390/applnano3040015 · Cited by 29
Postoperative Infections of the Spine
Finn, M. A., & Schmidt, M. H. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-5316-3.00042-3 · Cited by 28
Complement Activation and STAT4 Expression Are Associated with Early Inflammation in Diabetic Wounds
Cunnion, K. M., Krishna, N. K., Pallera, H. K., Piñeros-Fernandez, A., Rivera, M. G., Hair, P. S., Lassiter, B. P., Huyck, R. W., Clements, M. A., Hood, A. F., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170500 · Cited by 28
The Protective Effect of Snail Secretion Filtrate in an Experimental Model of Excisional Wounds in Mice
Gugliandolo, E., Macrì, F., Fusco, R., Siracusa, R., D’Amico, R., Cordaro, M., Peritore, A. F., Impellizzeri, D., Genovese, T., Cuzzocrea, S., et al. (2021) · Veterinary Sciences · doi:10.3390/vetsci8080167 · Cited by 31
Enhancing Cutaneous Wound Healing Based on Human Induced Neural Stem Cell-derived Exosomes
Li, J., Gao, H. Z., Xiong, Y., Wang, L., Zhang, H., He, F., Zhao, J., Liu, S., Gao, L., Guo, Y., et al. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s377502 · Cited by 27
Polylactic Acid/Poly(vinylpyrrolidone) Co-Electrospun Fibrous Membrane as a Tunable Quercetin Delivery Platform for Diabetic Wounds
Cristo, F. D., Valentino, A., Luca, I. D., Peluso, G., Bonadies, I., Salle, A. D., & Calarco, A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030805 · Cited by 27
Comparison of the Therapeutic Effects Recombinant Human Acidic and Basic Fibroblast Growth Factors in Wound Healing in Diabetic Patients
Tan, Y., Xiao, J., Huang, Z., Xiao, Y., Lin, S., Jin, L., Feng, W., Cai, L., & Li, X. (2008) · Eisei kagaku · doi:10.1248/jhs.54.432 · Cited by 27
Acute Primary Actinomycosis Involving the Hard Palate of a Diabetic Patient
de Andrade, A. L. D. L., Novaes, M. M., Germano, A. R., Luz, K. G., Freitas, R. D. A., & Galvão, H. C. (2014) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2013.08.006 · Cited by 27
Bioactivity and multi-omics profiling of purslane-derived nanovesicles with therapeutic implications in diabetic wounds
Song, Y., Wang, F., Xia, J., Zhang, Q., He, K., Wang, L., Zhu, M., Liu, J., Liu, L., & Liu, J. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.10.042 · Cited by 26
Hypoxia impairs mesenchymal stromal cell-induced macrophage M1 to M2 transition
Faulknor, R., Olekson, M. A., Ekwueme, E. C., Krzyszczyk, P., Freeman, J. W., & Francois Berthiaume, B. (2017) · TECHNOLOGY · doi:10.1142/s2339547817500042 · Cited by 26
Patients With Diabetes Mellitus Have a Higher Risk of Tendon Retear After Arthroscopic Rotator Cuff Repair: A Meta-analysis
Hong, C., Chang, C., Kuan, F., Hsu, K., Chen, Y., Chiang, C.-H., & Su, W. (2020) · Orthopaedic Journal of Sports Medicine · doi:10.1177/2325967120961406 · Cited by 26
Polyherbal formulation exerts wound healing, anti-inflammatory, angiogenic and antimicrobial properties: Potential role in the treatment of diabetic foot ulcers
Chumpolphant, S., Suwatronnakorn, M., Issaravanich, S., Tencomnao, T., & Prasansuklab, A. (2022) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2022.103330 · Cited by 26
ROS scavenging activity of polydopamine nanoparticle-loaded supramolecular gelatin-based hydrogel promoted cardiomyocyte proliferation
Zarkesh, I., Movahedi, F., Abandansari, H. S., Pahlavan, S., Soleimani, M., & Baharvand, H. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.129228 · Cited by 26
Linagliptin: from bench to bedside
Doupis, J. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s59523 · Cited by 26
The role of endothelial dysfunction in the pathogenesis of impaired diabetic wound healing: A novel therapeutic target?
Laing, T., Hanson, R. P., Chan, F. C., & Bouchier-Hayes, D. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2007.02.040 · Cited by 26
Kinship care of the abused child: the New Zealand experience.
Worrall, J. (2001) · PubMed · Cited by 26
Does Diabetes Mellitus Affect Tendon Healing?
Ahmed, A. S. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-33943-6_16 · Cited by 26
Fabrication of carboxymethylcellulose hydrogel containing β-cyclodextrin–eugenol inclusion complexes for promoting diabetic wound healing
Li, M., Li, F., Wang, T., Zhao, L., & Shi, Y. (2019) · Journal of Biomaterials Applications · doi:10.1177/0885328219873254 · Cited by 26
Nanotechnology Allied to Nitric Oxide Release Materials for Dermatological Applications
Seabra, A. B., & Durán, N. (2012) · Current Nanoscience · doi:10.2174/157341312801784159 · Cited by 25
Deficiency of liver-derived insulin-like growth factor-I (IGF-I) does not interfere with the skin wound healing rate
Botusan, I. R., Zheng, X., Narayanan, S., Grünler, J., Sunkari, V. G., Calissendorff, F. S., Ansurudeen, I., Illies, C., Svensson, J., Jansson, J., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0193084 · Cited by 25
Selected conditions associated with an increased incidence of incisional hernia: A review of molecular biology
Reilly, M. J., Larsen, N. K., Agrawal, S., Thankam, F. G., Agrawal, D. K., & Fitzgibbons, R. J. (2020) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2020.09.004 · Cited by 25
Nanofibrous insulin/vildagliptin core-shell PLGA scaffold promotes diabetic wound healing
Lee, C., Chen, D., Hsieh, M., Hung, K., Huang, S.-C., Cho, C., & Liu, S. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1075720 · Cited by 25
Sinapic acid-loaded gel accelerates diabetic wound healing process by promoting re-epithelialization and attenuating oxidative stress in rats
Kaltalıoğlu, K. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114788 · Cited by 25
Human umbilical cord mesenchymal stem cells in diabetes mellitus and its complications: applications and research advances
Li, L.-Y., Li, J.-C., Guan, H.-F., Oishi, H., Takahashi, S., & Zhang, C. (2023) · International Journal of Medical Sciences · doi:10.7150/ijms.87472 · Cited by 17
Increased expression of endosomal members of toll‐like receptor family abrogates wound healing in patients with type 2 diabetes mellitus
Singh, K., Agrawal, N. K., Gupta, S., Mohan, G., Chaturvedi, S., & Singh, K. (2015) · International Wound Journal · doi:10.1111/iwj.12411 · Cited by 26
High-Voltage Pulsed Current Stimulation Enhances Wound Healing in Diabetic Rats by Restoring the Expression of Collagen, α-Smooth Muscle Actin, and TGF-β1
Kim, T. H., Cho, H.-Y., & Lee, S. M. (2014) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.234.1 · Cited by 25
Chemokines as Therapeutic Targets to Improve Healing Efficiency of Chronic Wounds
Satish, L. (2014) · Advances in Wound Care · doi:10.1089/wound.2014.0602 · Cited by 27
Wound closure in patients with DFU: a cost-effectiveness analysis of two cellular/tissue-derived products
Gilligan, A. M., Waycaster, C. R., & Landsman, A. L. (2015) · Journal of Wound Care · doi:10.12968/jowc.2015.24.3.149 · Cited by 25
Nesfatin-1 improves oxidative skin injury in normoglycemic or hyperglycemic rats
Solmaz, A., Bahadır, E., Gülçiçek, O. B., Yiğitbaş, H., Çelik, A., Köroğlu, A. K., Özsavcı, D., Şirvancı, S., & Yeğen, B. Ç. (2016) · Peptides · doi:10.1016/j.peptides.2015.12.006 · Cited by 25
Heparan sulfate inhibits inflammation and improves wound healing by downregulating the NLR family pyrin domain containing 3 ( NLRP3 ) inflammasome in diabetic rats
Wang, T., Zhao, J., Zhang, J., Mei, J., Shao, M., Pan, Y., Yang, W., Jiang, Y., Liu, F., & Jia, W. (2017) · Journal of Diabetes · doi:10.1111/1753-0407.12630 · Cited by 26
Phytoecdysteroids-containing extract from Stachys hissarica plant and its wound-healing activity
Ramazanov, N. S., Bobayev, I. D., Yusupova, U. Y., Aliyeva, N. K., Egamova, F. R., Yuldasheva, N. K., & Syrov, V. N. (2017) · Natural Product Research · doi:10.1080/14786419.2016.1205058 · Cited by 24
Sustainable dressings for wound healing
Gupta, M. N., Rangaraju, A., & Ambre, P. (2025) · Biotechnology for Sustainable Materials · doi:10.1186/s44316-024-00023-w · Cited by 27
A Magnetically Responsive Biomaterial System for Flexibly Regulating the Duration between Pro‐ and Anti‐Inflammatory Cytokine Deliveries
Tolouei, A. E., Dülger, N., Ghatee, R., & Kennedy, S. M. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800227 · Cited by 26
Lecithin-based deferoxamine nanoparticles accelerated cutaneous wound healing in diabetic rats
Qayoom, A., Aneesha, V. A., Anagha, S., Dar, J. A., Kumar, P., & Kumar, D. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172478 · Cited by 24
The Anti-inflammatory and Proangiogenic Properties of High-Density Lipoproteins: An Emerging Role in Diabetic Wound Healing
Lotfollahi, Z., Dawson, J. A., Fitridge, R., & Bursill, C. A. (2020) · Advances in Wound Care · doi:10.1089/wound.2020.1308 · Cited by 24
Nod2 deficiency impairs inflammatory and epithelial aspects of the cutaneous wound‐healing response
Campbell, L., Williams, H., Crompton, R. A., Cruickshank, S. M., & Hardman, M. J. (2012) · The Journal of Pathology · doi:10.1002/path.4095 · Cited by 24
Cell motility in models of wounded human skin is improved by Gap27 despite raised glucose, insulin and IGFBP-5
Wright, C., Berends, R. F., Flint, D. J., & Martin, P. E. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.12.013 · Cited by 24
Nanoparticles combined with growth factors: recent progress and applications
Chu, C., Deng, J., Liu, L., Cao, Y., Wei, X., Li, J., & Man, Y. (2016) · RSC Advances · doi:10.1039/c6ra13636b · Cited by 24
The characterization of a full-thickness excision open foot wound model in n5-streptozotocin (STZ)-induced type 2 diabetic rats that mimics diabetic foot ulcer in terms of reduced blood circulation, higher C-reactive protein, elevated inflammation, and reduced cell proliferation
Yu, C. O.-L., Leung, K.-S., Fung, K., Lam, F. F. Y., Ng, E. S.-K., Lau, K.-M., Chow, S. K., & Cheung, W. (2017) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.17-0016 · Cited by 24
Human Fibroblast-Derived Dermal Substitute
Warriner, R. A., & Cardinal, M. (2011) · Advances in Skin & Wound Care · doi:10.1097/01.asw.0000399647.80210.61 · Cited by 24
Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors
Wardecki, T., Werner, P., Thomas, M., Templin, M. F., Schmidt, G., Brandner, J. M., & Merfort, I. (2016) · Journal of Natural Products · doi:10.1021/acs.jnatprod.6b00027 · Cited by 23
Wound Healing Property of Curcuminoids as a Microcapsule-Incorporated Cream
Ang, L., Darwis, Y., Koh, R. Y., Leong, K. V. G., Yew, M. Y., Por, L. Y., & Yam, M. F. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11050205 · Cited by 23
Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases
Lashgari, N., Roudsari, N. M., Zadeh, S. S. T., Momtaz, S., Abbasifard, M., Reiner, Ž., Abdolghaffari, A. H., & Sahebkar, A. (2022) · Inflammopharmacology · doi:10.1007/s10787-022-01077-w · Cited by 23
Understanding Diabetic Wounds: A Review of Mechanisms, Pathophysiology, and Multimodal Management Strategies
Manisha, M., Niharika, Gaur, P. K., Goel, R., Lata, K., & Mishra, R. (2024) · Current Clinical Pharmacology · doi:10.2174/0127724328326480240927065600 · Cited by 23
Pentoxifylline Accelerates Wound Healing Process by Modulating Gene Expression of MMP-1, MMP-3, and TIMP-1 in Normoglycemic Rats
Babaei, S., & Bayat, M. (2015) · Journal of Investigative Surgery · doi:10.3109/08941939.2014.1002642 · Cited by 23
Human α defensins promote the expression of the inflammatory cytokine interleukin‐8 under high‐glucose conditions: Novel insights into the poor healing of diabetic foot ulcers
Meng, L., Guo, X., Yang, X., Liu, H., Yu, M., Wu, Y., & Zhu, Z. (2019) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22351 · Cited by 24
Effect of collagen scaffold with adipose-derived stromal vascular fraction cells on diabetic wound healing: A study in a diabetic porcine model
Jiang, Y., Chen, B., Liu, Y., Zhufu, Z., Yan, X., Hou, X., Dai, J., & Tan, Q. (2013) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-013-0001-8 · Cited by 23
Healing effect of a fibrin-based scaffold loaded with platelet lysate in full-thickness skin wounds
Losi, P., Briganti, E., Sanguinetti, E., Burchielli, S., Kayal, T. A., & Soldani, G. (2015) · Journal of Bioactive and Compatible Polymers · doi:10.1177/0883911514568436 · Cited by 23
Fluorinated methacrylamide chitosan sequesters reactive oxygen species to relieve oxidative stress while delivering oxygen
Patil, P. S., & Leipzig, N. D. (2017) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36079 · Cited by 23
Pharmacological Features and Therapeutic Implications of Plumbagin in Cancer and Metabolic Disorders: A Narrative Review
Sharma, B., Dhiman, C., Hasan, G. M., Shamsi, A., & Hassan, M. I. (2024) · Nutrients · doi:10.3390/nu16173033 · Cited by 24

Authors: Blakytny, R., & Jude, E.
Affiliations: Fachklinik Hornheide (DE)
Tameside Hospital (GB)
Corresponding author: Jude, E.
ORCID: Jude, E.
Venue: Diabetic Medicine
Publisher: Wiley
Published: 2006-02-13
Volume: 23
Issue: 6
Pages: 594-608
ISSN: 0742-3071 (ISSN-L)
1464-5491
DOI: 10.1111/j.1464-5491.2006.01773.x
OpenAlex: W1967162280
Cited by: 632
References: 224
Citations by year: 2026: 13 · 2025: 32 · 2024: 34 · 2023: 50 · 2022: 38 · 2021: 65 · 2020: 41 · 2019: 36 · 2018: 32 · 2017: 38 · 2016: 43 · 2015: 37 · 2014: 40 · 2013: 31 · 2012: 22
FWCI: 2.23
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Diabetic Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
Keywords: chronic wounds, diabetic ulcers, delayed wound healing, diabetes mellitus, molecular mechanisms, lower limb amputation, animal models of diabetes
MeSH terms: Animals, Diabetes Mellitus, Experimental, Extracellular Matrix, Glucose, Humans, Nitric Oxide, Oxidation-Reduction, Skin, Wound Healing, Cytokines, Intercellular Signaling Peptides and Proteins, Diabetes Complications

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The molecular biology of chronic wounds and delayed healing in diabetes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks