Effect of cranberry extracts on lipid profiles in subjects with type 2 diabetes
Abstract
AIM: To examine the effect of cranberry ingestion on lipid profiles in Type 2 diabetic patients taking oral glucose-lowering drugs. METHODS: Thirty Type 2 diabetic subjects (16 males and 14 females; mean age 65 +/- 1 years) who were taking oral glucose-lowering medication regularly were enrolled in this randomized, placebo-controlled, double-blind study. Changes in lipid profiles, oxidized low-density lipoprotein (ox-LDL), glycaemic control, components of the metabolic syndrome, C-reactive protein (CRP) and urinary albumin excretion (UAE) were assessed after cranberry or placebo treatment for 12 weeks. RESULTS: Low-density lipoprotein (LDL) cholesterol decreased significantly in the cranberry group (from 3.3 +/- 0.2 to 2.9 +/- 0.2 mmol/l, P = 0.005) and the decrease was significantly greater than that in the placebo group (-0.4 +/- 0.1 vs. 0.2 +/- 0.1 mmol/l, P < 0.001). Total cholesterol and total : high-density lipoprotein (HDL) cholesterol ratio also decreased significantly (P = 0.020 and 0.044, respectively) in the cranberry group and the reductions were significantly different from those in the placebo group (P < 0.001 and P = 0.032, respectively). However, ox-LDL levels did not change significantly in response to cranberry consumption. Neither fasting glucose nor glycated haemoglobin improved in either group. Changes in components of the metabolic syndrome, UAE and CRP were not significantly different between groups. CONCLUSIONS: Cranberry supplements are effective in reducing atherosclerotic cholesterol profiles, including LDL cholesterol and total cholesterol levels, as well as total : HDL cholesterol ratio, and have a neutral effect on glycaemic control in Type 2 diabetic subjects taking oral glucose-lowering agents.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some clinical studies have found antidiabetic and antihyperlipidemic effects of encapsulated berry supplements.
“Since some clinical studies have also found antidiabetic and antihyperlipidemic effects of encapsulated berry supplements, these forms may be suitable for the management of specific metabolic conditions.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [47]
Cites
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011 · see citing works
The oxidation hypothesis of atherosclerosis
Witztum, J. L. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92346-9 · Cited by 1,394 · see citing works
Epidemiology of coronary heart disease: the Framingham study.
Castelli, W. (1984) · American Journal of Medicine · doi:10.1016/0002-9343(84)90952-5 · Cited by 1,106 · see citing works
Diagnosis and Classification of Diabetes Mellitus
American Diabetes Association (2006) · Diabetes Care · doi:10.2337/diacare.29.s1.06.s43 · Cited by 924 · see citing works
Cranberry and blueberry: Evidence for protective effects against cancer and vascular diseases
Neto, C. C. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600279 · Cited by 460 · see citing works
McPherson, R., Frohlich, J. J., Fodor, G. J., & Genest, J. J. (2006) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(06)70310-5 · Cited by 305 · see citing works
Antioxidant status and lipid peroxidation in type II diabetes mellitus
Memişoğulları, R., Tayşi, S., Bakan, E., et al. (2003) · Cell Biochemistry and Function · doi:10.1002/cbf.1025 · Cited by 204 · see citing works
Cranberry Flavonoids, Atherosclerosis and Cardiovascular Health
Reed, J. D. (2002) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390209351919 · Cited by 180 · see citing works
Kreisberg, R. A. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00848-0 · Cited by 154 · see citing works
Ruel, G., Pomerleau, S., Couture, P., Lamarche, B., & Couillard, C. (2005) · Metabolism · doi:10.1016/j.metabol.2005.01.031 · Cited by 148 · see citing works
Cranberries (Vaccinium macrocarpon) and Cardiovascular Disease Risk Factors
McKay, D. L., & Blumberg, J. B. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00273.x · Cited by 142 · see citing works
Tebib, K., Besançon, P., & Rouanet, J. (1994) · Journal of Nutrition · doi:10.1093/jn/124.12.2451 · Cited by 122 · see citing works
Ruel, G., Pomerleau, S., Couture, P., Lemieux, S., Lamarche, B., & Couillard, C. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061814 · Cited by 122 · see citing works
Vergès, B. L. (1999) · PubMed · Cited by 108 · see citing works
Ruel, G., Pomerleau, S., Couture, P., Lemieux, S., Lamarche, B., & Couillard, C. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114507811986 · Cited by 96 · see citing works
Cranberries inhibit LDL oxidation and induce LDL receptor expression in hepatocytes
Chu, Y., & Liu, R. H. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.04.002 · Cited by 88 · see citing works
Kahlon, T. S., & Smith, G. E. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2005.10.066 · Cited by 82 · see citing works
Can cranberry supplementation benefit adults with type 2 diabetes?
Chambers, B. K., & Camire, M. E. (2003) · Diabetes Care · doi:10.2337/diacare.26.9.2695-a · Cited by 74 · see citing works
Wang, T., Chen, W., Chien, K., Su, S., Hsu, H., Chen, M.-F., Liau, C., & Lee, Y. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01843-4 · Cited by 72 · see citing works
Lee, I., Huang, C., Lee, W., Lee, H., & Sheu, W. H. (2007) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2007.10.002 · Cited by 15 · see citing works
Self-citationLee, I., Lin, T. M., Lee, W., Ou, H., Chien, Y.-H., Lee, W.-L., Tang, Y., Yang, C.-H., & Sheu, W. H. (2005) · Metabolism · doi:10.1016/j.metabol.2005.05.012 · Cited by 8 · see citing works
Self-citationErgüder, İ., Karagenç, N., & Karaca, L. (2006) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Anhê, F. F., Roy, D., Pilon, G., Dudonné, S., Matamoros, S., Varin, T. V., Garofalo, C., Moine, Q., Desjardins, Y., Levy, E., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307142 · Cited by 1,137 · see citing works
Berries: emerging impact on cardiovascular health
Basu, A., Rhone, M., & Lyons, T. J. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00273.x · Cited by 462 · see citing works
“…for 4 weeks Decrease in plasma ox-LDL, adhesion molecules (ICAM, VCAM), and systolic blood pressure following cranberry intervention at 12 or 16 weeks (P < 0.05) Lee et al. (2008)47 Twelve weeks Randomized, placebocontrolled, double-blind study Thirty type 2 diabetic subjects (mean age, 65 ± 1…”
InfluentialStrawberry As a Functional Food: An Evidence-Based Review
Basu, A., Nguyen, A., Betts, N. M., & Lyons, T. J. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.608174 · Cited by 312 · see citing works
Yang, L., Ling, W., Du, Z., Chen, Y., Li, D., Deng, S., Liu, Z., & Yang, L. (2017) · Advances in Nutrition · doi:10.3945/an.116.014852 · Cited by 167 · see citing works
Strawberries, Blueberries, and Cranberries in the Metabolic Syndrome: Clinical Perspectives
Basu, A., & Lyons, T. J. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf203488k · Cited by 116 · see citing works
Zhang, P.-W., Chen, F.-X., Li, D., Ling, W.-H., & Guo, H.-H. (2015) · Medicine · doi:10.1097/md.0000000000000758 · Cited by 116 · see citing works
Kim, K., Vance, T., & Chun, O. (2016) · Nutrients · doi:10.3390/nu8010015 · Cited by 74 · see citing works
- Authors
- Lee, I. T., Chan, Y. C., Lin, C. W., Lee, W. J., & Sheu, W. H.
- Affiliations
- Taichung Veterans General Hospital (TW)
- Providence University (TW)
- National Chung Hsing University (TW)
- Corresponding author
- Sheu, W. H‐H.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 2008-11-27
- Volume
- 25
- Issue
- 12
- Pages
- 1473-1477
- ISSN
- 0742-3071 (ISSN-L)
- 1464-5491
- OpenAlex
- W2064902726
- Cited by
- 150
- References
- 23
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 9 · 2023: 11 · 2022: 10 · 2021: 10 · 2020: 7 · 2019: 7 · 2018: 10 · 2017: 8 · 2016: 13 · 2015: 13 · 2014: 14 · 2013: 10 · 2012: 5
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Taichung Veterans General Hospital
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Keywords
- cranberry extract, type 2 diabetes, lipid profile, LDL cholesterol, total cholesterol, oxidized LDL, glycemic control, HbA1c, metabolic syndrome, C-reactive protein, urinary albumin excretion, oral glucose-lowering agents, dietary supplementation
- MeSH terms
- Aged, Diabetes Mellitus, Type 2, Humans, Male, Phytotherapy, Plant Extracts, Risk Factors, Vaccinium macrocarpon, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
