The DOI matches its Crossref record; 288 of the 288 references it cites were found in a registry or an index.
Epigenetics and the biological definition of gene×environment interactions
Abstract
Variations in phenotype reflect the influence of environmental conditions during development on cellular functions, including that of the genome. The recent integration of epigenetics into developmental psychobiology illustrates the processes by which environmental conditions in early life structurally alter DNA, providing a physical basis for the influence of the perinatal environmental signals on phenotype over the life of the individual. This review focuses on the enduring effects of naturally occurring variations in maternal care on gene expression and phenotype to provide an example of environmentally driven plasticity at the level of the DNA, revealing the interdependence of gene and environmental in the regulation of phenotype.
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In the citing paper
“Through stress physiology, the feedback system extends to the genetic level to influence gene expression”
From School Readiness and Self-Regulation: A Developmental Psychobiological Approach (2015) · cites this paper as Meaney 2010
In the citing paper
“This process begins before conception (via parental experiences) and contributes to the transmission of behaviors and experiences to future generations (e.g., Keating, 2016;Meaney, 2010)”
From Malleability, plasticity, and individuality: How children learn and develop in context1 (2019) · cites this paper as Meaney, 2010
In the citing paper
“Intergenerational transmission of behavior (mediated by genes, experience, and their interplay) or risk can also be viewed as cascade effects linking multiple generations and multiple behaviors or levels of analysis (Meaney, 2010).”
From Developmental cascades (2010) · cites this paper as Meaney, 2010
In the citing paper
“relatively low quality maternal care in the rat (i.e., low levels of maternal licking and grooming) alters pups’ stress physiology and brain morphology.”
From The Adaptive Calibration Model of stress responsivity (2011) · cites this paper as Meaney, 2010
In the citing paper
“variations in stress physiology and brain morphology apparently represent strategic – that is, functional – ways of developing under different rearing conditions”
From The Adaptive Calibration Model of stress responsivity (2011) · cites this paper as Meaney, 2010
In the citing paper
“The social context is the setting in which OT exerts its cross-generational effects in mammals (3,28)”
From Oxytocin administration to parent enhances infant physiological and behavioral readiness for social engagement (2012) · cites this paper as [28]
In the citing paper
“Porges and Carter (59) suggest that the oxytocinergic and autonomic systems enhance each other through positive feedback mechanisms and jointly establish a sense of safety that enables the formation of affiliative bonds (28,59,60).”
From Oxytocin administration to parent enhances infant physiological and behavioral readiness for social engagement (2012) · cites this paper as [28]
Citations
Cites
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Crystal structure of the nucleosome core particle at 2.8 Å resolution
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Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
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DNA methylation patterns and epigenetic memory
Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177
Self-citationPhysiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429 · cited 5×
“…these same responses: chronically enhanced emotional arousal, sustained increases in blood sugars and fats, possible hyperinflammation, disruption of sleep and normal cognitive function, among others (Chrousos & Gold, 1992; Dallman et al., 2005; McEwen, 2007; Sapolsky et al., 2000; Walker, 2007).”
BackgroundInfluential
Research works printed but not linked: 7
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Cited by
Sorted by citations
The Lifelong Effects of Early Childhood Adversity and Toxic Stress
Shonkoff, J. P., Garner, A. S., THE COMMITTEE ON PSYCHOSOCIAL ASPECTS OF CHILD AND FAMILY HEALTH, C. O. E. C., Siegel, B. S., Dobbins, M. I., Earls, M. F., Garner, A. S., McGuinn, L., Pascoe, J., & Wood, D. L. (2012) · Pediatrics · doi:10.1542/peds.2011-2663 · Cited by 5,164
Norman, R. E., Byambaa, M., De, R., Butchart, A., Scott, J., & Vos, T. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001349 · Cited by 3,387
Masten, A. S., & Cicchetti, D. (2010) · Development and Psychopathology · doi:10.1017/s0954579410000222 · Cited by 1,800
Global perspectives on resilience in children and youth
Masten, A. S. (2014) · Child Development · doi:10.1111/cdev.12205 · Cited by 1,710
The Adaptive Calibration Model of stress responsivity
Del Giudice, M., Ellis, B. J., & Shirtcliff, E. A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.11.007 · Cited by 1,373
Metadata
- Authors
- Meaney, M. J.
- Affiliations
- McGill University (CA)
- Corresponding author
- Meaney, Michael J
- ORCID
- Meaney, Michael J
- Venue
- Child Development
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-01-01
- Volume
- 81
- Issue
- 1
- Pages
- 41-79
- ISSN
- 0009-3920 (ISSN-L)
- 1467-8624
- OpenAlex
- W2128782957
- Cited by
- 1,239
- References
- 287
- Citations by year
- 2026: 57 · 2025: 42 · 2024: 25 · 2023: 33 · 2022: 35 · 2021: 41 · 2020: 151 · 2019: 65 · 2018: 75 · 2017: 84 · 2016: 98 · 2015: 122 · 2014: 111 · 2013: 97 · 2012: 96
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Child Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- epigenetics, gene-environment interaction, maternal care, early life environment, DNA methylation, gene expression, phenotypic plasticity, developmental psychobiology, perinatal environment
- MeSH terms
- Child, Child Development, Critical Period, Psychological, DNA, Humans, Maternal Behavior, Phenotype, Social Environment, Genome, Human, Gene Expression Regulation, Developmental, Epigenesis, Genetic
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