Cited by 1,239Epigenetics and DNA MethylationBirth, Development, and HealthNeuroendocrine regulation and behavior

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Epigenetics and the biological definition of gene×environment interactions

Meaney, Michael J·2010·Child Development

DOI 10.1111/j.1467-8624.2009.01381.x

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Abstract

Variations in phenotype reflect the influence of environmental conditions during development on cellular functions, including that of the genome. The recent integration of epigenetics into developmental psychobiology illustrates the processes by which environmental conditions in early life structurally alter DNA, providing a physical basis for the influence of the perinatal environmental signals on phenotype over the life of the individual. This review focuses on the enduring effects of naturally occurring variations in maternal care on gene expression and phenotype to provide an example of environmentally driven plasticity at the level of the DNA, revealing the interdependence of gene and environmental in the regulation of phenotype.

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Authors: Meaney, M. J.
Affiliations: McGill University (CA)
Corresponding author: Meaney, Michael J
ORCID: Meaney, Michael J
Venue: Child Development
Publisher: Oxford University Press (OUP)
Published: 2010-01-01
Volume: 81
Issue: 1
Pages: 41-79
ISSN: 0009-3920 (ISSN-L)
1467-8624
DOI: 10.1111/j.1467-8624.2009.01381.x
OpenAlex: W2128782957
Cited by: 1,239
References: 287
Citations by year: 2026: 57 · 2025: 42 · 2024: 25 · 2023: 33 · 2022: 35 · 2021: 41 · 2020: 151 · 2019: 65 · 2018: 75 · 2017: 84 · 2016: 98 · 2015: 122 · 2014: 111 · 2013: 97 · 2012: 96
FWCI: 8.37
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 34 d)
Locations: Child Development (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: epigenetics, gene-environment interaction, maternal care, early life environment, DNA methylation, gene expression, phenotypic plasticity, developmental psychobiology, perinatal environment
MeSH terms: Child, Child Development, Critical Period, Psychological, DNA, Humans, Maternal Behavior, Phenotype, Social Environment, Genome, Human, Gene Expression Regulation, Developmental, Epigenesis, Genetic

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Epigenetics and the biological definition of gene×environment interactions

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