Uncoupling protein 3 expression levels influence insulin sensitivity, fatty acid oxidation, and related signaling pathways

Senese, Rosalba; Valli, Vivien; Moreno, Maria; Lombardi, Assunta; Busiello, Rosa Anna; Cioffi, Federica; Silvestri, Elena; Goglia, Fernando; Lanni, Antonia; de Lange, Pieter

doi:10.1007/s00424-010-0892-3

Cited by 52Metabolism, Diabetes, and CancerAdipose Tissue and MetabolismMitochondrial Function and Pathology

Uncoupling protein 3 expression levels influence insulin sensitivity, fatty acid oxidation, and related signaling pathways

Senese, Rosalba, Valli, Vivien, Moreno, Maria, Lombardi, Assunta, Busiello, Rosa Anna, Cioffi, Federica, Silvestri, Elena, Goglia, Fernando +2 more·2011·Pflügers Archiv - European Journal of Physiology

DOI 10.1007/s00424-010-0892-3

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Abstract

Controversy exists on whether uncoupling protein 3 (UCP3) positively or negatively influences insulin sensitivity in vivo, and the underlying signaling pathways have been scarcely studied. We studied how a progressive reduction in UCP3 expression (using UCP3 +/+, UCP3 +/-, and UCP3 -/- mice) modulates insulin sensitivity and related metabolic parameters. In order to further validate our observations, we also studied animals in which insulin resistance was induced by administration of a high-fat diet (HFD). In UCP3 +/- and UCP3 -/- mice, gastrocnemius muscle Akt/protein kinase B (Akt/PKB) (serine 473) and AMP-activated protein kinase (AMPK) (threonine 171) phosphorylation, and glucose transporter 4 (GLUT4) membrane levels were reduced compared to UCP3 +/+ mice. The HOMA-IR index (insulin resistance parameter) was increased both in the UCP3 +/- and UCP3 -/- mice. In these mice, insulin administration normalized Akt/PKB phosphorylation between genotypes while AMPK phosphorylation was further reduced, and sarcolemmal GLUT4 levels were induced but did not reach control levels. Furthermore, non-insulin-stimulated muscle fatty acid oxidation and the expression of several involved genes both in muscle and in liver were reduced. HFD administration induced insulin resistance in UCP3 +/+ mice and the aforementioned parameters resulted similar to those of chow-fed UCP3 +/- and UCP3 -/- mice. In conclusion, high-fat-diet-induced insulin resistance in wild-type mice mimics that of chow-fed UCP3 +/- and UCP3 -/- mice showing that progressive reduction of UCP3 levels results in insulin resistance. This is accompanied by decreased fatty acid oxidation and a less intense Akt/PKB and AMPK signaling.

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UCP3 expression in cultured myotubes and rodent skeletal muscle has been linked to modulation of fatty acid oxidation, mitochondrial integrity, and management of ROS/oxidative stress.
“its expression in cultured myotubes and rodent skeletal muscle has been linked to modulation of fatty acid oxidation [56–58], mitochondrial integrity, and to management of ROS/oxidative stress [59–62].”
From Proinflammatory NFkB signalling promotes mitochondrial dysfunction in skeletal muscle in response to cellular fuel overloading (2019) · cites this paper as [57]

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Authors: Senese, R., Valli, V., Moreno, M., Lombardi, A., Busiello, R. A., Cioffi, F., Silvestri, E., Goglia, F., Lanni, A., & de Lange, P.
Affiliations: University of Campania "Luigi Vanvitelli" (IT)
University of Naples Federico II (IT)
University of Sannio (IT)
Corresponding author: Lanni, Antonia
ORCID: Senese, Rosalba
Lombardi, Assunta
Cioffi, Federica
Silvestri, Elena
Goglia, Fernando
Lanni, Antonia
Venue: Pflügers Archiv - European Journal of Physiology
Publisher: Springer Science and Business Media LLC
Published: 2010-11-07
Volume: 461
Issue: 1
Pages: 153-164
ISSN: 0031-6768 (ISSN-L)
1432-2013
DOI: 10.1007/s00424-010-0892-3
OpenAlex: W2136747158
Cited by: 52
References: 40
Citations by year: 2025: 1 · 2024: 4 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 5 · 2012: 4
FWCI: 1.56
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Pflügers Archiv - European Journal of Physiology (publishedVersion)
PubMed (publishedVersion)
Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: UCP3, insulin sensitivity, insulin resistance, fatty acid oxidation, AMPK, GLUT4 translocation, skeletal muscle, high-fat diet, HOMA-IR, liver
MeSH terms: Uncoupling Protein 3, Animals, Dietary Fats, Fatty Acids, Insulin Resistance, Ion Channels, Male, Mitochondria, Muscle, Oxidation-Reduction, Phosphorylation, Signal Transduction, Muscle, Skeletal, Mitochondrial Proteins, Proto-Oncogene Proteins c-akt, Glucose Transporter Type 4, Mice, AMP-Activated Protein Kinases

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Uncoupling protein 3 expression levels influence insulin sensitivity, fatty acid oxidation, and related signaling pathways

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