The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism, obesity and diabetes

Obesity as a medical problem

Kopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795 · see citing works

The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

Weyer, C., Bogardus, C., Mott, D. M., & Pratley, R. E. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7231 · Cited by 1,940 · see citing works

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

Fleury, C., Neverova, M., Collins, S., Raimbault, S., Champigny, O., Lévi-Meyrueis, C., Bouillaud, F., Seldin, M. F., Surwit, R. S., Ricquier, D., et al. (1997) · Nature Genetics · doi:10.1038/ng0397-269 · Cited by 1,630 · see citing works

The Human Obesity Gene Map: The 2005 Update

Rankinen, T., Zuberi, A., Chagnon, Y. C., Weisnagel, S. J., Argyropoulos, G., Walts, B., Pérusse, L., & Bouchard, C. (2006) · Obesity · doi:10.1038/oby.2006.71 · Cited by 1,119 · see citing works

Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins

Brand, M. D., Affourtit, C., Esteves, T. C., Green, K., Lambert, A. J., Miwa, S., Pakay, J. L., & Parker, N. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.034 · Cited by 1,032 · see citing works

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β-cell dysfunction, and type 2 diabetes.

Zhang, C.-Y., Baffy, G., Perret, P., Krauss, S., Peroni, O., Grujic, D., Hagen, T., Vidal-Puig, A. J., Boss, O., Kim, Y.-B., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00378-6 · Cited by 917 · see citing works

Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3

Brand, M. D., & Esteves, T. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.002 · Cited by 785 · see citing works

Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

Clapham, J. C., Arch, J. R. S., Chapman, H., Haynes, A., Lister, C., Moore, G. B. T., Piercy, V., Carter, S. A., Lehner, I., Smith, S. A., et al. (2000) · Nature · doi:10.1038/35019082 · Cited by 604 · see citing works

A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans

Esterbauer, H., Schneitler, C., Oberkofler, H., Ebenbichler, C. F., Paulweber, B., Sandhofer, F., Ladurner, G., Hell, E., Strosberg, A. D., Patsch, J. R., et al. (2001) · Nature Genetics · doi:10.1038/88911 · Cited by 359 · see citing works

Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians

Walder, K. R. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.9.1431 · Cited by 293 · see citing works

Contribution of BAT and skeletal muscle to thermogenesis induced by ephedrine in man

Astrup, A. V., Bülow, J., Madsen, J., & Christensen, N. J. (1985) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1985.248.5.e507 · Cited by 241 · see citing works

Invited Review: Uncoupling proteins and thermoregulation

Argyropoulos, G., & Harper, M. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00994.2001 · Cited by 231 · see citing works

Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes

Dalgaard, L. T., & Pedersen, O. B. (2001) · Diabetologia · doi:10.1007/s001250100596 · Cited by 217 · see citing works

Uncoupling protein gene: quantification of expression levels in adipose tissues of obese and non-obese humans

Oberkofler, H., Dallinger, G., Liu, Y. M., Hell, E., Krempler, F., & Patsch, W. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37142-x · Cited by 191 · see citing works

DNA polymorphism in the uncoupling protein (UCP) gene and human body fat.

Oppert, J., Vohl, M., Chagnon, M., Dionne, F. T., Cassard, A., Ricquier, D., Përusse, L., & Bouchard, C. (1994) · PubMed · Cited by 185 · see citing works

A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans.

Krempler, F., Esterbauer, H., Weitgasser, R., Ebenbichler, C., Patsch, J., Miller, K., Xie, M., Linnemayr, V., Oberkofler, H., & Patsch, W. (2002) · Diabetes · doi:10.2337/diabetes.51.11.3331 · Cited by 178 · see citing works

The Human Uncoupling Protein-3 Gene

Solanes, G., Vidal‐Puig, A., Grujić, D., Flier, J. S., & Lowell, B. B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25433 · Cited by 172 · see citing works

Influences of genes and shared family environment on adult body mass index assessed in an adoption study by a comprehensive path model.

Vogler, G. P., Sørensen, T. I. A., Stunkard, A. J., Srinivasan, M. R., & Rao, D. C. (1995) · PubMed · Cited by 168 · see citing works

A genetic variation in the 5 ′ flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity

Otabe, S., Clément, K., Christian Dina, C., Pelloux, V., Guy-grand, B., Froguel, P., & Vasseur, F. (2000) · Diabetologia · doi:10.1007/s001250050037 · Cited by 161 · see citing works

Heritability of Pancreatic -Cell Function among Nondiabetic Members of Caucasian Familial Type 2 Diabetic Kindreds

Elbein, S. C., Hasstedt, S. J., Wegner, K., & Kahn, S. E. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.4.5604 · Cited by 150 · see citing works

Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion

Wang, H., Chu, W. S., Lu, T., Hasstedt, S. J., Kern, P. A., & Elbein, S. C. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00231.2003 · Cited by 146 · see citing works

A Common Polymorphism in the Promoter of UCP2 Contributes to the Variation in Insulin Secretion in Glucose-Tolerant Subjects

Sesti, G., Cardellini, M., Marini, M. A., Frontoni, S., D’Adamo, M., Guerra, S. D., Lauro, D., de Nicolais, P., Sbraccia, P., Prato, S. D., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.5.1280 · Cited by 131 · see citing works

The association between the val/ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency

Buemann, B., Schierning, B., Toubro, S., Bibby, B. M., Sørensen, T. I. A., Dalgaard, L. T., Pedersen, O. B., & Astrup, A. V. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801564 · Cited by 131 · see citing works

The Role of Energy Expenditure in Energy Regulation: Findings from a Decade of Research

Saltzman, E. J., & Roberts, S. B. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1995.tb01554.x · Cited by 122 · see citing works

A novel polymorphism in the proximal UCP3 promoter region: effect on skeletal muscle UCP3 mRNA expression and obesity in male non-diabetic Pima Indians

Schrauwen, P., Xia, J., Walder, K. R., Snitker, S., & Ravussin, É. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0801057 · Cited by 117 · see citing works

Uncoupling Protein—A Useful Energy Dissepator

Klingenberg, M. (1999) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1005440221914 · Cited by 116 · see citing works

Impact of the v/v 55 polymorphism of the uncoupling protein 2 gene on 24‐h energy expenditure and substrate oxidation

Astrup, A. V., Toubro, S., Dalgaard, L. T., Urhammer, S., Ti, S., & Pedersen, O. B. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0801040 · Cited by 112 · see citing works

An uncoupling protein 2 gene variant is associated with a raised body mass index but not Type II diabetes

Cassell, P. G., Neverova, M., Janmohamed, S. G., Uwakwe, N., Qureshi, A., McCarthy, M. I., Saker, P. J., Albon, L., Kopelman, P., Noonan, K., et al. (1999) · Diabetologia · doi:10.1007/s001250051216 · Cited by 109 · see citing works

Racial differences in the relation between uncoupling protein genes and resting energy expenditure

Kimm, S. Y. S., Glynn, N. W., Aston, C. E., Damcott, C., Poehlman, É. T., Daniels, S. R., & Ferrell, R. E. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.4.714 · Cited by 105 · see citing works

The −866A/A Genotype in the Promoter of the Human Uncoupling Protein 2 Gene Is Associated With Insulin Resistance and Increased Risk of Type 2 Diabetes

D’Adamo, M., Perego, L., Cardellini, M., Marini, M. A., Frontoni, S., Andreozzi, F., Sciacqua, A., Lauro, D., Sbraccia, P., Federici, M., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.7.1905 · Cited by 102 · see citing works

Uncoupling Protein 2 Promoter Polymorphism −866G/A Affects Its Expression in β-Cells and Modulates Clinical Profiles of Japanese Type 2 Diabetic Patients

Sasahara, M., Nishi, M., Kawashima, H., Ueda, K., Sakagashira, S., Furuta, H., Matsumoto, E., Hanabusa, T., Sasaki, H., & Nanjo, K. (2004) · Diabetes · doi:10.2337/diabetes.53.2.482 · Cited by 101 · see citing works

Uncoupling protein-2: evidence for its function as a metabolic regulator

Saleh, M. C., Wheeler, M. B., & Chan, C. B. (2002) · Diabetologia · doi:10.1007/s00125-001-0737-x · Cited by 99 · see citing works

Human Uncoupling Protein‐3 and Obesity: An Update

Hesselink, M. K. C., Mensink, M., & Schrauwen, P. (2003) · Obesity Research · doi:10.1038/oby.2003.192 · Cited by 85 · see citing works

The Common −866G/A Polymorphism in the Promoter Region of the UCP-2 Gene Is Associated with Reduced Risk of Type 2 Diabetes in Caucasians from Italy

Bulotta, A., Ludovico, O., Coco, A., Paola, R. D., Quattrone, A., Carella, M., Pellegrini, F., Prudente, S., & Trischitta, V. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1072 · Cited by 79 · see citing works

An uncoupling protein 3 gene polymorphism associated with a lower risk of developing Type II diabetes and with atherogenic lipid profile in a French cohort

Meirhaeghe, A., Amouyel, P., Helbecque, N., Cottel, D., Otabe, S., Froguel, P., & Vasseur, F. (2000) · Diabetologia · doi:10.1007/s001250051549 · Cited by 76 · see citing works

Fat tissue accumulation during peritoneal dialysis is associated with a polymorphism in uncoupling protein 2

Nordfors, L., Heimbürger, O., Lönnqvist, F., Lindholm, B., Helmrich, J., Schalling, M., & Stenvinkel, P. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00016.x · Cited by 74 · see citing works

Variation in the UCP2-UCP3 Gene Cluster Predicts the Development of Type 2 Diabetes in Healthy Middle-Aged Men

Gable, D. R., Stephens, J. W., Cooper, J. A., Miller, G. J., & Humphries, S. E. (2006) · Diabetes · doi:10.2337/db05-1645 · Cited by 74 · see citing works

Frequency of and interaction between polymorphisms in the β3-adrenergic receptor and in uncoupling proteins 1 and 2 and obesity in Germans

Evans, D., Minouchehr, S., Hagemann, G., Mann, W., Wendt, D., Wolf, A. M., & Beisiegel†, U. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801402 · Cited by 73 · see citing works

Association of a common polymorphism in the promoter of UCP2 with susceptibility to multiple sclerosis

Vogler, S., Goedde, R., Miterski, B., Gold, R., Kroner, A., Koczan, D., Zettl, U. K., Rieckmann, P., Epplen, J. T., & Ibrahim, S. M. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0661-5 · Cited by 72 · see citing works

Functional Polymorphisms of UCP2 and UCP3 Are Associated With a Reduced Prevalence of Diabetic Neuropathy in Patients With Type 1 Diabetes

Rudofsky, G., Schroedter, A., Schlotterer, A., Voronko, O. E., Schlimme, M., Tafel, J., Isermann, B., Humpert, P. M., Morcos, M., Bierhaus, A., et al. (2006) · Diabetes Care · doi:10.2337/diacare.29.01.06.dc05-0757 · Cited by 70 · see citing works

Sex and age specific assessment of genetic and environmental influences on body mass index in twins.

Herskind, A. M., McGue, M., Sørensen, T. I. A., & Harvald, B. (1996) · PubMed · Cited by 69 · see citing works

Association between obesity and insulin resistance with UCP2–UCP3 gene variants in Spanish children and adolescents

Ochoa, M. C., Santos, J. L., Azcona, C., Moreno-Aliaga, M. J., Martínez‐González, M. Á., Martínez, J. A., & Martí, A. (2007) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2007.07.011 · Cited by 66 · see citing works

Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population

Halsall, D., Luan, J., Saker, P. J., Huxtable, S. J., Farooqi, I. S., Keogh, J. M., Wareham, N. J., & O’Rahilly, S. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801584 · Cited by 66 · see citing works

Ala55Val Polymorphism on UCP2 Gene Predicts Greater Weight Loss in Morbidly Obese Patients Undergoing Gastric Banding

Chen, H., Lee, W., Wang, W., Huang, M., Lee, Y.-C., & Pan, W. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9171-6 · Cited by 60 · see citing works

Linkage and association analyses of the UCP3 gene with obesity phenotypes in Caucasian families

Liu, Y., Liu, P.-Y., Long, J., Lü, Y., Elze, L., Recker, R. R., & Deng, H. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00031.2005 · Cited by 60 · see citing works

The Common −866 G/A Polymorphism in the Promoter of Uncoupling Protein 2 Is Associated With Increased Carbohydrate and Decreased Lipid Oxidation in Juvenile Obesity

Fur, S. L., Stunff, C. L., Santos, C. D., & Bougneres, P. F. (2004) · Diabetes · doi:10.2337/diabetes.53.1.235 · Cited by 60 · see citing works

Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio

Herrmann, S.-M., Wang, J., Staessen, J. A., Kertmen, E., Schmidt‐Petersen, K., Zidek, W., Paul, M., & Brand, E. (2003) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0431-1 · Cited by 59 · see citing works

Mutational Analysis of the UCP2 Core Promoter and Relationships of Variants with Obesity

Dalgaard, L. T., Andersen, G., Larsen, L. H., Sørensen, T. I. A., Andersen, T., Drivsholm, T., Borch‐Johnsen, K., Fleckner, J., Hansen, T. F., Din, N., et al. (2003) · Obesity Research · doi:10.1038/oby.2003.191 · Cited by 54 · see citing works

Uncoupling Protein 2 Promoter Polymorphism −866G/A, Central Adiposity, and Metabolic Syndrome in Asians

Shen, H., Qi, L., Tai, E. S., Chew, S. K., Tan, C. E., & Ordovás, J. M. (2006) · Obesity · doi:10.1038/oby.2006.74 · Cited by 47 · see citing works

The Common −866G>A Variant in the Promoter of UCP2 Is Associated With Decreased Risk of Coronary Artery Disease in Type 2 Diabetic Men

Cheurfa, N., Dubois‐Laforgue, D., Ferrarezi, D. A. F., Reis, A. F., Brenner, G. M., Bouché, C., Feuvre, C. L., Fumeron, F., Timsit, J., Marre, M., et al. (2008) · Diabetes · doi:10.2337/db07-1292 · Cited by 47 · see citing works

Effects of genetic polymorphisms of UCP2 and UCP3 on very low calorie diet-induced body fat reduction in Korean female subjects

Yoon, Y., Park, B. L., Ho, M., Kim, K. S., Cheong, H. S., Choi, Y. H., & Shin, H. D. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.05.110 · Cited by 46 · see citing works

The Uncoupling Protein 2 Ala55Val Polymorphism Is Associated with Diabetes Mellitus: The CARDIA Study

Yu, X., Jacobs, D. R., Schreiner, P. J., Gross, M. D., Steffes, M. W., & Fornage, M. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2004.044859 · Cited by 46 · see citing works

Interactions between physical activity and variants of the genes encoding uncoupling proteins −2 and −3 in relation to body weight changes during a 10-y follow-up

Berentzen, T. L., Dalgaard, L. T., Petersen, L. V., Pedersen, O. B., & Sørensen, T. I. A. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802841 · Cited by 45 · see citing works

Higher obesity risk associated with the exon-8 insertion of the UCP2 gene in a Spanish case-control study

Martí, A., Corbalán, M. S., Luis Forga, L., Martínez‐González, M. Á., & Martínez, J. A. (2004) · Nutrition · doi:10.1016/j.nut.2004.03.019 · Cited by 42 · see citing works

Association of UCP3 Gene –55C>T Polymorphism and Obesity in a Spanish Population

Alonso, Á., Martí, A., Corbalán, M. S., Martínez‐González, M. Á., Forga, L., & Martínez, J. A. (2005) · Annals of Nutrition and Metabolism · doi:10.1159/000086883 · Cited by 42 · see citing works

A polymorphism in the promoter of UCP2 gene modulates lipid levels in patients with type 2 diabetes

Reis, A. F., Dubois‐Laforgue, D., Bellanné‐Chantelot, C., Timsit, J., & Velho, G. (2004) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2004.06.008 · Cited by 41 · see citing works

Genetic Variants in the UCP2-UCP3 Gene Cluster and Risk of Diabetes in the Women's Health Initiative Observational Study

Hsu, Y., Niu, T., Song, Y., Tinker, L. F., Kuller, L. H., & Liu, S. (2008) · Diabetes · doi:10.2337/db07-1269 · Cited by 40 · see citing works

Association of the ins/del polymorphisms of uncoupling protein 2 (UCP2) with BMI in a Korean population

Lee, Y. H., Kim, W. B., Yu, B. C., Park, B. L., Kim, L. H., & Shin, H. D. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.04.144 · Cited by 37 · see citing works

Changes in fat mass after initiation of maintenance dialysis is influenced by the uncoupling protein 2 exon 8 insertion/deletion polymorphism

Wang, X., Axelsson, J., Nordfors, L., Qureshi, A. R., Avesani, C. M., Barany, P. F., Schalling, M., Heimbürger, O., Lindholm, B., & Stenvinkel, P. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl504 · Cited by 34 · see citing works

Role of UCP2 and UCP3 in nutrition and obesity

Nagy, T. R., Blaylock, M. L., & Garvey, W. T. (2003) · Nutrition · doi:10.1016/j.nut.2003.09.024 · Cited by 34 · see citing works

The common −55 C/T polymorphism in the promoter region of the uncoupling protein 3 gene reduces prevalence of obesity and elevates serum high-density lipoprotein cholesterol levels in the general Japanese population

Hamada, T., Kotani, K., Fujiwara, S., Sano, Y., Domichi, M., Tsuzaki, K., & Sakane, N. (2008) · Metabolism · doi:10.1016/j.metabol.2007.10.019 · Cited by 32 · see citing works

Putative role of polymorphisms in UCP1-3 genes for diabetic nephropathy

Lindholm, E., Klannemark, M., Agardh, E., Groop, L., & Agardh, C. (2004) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(03)00019-9 · Cited by 31 · see citing works

Uncoupling Protein 2 Promoter Polymorphism −866G/A Affects Peripheral Nerve Dysfunction in Japanese Type 2 Diabetic Patients

Yamasaki, H., Sasaki, H., Ogawa, K., Shono, T., Tamura, S., Doi, A., Sasahara, M., Kawashima, H., Nakao, T., Furuta, H., et al. (2006) · Diabetes Care · doi:10.2337/diacare.29.04.06.dc05-1984 · Cited by 30 · see citing works

Interaction between the uncoupling protein 2 −866G>A gene variant and cigarette smoking to increase oxidative stress in subjects with diabetes

Stephens, J. W., Dhamrait, S. S., Mani, A. R., Acharya, J., Moore, K. P., Hurel, S. J., & Humphries, S. E. (2007) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.01.010 · Cited by 17 · see citing works

Uncoupling protein-2/uncoupling protein-3 gene polymorphism is not associated with anorexia nervosa

Ando, T., Kodama, N., Ishikawa, T., Naruo, T., Tachikawa, N., Nozaki, T., Okabe, K., Takeuchi, K., Masuda, A., Kawamura, N., et al. (2004) · Psychiatric Genetics · doi:10.1097/00041444-200412000-00009 · Cited by 11 · see citing works

Is UCP2 Gene Polymorphism Associated With Decreased Resting Energy Expenditure in Nondialyzed Chronic Kidney Disease Patients?

Avesani, C. M., Kamimura, M. A., Utaka, S., Pecoits‐Filho, R., Nordfors, L., Stenvinkel, P., Lindholm, B., Draibe, S. A., & Cuppari, L. (2008) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2008.08.009 · Cited by 10 · see citing works

Mitochondrial uncoupling, ROS generation and cardioprotection

Cadenas, S. (2018) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2018.05.019 · Cited by 591 · see citing works

Oxidative stress and inflammation interactions in human obesity

Bondia‐Pons, I., Ryan, L., & Martínez, J. A. (2012) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-012-0154-2 · Cited by 415 · see citing works

Recent Progress Toward Hydrogen Medicine: Potential of Molecular Hydrogen for Preventive and Therapeutic Applications

Ohta, S. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211797052664 · Cited by 299 · see citing works

The Metabolic Basis of Pulmonary Arterial Hypertension

Sutendra, G., & Michelakis, E. D. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.004 · Cited by 269 · see citing works

Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism

Diano, S., & Horváth, T. L. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.08.003 · Cited by 216 · see citing works

Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases

Ohta, S. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.05.006 · Cited by 202 · see citing works

Mitochondrial metabolism in pulmonary hypertension: beyond mountains there are mountains

Culley, M. K., & Chan, S. Y. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120847 · Cited by 178 · see citing works

Astaxanthin-Rich Extract from the Green Alga Haematococcus pluvialis Lowers Plasma Lipid Concentrations and Enhances Antioxidant Defense in Apolipoprotein E Knockout Mice

Yang, Y. J., Seo, J. M., Nguyen, A. T. H., Pham, T. X., Park, H. J., Park, Y., Kim, B., Bruno, R. S., & Lee, J. (2011) · Journal of Nutrition · doi:10.3945/jn.111.142109 · Cited by 159 · see citing works

Solute Carrier Transporters as Potential Targets for the Treatment of Metabolic Disease

Schumann, T., König, J., Henke, C., Willmes, D. M., Bornstein, S. R., Jordan, J., Fromm, M. F., & Birkenfeld, A. L. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015735 · Cited by 152 · see citing works

Uncoupling Protein 2 Deficiency Mimics the Effects of Hypoxia and Endoplasmic Reticulum Stress on Mitochondria and Triggers Pseudohypoxic Pulmonary Vascular Remodeling and Pulmonary Hypertension

Dromparis, P., Paulin, R., Sutendra, G., Qi, A. C., Bonnet, S., & Michelakis, E. D. (2013) · Circulation Research · doi:10.1161/circresaha.112.300699 · Cited by 143 · see citing works

Meta-Analysis Reveals the Association of Common Variants in the Uncoupling Protein (UCP) 1–3 Genes with Body Mass Index Variability

Brondani, L. D. A., Assmann, T. S., de Souza, B. M., Bouças, A. P., Canani, L. H. S., & Crispim, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096411 · Cited by 139 · see citing works

Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart

Akhmedov, A. T., Rybin, V. O., & Marı́n-Garcı́a, J. (2014) · Heart Failure Reviews · doi:10.1007/s10741-014-9457-4 · Cited by 125 · see citing works

Mitochondrial UCP2 in the central regulation of metabolism

Toda, C., & Diano, S. (2014) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2014.02.006 · Cited by 126 · see citing works

The Role of Uncoupling Proteins in Diabetes Mellitus

Liu, J., Li, J., Li, W., & Wang, C. (2013) · Journal of Diabetes Research · doi:10.1155/2013/585897 · Cited by 107 · see citing works

Important Trends in UCP3 Investigation

Pohl, E. E., Rupprecht, A., Macher, G., & Hilse, K. E. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00470 · Cited by 102 · see citing works

Polyphenol-rich blackcurrant extract prevents inflammation in diet-induced obese mice

Benn, T., Kim, B., Park, Y., Wegner, C., Harness, E., Nam, T. G., Kim, D., Lee, J. S., & Lee, J.-Y. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.05.008 · Cited by 90 · see citing works

The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications

de Souza, B. M., Assmann, T. S., Kliemann, L. M., Gross, J. L., Canani, L. H. S., & Crispim, D. (2011) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302011000400001 · Cited by 86 · see citing works

Obesity is associated with a decrease in expression but not with the hypermethylation of thermogenesis-related genes in adipose tissues

Kuryłowicz, A., Jonas, M. I., Lisik, W., Jonas, M., Wicik, Z., Wierzbicki, Z., Chmura, A., & Puzianowska‐Kuźnicka, M. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0395-2 · Cited by 86 · see citing works

Genetic background in nonalcoholic fatty liver disease: A comprehensive review

Macaluso, F. S. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i39.11088 · Cited by 81 · see citing works

Pulmonary Arterial Hypertension: Challenges in Translational Research and a Vision for Change

Sutendra, G., & Michelakis, E. D. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005428 · Cited by 78 · see citing works

Associations between UCP1 -3826A/G, UCP2 -866G/A, Ala55Val and Ins/Del, and UCP3 -55C/T Polymorphisms and Susceptibility to Type 2 Diabetes Mellitus: Case-Control Study and Meta-Analysis

de Souza, B. M., Brondani, L. D. A., Bouças, A. P., Sortica, D. A., Kramer, C. K., Canani, L. H. S., Leitão, C. B., & Crispim, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054259 · Cited by 72 · see citing works

Further Support to the Uncoupling-to-Survive Theory: The Genetic Variation of Human UCP Genes Is Associated with Longevity

Rose, G., Crocco, P., Rango, F. D., Montesanto, A., & Passarino, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029650 · Cited by 68 · see citing works

Population Genetic Analysis of the Uncoupling Proteins Supports a Role for UCP3 in Human Cold Resistance

Hancock, A. M., Clark, V. J., Qian, Y., & Rienzo, A. D. (2010) · Molecular Biology and Evolution · doi:10.1093/molbev/msq228 · Cited by 66 · see citing works

Oleoylethanolamide supplementation in obese patients newly diagnosed with non-alcoholic fatty liver disease: Effects on metabolic parameters, anthropometric indices, and expression of PPAR-α, UCP1, and UCP2 genes

Tutunchi, H., Ostadrahimi, A., Saghafi‐Asl, M., Hosseinzadeh‐Attar, M. J., Shakeri, A., Jafarabadi, M. A., Roshanravan, N., Farrin, N., Naemi, M., & Hasankhani, M. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104770 · Cited by 60 · see citing works

Genetic Variance inUncoupling Protein 2in Relation to Obesity, Type 2 Diabetes, and Related Metabolic Traits: Focus on the Functional −866G>A Promoter Variant (rs659366)

Dalgaard, L. T. (2011) · Journal of Obesity · doi:10.1155/2011/340241 · Cited by 57 · see citing works

Emerging Metabolic Therapies in Pulmonary Arterial Hypertension

Harvey, L. D., & Chan, S. Y. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6040043 · Cited by 56 · see citing works

Mitochondrial ion transport pathways: Role in metabolic diseases

Cardoso, A. R., Queliconi, B. B., & Kowaltowski, A. J. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.12.017 · Cited by 54 · see citing works

Uncoupling protein 3 expression levels influence insulin sensitivity, fatty acid oxidation, and related signaling pathways

Senese, R., Valli, V., Moreno, M., Lombardi, A., Busiello, R. A., Cioffi, F., Silvestri, E., Goglia, F., Lanni, A., & de Lange, P. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0892-3 · Cited by 52 · see citing works

Identification of key genes affecting porcine fat deposition based on co-expression network analysis of weighted genes

Xing, K., Liu, H., Zhang, F., Liu, Y., Shi, Y., Ding, X., & Wang, C. (2021) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-021-00616-9 · Cited by 52 · see citing works

The intestinal microbiome associated with lipid metabolism and obesity in humans and animals

Jian, Z., Zeng, L., Xu, T., Sun, S., Yan, S., Zhao, S., Su, Z., Ge, C., Zhang, Y., Jia, J., et al. (2022) · Journal of Applied Microbiology · doi:10.1111/jam.15740 · Cited by 53 · see citing works

mRNA m6A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes

Wang, X., Sun, B., Jiang, Q. L., Wu, R., Cai, M., Yao, Y., Liu, Q., Shi, H., Feng, J., & Wang, Y. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0027-z · Cited by 51 · see citing works

Association of the UCP polymorphisms with susceptibility to obesity: case–control study and meta-analysis

Brondani, L. D. A., de Souza, B. M., Assmann, T. S., Bouças, A. P., Bauer, A. C., Canani, L. H. S., & Crispim, D. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3371-7 · Cited by 48 · see citing works

The UCP 2 ‐866 G>A promoter region polymorphism is associated with nonalcoholic steatohepatitis.

Fares, R., Petta, S., Lombardi, R., Grimaudo, S., Dongiovanni, P., Pipitone, R. M., Rametta, R., Fracanzani, A. L., Mozzi, E., Craxı̀, A., et al. (2014) · Liver International · doi:10.1111/liv.12707 · Cited by 45 · see citing works

Vitamin D3/VDR resists diet-induced obesity by modulating UCP3 expression in muscles

Fan, Y., Futawaka, K., Koyama, R., Fukuda, Y., Hayashi, M., Imamoto, M., Miyawaki, T., Kasahara, M., Tagami, T., & Moriyama, K. (2016) · Journal of Biomedical Science · doi:10.1186/s12929-016-0271-2 · Cited by 44 · see citing works

Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review

Theodorakis, N., Kreouzi, M., Pappas, A., & Nikolaou, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413438 · Cited by 43 · see citing works

Inactivation of adipose angiotensinogen reduces adipose tissue macrophages and increases metabolic activity

LeMieux, M. J., Ramalingam, L., Mynatt, R. L., Kalupahana, N. S., Kim, H. J., & Moustaïd‐Moussa, N. (2015) · Obesity · doi:10.1002/oby.21352 · Cited by 41 · see citing works

UCP2 −866G/A and Ala55Val, and UCP3 −55C/T polymorphisms in association with type 2 diabetes susceptibility: a meta-analysis study

Xu, K., Zhang, M., Cui, D., Fu, Y., Qian, L., Gu, R., Wang, M., Shen, C., Yu, R., & Yang, T. (2011) · Diabetologia · doi:10.1007/s00125-011-2245-y · Cited by 40 · see citing works

Polyphenol-rich blackcurrant extract exerts hypocholesterolaemic and hypoglycaemic effects in mice fed a diet containing high fat and cholesterol

Benn, T., Kim, B., Park, Y., Yang, Y. J., Pham, T. X., Ku, C. S., Farruggia, C., Harness, E., Smyth, J. A., & Lee, J. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515001105 · Cited by 39 · see citing works

The Slo(w) path to identifying the mitochondrial channels responsible for ischemic protection

Smith, C. O., Nehrke, K. W., & Brookes, P. S. (2017) · Biochemical Journal · doi:10.1042/bcj20160623 · Cited by 37 · see citing works

Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain

Senapedis, W. T., Kennedy, C. J., Boyle, P. M., & Silver, P. A. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-10-0854 · Cited by 35 · see citing works

The Liver in Children With Metabolic Syndrome

D’Adamo, E., Castorani, V., & Nobili, V. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00514 · Cited by 35 · see citing works

Hypoxanthine Induces Muscular ATP Depletion and Fatigue via UCP2

Yin, C., Ma, Z., Li, F., Duan, C., Yuan, Y., Zhu, C., Wang, L., Zhu, X., Wang, S., Gao, P., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.647743 · Cited by 35 · see citing works

Nutrigenetics and Nutrigenomics of Caloric Restriction

Abete, I., Navas‐Carretero, S., Martí, A., & Martínez, J. A. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-398397-8.00013-7 · Cited by 35 · see citing works

Association betweenUCP3gene polymorphisms and nonalcoholic fatty liver disease in Chinese children

Xu, Y.-P. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i35.5897 · Cited by 33 · see citing works

Emerging Therapies and Future Directions in Pulmonary Arterial Hypertension

Gurtu, V., & Michelakis, E. D. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.01.028 · Cited by 33 · see citing works

Implications of mitochondrial uncoupling in skeletal muscle in the development and treatment of obesity

Thrush, A. B., Dent, R., McPherson, R., & Harper, M. (2013) · FEBS Journal · doi:10.1111/febs.12399 · Cited by 33 · see citing works

Identification of Key Pathways and Genes in Obesity Using Bioinformatics Analysis and Molecular Docking Studies

Joshi, H. R., Vastrad, B. M., Joshi, N., Tengli, A., Vastrad, C. M., & Kotturshetti, I. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.628907 · Cited by 31 · see citing works

Evaluating a new obesity indicator for stroke risk prediction: comparative cohort analysis in rural settings of two nations

Yao, F., Cui, J., Shen, Y., Jiang, Y., Li, Y., Liu, X., Feng, H., Jiao, Z., Liu, C., Hu, F., et al. (2024) · BMC Public Health · doi:10.1186/s12889-024-20631-5 · Cited by 30 · see citing works

Uncoupling proteins: Martin Klingenberg's contributions for 40 years

Echtay, K. S., Bienengraeber, M., Mayinger, P., Heimpel, S., Winkler, E., Druhmann, D., Frischmuth, K., Kamp, F., & Huang, S. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.09.006 · Cited by 30 · see citing works

Polymorphisms of the UCP2 gene are associated with body fat distribution and risk of abdominal obesity in Spanish population

Martínez‐Hervás, S., Mansego, M. L., de Marco, G., Martínez, F., Alonso, M. P., Morcillo, S., Rojo‐Martínez, G., Real, J. T., Ascaso, J. F., Redón, J., et al. (2011) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2011.02570.x · Cited by 30 · see citing works

Metabolic basis of solute carrier transporters in treatment of type 2 diabetes mellitus

Le, J., Chen, Y., Yang, W., Chen, L., & Ye, J. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.09.004 · Cited by 29 · see citing works

Polymorphisms of the UCP2 Gene Are Associated with Glomerular Filtration Rate in Type 2 Diabetic Patients and with Decreased UCP2 Gene Expression in Human Kidney

de Souza, B. M., Michels, M., Sortica, D. A., Bouças, A. P., Rheinheimer, J., Buffon, M. P., Bauer, A. C., Canani, L. H. S., & Crispim, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132938 · Cited by 29 · see citing works

Genetic polymorphisms and oxidative stress in non-alcoholic steatohepatitis (NASH): A mini review

de Oliveira, C. P. M. S., & Stefano, J. T. (2015) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2015.05.014 · Cited by 29 · see citing works

Variant in CAPN10 gene and environmental factors show evidence of association with excess weight among young people in a Colombian population.

Orozco, A. C., Contreras, A. M. M., Velásquez, C., Uscátegui, R. M., Parra, M. V., Villada, F. A. P., Correa, L. M. M., Parra, B. E., Estrada, A., & Agudelo, G. M. (2014) · PubMed · doi:10.1590/s0120-41572014000400007 · Cited by 28 · see citing works

The association of insertions/deletions (INDELs) and variable number tandem repeats (VNTRs) with obesity and its related traits and complications

Say, Y.-H. (2017) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-017-0142-x · Cited by 27 · see citing works

Mitochondrial function, mitochondrial DNA and ageing: a reappraisal

Passarino, G., Rose, G., & Bellizzi, D. (2010) · Biogerontology (Dordrecht) · doi:10.1007/s10522-010-9294-3 · Cited by 32 · see citing works

A 45-bp insertion/deletion polymorphism of UCP2 gene is associated with metabolic syndrome

Hashemi, M. M., Rezaei, H., Kaykhaei, M. A., & Taheri, M. (2014) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/2251-6581-13-12 · Cited by 25 · see citing works

Uncoupling Protein-2 45-Base Pair Insertion/Deletion Polymorphism: Is There an Association with Severe Obesity and Weight Loss in Morbidly Obese Subjects?

Papazoglou, D., Papathanasiou, P., Παπάνας, Ν., Papatheodorou, K., Chatziangeli, E., Nikitidis, I., Kotsiou, S., & Maltezos, E. S. (2012) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2012.0003 · Cited by 23 · see citing works

Molecular cloning and tissue expression of uncoupling protein 1, 2 and 3 genes in Chinese perch (Siniperca chuatsi)

Wen, Z., Liang, X., He, S., Li, L., Shen, D., & Tao, Y. (2015) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2015.03.005 · Cited by 22 · see citing works

Lycium barbarum Polysaccharides Promotes Mitochondrial Biogenesis and Energy Balance in a NAFLD Cell Model

Zhang, Y., Guo, Y.-Q., Fan, Y., Tao, X., Gao, Q., & Yang, J. (2021) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-021-3309-6 · Cited by 20 · see citing works

Integrative system biology and mathematical modeling of genetic networks identifies shared biomarkers for obesity and diabetes

Bima, A. I. H., Elsamanoudy, A. Z., Albaqami, W. F., Khan, Z., Snijesh, V. P., Alrayes, N. M., Kaipa, P. R., Elango, R., Banaganapalli, B., & Shaik, N. A. (2022) · Mathematical Biosciences & Engineering · doi:10.3934/mbe.2022107 · Cited by 22 · see citing works

Polymorphisms in the autosomal genes for mitochondrial function TFAM and UCP2 are associated with performance and longevity in dairy cows

Clempson, A. M., Pollott, G. E., Brickell, J. S., Bourne, N., Munce, N., & Wathes, D. C. (2011) · animal · doi:10.1017/s1751731111000346 · Cited by 20 · see citing works

The -866G/A polymorphism in the promoter of the UCP2 gene is associated with risk for type 2 diabetes and with decreased insulin levels

Gomathi, P., Samarth, A. P., Raj, N. B. A. J., Sasikumar, S., Murugan, P. S., Nallaperumal, S., & Selvam, G. S. (2019) · Gene · doi:10.1016/j.gene.2019.03.041 · Cited by 20 · see citing works

Yerba Mate Stimulates Mitochondrial Biogenesis and Thermogenesis in High‐Fat‐Diet‐Induced Obese Mice

dos Santos, T. W., Miranda, J., Teixeira, L., Aiastui, A., Matheu, A., Gambero, A., Portillo, M. P., & Ribeiro, M. L. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800142 · Cited by 20 · see citing works

The presence of the −866A/55Val/Ins haplotype in the uncoupling protein 2 (UCP2) gene is associated with decreased UCP2 gene expression in human retina

de Souza, B. M., Assmann, T. S., Kliemann, L. M., Marcon, A. S., Gross, J. L., Canani, L. H. S., & Crispim, D. (2011) · Experimental Eye Research · doi:10.1016/j.exer.2011.11.004 · Cited by 17 · see citing works

Effects of breeds and dietary protein levels on the growth performance, energy expenditure and expression of avUCP mRNA in chickens

Li, Q., Xu, Z., Liu, L., Yu, H., Hua, R., Tao, L., Zhang, X., Chen, X., Gu, D., Fan, Y., et al. (2013) · Molecular Biology Reports · doi:10.1007/s11033-012-2030-0 · Cited by 17 · see citing works

UCP3 Ablation Exacerbates High-Salt Induced Cardiac Hypertrophy and Cardiac Dysfunction

Lang, H., Yang, X., Ai, Z., You, Z., Jin, X., Wan, Y., & Yang, Y. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000489244 · Cited by 16 · see citing works

UCP2 I/D Modulated Change in BMI During a Lifestyle Modification Intervention Study in Japanese Subjects

Mutombo, P. B. W. B., Yamasaki, M., & Shiwaku, K. (2012) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2012.0229 · Cited by 15 · see citing works

Response of skeletal muscle UCP2-expression during metabolic adaptation to caloric restriction

Heinitz, S., Piaggi, P., Yang, S., Bonfiglio, S. M., Steel, J., Krakoff, J. A., & Votruba, S. B. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0085-2 · Cited by 15 · see citing works

sfkit: a web-based toolkit for secure and federated genomic analysis

Mendelsohn, S., Froelicher, D., Loginov, D., Bernick, D. L., Berger, B., & Cho, H. (2023) · Nucleic Acids Res. · doi:10.1093/nar/gkad464 · Cited by 12 · see citing works

Association of uncoupling protein gene polymorphisms with essential hypertension in a northeastern Han Chinese population

Sun, H., Zhang, J., Xie, X.-R., Li, T., Li, X., Wang, N., Li, J., Deng, Z.-H., & Qiu, C. (2018) · Journal of Human Hypertension · doi:10.1038/s41371-018-0141-3 · Cited by 13 · see citing works

Association between UCP1, UCP2, and UCP3 gene polymorphisms with markers of adiposity in European adolescents: The HELENA study

Pascual-Gamarra, J. M., Salazar‐Tortosa, D. F., Martínez‐Téllez, B., Labayen, I., Rupérez, A. I., Censi, L., Μanios, Y., Nova, E., Gesteiro, E., Moreno, L. A., et al. (2019) · Pediatric Obesity · doi:10.1111/ijpo.12504 · Cited by 13 · see citing works

Uncoupling protein 2 modulates polarization and metabolism of human primary macrophages via glycolysis and the NF‑κB pathway

Lang, L., Zheng, D., Jiang, Q., Meng, T., Ma, X., & Yang, Y. (2023) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2023.12282 · Cited by 12 · see citing works

Mitochondrial uncoupling protein 2: a central player in pancreatic disease pathophysiology

Wang, K., Zhang, L., Deng, B., Zhao, K., Chen, C., & Wang, W. (2024) · Molecular Medicine · doi:10.1186/s10020-024-01027-y · Cited by 12 · see citing works

The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican population

Gamboa, R., Huesca‐Gómez, C., López-Pérez, V., Posadas‐Sánchez, R., Cardoso-Saldaña, G. C., Medina-Urrutia, A. X., Juárez-Rojas, J. G., Soto, M. E., Posadas‐Romero, C., & Vargas‐Alarcón, G. (2018) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2017-0008 · Cited by 12 · see citing works

Berberine induces lipolysis in porcine adipocytes by activating the AMP‑activated protein kinase pathway

Yang, Y., Lu, R., Gao, F., Zhang, J., & Liu, F. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11070 · Cited by 12 · see citing works

UCP2–866G/A Polymorphism is Associated with Prediabetes and Type 2 Diabetes

Hou, G., Jin, Y., Liu, M., Wang, C., & Song, G. (2020) · Archives of Medical Research · doi:10.1016/j.arcmed.2020.06.001 · Cited by 12 · see citing works

Germinated Waxy Black Rice Suppresses Weight Gain in High-Fat Diet-Induced Obese Mice

Lim, W., Ho, J., Lee, H.-S., & Cho, H. (2016) · Journal of Medicinal Food · doi:10.1089/jmf.2015.3590 · Cited by 11 · see citing works

Vitamin D–vitamin D receptor system down-regulates expression of uncoupling proteins in brown adipocyte through interaction with Hairless protein

Wang, P.-Q., Pan, D.-X., Hu, C., Zhu, Y., & Liu, X.-J. (2020) · Bioscience Reports · doi:10.1042/bsr20194294 · Cited by 10 · see citing works

Network-Based Association Study of Obesity and Type 2 Diabetes with Gene Expression Profiles

Zhang, S., Wang, B., Shi, J., & Li, J. (2015) · BioMed Research International · doi:10.1155/2015/619730 · Cited by 9 · see citing works

Maya gene variants related to the risk of type 2 diabetes in a family-based association study

Domínguez-Cruz, M. G., Muñoz, M. D. L., Totomoch-Serra, A., García‐Escalante, M. G., Burgueño, J. A., Valadéz-González, N., Pinto-Escalante, D. D. C., & Díaz-Badillo, Á. (2019) · Gene · doi:10.1016/j.gene.2019.144259 · Cited by 9 · see citing works

The impact of solute carrier proteins on disrupting substance regulation in metabolic disorders: insights and clinical applications

Du, J., Shen, M., Chen, J., Yan, H., Xu, Z., Yang, X., Yang, B., Luo, P., Ding, K., Hu, Y., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1510080 · Cited by 9 · see citing works

Uncoupling Protein 2 as genetic risk factor for systemic lupus erythematosus: association with malondialdehyde levels and intima media thickness

Gambino, C. M., Accardi, G., Aiello, A., Caruso, C., Carru, C., Gioia, B. G., Guggino, G., Rizzo, S., Zinellu, A., Ciaccio, M., et al. (2020) · Minerva Cardioangiologica · doi:10.23736/s0026-4725.20.05225-1 · Cited by 8 · see citing works

Frequency of UCP2 45-bp Ins/Del polymorphism in Saudi population from Jazan area and its association with autoimmune hypothyroidism UCP2 45-bp Ins/Del frequency in hypothyroidism.

Kaabi, Y. A., Mansor, A. S., Alfagih, A. S., Hakami, A. M., Summ, M. A., Mjery, Y. A., Alzughbi, M. N., & Habibullah, M. M. (2020) · PubMed Central · Cited by 8 · see citing works

Uncoupling Protein 2 and Peroxisome Proliferator-Activated Receptor γ Gene Polymorphisms in Association with Diabetes Susceptibility in Chinese Han Population with Variant Glucose Tolerance

Zhou, M., He, S., Ping, F., Li, W., Zhu, L., Cui, X., Feng, L., Zhao, X., Zhang, H., Li, Y., et al. (2018) · International Journal of Endocrinology · doi:10.1155/2018/4636783 · Cited by 8 · see citing works

The energy intake modulates the association of the –55CT polymorphism of UCP3 with body weight in type 2 diabetic patients

Lapice, E., Monticelli, A., Cocozza, S., Pinelli, M., Giacco, A., Rivellese, A. A., Cocozza, S., Riccardi, G., & Vaccaro, O. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.174 · Cited by 7 · see citing works

Polymorphisms in the uncoupling protein 3 gene and their associations with feed efficiency in chickens

Jin, S., Yang, L., He, T., Fan, X., Wang, Y., Ge, K., & Geng, Z. (2018) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.18.0217 · Cited by 7 · see citing works

Loss of Uncoupling Protein 3 Attenuates Western Diet–Induced Obesity, Systemic Inflammation, and Insulin Resistance in Rats

Lomax, T. M., Ashraf, S., Yilmaz, G., & Harmancey, R. (2020) · Obesity · doi:10.1002/oby.22879 · Cited by 7 · see citing works

Protein Uncoupling as an Innovative Practice in Diabetes Mellitus Treatment: A Metabolic Disorder

Chaudhary, R., Gupta, S., & Chauhan, S. (2022) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530322666220902143401 · Cited by 7 · see citing works

The roles of orexins on sleep/wakefulness, energy homeostasis and intestinal secretion

Mäkelä, K. A. (2010) · Cited by 7 · see citing works

Role of UCP2 polymorphisms on dietary intake of obese patients who underwent bariatric surgery

Nicoletti, C. F., Kimura, B. M., de Oliveira, B. A. P., Pinhel, M. A. S., Salgado, W., Marchini, J. S., & Nonino, C. B. (2016) · Clinical Obesity · doi:10.1111/cob.12148 · Cited by 6 · see citing works

The A allele of the UCP2 -866G/A polymorphism changes UCP2 promoter activity in HUVECs treated with high glucose

Crispim, D., Rodrigues, M. A., da Silva, L. P. A., Bouças, A. P., Canani, L. H. S., Carlessi, R., & de Souza, B. M. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-04918-0 · Cited by 5 · see citing works

The effect of cranberry consumption on lipid metabolism and inflammation in human apo A-I transgenic mice fed a high-fat and high-cholesterol diet

Caceres, C., Kim, M., Bae, M., Pham, T. X., Lee, Y., Hu, S., O’Neill, E. N., Kim, B., Park, Y., & Lee, J. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520004080 · Cited by 5 · see citing works

Dynamic transcriptome profiles of skeletal muscle growth and development in Shaziling and Yorkshire pigs using RNA‐sequencing

Zheng, C., Zhong, Y., Zhang, P., Guo, Q., Li, F., & Duan, Y. (2024) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.13551 · Cited by 5 · see citing works

Potential protective effect of leptin and uncoupling protein-2 genes polymorphism in Egyptian patients with chronic kidney disease

Ghazaly, E. A., EL-Saeed, A. M., Abdelsalam, M., & Seoudi, D. M. (2020) · International Urology and Nephrology · doi:10.1007/s11255-020-02567-y · Cited by 5 · see citing works

Lack of association between 11 gene polymorphisms on weight loss 1 year after Roux‐en‐y gastric bypass surgery in woman

Novais, P. F. S., Crisp, A. H., Leandro‐Merhi, V. A., Verlengia, R., Rasera, I., & de Oliveira, M. R. M. (2022) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.13000 · Cited by 5 · see citing works

Genetic etiology and clinical features of non-syndromic pediatric obesity in the Chinese population: a large cohort study

Huang, H., Yang, Y., Yiwei, L., Li, Y., Liling, X., & Dongguang, Z. (2025) · BMC Pediatrics · doi:10.1186/s12887-025-05702-9 · Cited by 4 · see citing works

Relationship of short tandem repeats flanking leptin-melanocortin pathway genes with anthropometric profile and leptinemia in Brazilian individuals

Hinuy, H. M., Arazi, S. S., Hirata, M. H., Sampaio, M. F., Armaganijan, D., Cavalli, S. A., & Hirata, R. D. C. (2012) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302012000100008 · Cited by 4 · see citing works

Variante en CAPN10 y factores ambientales muestran evidencia de asociación con exceso de peso en jóvenes de Medellín, Colombia

Orozco, A. C., Contreras, A. M. M., Uscátegui, R. M., Parra, M. V., Villada, F. A. P., Correa, L. M. M., Parra, B. E., Estrada, A., Agudelo, G. M., & Velásquez, C. (2014) · Biomédica · doi:10.7705/biomedica.v34i4.2246 · Cited by 4 · see citing works

-866G/A and Ins/Del polymorphisms in the UCP2 gene and diabetic kidney disease: case-control study and meta-analysis

Dieter, C., Assmann, T. S., Lemos, N. E., Massignam, E. T., de Souza, B. M., Bauer, A. C., & Crispim, D. (2019) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2018-0374 · Cited by 4 · see citing works

The Polymorphisms of UCPs Genes Associated with Fat Metabolism

Jia, J. (2010) · China Animal Husbandry & Veterinary Medicine · Cited by 1 · see citing works

The polymorphisms of UCP1 genes associated with fat metabolism, obesity and diabetes

Jia, J., Tian, Y., Cao, Z.-H., Tao, L., Zhang, X., Gao, S., Ge, C., Lin, Q., & Jois, M. (2009) · Molecular Biology Reports · doi:10.1007/s11033-009-9550-2 · Cited by 96 · see citing works

Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes

Dalgaard, L. T., & Pedersen, O. B. (2001) · Diabetologia · doi:10.1007/s001250100596 · Cited by 217 · see citing works

Genetic variation in uncoupling protein 3 is associated with dietary intake and body composition in females

Damcott, C., Feingold, E., Moffett, S. P., Barmada, M. M., Marshall, J. A., Hamman, R. F., & Ferrell, R. E. (2004) · Metabolism · doi:10.1016/j.metabol.2003.11.019 · Cited by 33 · see citing works

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Zhang, S. (2006) · Medical Recapitulate