Have we entered the brown adipose tissue renaissance?
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Summary: In the 1970s and 1980s, it was observed that rodents could offset excess calories ingested when they were fed a human‐like ‘cafeteria diet’. Although it was erroneously concluded that this so‐called diet‐induced thermogenesis was because of brown adipose tissue (BAT), it led to efforts to test whether variations in brown fat in humans may explain the susceptibility to obesity. However, from evidence on the inability of ephedrine or beta‐3 adrenergic agonists to induce BAT thermogenesis, it was concluded that the thermogenic role of BAT was unimportant in adult humans largely because humans had low numbers of brown adipocytes. Solid evidence on the actual numbers of brown adipocytes in humans was not available. We are now re‐evaluating the role of BAT for the treatment of obesity given the following recent observations (i) studies in nuclear medicine by using PET/CT scanning reveal the presence of BAT in adult humans; and (ii) recent data suggest that a new transcription factor called PDRM16 may control the induction of BAT. These recent discoveries should revamp our effort to target the molecular development of brown adipogenesis in the treatment of obesity.
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The identification of functional brown adipose tissue in adult humans has led to a rethinking that BAT may play a role in normal physiology and could be a target for obesity treatment.
“This identification of functional brown adipose tissue in adult humans has led to a rethinking within the medical and scientific communities that BAT may play a role in normal physiology and could be a target for obesity treatment 81,85.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [85]
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Cites
Prevalence and Trends in Obesity Among US Adults, 1999-2008
Flegal, K. M. (2010) · JAMA · doi:10.1001/jama.2009.2014 · Cited by 7,580 · see citing works
Prevalence and trends in obesity among US adults, 1999–2000
Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190 · see citing works
A Potential Decline in Life Expectancy in the United States in the 21st Century
Olshansky, S. J., Passaro, D. J., Hershow, R. C., Layden, J., Carnes, B. A., Brody, J., Hayflick, L., Butler, R. N., Allison, D. B., & Ludwig, D. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmsr043743 · Cited by 2,612 · see citing works
PRDM16 controls a brown fat/skeletal muscle switch
Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347 · see citing works
A Potential Decline in Life Expectancy in the United States in the 21st Century
Olshansky, S. J., Passaro, D. J., Hershow, R. C., Layden, J. E., Carnes, B. A., Brody, J. A., Hayflick, L., Butler, R. N., Allison, D. B., & Ludwig, D. S. (2005) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000167407.83915.e7 · Cited by 1,944 · see citing works
Unexpected evidence for active brown adipose tissue in adult humans
Nedergaard, J., Bengtsson, T., & Cannon, B. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00691.2006 · Cited by 1,824 · see citing works
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
Tseng, Y.-H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., et al. (2008) · Nature · doi:10.1038/nature07221 · Cited by 1,099 · see citing works
Kopecky, J., Clarke, G., Enerbäck, S., Spiegelman, B., & Kozak, L. P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118363 · Cited by 553 · see citing works
Self-citationLong‐Term Safety and Efficacy of Circumferential Ablation with Pulmonary Vein Isolation
Cheema, A., Dong, J., Dalal, D., Vasamreddy, C. R., Marine, J. E., Henrikson, C. A., SPRAGG, D. D., Cheng, A., Nazarian, S., Sinha, S. K., et al. (2006) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2006.00569.x · Cited by 452 · see citing works
Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A
Cummings, D. E., Brandon, E. P., Planas, J. V., Motamed, K., Idzerda, R. L., & McKnight, G. S. (1996) · Nature · doi:10.1038/382622a0 · Cited by 418 · see citing works
Heaton, G. M., Wagenvoord, R. J., Kemp, A., & Nicholls, D. G. (1978) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1978.tb12045.x · Cited by 407 · see citing works
Xue, B., Rim, J.-S., Hogan, J. C., Coulter, A. A., Koza, R. A., & Kozak, L. P. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m600287-jlr200 · Cited by 288 · see citing works
Self-citationRicquier, D., & Kader, J. (1976) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(76)90849-4 · Cited by 269 · see citing works
Ghorbani, M., & Himms‐Hagen, J. (1997) · International Journal of Obesity · doi:10.1038/sj.ijo.0800432 · Cited by 250 · see citing works
Contribution of BAT and skeletal muscle to thermogenesis induced by ephedrine in man
Astrup, A. V., Bülow, J., Madsen, J., & Christensen, N. J. (1985) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1985.248.5.e507 · Cited by 241 · see citing works
Breslau, N. A., Zerwekh, J. E., Nicar, M. J., & Pak, C. Y. C. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-4-803 · Cited by 164 · see citing works
Intense (18)F-FDG uptake in brown fat can be reduced pharmacologically.
Tatsumi, M., Engles, J. M., Ishimori, T., Nicely, O., Cohade, C., & Wahl, R. L. (2004) · PubMed · Cited by 162 · see citing works
Ephedrine-Induced Thermogenesis in Man: No Role for Interscapular Brown Adipose Tissue
Astrup, A. V., Bülow, J., Christensen, N. J., & Madsen, J. (1984) · Clinical Science · doi:10.1042/cs0660179 · Cited by 88 · see citing works
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Cellular bioenergetics as a target for obesity therapy
Tseng, Y.-H., Cypess, A. M., & Kahn, C. R. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3138 · Cited by 591 · see citing works
Brown adipose tissue: Development, metabolism and beyond
Schulz, T. J., & Tseng, Y.-H. (2013) · Biochemical Journal · doi:10.1042/bj20130457 · Cited by 173 · see citing works
Brown Adipose Tissue: Mechanisms and Potential Therapeutic Targets
Tam, C. S., Lecoultre, V., & Ravussin, E. (2012) · Circulation · doi:10.1161/circulationaha.111.042929 · Cited by 116 · see citing works
Self-citationThyroid Hormone Signaling and Homeostasis During Aging
Bowers, J., Terrien, J., Clerget-Froidevaux, M. S., Gothié, J. D., Rozing, M. P., Westendorp, R. G. J., van Heemst, D., & Demeneix, B. A. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1056 · Cited by 117 · see citing works
- Authors
- Ravussin, E., & Kozak, L. P.
- Affiliations
- Pennington Biomedical Research Center (US)
- ORCID
- Kozak, L. P.
- Venue
- Obesity Reviews
- Publisher
- Wiley
- Published
- 2009-04-24
- Volume
- 10
- Issue
- 3
- Pages
- 265-268
- ISSN
- 1467-7881 (ISSN-L)
- 1467-789X
- PMC
- PMC3960797
- OpenAlex
- W2131231952
- Cited by
- 65
- References
- 18
- Citations by year
- 2021: 3 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 5 · 2015: 4 · 2014: 1 · 2013: 12 · 2012: 8
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Obesity Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK072476)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- brown adipose tissue, thermogenesis, obesity, brown adipocytes, cafeteria diet, diet-induced thermogenesis, ephedrine, beta3-adrenergic agonists, brown adipogenesis, obesity treatment
- MeSH terms
- Animals, Adipose Tissue, Brown, Humans, Obesity, Transcription Factors, Adipogenesis
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